Clinica Terapeutica最新文献

{"title":"The critical role of vaccinations for Healthcare Workers after COVID-19.","authors":"D Shaholli","doi":"10.7417/CT.2025.5199","DOIUrl":"10.7417/CT.2025.5199","url":null,"abstract":"<p><strong>Abstract: </strong>The COVID-19 pandemic underscored the importance of vaccinations in protecting both healthcare workers (HCWs) and their patients. With the retreat of the pandemic, attention must now shift to reinforcing routine immunizations among HCWs, including measles, varicella, rubella, and other vaccine-preventable diseases. This letter highlights the need for mandatory vaccinations for HCWs to minimize nosocomial infections and ensure patient safety, drawing insights from recent studies on vaccine coverage and attitudes in the healthcare sector.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"158-159"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedical care for maritime workers: health care liability issues related to possible regulatory decoupl.","authors":"G D'Antonio, G Bolino, S Del Prete, L Pellegrini, T Berloco, M Treglia, M Arcangeli","doi":"10.7417/CT.2025.5185","DOIUrl":"10.7417/CT.2025.5185","url":null,"abstract":"<p><strong>Abstract: </strong>Telemedicine has now spread globally because of the many benefits it offers both to health care facilities and to people living in unfavorable conditions (the elderly, patients with reduced mobility, residents in remote areas, etc.). The COVID-19 pandemic has resulted in further impetus for telemedicine application development, to maximize available resources. However, this innovative type of physician/healthcare facility/patient relationship has opened up several questions in relation to various possible assumptions of professional liability. In fact, the medico-legal issues that can arise in scenarios involving equipment, professionals and patients that also belong to different nationalities and, therefore, subject to different regulatory systems are obvious: precisely the regulatory decoupling represents one of the thorniest and most debated issues at the international level on the subject of teleme-dicine. In the maritime sphere, this issue could be further amplified (e.g., telehealth for a patient from one nation, on ships under the flag of a different nationality, within the maritime boundaries of a third nation). In Italy, the use of telemedicine has its roots precisely in the maritime sector back in the early 20th century, when the International Center for Medical Radiocommunications (CIRM) was established. In 2002, CIRM was identified internationally as the Italian Center Responsible for Maritime Telemedical Assistance (TMAS), with the purpose of providing remote health care for passengers on any ship that required it, 24 hours a day, while also being able to suggest their transfer to land. Indeed, since TMAS is a national competence, should professional liability profiles occur, CIRM physicians would be liable under Italian law. Therefore, the example of CIRM as a referral center for telemedicine in the maritime sphere could be a model for reference in other contexts as well: in particular, the identification of telemedicine service delivery centers dependent on the National Health Services (NHS) could allow for the appropriate regulatory contextualization of telemedical malpractice cases, thereby resolving the medico-legal uncertainties that could hinder the dissemination as well as the proper application of telemedicine.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 Suppl 1(2)","pages":"40-43"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Maternal and Fetal Death by Idiopathic spontaneous intraperitoneal hemorrhage in a nulliparous Pregnant at the Second Trimester.","authors":"N Pascale, G Bertozzi, M Ferrara, M Treglia, M Calvano, A Di Fazio","doi":"10.7417/CT.2025.5182","DOIUrl":"10.7417/CT.2025.5182","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous intraperitoneal hemorrhage is a rare and potentially fatal condition historically known as \"abdominal apoplexy\". It refers to the non-traumatic and non-iatrogenic rupture of one or more small splanchnic vessels causing massive abdominal bleeding. In general, hemoperitoneum can be associated with various causes, however, in other cases, known as spontaneous hemoperitoneum during pregnancy, the etiology remains unidentified.