Clinica Terapeutica最新文献

{"title":"Adolescent mothers and postpartum depression: a possible connection? A Scoping review.","authors":"R Ferrara, L Iovino, R Latina, A Avallone, E Greco, G Montanari Vergallo, M Calderaro, P Ricci","doi":"10.7417/CT.2025.5169","DOIUrl":"https://doi.org/10.7417/CT.2025.5169","url":null,"abstract":"<p><strong>Abstract: </strong>Motherhood during adolescence is a sensitive phenomenon that draws attention to the mental health of adolescent mothers, including the risk of postpartum depression (PDR). This systematic review explores the correlation between motherhood and the development of PLD in adolescent mothers, analysing the associated risk factors. The included studies investigated the prevalence and risk factors of PPD in adolescent population samples, revealing a significant incidence of depressive disorders among adolescent mothers compared to adult mothers. Among the risk factors identified were low socioeconomic status, limited education and negative family dynamics. These findings highlight the importance of considering teenage pregnancy as a significant risk factor for PLD. Social support and targeted interventions can play a key role in preventing and managing postpartum depression in teenage mothers. Early identification of symptoms related to the mother's mental health during pregnancy and the postpartum period is of paramount importance to ensure the well-being of both mother and child. It is crucial to conduct further research to deepen the understanding of this complex relationship and to develop effective intervention strategies to support young mothers' mental health during the postpartum period. Investing in training health workers to recognise and treat pregnancy- and postpartum-related mental disorders, as well as educating women about available resources and the importance of seeking help when needed, can help reduce the public health burden of these problems.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"81-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing patient safety and delineating professional liability in radiological procedures involving contrast medium administration.","authors":"V Martines, S Magnaldi, N Di Fazio, G Volonnino, E Marinelli, L De Paola","doi":"10.7417/CT.2025.5163","DOIUrl":"https://doi.org/10.7417/CT.2025.5163","url":null,"abstract":"<p><strong>Abstract: </strong>Radiological procedures requiring the administration of contrast medium are considered invasive procedures and require obtaining written consent from the patient. The risks of the procedure must be weighed against the risks of a potential missed diagnosis. Understanding the clinical question of the exam is crucial. For evaluating the risks to which the patient is exposed, both in contrast procedures and in the case of magnetic field use, a thorough analysis of the patient's medical history is equally important. The radiologists' liability is intertwined with that of the prescribing physician. However, in the absence of a prescription, demonstrating that correct action was taken may be challenging. Therefore, our opinion is therefore that it is advisable to encourage both the radiologist and the prescribing physician to sign a form that includes the examination indication on one side and the execution technique of the radiological investigations on the other, especially when contrast medium injection is involved.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicalisation in the Post-Genomic Era: Transformations in Identity, Autonomy, and Ethics.","authors":"M Karaboue, G V Lacasella","doi":"10.7417/CT.2025.5173","DOIUrl":"https://doi.org/10.7417/CT.2025.5173","url":null,"abstract":"<p><strong>Abstract: </strong>The advent of the post-genomic society has fundamentally transformed the concept of medicalisation, expanding its scope from disease treatment to reshaping personal identity, autonomy, and societal norms. This paper examines the profound implications of genomic knowledge on individual and collective experiences, exploring its dual roles as a liberating force and a source of new constraints. Key areas of focus include the intersection of genomic data with social structures, the ethical tensions faced by healthcare professionals, and the evolving roles of patients and research subjects in the context of predictive and precision medicine. The discussion highlights the challenges posed by genetic determinism, the ethical complexities of consent, and the societal impact of genomic categorization on equity and justice. By integrating multidisciplinary perspectives, this study offers insights into the promises and perils of genomic innovation, charting pathways for ethical frameworks that balance scientific progress with human dignity and social responsibility.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"109-113"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinoptilolite in the drug refractory chronic diarrhoea.","authors":"B Palmieri, M Vadalà","doi":"10.7417/CT.2025.5159","DOIUrl":"https://doi.org/10.7417/CT.2025.5159","url":null,"abstract":"<p><strong>Objective: </strong>The aim of study was to assess the safety and tolerability of a specific zeolite powder (Xeoderm powder, Phytoitalia S.r.l -Corbetta, Italy) and its effectiveness on health-related quality of life, bowel habits, psychological status (i.e., anxiety, depression, and stress).