Behavioural Neurology最新文献

{"title":"Understanding Routine Treatment and Resource Availability for Fatigue in Multiple Sclerosis in the United Kingdom.","authors":"Federica Picariello, Madison Milne-Ives, Jennifer Freeman, Rona Moss-Morris","doi":"10.1155/bn/8169644","DOIUrl":"https://doi.org/10.1155/bn/8169644","url":null,"abstract":"<p><strong>Background: </strong>Fifty-five to ninety percent of people with multiple sclerosis (MS) report disabling fatigue, but a previous survey found that only 31% of UK adults with MS experiencing fatigue report being offered any treatment. The aim of this study was to capture the service perspective of routine care for MS fatigue and resource availability.</p><p><strong>Methods: </strong>A cross-sectional online survey was distributed to NHS services across the United Kingdom to be completed by healthcare professionals working with people with MS.</p><p><strong>Results: </strong>Eighteen services completed the survey. Services supported a median of 1100 patients. Allied healthcare professional availability varied across services but was generally low (median range 0-6 staff per type). On average, services estimated that only 28% (SD = 26.51) of patients were receiving fatigue treatments.</p><p><strong>Conclusions: </strong>Findings highlighted the unmet need around MS fatigue management, complementing previously captured patient perspectives. Although the study included a small, self-selecting subset of services and may have been influenced by the COVID-19 pandemic, it demonstrates the necessity of accounting for resource availability to successfully implement new fatigue interventions.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e8169644"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher HbA1c-Hemoglobin Ratio Was Associated With Poor Outcome in Endovascular Thrombectomy Patients.","authors":"Feng Gao, Shuaiyu Chen, Xingjing Guo, Weiyao Xu, Chengfeng Guan, Shiyao Wang, Yanyan Shi, Shuo Wang","doi":"10.1155/bn/6668235","DOIUrl":"https://doi.org/10.1155/bn/6668235","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recent studies have identified the HbA1c-to-hemoglobin ratio (HHR) as a potential indicator for increased mortality from all causes and cardiovascular diseases. This investigation sought to determine whether HHR could serve as a prognostic marker for neurological function at 90 days in patients undergoing endovascular thrombectomy procedures.</p><p><strong>Methodology: </strong>This study performed a retrospective evaluation of patients undergoing endovascular treatment (EVT) at Nanjing First Hospital from April 2022 to June 2024. The HHR was determined by dividing HbA1c levels by hemoglobin values. Poor clinical outcomes were characterized by modified Rankin Scale scores ranging from 3 to 6 at the 90-day follow-up. Multivariate logistic regression analysis was employed to examine the association between HHR values and posttreatment functional outcomes.</p><p><strong>Results: </strong>The study enrolled 353 participants (average age of 70.5 years with a standard deviation of 12.2 years; 218 were male), of whom 181 (51.3%) showed adverse clinical results after 90 days. Multivariate regression analysis revealed that higher HHR levels upon hospital admission independently predicted worse functional recovery (adjusted OR: 10.484; 95% confidence interval: 4.581-23.990; p = 0.001). Additional investigation using restricted cubic spline methodology confirmed a nonlinear, dose-dependent relationship between HHR values and negative prognosis likelihood (nonlinearity p value = 0.001). When implemented in a predictive framework, continuous HHR measurements exhibited a strong discriminatory capability, achieving a receiver operating characteristic curve value of 0.760 (95% CI: 0.710-0.810).</p><p><strong>Conclusion: </strong>Increased HHR levels demonstrate an independent correlation with poorer 90-day recovery rates among ischemic stroke patients undergoing endovascular thrombectomy. This evidence positions HHR as a potentially valuable indicator for clinical prognosis assessment in such cases.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e6668235"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Verification of Mitochondria-Related Diagnostic Markers of Spinal Cord Injury by WGCNA and Machine Learning.","authors":"Haifeng Chen, Wei Cai, Yunpeng Zhang, Xiaoming Tang, Jian Dai, Yao Li, Jian Ma","doi":"10.1155/bn/1749750","DOIUrl":"https://doi.org/10.1155/bn/1749750","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) significantly impacts patients, with mitochondrial dysfunction playing a critical role in its pathology. Identifying mitochondria-related genes may offer new therapeutic and prognostic insights.