</p><p><strong>Case report: </strong>The case of a 33-year-old, otherwise healthy and with no traumatic history, primigravida-23-week pregnant is presented. It dealt with a suddenly developed shock status, during a dinner in a public place. At Emergency Service arrival, she was already dead. A judicial autopsy was decided, in suspect of a rescue delay. The full autopsy showed a massive hemoperitoneum, with no origin of hemorrhage; the histological examination confirmed the hypovolemic shock with hypoxic-ischemic suffering of the intestinal mucosa. In conclusion, the cause of death was attributed to a hypovolemic shock due to idiopathic spontaneous intraperitoneal hemorrhage. Any responsibility in Rescue Emergency was excluded.</p><p><strong>Discussion: </strong>In similar cases of unknown bleeding etiopathogenesis, the hypothesis is that the repeated distension of the vessels during pregnancy, together with defects or thinning of the vascular wall, predisposes to its rupture, causing bleeding with no identifiable origin, probably involving branch of the celiac axis. The present case suggests the need to consider the diagnostic suspicion of this condition when atypical and unrelated symptoms in pregnant women appeared. To the best of our knowledge not many cases reported as much ble-eding as in this case whereby the bleeding point was obscured. As a result of these assessments, the liability of healthcare professionals was excluded. Therefore, in all analogous cases the autopsy, clinical or judicial, is mandatory both for the analysis of the process as a tool for risk management, and for the economic evaluation from a medico-legal perspective.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 Suppl 1(2)","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence Of Long COVID In Healthcare Workers At A University Hospital And Challenges In Insurance And Compensation Evaluation.","authors":"C Giorgianni, V Cianci, C Pitrone, G Burrascano, C Mondello, N Gullì, P Gualniera, A Asmundo, D Sapienza","doi":"10.7417/CT.2025.5208","DOIUrl":"10.7417/CT.2025.5208","url":null,"abstract":"<p><strong>Introduction: </strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developed in 2019, led to the outbreak of the COVID-19 pandemic state, which have significantly impacted on healthcare systems worldwide. During the pandemic state, in addition to all the problems related to high mortality and morbidity during the active phase of the disease, it had to deal with a condition known as \"Long-COVID\". Long-COVID includes both persistent symptomatic forms, where signs and symptoms last between 4 and 12 weeks, and post-COVID syndrome, where symptoms persist beyond 12 weeks. The evaluation system categorizes COVID-19 outcomes into four classes based on the degree of biological validity impairment: mild, moderate, moderate-severe, and severe. In the insurance field, this new \"entity\" led to difficulties related to damages compensation for infections developed in workplace, which has not completely been clarified nor today.</p><p><strong>Methods: </strong>The study was conducted on a sample of 3,127 health-care workers employed at the \"G. Martino\" University Hospital, in Messina. The percentage of individuals who contracted COVID-19 was analysed, evaluating how many were infected at workplace. Among those who contracted the virus at work, we further examined how many healthcare professionals were eligible for compensation under insurance frameworks related to Long- COVID.</p><p><strong>Results: </strong>The data analysis reveals that, out of the entire sample examined, 10 healthcare workers developed Long-COVID syndrome, with a severity classified as moderate (Biological Damage according to social insurance of healthcare workers: 1-15%). The lingering ef-fects included persistent asthenia, anosmia, stress-induced dyspnoea, outcomes of instrumentally documented pneumonia and myocarditis, as well as neuromuscular disorders. The collected data confirms that healthcare professionals had the highest percentage of COVID-19 infections (Fig. 1), with an infection rate of 23%, more than half of which occurred in the workplace.</p><p><strong>Discussion and conclusions: </strong>The definition of long-COVID is still quite complicated, as the ever-increasing number of symptoms that are attributable to this pathology, and the variability in the times of its onset, make its nosographic framework extremely difficult. In addition to the clinical-scientific difficulties arising from this condition, the impossibility of adequately classifying the pathology is associated with an equally complex management of the costs that the State must bear to restore the damage, as it usually happens in case of sequelae of infections contracted at workplace.