</p><p><strong>Materials and methods: </strong>100 patients affected by inadequately treated chronic or recurrent diarrhoea were educated to take Xeoderm [one spoon (15 mg) after lunch and after dinner mixed in 20 ml of water or fruits juice] for 8 weeks, then reduced to one single administration in the evening for one month. The patients were invited to keep records of the number of stool discharge, and of the bowel sounds and movements frequency and intensity, possible haemorrhoids, or anal fissures or anitis symptoms. H.pylori test to assess the presence of H.pylori, a Subject's Global Assessment (SGA) of Relief questionnaire to as-sess the impact of treatment on irritable bowel syndrome, the Bristol Stool Form Scale (BSFS) to evaluate stool form measurement; and the 12-item Short Form Survey (SF-12) to assess the quality of life, were administered before and after treatment to each patient.</p><p><strong>Results: </strong>Zeolite was shown to be quite effective in taking control of the frequent stool's emission. In the majority of clinical cases, in fact whether administered alone or with other curing-disease -tailored-therapies, it reached the required goal to restore the number and quality of stools output, improving the daily life. In addition, patients with irritable bowel disease strongly decreased diarrhoea, reducing the discomfort, and increasing the social self-confidence. Changes in blood and faecal parameters were observed during and after Xeoderm treatment.</p><p><strong>Discussion: </strong>This study provided anecdotal evidence of effectiveness and safety of the prescribed zeolite brand, with improvement of the specific symptoms of diarrhoea: stool consistency, and possible abdominal colicky pain. A reasonable explanation might be that probably some immune modification of the inflammatory background, with reduction of the cytokine cascade normalized the colonic mucosa cells turnover with drainage of submucous oedema and reabsorption of the inflammatory granulocyte and lymphomonocytes infiltration.</p><p><strong>Conclusions: </strong>This specific brand of zeolite has to be taken into account in the symptomatic treatment of acute and chronic diarrhoea especially when anti-diarrhoeic classic protocol has failed.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCL footprints are potential predictor of ACL graft size or the femoral footprint of the anterior cruciate ligament changes with aging?","authors":"R Gupta, A K Nayyar","doi":"10.7417/CT.2025.5158","DOIUrl":"https://doi.org/10.7417/CT.2025.5158","url":null,"abstract":"<p><strong>Objective: </strong>In spite of the advancement to anatomic ACL recon-struction (ACLR), approximation of the native ACL size in pre-op conditions is a challenging task. Therefore, a method was developed for using an intact posterior cruciate ligament (PCL) as an interpreter of anterior cruciate ligament (ACL) graft size.</p><p><strong>Material and method: </strong>Fifty embalmed knees of known gender and age (15 male/10 female) were dissected. The length of ACL and PCL, as well as the size and shape of femoral and tibial footprints of both cruciate ligaments, were measured, and evaluate the correlation. Linear regression models were used to identify the relationship between ACL and PCL measurement.</p><p><strong>Result: </strong>PCL femoral and tibial footprints were statistically signi-ficant predictors of ACL femoral and tibial footprints. The following equations were developed to calculate ACL femoral and tibial foot-print measurements from an intact PCL measurement: ACL femoral footprint = 67.03 + 0.046*PCL femoral footprint, ACL tibial footprint = 240.23 - 0.77* PCL tibial footprint. A significant difference was observed between the frequency rates of the morphologies of femoral and tibial footprints of the younger and older groups (p < 0.001 for both genders). However, no differences were observed between males and females of the same age group.</p><p><strong>Conclusion: </strong>Associations be present in between ACL and PCL measurements. The length of ligaments was higher in male than female. There was a strong correlation between height and length of ligaments but no correlation with age.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Observational Study on the Prediction of Cardiovascular Events and Mortality from Cardiovascular Diseases in Patients from Different Socio-Demographic and Ethnic Groups.","authors":"A Sivkov, N Chernus, A Spaska, M Kubareva","doi":"10.7417/CT.2025.5162","DOIUrl":"https://doi.org/10.7417/CT.2025.5162","url":null,"abstract":"<p><strong>Background: </strong>Currently, additional risk factors for cardiovascular diseases (CVD), including nationality, psychological characteristics, and social status, are under consideration. Therefore, there is a need for the exploration and assessment of the contribution and consideration of the aforementioned factors to determine patient-oriented management strategies.</p><p><strong>Methods: </strong>Participants underwent a survey using the \"social determinants\" questionnaire, which was developed and initially utilized in the context of the extensive American MESA study. Based on the identified set of adverse socio-demographic factors during the survey, an assessment of their cumulative impact on major cardiovascular risk factors, systemic inflammation, subclinical atherosclerosis, and cardiovascular diseases was conducted.</p><p><strong>Results: </strong>An association was established between increasing social adversity and an elevated likelihood of developing all cardiovascular risk factors, except for dyslipidemia. Smoking exhibited the most significant association with deteriorating health-related social determinants (odds ratio [OR], 2.67 for quartile 4 versus quartile 1 [95% CI, 2.13-3.34]). Compared to patients in quartile 1 of health-related social determinants, those in quartile 4 had a one-third increased risk of elevated C-reactive protein (OR, 1.33 [95% CI, 1.11-1.60]) and a 31% increased risk of all cardiovascular diseases (risk ratio, 1.31 [95% CI, 1.03-1.67]).