</p><p><strong>Methods: </strong>RNA sequencing data from the GEO database were analyzed to identify differentially expressed genes (DEGs). Functional enrichment analyses were conducted, and weighted gene coexpression network analysis (WGCNA) alongside machine learning algorithms was used to identify key mitochondria-related genes. Immune infiltration was assessed using the EPIC algorithm, and single-cell RNA sequencing (scRNA-seq) data were analyzed for cellular diversity.</p><p><strong>Results: </strong>A total of 2566 upregulated and 2634 downregulated genes were identified in SCI versus control samples. GO and KEGG enrichment analyses revealed these DEGs were primarily involved in oxidative stress, mitochondrial function, and immune pathways, including necroptosis and T cell receptor signaling. Then, 1578 genes with the strongest correlation to SCI were selected by WGCNA. By integrating DEGs, WGCNA module genes, and mitochondria-related genes, 76 candidate genes were obtained and used to construct a PPI network. Six hub genes (NDUFB3, SLC25A24, SLC25A40, GSTZ1, MAOA, and MRPL12) were identified by machine learning, all showing strong diagnostic potential (AUC > 0.77). Immune infiltration analysis indicated reduced B and T cell infiltration and increased macrophage activity in SCI samples. scRNA-seq analysis further revealed higher expression of NDUFB3 in dendritic cells and MAOA in pro-B cells, suggesting their involvement in immune regulation and mitochondrial dysfunction.</p><p><strong>Conclusion: </strong>These six genes represent potential biomarkers and therapeutic targets for SCI, providing insights into its molecular mechanisms and immune response.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e1749750"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden of Epilepsy in Thailand: Estimating Societal Costs and Quality of Life.","authors":"Prapassara Sirikarn, Surachai Phimha, Luxzup Wattanasukchai, Sineenard Mungmanitmongkol, Somsak Tiamkao","doi":"10.1155/bn/2885542","DOIUrl":"https://doi.org/10.1155/bn/2885542","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy imposes both economic and quality-of-life (QOL) burdens. Therefore, this study is aimed at evaluating the costs of illness and QOL in patients with epilepsy (PWE) and their caregivers and to examine the differences in costs and QOL across patient characteristics.</p><p><strong>Methods: </strong>This prevalence-based cost-of-illness study was conducted from a societal perspective. Data were collected from patients who attended the Epilepsy Clinic at Srinagarind Hospital, Khon Kaen University, between April and August 2023. QOLs were assessed using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) for PWE and the EuroQoL-5D-5L (EQ-5D-5L) for caregivers. A generalized linear model was used to assess the differences in costs and QOL across patient and caregiver characteristics.</p><p><strong>Results: </strong>A total of 214 subjects were enrolled in this study, comprising 129 PWE and 85 caregivers. The mean total cost of illness per outpatient visit was 452.27 PPP-USD, with 58.0% attributed to direct medical costs, 24.4% to direct nonmedical costs, and 17.6% to indirect costs. Direct medical costs differed significantly based on employment status (p value = 0.031) and seizure control (p value = 0.018). Direct nonmedical costs showed differences by residential distance (p value < 0.001). Indirect costs also showed differences by age (p value = 0.019) and residential distance (p value = 0.002). The lifetime productivity loss from unemployment reached 14638.37 PPP-USD per patient. The mean overall QOLIE-31 score was 74.04 points, and the mean EQ-5D-5L index was 0.90. There were differences in QOL based on age and seizure control in PWE, as well as age and unemployment status in caregivers.</p><p><strong>Conclusion: </strong>Direct medical costs were the largest component of total costs. Cost differences were found across age, employment status, residential distance, and seizure control. QOL varied by age and seizure control in PWE and by age and unemployment status in caregivers.