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short forms to assess Quality of Life Among elderly Women considering Stress Urinary Incontinence management with obesity co-morbidity.","authors":"A A Amr, F A Hesham, M A Ahmed, A E Yumna, A E Adel, A S Amany, A S Ahmed, A A Muhamed, S T S Wael, M S D Yasser, E M Bahaa Eldin, M T Elsayed, A A Mohamed, M A Walaa, R Rania, F E Ahmed, I M Mohamed, A Ahmed, H A A Alshaimaa, M A Attia, M E Fadila, H Yasmine, F S Ahmed","doi":"10.7417/CT.2025.5207","DOIUrl":"10.7417/CT.2025.5207","url":null,"abstract":"<p><strong>Aim: </strong>The intention is to make clear the detrimental clinical effects of obesity on older women's stress urine incontinence and quality of life.</p><p><strong>Patients and methods: </strong>This cross-sectional study included 150 women, 60 years of age or older, who were receiving treatment at the university hospitals in Alhussine, Alzahraa, Ain Shams, Assiut (Alazhar university), Damietta (Alazhar university),ZAGAZIG, HELWAN, Misr University for Science and Technology, Menoufia and Benha for urodynamic stress urine incontinence. Patients were categorised based on their body mass index (BMI), and appointments were made for the Incontinence Quality of Life Questionnaire and the Incontinence Severity Index.</p><p><strong>Results: </strong>The participants' mean ages were 64.1 ± 2.3 years for group I and 64.3 ± 2.1 years for group II, respectively. The mean (±SD) BMI in group I was 34.8 ± 3.4, whereas the mean (±SD) BMI in group II was 22.6 ± 2.4. There was no discernible difference between the two groups' mean gravidity or parity or prior delivery modes. In particular, obese women reported higher levels of symptom discomfort, had an increased incidence of incontinence episodes, and had a stronger impact on quality of life due to specific symptoms. Group II had a higher prevalence of mild symptoms, whereas group I had a higher prevalence of intermediate symptoms. Also, group I had a higher distribution of severe symptoms.</p><p><strong>Conclusion: </strong>Obesity reduces older women's quality of life ratings and influences the severity of urodynamic stress incontinence.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"207-212"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Diagnostic Biomarker of Preeclampsia: MicroRNAs in Maternal Blood Leukocytes in Preeclamptic Women Compared to Normal Pregnant Women.","authors":"S I Elshennawy, F G Yehia, H Elhakeem, L A Gad, A A Eldamanhory, A M Attia, I R Alsawy, A M I Ghit, M A Mohamed, A A Elboghdady, E G Rezk, M F I Mosa, M R Zohri, M A M El Kholy, W A Ayad, A A H Emam, M Y M Ahmed","doi":"10.7417/CT.2025.5216","DOIUrl":"10.7417/CT.2025.5216","url":null,"abstract":"<p><strong>Aim of the work.: </strong>The purpose of this study is to compare the expression levels of miR-21-3p and miR-155-5p in leukocytes from preeclampsia (PE) patients to healthy controls.</p><p><strong>Patients and methods: </strong>The miR-21-3p and miR-155-5p that have been linked to PE were our choices. In comparison to 50 healthy controls, the expression levels of miR-21-3p and miR-155-5p were examined in PE (n = 50). Quantitative PCR in real-time is used for this. Relative quantification values were produced by comparing the target miR's relative expression in the samples to that of the calibrator in the lab.</p><p><strong>Results: </strong>There was a significant decrease in the expression levels of miR-21-3p and miR-155-5p in PE group. The mean expression levels of miR-21-3p and miR-155-5p in PE were 1.12 ± 0.6 and 0.82 ±0.5, respectively compared to 1.52 ± 0.8 and 1.44 ± 0.9 in normal individuals.</p><p><strong>Conclusion: </strong>Our findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE. A significant part of the pathophysiology of PE is played by miRNAs. Findings differentially expressed miRNAs in mother blood presents a chance to identify a simple-to-use PE biomarker.