Behavioural Neurology最新文献

{"title":"Association Between Neutrophil Percentage-to-Albumin Ratio and Depression in Middle-Aged and Elderly Adults: A National Study.","authors":"Leiyong Zhao, Chengjun Li, Hequn Lv, Chunli Zeng, Yongjun Peng","doi":"10.1155/bn/4199054","DOIUrl":"10.1155/bn/4199054","url":null,"abstract":"<p><p><b>Background:</b> The association between inflammatory markers and depression has garnered increasing attention. The neutrophil percentage-to-albumin ratio (NPAR) is an emerging inflammatory marker, but its association with depression in middle-aged and elderly adults was not previously explored. The purpose of this study was to investigate the association through a national study in the United States. <b>Methods:</b> All study data were weighted to ensure representativeness. Multivariate logistic regression models were applied to explore the independent relationship of NPAR with depression in middle-aged and elderly adults. Restricted cubic splines were employed to examine potential nonlinear association, with turning points calculated using a recursive algorithm upon detecting nonlinearity. Stratified analyses and interaction tests were conducted to explore subgroup differences. <b>Results:</b> In the model adjusted for all confounding factors, no significant relationship was found between NPAR and depression in middle-aged and elderly adults [1.02 (0.92, 1.12)]. Further sensitivity analysis indicated a potential U-shaped relationship between NPAR and depression in middle-aged and elderly adults, with the OR (95% CI) of 0.74 (0.60, 0.92), 0.87 (0.70, 1.08), 0.92 (0.72, 1.19) for Q2, Q3, and Q4, respectively, compared to Q1. The U-shaped association was confirmed by the restricted cubic spline. Subsequent analysis identified an inflection point at 14.05, revealing inverse relationships before and after this point. Subgroup analysis indicated sex differences in this association. <b>Conclusion:</b> This large-scale cross-sectional study identified a U-shaped association between NPAR and depression in American middle-aged and elderly adults.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"4199054"},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.","authors":"Peile Liu, Jian Hu, Beiyao Gao, Yan Hua, Ying Xing, Yulong Bai, Nan Liu","doi":"10.1155/bn/3631524","DOIUrl":"10.1155/bn/3631524","url":null,"abstract":"<p><p>For decades, scientists have explored the patterns of neural network remodeling that occur after a stroke. Several studies have shown that both motor cortexes (MCs) undergo crucial remodeling after cerebral ischemia. However, the mechanism by which corticofugal fibers are remodeled is not well understood. Therefore, this study was aimed at investigating the changes in the bilateral red nucleus (RN) and MC-RN projections during recovery from a large-area stroke in a rat stroke model with or without constraint-induced movement therapy (CIMT). A large-area middle cerebral artery occlusion (MCAO) model was established in rats using the Longa method. CIMT was initiated 7 days after MCAO and continued for 1, 2, or 3 weeks. Rats in the control group underwent spontaneous recovery. Locomotor impairment was evaluated using the CatWalk automated gait analysis system, and overall neurological function was evaluated with the modified neurological severity score. Bilateral MC-RN projections were visualized by labeling fiber tracts with an anterograde tracer. Postsynaptic density 95 (PSD95), growth-associated protein 43 (GAP43), and synaptophysin expression levels in the RN were detected using western blotting and immunohistochemistry. The results showed that CIMT promoted motor recovery after a stroke, increased levels of GAP43 and PSD95 in the contralesional but not ipsilesional RN, and increased projections from the MC to the bilateral RN. Thus, CIMT promotes neuroplasticity after a large-area stroke by stimulating axon outgrowth, improving postsynaptic membrane function in the contralesional RN, and increasing bilateral projections of the MC-RN. These results provide evidence for the therapeutic efficacy of CIMT in restoring motor function and help with understanding RN plasticity after a large-area stroke.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"3631524"},"PeriodicalIF":2.