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e2885542"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiolytic and Antidepressant-Like Effects of a Probiotic Mixture HMLH123 Potentially via the Serotonergic Pathway in Wistar Rats.","authors":"Gilberto Uriel Rosas-Sánchez, León Jesús Germán-Ponciano, Angélica Yanet Nápoles-Medina, Blanca Rosa Aguilar-Uscanga, Mario Eduardo Flores-Soto, Cesar Soria-Fregozo","doi":"10.1155/bn/6680245","DOIUrl":"https://doi.org/10.1155/bn/6680245","url":null,"abstract":"<p><p>Anxiety and depression are a major health problem worldwide with increasing prevalence and limitations in pharmacologic treatment. The gut-brain axis has emerged as a potential therapeutic target, with probiotics showing promise in the regulation of mental health. To evaluate the anxiolytic and antidepressant-like effects of a probiotic mixture HMLH123 and its pharmacologic interaction with fluoxetine, 60 male Wistar rats were divided into six experimental groups that received either vehicle, fluoxetine (0.5 or 1 mg/kg), probiotic mixture HMLH123 200 μL to a concentration of 10⁹ CFU/mL (Lactiplantibacillus sp. LH01, Lactiplantibacillus sp. LH02, and Lactiplantibacillus sp. LH3), or a combination of fluoxetine and probiotic mixture HMLH123. Behavioral assessments included the locomotor activity test (LAT), the elevated plus maze (EPM), and the forced swim test (FST). Data were analyzed using one-way ANOVA with a significance level of p ≤ 0.05. Administration of probiotic mixture HMLH123 or in combination with fluoxetine significantly increased the time spent in the open arms of the EPM, indicating anxiolytic-like effects. In the FST, groups treated with probiotic mixture HMLH123 showed reduced immobility time and increased swimming behavior, suggesting a possible modulation of the serotonergic system. These findings support the potential of probiotic mixture HMLH123 as a preclinical alternative approach for the treatment of anxiety and depression. While no synergistic interaction with fluoxetine was observed, treatment with the probiotic mixture showed positive effects independently. Further research should explore its mechanisms of action and therapeutic applications as a standalone intervention.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e6680245"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Cognition in Multiple Sclerosis: A Multidomain Investigation.","authors":"Dalya Eda Akbalık, Murat Kürtüncü, Tuncay Gündüz, Mario Bonato","doi":"10.1155/bn/5973577","DOIUrl":"https://doi.org/10.1155/bn/5973577","url":null,"abstract":"<p><p>While cognitive functioning in multiple sclerosis has been extensively studied, the presence of social cognition deficits in persons affected by relapsing-remitting multiple sclerosis (RRMS) remains comparatively less explored. This study recruited 30 Turkish patients with RRMS and 30 healthy controls (HCs) matched for demographic characteristics and cognitive status. We tested their social cognition abilities within two main subdomains, namely, theory of mind (ToM) and emotion recognition. The combination of tests we used was novel and rather broad as ToM was evaluated in both its affective and cognitive components while emotion recognition was evaluated in two tasks requiring either naming or discriminating facial expressions. All tests required verbal responses and were scored in terms of accuracy. The results indicated that patients with RRMS exhibited significantly lower accuracy compared to the HC group across all social cognition tasks. Correlation analyses revealed a significant negative relationship between emotion discrimination performance and both level of disability and disease duration. Additionally, RRMS patients showed significant deficits in recognizing negative emotions, while no differences with the HC group were observed for positive emotion recognition. The presence of a domain-specific, selective deficit for social cognition was also confirmed after further controlling for overall cognitive functioning. Our findings capitalize on previous evidence demonstrating that social cognition impairments in RRMS have domain-specific characteristics and can be reliably detected in a new cultural context.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e5973577"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Muscle Relaxation Therapy in Epilepsy Management: Its Influence on Stress, Fatigue, and Quality of Life.","authors":"Serpil Özmen, Afife Yurttaş","doi":"10.1155/bn/1370445","DOIUrl":"https://doi.org/10.1155/bn/1370445","url":null,"abstract":"<p><p>The purpose of this study is to assess the impact of progressive muscle relaxation exercises on fatigue, stress, and quality of life among individuals with epilepsy. This study was conducted as a randomized controlled intervention, incorporating a control group and pretest and posttest assessments. Between July 2019 and April 2020, a total of 75 patients with epilepsy participated, with 35 assigned to the intervention group and 40 to the control group. Participants in