Sex Differences in the Relationship Between Cortical Thickness and Sensory Motor Symptoms in Adults on the Autism Spectrum.

Abstract

Background: Autism spectrum disorder (ASD) involves alterations in both cortical morphology and sensory processing. These structural and perceptual changes may lie on a continuum with typically developing (TD) individuals. However, investigations on possible links between these two factors are lacking, and it remains to be seen if their relationship differs by sex. We hypothesized that cortical thickness in the postcentral gyrus (a somatosensory processing hub) would correlate with sensory processing symptoms in a combined cohort of autistic and TD individuals. We also hypothesized that these correlations would differ based on sex. Methods: We studied 23 autistic adults and 27 TD adults using magnetic resonance imaging to measure the cortical thickness of the postcentral gyrus and the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) to measure autism characteristics, with a particular focus on the sensory motor subscale. Results: The left postcentral gyrus (PCG) was found to be thicker in the autism group than in the TD group (d = 0.946, p = 0.003), particularly in autistic males compared to TD males and TD females. The RAADS-R sensory motor subscale and bilateral PCG cortical thickness were positively correlated across both autistic and TD males (Spearman's rho = 0.481, p = 0.008) but not females. These correlations were specific to the sensory motor subscale, as no correlations were found for RAADS-R total score or any of the other subscales. Conclusions: These results demonstrate sex-specific differences in the relationship between cortical thickness at the PCG and sensory processing in autistic individuals and that these differences exist along a continuum that extends into the TD population. Our findings contribute to furthering our understanding of sex-specific neuroanatomical differences in people on the autism spectrum. The left PCG thickness could be a potential sex-specific biomarker for sensorimotor function that is generally applicable in both neurotypical and autism populations. With further validations, this biomarker could be used to track responses to interventions targeting sensorimotor challenges in people on the autism spectrum.