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Relationship Between Cortical Thickness and Sensory Motor Symptoms in Adults on the Autism Spectrum.","authors":"David James, Vicky T Lam, Booil Jo, Lawrence K Fung","doi":"10.1155/bn/2951294","DOIUrl":"10.1155/bn/2951294","url":null,"abstract":"<p><p><b>Background:</b> Autism spectrum disorder (ASD) involves alterations in both cortical morphology and sensory processing. These structural and perceptual changes may lie on a continuum with typically developing (TD) individuals. However, investigations on possible links between these two factors are lacking, and it remains to be seen if their relationship differs by sex. We hypothesized that cortical thickness in the postcentral gyrus (a somatosensory processing hub) would correlate with sensory processing symptoms in a combined cohort of autistic and TD individuals. We also hypothesized that these correlations would differ based on sex. <b>Methods:</b> We studied 23 autistic adults and 27 TD adults using magnetic resonance imaging to measure the cortical thickness of the postcentral gyrus and the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) to measure autism characteristics, with a particular focus on the sensory motor subscale. <b>Results:</b> The left postcentral gyrus (PCG) was found to be thicker in the autism group than in the TD group (<i>d</i> = 0.946, <i>p</i> = 0.003), particularly in autistic males compared to TD males and TD females. The RAADS-R sensory motor subscale and bilateral PCG cortical thickness were positively correlated across both autistic and TD males (Spearman's rho = 0.481, <i>p</i> = 0.008) but not females. These correlations were specific to the sensory motor subscale, as no correlations were found for RAADS-R total score or any of the other subscales. <b>Conclusions:</b> These results demonstrate sex-specific differences in the relationship between cortical thickness at the PCG and sensory processing in autistic individuals and that these differences exist along a continuum that extends into the TD population. Our findings contribute to furthering our understanding of sex-specific neuroanatomical differences in people on the autism spectrum. The left PCG thickness could be a potential sex-specific biomarker for sensorimotor function that is generally applicable in both neurotypical and autism populations. With further validations, this biomarker could be used to track responses to interventions targeting sensorimotor challenges in people on the autism spectrum.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"2951294"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Public Knowledge, Attitudes, and Awareness Toward Seizure Episodes Among Residents of Madinah: A Saudi Cross-Sectional Study.","authors":"Bayan M Almarwani, Sadin Ayman Alamri, Aseel Ayman Alamri, Ahmad Salim Badawi, Zakaria Yahya Khawaji, Afnan Mohammad Akhwan, Basel MohammedBassam Garah, Abdullah A Tawakul","doi":"10.1155/bn/2142400","DOIUrl":"10.1155/bn/2142400","url":null,"abstract":"<p><p><b>Background:</b> Epilepsy is a prevalent condition that affects a large population. However, a lack of knowledge and misconceptions about seizures can lead to inappropriate reactions and negative attitudes toward people with epilepsy, who are more likely to experience stigma because of their illness. This study explored public knowledge, attitudes, and awareness of epilepsy and seizures among residents of Madinah, Saudi Arabia. <b>Methods:</b> A descriptive, cross-sectional study was conducted between September and November 2023 involving 2626 random adult residents of the Madinah Region in Saudi Arabia. Data were collected through an online survey consisting of 27 questions concerning epilepsy. <b>Results:</b> Regarding participants' awareness of epilepsy, 92.2% reported having heard or read about it, and 12.8% had attended a course on controlling epileptic seizures. The results showed an acceptable level of understanding about epilepsy. The mean knowledge and attitude scores about epilepsy for the sample were 22 (SD ± 3.2) and 27.1 (SD ± 3.1), respectively, indicating moderate knowledge and positive attitudes toward epilepsy. Among demographic characteristics, knowledge about epilepsy was significantly associated with gender, age, marital status, educational level, occupation, household monthly income, having heard about epilepsy, having a family member diagnosed with epilepsy, and course attendance. However, attitudes toward epilepsy were only significantly associated with gender, having heard about epilepsy, having a family member diagnosed with epilepsy, and course attendance. Similarly, actions toward seizure attacks were significantly associated with all demographic characteristics except education. <b>Conclusions:</b> The residents of Madinah have generally positive attitudes regarding epilepsy, although their knowledge levels could be enhanced by education. Therefore, more educational awareness campaigns are required to improve public understanding of epilepsy and appropriate actions to take when witnessing a seizure. The results of this study provide a foundation for worldwide comparisons of general levels of knowledge and attitudes concerning epilepsy in Saudi Arabia.