the intervention group were instructed to perform progressive muscle relaxation exercises three times per week for 6 weeks. No interventions were provided to the control group. Data were gathered using the personal information form, the Perceived Stress Scale (PSS), the Fatigue Severity Scale (FSS), and the Quality of Life in Epilepsy Inventory (QOLIE-31). The mean FSS total score of the patients in the intervention group decreased significantly compared to those in the control group after the intervention (p < 0.05). No statistically significant change was observed in the stress scores. Cognitive and social function scores of the QOLIE-31 scale subdimensions of the patients in the control and intervention groups were found to be significant (p < 0.05). Cognitive and social function scores of the patients in the intervention group were higher than those in the control group. Progressive muscle relaxation exercises were determined that progressive relaxation exercises did not reduce stress in patients with epilepsy but had a positive effect on fatigue and cognitive and social function scores, which are subscales of quality of life. Progressive relaxation exercises may be proposed as a complementary nursing intervention for patients undergoing epilepsy treatment. TRIAL REGISTRATION: ClinicalTrials.gov identifier: 1370445.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e1370445"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Patients, Preventing Strokes: Knowledge of Risk Factors and Associated Factors, Prevention Strategies, and Treatment Awareness Among Chronic Disease Patients in Southern Ethiopia.","authors":"Takla Tamir, Selamawit Yizelkal, Bekahegn Girma, Abraham Dessie Gessesse, Atrsaw Shimekaw","doi":"10.1155/bn/7202918","DOIUrl":"https://doi.org/10.1155/bn/7202918","url":null,"abstract":"<p><strong>Background: </strong>The burden of stroke is largely due to modifiable risk factors. Lack of knowledge about stroke and its risk factors hinders prevention and treatment. Effective health promotion programs need context-specific data on the target population's knowledge and practices. However, there is a shortage of data on the public's understanding of stroke and its risk factors in sub-Saharan Africa.</p><p><strong>Objective: </strong>This study is aimed at assessing the knowledge of chronic disease patients about stroke risk factors, prevention methods, treatment options, and associated factors.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in southern Ethiopia from February to April 2024. A total of 430 chronic disease patients were included by systematic random sampling. Data were collected using a structured questionnaire and medical records. Statistical analysis was performed using SPSS. Ethical clearance was obtained.</p><p><strong>Result: </strong>A total of 430 patients participated, with hypertension being the most prevalent chronic disease. Only 25.1% demonstrated good knowledge of stroke risk factors. In multivariable analysis, good knowledge of stroke risk factors was significantly associated with receiving care in private institutions (AOR = 2.6; 95% CI: 1.1-5.9), having a degree or higher education (AOR = 6.5; 95% CI: 1.9-21.9), urban residence (AOR = 3.3; 95% CI: 1.4-7.9), family history of stroke (AOR = 5.3; 95% CI: 2.1-13.0), appropriate follow-up (AOR = 3.4; 95% CI: 1.4-8.4), and prior information from healthcare providers (AOR = 2.2; 95% CI: 1.0-4.5). In contrast, merchants, farmers/housewives, and other occupational groups had significantly lower odds of good knowledge compared with employees. Some estimates showed wide confidence intervals, indicating limited precision and the need for cautious interpretation. Awareness of treatment and prevention methods was limited, with only 33.3% answering over 50% of prevention questions correctly.</p><p><strong>Conclusion: </strong>The study revealed a significant lack of knowledge about stroke risk factors and prevention methods among chronic disease patients in southern Ethiopia. This highlights the urgent need for targeted health education interventions. Implementing comprehensive health promotion programs that address stroke-related knowledge gaps is crucial. These should be tailored to specific demographics and delivered through various channels, healthcare settings, communities, and media.