Evaluation of the Neuroprotective Potential of Sutherlandia frutescens in a Rotenone-Induced Rat Model of Parkinson's Disease.

Sutherlandia frutescens (SF) is a plant used traditionally in South Africa for various health conditions, including neurological disorders. Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra, resulting in motor symptoms. Rotenone, a pesticide, has been linked to PD-like symptoms in both in vitro and in vivo studies. However, SF-specific effects of SF on PD-related symptoms have not been extensively studied. This study was aimed at investigating the potential neuroprotective effects of SF against rotenone-induced PD using in vivo electrophysiological recordings from the hippocampus and an open-field test to assess motor behavior. Rats were divided into three groups: a control group receiving sunflower oil, a rotenone group treated with rotenone (2.0 mg/kg), and an SF group treated with hydroponically grown SF extract. Electrophysiological recordings from the hippocampus were conducted to assess neuronal activity, and an open-field test was used to evaluate motor behavior. Rats treated with SF exhibited significantly higher motor activity compared to both the sunflower oil and rotenone groups, suggesting an activating effect of SF on motor behavior. In contrast, the rotenone group displayed reduced activity levels and exploratory behavior, highlighting the suppressive impact of rotenone on motor function. These findings suggest that SF modulates hippocampal neuronal activity and may offer neuroprotective benefits against rotenone-induced PD-like symptoms. SF, a plant with traditional medicinal applications, shows potential in modulating motor behavior and hippocampal neuronal activity in a rotenone-induced PD model. Further studies are needed to clarify the underlying mechanisms and evaluate the clinical relevance of SF in PD management.