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"2142400"},"PeriodicalIF":2.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Factors in Children With Status Epilepticus and Status Epilepticus Severity Score Scales.","authors":"Serap Bilge, Gülen Gül Mert, Özlem Hergüner, Faruk İncecik, Şakir Altunbaşak, Dinçer Yıldızdaş, Özden Özgür Horoz, Duygu Kuşcu","doi":"10.1155/bn/6660355","DOIUrl":"10.1155/bn/6660355","url":null,"abstract":"<p><p><b>Background:</b> According to the International League Against Epilepsy (ILAE) 2015 classification, status epilepticus (SE) is a seizure that lasts longer than 5 min or a frequency of more than one seizure within 5 min, without returning to a normal level of consciousness between episodes. In this study, we aimed to evaluate the prognostic factors of SE and compare our patients with those of patients treated internationally with the modified status epilepticus severity score (mSTESS) to determine the reliability of this scoring system. <b>Methods:</b> The medical records of patients aged 1 month-17 years with SE who were treated at Çukurova University-Balcalı Training and Research Hospital between September 2018 and September 2021 and who were followed in the intensive care unit were included in the study. <b>Results:</b> Seventy-two patients were included in this study. The mean age of the patients with SE was 5 years (3-8). The male/female ratio was 34 (47%)/38 (53%). A history of epilepsy was present in 53% of the patients. The most common etiologies behind SE were meningoencephalitis (19%), febrile status (8%), unknown status (12%), and genetic causes (7%). Comorbidities, including developmental delay/intellectual disability, cerebral palsy, hyperactivity, and autism spectrum disorder, were present in 44 (61%) of the patients. The cutoff was ≥ 2 for unfavorable outcomes and 4 for mortality in our patients according to the mSTESS system. The case mortality rate was 1% in our study. Nonconvulsive SE, slowing and abnormal ground on EEG, being stuporous or comatose, having abnormal MRI-CT, and having a comorbid condition were associated with an unfavorable prognosis in SE patients. <b>Conclusion:</b> The mSTESS is a useful and practical scoring system for predicting the prognosis of SE patients. Nonconvulsive SE, slowing and abnormal ground in EEG, being stuporous or comatose, abnormal MRI-CT, and the presence of comorbid conditions indicated poor prognosis of SE in children.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"6660355"},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety, Depression, and Expanded Disability Status Scale Independently Predict the Perception of Disability in Persons With Multiple Sclerosis: A Cross-Sectional Study.","authors":"Chiara Curatoli, Alessia Marcassoli, Filippo Barbadoro, Arianna Fornari, Matilde Leonardi, Alberto Raggi, Silvia Schiavolin, Rachele Terragni, Carlo Antozzi, Laura Brambilla, Valentina Torri Clerici, Paolo Confalonieri, Renato Mantegazza, Martina Lanza","doi":"10.1155/bn/2744955","DOIUrl":"10.1155/bn/2744955","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is the most common cause of disability in young adults due to several motor, sensory, and cognitive symptoms. However, little is still known about the impact of psychological, cognitive, and social-support variables on subjective disability. This study is aimed at exploring the role of clinical, psychological, cognitive, and social-support variables in predicting disability levels as perceived by persons with multiple sclerosis (pwMS). The World Health Organization Disability Assessment Schedule (WHODAS 2.0) and the Expanded Disability Status Scale (EDSS) were used as subjective and objective measures of disability, respectively. State-Trait Anxiety Inventory and Beck Depression Inventory-II assessed symptoms of anxiety and depression; 19-item Medical Outcome Study-Social Support Survey assessed social support; and Rao's Brief Repeatable Battery assessed cognitive functioning. A multivariable regression analysis was applied using the WHODAS 2.0 as an outcome. One hundred and fifty-one pwMS (93 females, mean age 51.6, standard deviation (SD) 5.8) were enrolled. EDSS (<i>β</i> = 7.190; <i>p</i> < 0.001), state anxiety (<i>β</i> = 0.265; <i>p</i> = 0.009), and symptoms of depression (<i>β</i> = 0.835; <i>p</i> < 0.001) explained a large amount of the variance of subjective disability (Adj.