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"255-260"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reproducibility of Conventional Minimally Invasive Osteosynthesis for the treatment of Intra articular Calcaneal fractures: The Traditional Technique is Regaining Popularity (prospective interventional study).","authors":"S A E Ahmed, A A Mohamed, A I E Mohammed, A Z Ali, N A I Mohamed, H A E Mohamed, E H W Yaser, A I M Mahmoud, A O Mohamed, E M Ibrahim, G A Usama, G A Mahmoud, R E Mohamed","doi":"10.7417/CT.2025.5196","DOIUrl":"10.7417/CT.2025.5196","url":null,"abstract":"<p><strong>Background: </strong>Despite the relative prevalence of intra-articular calcaneal fractures, definitive treatment is controversial. Historically the closed treatment of these injuries had been unsatisfactory. Avoid the soft tissue complications,several minimally-invasive approaches have been proposed throughout the history of calcaneal fracture treatment and recently gained popularity.</p><p><strong>Objective: </strong>The aim of the study was to verify the effectiveness of minimally invasive osteosynthesis for the treatment of intra articular calcaneal fractures in 20 cases.</p><p><strong>Patients and methods: </strong>Twenty one percutaneous and minimally invasive ostyosynsesis of calcaneal fractures in 20 patients were included in prospective interventional study. This study was done at Alzaitoun Specialized Hospital and Al-Azhar University hospitals between October 2022 and January 2024. These patients were followed up for at least 6 months post-operatively. This study included closed intra-articular calcaneal fractures type II and III in adult patients and excluded open, extra-articular, type I and IV fractures.</p><p><strong>Results: </strong>The mean pre-operative Böhler's angle was 17.81 ± 4.48 (range 13 - 25 0) and the mean post-operative Böhler's angle was 29.24 ± 5.15 (range 25 - 40 0) The result was found to be highly significant (p-value <0.001) using paired-samples T test. Restoration of normal range Bohler angle was achieved. The mean pre-operative Gissane angle was 136.95 ± 13.84 (range 110 - 165 0) and the mean post-operative Gissane angle was 117.81 ± 15.66 (range 100 - 145 0). The result was found to be highly significant (p-value <0.001) using paired-samples T test. Restoration of normal range Gissane angle was achieved. These results were found to be highly significant. That meant improvement of Böhler' and Gissane angles after fixation. Sixteen patients (80%) started weight bearing at 12 weeks while two patients (10%) started weight bearing at 16 weeks and two patients (10%) started weight bearing at 10 weeks. Three patients developed superficial wound infection treated by aily dressing and antibiotics for one week. Two patients developed malnion, one patient developed Positional wrist drop, seven patients developed subtalar joint pain, three patients developed Implant com-plications and two patients developed Fixed flat foot.</p><p><strong>Conclusion: </strong>We presented a minimally invasive technique for the treatment of intra-articular calcaneus fractures and could obtain results comparable with other minimally invasive techniques, avoiding the dangerous soft-tissue complications encountered with ORIF. most of cases, Böhler's angle, gissane angle and geometry of the calcaneus were restored to normal values. We believe that our minimally invasive technique is a valuable alternative for management of intra-articular calcaneal fractures.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"136-147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of Sexual Activity-Related Deaths due to Vascular Dissection: investigating the Potential Link to phosphodiesterase type 5 inhibitor administration.","authors":"G Napoletano, B Treves, L De Paola, A Ghamlouch, F Del Duca, A De Matteis, L Di Mauro","doi":"10.7417/CT.2025.5191","DOIUrl":"10.7417/CT.2025.5191","url":null,"abstract":"<p><strong>Abstract: </strong>Sexual activity-related sudden death (SArSD) is an uncommon phenomenon in forensic pathology, typically associated with preexisting vascular abnormalities that rupture due to sudden changes in blood pressure or heart rate during sexual activity. The current report presents two cases of SArSD in men with positive anamnesis for chronic sildenafil use. In Case 1, the cause of death was determined to be an intracranial hemorrhage that occurred shortly before sexual intercourse. In Case 2, death was attributed to the rupture of an abdominal aortic aneurysm, occurring during sexual activity and linked to substance abuse. While both deaths were attributed to SArSD, the potential role of sildenafil in promoting aneurysm formation or rupture remains a subject of debate. Intracerebral