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e7202918"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the Gap: A Systematic Review of Borderline Intellectual Functioning in Childhood and Adolescence.","authors":"Paolo Stievano, Valeria Mammarella, Carlo Di Brina","doi":"10.1155/bn/9979097","DOIUrl":"10.1155/bn/9979097","url":null,"abstract":"<p><strong>Background: </strong>Borderline intellectual functioning (BIF) is characterized by an IQ between 70 and 84/85, representing a cognitive condition associated with significant learning, academic, and behavioral challenges. Despite its prevalence and impact, BIF remains underrecognized in diagnostic classifications, leading to inconsistent clinical management and limited research attention.</p><p><strong>Objectives: </strong>This systematic review is aimed at synthesizing the current literature on BIF in childhood and adolescence, focusing on its neuropsychological profiles, prevalence, and effective strategies to improve quality of life.</p><p><strong>Methods: </strong>We conducted a systematic review following the PRISMA 2020 guidelines. Articles published between 2013 and 2023 were identified through electronic databases, including MEDLINE, PsycInfo, and CINAHL. Inclusion criteria were studies presenting empirical data on BIF in individuals aged 0-18 years, with quantitative results on intellectual and adaptive functioning. Excluded were intervention studies, reviews, and studies focusing on unrelated neuropsychological domains.</p><p><strong>Results: </strong>From 455 articles identified, eight met the inclusion criteria. Key findings include that BIF is associated with cognitive deficits, particularly in working memory and academic skills, with a 2-year developmental lag in reading and arithmetic. Prevalence estimates range from 7% to 14%, influenced by socioeconomic factors and environmental stressors. Tailored educational programs and vocational training are effective in addressing cognitive and adaptive challenges, highlighting the need for personalized interventions.</p><p><strong>Conclusions: </strong>BIF presents significant clinical, educational, and social challenges that require standardized diagnostic criteria and targeted interventions. Future research should focus on refining diagnostic approaches, exploring cognitive subtyping, and implementing cost-effective support systems to enhance the well-being of individuals with BIF.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e9979097"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Syndrome Mediates the Association Between Body Roundness Index and Incident Stroke Risk in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.","authors":"Gaiying Ma, Hongwei Liu, Haiyan Wu, Minheng Zhang, Yonglai Zhang, Haixia Fan, Ke Shi","doi":"10.1155/bn/1282354","DOIUrl":"https://doi.org/10.1155/bn/1282354","url":null,"abstract":"<p><strong>Background: </strong>Despite BRI being a novel measure for chronic disease risk, the relationship between BRI and stroke risk under varying circadian syndrome (CircS) conditions is still unclear.</p><p><strong>Methods: </strong>The analysis utilized data from 7535 participants involved in the China Health and Retirement Longitudinal Study (CHARLS). CircS was defined by at least four concurrent metabolic disturbances due to circadian rhythm disruption. To ensure robustness, the BRI-stroke association was assessed using Cox models, restricted cubic splines, Kaplan-Meier curves, and mediation analyses, along with subgroup and sensitivity analyses. The receiver operating characteristic (ROC) analysis was used to compare the stroke risk prediction performance of BRI with conventional metabolic indices.</p><p><strong>Results: </strong>Following full adjustment, higher log (BRI) values were significantly associated with an increased risk of stroke (HR = 2.50, 95% CI: 1.81-3.44, p < 0.001), with Q4 showing a greater risk than Q1 (HR = 2.23, 95% CI: 1.63-3.04, p < 0.001). In CircS patients, no significant association was observed (log (BRI) HR = 1.23, 95% CI: 0.55-2.76; Q4 vs. Q1 HR = 0.61, 95% CI: 0.21-1.77; all p > 0.05). However, the association remained significant in non-CircS individuals (log (BRI) HR = 2.36, 95% CI: 1.61-3.47; Q4 vs. Q1 HR = 2.08, 95% CI: 1.46-2.98; all p < 0.001). Subgroup and sensitivity analyses bolstered the robustness of our findings. CircS mediated 21.0% of the association between BRI and stroke risk (95% CI: 18%-91%, p < 0.001). With an area under the curve (AUC) of 0.656, BRI demonstrated moderate predictive capability for stroke, outperforming other anthropometric indices.</p><p><strong>Conclusions: </strong>An increased BRI is associated with a higher stroke risk, partially mediated by CircS, highlighting the potential role of circadian health in stroke prevention.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2026 1","pages":"e1282354"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}