<i>R</i> ² = 0.705; <i>p</i> < 0.001) measured through the WHODAS 2.0. Contrarily, cognitive functioning and perceived social support are not independently associated with the WHODAS 2.0 score. Psychosocial interventions in rehabilitation settings, aimed at reducing the overall perceived disability of pwMS, should be implemented in rehabilitation programs.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"2744955"},"PeriodicalIF":2.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiamnesic and Neurotrophic Effects of <i>Parkia biglobosa</i> (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity.","authors":"Antoine Kavaye Kandeda, Liliane Yimta Foutse, Corneille Tongoue, Jean Philippe Djientcheu, Théophile Dimo","doi":"10.1155/bn/8815830","DOIUrl":"10.1155/bn/8815830","url":null,"abstract":"<p><p>Amnesia is a memory disorder marked by the inability to recall or acquire information. Hence, drugs that also target the neurogenesis process constitute a hope to discover a cure against memory disorders. This study is aimed at evaluating the antiamnesic and neurotrophic effects of the aqueous extract of <i>Parkia biglobosa</i> (<i>P. biglobosa</i>) on in vivo and in vitro models of excitotoxicity. For the in vivo study, 42 adult male rats were divided into six groups of seven rats each and treated daily for 30 days as follows: normal control group (distilled water, 10 mL/kg, po), negative control group (distilled water, 10 mL/kg, po), positive control group (piracetam, 200 mg/kg, po), and 03 test groups (extract, 44, 88, and 176 mg/kg, po). Scopolamine (0.5 mg/kg, ip) was administered once daily, 45 min after these treatments, for 14 days, except in the normal control group. The animals were then subjected to short-term memory (new object recognition and T-maze) and long-term memory (radial arm maze) tests for 15 following days. Animals were then euthanized, and biochemical analyses (neurotransmitters, oxidative status, and neuroinflammation) were performed in the prefrontal cortex, hippocampus, and serum. Histological analysis of these organs was also carried out. In the in vitro study, the effect of the extract (5, 10, 19, 40, 77, 153, 306, 615, 1225, and 2450 <i>μ</i>g/mL) was assessed on the viability of primary cortical neurons exposed to L-glutamate (0.1 mg/mL). Scopolamine induced memory impairment and increased oxidative stress, neuroinflammation, and neuronal loss. <i>P. biglobosa</i> extract (44 mg/kg) reduced (<i>p</i> < 0.001) short- and long-term memory deficit. It also increased (<i>p</i> < 0.01) the concentration of acetylcholine, reduced (<i>p</i> < 0.001) that of malondialdehyde, and limited (<i>p</i> < 0.001) neuroinflammation and neuronal loss (<i>p</i> < 0.001). In addition, the extract (2450 <i>μ</i>g/mL) increased (<i>p</i> < 0.001) the percentage of viable cells. These results suggest that the extract has effects on amnesia and neurogenesis. These effects seem to be mediated by antioxidant and anti-inflammatory modulations.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"8815830"},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activating the Astrocytes of the Dorsal Raphe Nucleus via Its Neural Circuits With the Medial Prefrontal Cortex Improves Depression in Mice.","authors":"Jingyu Zhao, Yuang Wang, Chunxiao Tian, Jialiang Wang, Feng Chen, Xi Dong, Jiayi Luo, Yuxuan Zhu, Aili Liu, Zengguang Ma, Hui Shen","doi":"10.1155/bn/8890705","DOIUrl":"10.1155/bn/8890705","url":null,"abstract":"<p><p>Astrocytes are the primary cell type in the central nervous system, responsible for maintaining the stability of the brain's internal environment and supporting neuronal functions. Researches have demonstrated the close relationship between astrocytes and the pathophysiology and etiology of major depressive disorder. However, the regulatory mechanisms of astrocytes during depression remain unclear. The aim of this study is to examine the alterations of calcium signaling of astrocytes in the dorsal raphe nucleus (DRN), the calcium signaling alterations of neurons in both the DRN and medial prefrontal cortex (mPFC), and the alteration of depressive-like behaviors by activation of DRN astrocytes using chemogenetics in chronic social defeat stress (CSDS) mice. The results showed that the intensity of calcium signaling in DRN astrocytes was decreased and the frequency of calcium signaling was lower after CSDS. The activation of DRN astrocytes increased the calcium signaling of the neurons including CaMKII<i>α</i> neurons in both DRN and mPFC (via neural circuit between DRN and mPFC). The depressive-like behaviors were improved by activating DRN astrocytes in CSDS mice. Our results suggest that the astrocytes in DRN have an important role in depression and the findings offer new insights for the treatment of depression.