慢性肾病患者饮食炎症指数与抑郁症状的关系

IF 2.7 4区 医学 Q2 CLINICAL NEUROLOGY
Behavioural Neurology Pub Date : 2025-03-07 eCollection Date: 2025-01-01 DOI:10.1155/bn/9253956
Rui Huang, Qixia Zhu
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引用次数: 0

摘要

目的:本研究旨在探讨慢性肾脏疾病(CKD)患者饮食炎症指数(DII)评分与抑郁症状之间的关系,探讨其作为抑郁风险指标的潜在作用,并为这一弱势人群的饮食干预提供新的见解。材料与方法:横断面调查纳入2007-2018年全国健康与营养调查中年龄≥18岁的CKD患者。采用患者健康问卷-9 (PHQ-9)评估抑郁症状。饮食信息通过24小时饮食回忆访谈获得。通过加权单变量和多变量逻辑回归模型,调整通过反向选择确定的相关协变量,探索DII与抑郁症之间的关系。结果以95%置信区间(ci)的优势比(ORs)表示。为了进一步研究这种关联,我们进行了限制性三次样条(RCS)和亚组分析。结果:489例(11.55%)CKD患者有抑郁症状。高DII评分与CKD患者抑郁症状发生率升高相关(OR: 1.67, 95% CI: 1.06-2.65)。调整所有协变量后,在年龄≥60岁(OR: 1.80, 95% CI: 1.16-2.79)、男性(OR: 2.05, 95% CI: 1.16-3.59)、吸烟者(OR: 1.70, 95% CI: 1.06-2.75)和无睡眠障碍(OR: 1.81, 95% CI: 1.01-3.23)患者中,DII评分与抑郁症状的关系仍然存在。结论:DII评分与慢性肾病患者抑郁症状相关。研究结果表明,饮食在心理健康中起着重要作用,尤其是在慢性肾病等慢性疾病中。研究结果强调了探索抗炎饮食干预以减轻这一人群抑郁症状的重要性。进一步的纵向研究是必要的,以建立因果关系,并确定有针对性的饮食改变对CKD合并抑郁症患者的疗效。局限性:作为一项横断面研究,因果关系不能从这些发现中推断出来。此外,对自我报告的饮食数据的依赖可能会引入偏差,未测量的混杂因素可能会影响观察到的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Dietary Inflammatory Index and Depression Symptoms in Chronic Kidney Disease.

Objective: The study is aimed at investigating the relationship between dietary inflammatory index (DII) score and depression symptoms in chronic kidney disease (CKD), exploring its potential role as an indicator of depression risk and offering new insights into dietary interventions for this vulnerable population. Materials and Methods: The cross-sectional investigation included CKD patients aged ≥ 18 in the 2007-2018 National Health and Nutrition Examination Survey. The Patient Health Questionnaire-9 (PHQ-9) was administered to evaluate depression symptoms. Dietary information was obtained from a 24-h dietary recall interview. The relationship between DII and depression was explored through weighted univariate and multivariate logistic regression models, adjusting for relevant covariates identified via backward selection. Results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). To further investigate the association, restricted cubic spline (RCS) and subgroup analyses were conducted. Results: Totally, 489 (11.55%) patients with CKD had depression symptoms. A high DII score was linked to elevated depression symptoms incidence in CKD (OR: 1.67, 95% CI: 1.06-2.65). Adjusting all covariates, the relationship between DII score and depression symptoms still existed in patients aged ≥ 60 years (OR: 1.80, 95% CI: 1.16-2.79), males (OR: 2.05, 95% CI: 1.16-3.59), smokers (OR: 1.70, 95% CI: 1.06-2.75), and those without sleep disorders (OR: 1.81, 95% CI: 1.01-3.23). Conclusion: DII score was associated with depression symptoms in patients with CKD. The findings suggest that diet plays a role in mental health, particularly in chronic conditions like CKD. The results underscore the importance of exploring anti-inflammatory dietary interventions to mitigate depression symptoms in this population. Further longitudinal research is necessary to establish causality and determine the efficacy of targeted dietary modifications in CKD patients with depression. Limitations: As a cross-sectional study, causality cannot be inferred from these findings. Additionally, the reliance on self-reported dietary data may introduce bias, and unmeasured confounders could influence the observed associations.

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来源期刊
Behavioural Neurology
Behavioural Neurology 医学-临床神经学
CiteScore
5.40
自引率
3.60%
发文量
52
审稿时长
>12 weeks
期刊介绍: Behavioural Neurology is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on various diseases and syndromes in behavioural neurology. The aim of the journal is to provide a platform for researchers and clinicians working in various fields of neurology including cognitive neuroscience, neuropsychology and neuropsychiatry. Topics of interest include: ADHD Aphasia Autism Alzheimer’s Disease Behavioural Disorders Dementia Epilepsy Multiple Sclerosis Parkinson’s Disease Psychosis Stroke Traumatic brain injury.
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