hemorrhages associated with sildenafil use appear to exhibit a consistent pattern, commonly affecting the basal nuclei, thalamus, and adjacent cerebral regions, particularly the lateral temporal lobe. Notably, in many cases descri-bed in literature sildenafil doses exceeding 50 mg were reported. The combined effects of sildenafil and substances (such as cocaine) in such events remain largely unexplored, underscoring the need for further research to elucidate their interaction. Cases of vascular dissections occurring independently of sexual activity suggest that sildenafil use warrants caution, particularly in individuals with underlying vascular vulnerabilities. Although rare clinical cases and autopsy findings have suggested a potential association between phosphodiesterase type 5 inhibitors (PDE5i) and hemorrhagic events, such as intracerebral hemorrhages or aneurysm ruptures, current evidence does not indicate that PDE5i have a significant or direct impact on blood pressure capable of causing the acute rupture of a healthy vessel. Nevertheless, further clinical and forensic studies are essential to elucidate the relationship between chronic or acute PDE5i use and hemorrhagic cerebrovascular accidents or aortic dissections.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 Suppl 1(2)","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origins and Development of Narrative-Based Medicine.","authors":"G V Lacasella","doi":"10.7417/CT.2025.5198","DOIUrl":"10.7417/CT.2025.5198","url":null,"abstract":"<p><strong>Abstract: </strong>In the early days of medicine, diagnosis was based on what a patient told the Hippocratic doctor. With the establishment of hospitals and their spread over the 18th century, objective data collection about disease began to be regarded as fundamental, with a patient's narrative taking second place. Over time, disease increasingly began to coincide with a biological entity that could be objectively observed and quantified, while medicine became a science on a par with physics and chemistry.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"155-157"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Open-Source Solution for Efficient Healthcare Data Management.","authors":"B Poojar, S K Ashok, S B Rao, S D Ullal, A H Rao, N Shenoy","doi":"10.7417/CT.2025.5210","DOIUrl":"10.7417/CT.2025.5210","url":null,"abstract":"<p><strong>Background: </strong>Data management software plays a pivotal role in healthcare, ensuring the organized storage, analysis, and scrutiny of vast amounts of data. EpiData, an open-source software, is a prime example of a versatile tool used in healthcare settings. This comprehensive article offers an overview of EpiData's historical evolution, functionalities, and practical applications in the healthcare domain.</p><p><strong>Methods: </strong>The article commences with a survey of Epi-Data's evolution and its progressive transformations, highlighting its relevance in the context of open-source medical software. EpiData's noteworthy attributes include its user-friendly interface, data valida-tion, and quality assurance mechanisms. Along with its remarkable versatility in managing healthcare data through \".REC\" and \".QES\" file formats, are discussed. To underscore its distinctive features and advantages, the article compares EpiData to other data management programs. EpiData's adaptability and diverse range of applications are exemplified through its use in clinical research and healthcare data management.</p><p><strong>Results and conclusions: </strong>In conclusion, EpiData is widely employed as a paramount open-source data management tool in healthcare. Its straightforward user interface and embedded safety measures make it an optimal choice for various medical and scientific projects. While EpiData excels in efficiently organizing and analyzing healthcare data, it does have certain limitations concerning advanced functionality and data analytical proficiency. A notable example is the successful two-day course conducted in India in 2013, focusing on quality-assured healthcare data collection using EpiData. A subsequent two-year follow-up study demonstrated the effectiveness of this training in knowledge transfer, offering the potential for integrating EpiData into medical school curricula and research organizations.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"225-232"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}