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2025 ","pages":"8890705"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Cognitive and Psychiatric Functioning in People With Cushing's Disease in Biochemical Remission and People With Nonfunctioning Adenomas.","authors":"Mary A Fernandes, Sabrina D Hickle, Suzanne Penna, Adriana G Ioachimescu, Erin B Tone","doi":"10.1155/2024/4393169","DOIUrl":"10.1155/2024/4393169","url":null,"abstract":"<p><p>People with Cushing's disease (CD) often experience both mood/anxiety disorders and cognitive impairments that persist during long-term biochemical remission. The relationship between persistent neurocognitive and psychiatric problems in patients with CD is not well understood. Also, mechanisms other than hypercortisolism are poorly understood, and studies comparing CD with nonfunctioning adenomas (NFA) patients postoperatively are scarce. We compared neuropsychological functioning in two groups: individuals with CD in remission (<i>n</i> = 20; 80% female; 61.6 [44.13] months since remission) and individuals with NFAs (<i>n</i> = 20). Evaluation was performed, on average, 4.9 years following pituitary surgery. We used mediation models to evaluate psychiatric dysfunction as a possible mediator of cognitive outcomes and assessed the influence of demographic and medical factors (age at diagnosis, remission duration, and radiation therapy) on neuropsychological outcomes. Neuropsychological outcomes did not differ significantly between groups; however, up to 30% of patients demonstrated mild impairments in attention, processing speed, executive functioning, and visual memory. Time since remission in the CD group was inversely correlated with processing speed; however, this relationship was no longer significant after controlling for the presence of hypertension and diabetes mellitus. Levels of anxiety, depression, or somatization were reported in up to 40% of people with CD. Further, 70% of people with CD and 35% of people with NFA reported continuous depressive symptoms lasting at least 2 years. In conclusion, neuropsychological screening in clinical practice and longitudinal studies in individuals with NFA and CD are needed to identify patients at risk for long-term neuropsychological dysfunction. Appropriate support and treatment are recommended for persistent cognitive and/or psychiatric dysfunction for both patient groups.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2024 ","pages":"4393169"},"PeriodicalIF":2.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dietary Fiber and the Severity of Depression Symptoms.","authors":"Yi Yang, Lubo Shi, Shihan Zeng, Chuyan Chen","doi":"10.1155/2024/5510304","DOIUrl":"10.1155/2024/5510304","url":null,"abstract":"<p><p><b>Aim:</b> Our study is aimed at exploring the correlation between consumption of dietary fiber and the severity of depression symptoms. <b>Methods:</b> This study utilized data from the National Health and Nutrition Examination Survey spanning from 2007 to 2018, employing a cross-sectional design. The relationship between the severity of depression symptoms and intake of total cereals, vegetables, and fruits dietary fiber was assessed using both univariate and multivariate linear/logistic regression analyses. Stratified analyses were conducted based on hypertension, diabetes, dyslipidemia, cancer or malignancy, and cardiovascular disease. <b>Results:</b> This study included 28,852 participants who were classified into 21,696 with nondepression symptoms, 4614 with mild depression symptoms, 1583 with moderate depression symptoms, 684 with moderately severe depression symptoms, and 275 with severe depression symptoms. After adjusting all confounding factors, we observed a negative correlation between total dietary fiber and depression symptoms (beta = -0.004, 95% confidence intervals [CIs]: -0.006, -0.002). Taking nondepression symptoms as a reference, total dietary fiber was found to have an inverse association with moderate (OR = 0.976, 95% CI: 0.962-0.991), moderately severe (OR = 0.963, 95% CI: 0.938-0.990), and severe depression symptoms (OR = 0.960, 95% CI: 0.921-1.001; marginal significance), respectively. <b>Conclusion:</b> The intakes of total dietary fibers might be related to moderate/moderately severe/severe depression symptoms, and a negative association was shown between total dietary fiber intakes and the risk of depression symptoms.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2024 ","pages":"5510304"},"PeriodicalIF":2.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}