</p><p><strong>Conclusions: </strong>The risk of cardiovascular diseases was higher in immigrants from the North Caucasus republics and Central Asia compared to the indigenous population and immigrants from Eastern Asia. For representatives of the mentioned ethnic groups, the prevalence was significantly higher in quartile 4 than in quartile 1: 43.0% versus 29.2%, respectively (p < 0.001).</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"27-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Asana and Pranayama on Heart Rate Variability and Cardiac Autonomic Functions in Young Femaleswith Premenstrual Syndrome: An Interventional Clinical Trial.","authors":"A Pai, L Shetty, G Bhasin, K Vasanthalaxmi, A K Nayanatara, G Shyamala, K Annapoorna, S D Manjula","doi":"10.7417/CT.2025.5171","DOIUrl":"https://doi.org/10.7417/CT.2025.5171","url":null,"abstract":"<p><strong>Background: </strong>Premenstrual syndrome (PMS) is known to be a prevalent health concern affecting a significant number of women globally and yoga is found to be beneficial in such psychosocial disorders.</p><p><strong>Objective: </strong>To evaluate the effectiveness of a structured yoga intervention by comparing pre-and post-intervention changes in the severity of PMS symptoms and cardiac autonomic functions in young, healthy female students over the course of three menstrual cycles.</p><p><strong>Methods: </strong>The present study is a trial conducted in the Department of Physiology, Kasturba Medical College, Manipal which consists of 49 young, healthy female volunteers suffering from moderate PMS. Heart rate variability (HRV) and autonomic functions were assessed via PowerLab, after which yoga training was provided for a 12-week duration in the Division of Yoga, CIMR. HRV and other autonomic function tests were again repeated postintervention.</p><p><strong>Results: </strong>Student's t-test was used to analyze the different parameters, and significant improvements were observed in the time domains of the HRV (i.e. SDNN). There was a significant decrease in the SBP and heart rate. Cardiac autonomic function tests revealed reduced sympathetic drive.</p><p><strong>Conclusion: </strong>This study revealed that significant alterations were seen in HRV and autonomic functions during the regular practice of yoga in young healthy females in the premenstrual phase. These findings suggest that regular yoga practice can have beneficial effects on parasympathetic dominance as well as overall well-being by creating a balance in the neuro-endocrinal axis.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The yield of using single-nucleotide polymorphism-based chromosomal microarray analysis in diagnosis the genetic etiology of fetal growth restriction.","authors":"P T Nguyen, T N L Hoang, D C Tran, Q T Nguyen","doi":"10.7417/CT.2025.5166","DOIUrl":"https://doi.org/10.7417/CT.2025.5166","url":null,"abstract":"<p><strong>Background and objects: </strong>Intrauterine growth restriction (IUGR) is a common and complex obstetricsc condition, especially when accompanied by congenital abnormalities. The aim of this research is to diagnose the genetic abnormalities in IUGR fetuses with malformation on ultrasound.</p><p><strong>Subjects and methods.: </strong>Cross-sectional descriptive study performed from 2021 to 2023 at the Prenatal diagnosis center of National Hos-pital of Obstetric and Gynecology, collected total of 129 cases IUGR suitable for research.</p><p><strong>Results: </strong>The average gestational age at which growth restriction was 25.40 ± 4.86 weeks, IUGR fetuses often accompanied malformations, most of them belong to the cardiovascular system, 75 cases undergoing amniocentesis for karyotyping and SNP Array testing to examine genetic abnormalities. There were 26 cases detected with genetic abnormalities, including 8 cases by both methods, 16 cases with positive Array but negative karyotype, Array SNP can detect twice the number of cases that could be missed, 16 pathogenic copy number variations (CNVs) including gains and deletions, related to some specific clinical syndromes.</p><p><strong>Conclusion: </strong>CMA technology shows quite effective application value in determining genetic causes of IUGR and Array SNP should be recommended for use.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life and health rights for italy's disabled without caregivers.","authors":"P Bailo, M Cennamo, A M Caraffa, F Gibelli, G Pesel, G Ricci","doi":"10.7417/CT.2025.5167","DOIUrl":"https://doi.org/10.7417/CT.2025.5167","url":null,"abstract":"<p><strong>Background: </strong>Individuals with severe disabilities face significant challenges when left without parental or familial support. Italian Law 112 of 2016, commonly referred to as the \"After Us\" law, was introduced to address these issues by ensuring long-term care and economic security for disabled individuals. Eight years after its enactment, there is a need to assess the law's effectiveness and whether the allocated resources meet the needs of the intended beneficiaries.</p><p><strong>Methods: </strong>This study provides a detailed examination of the \"After Us\" law, focusing on key protective measures designed to prevent the institutionalization of disabled individuals and support independent living. The analysis includes a review of co-housing options, accessible living facilities, and training programs aimed at fostering autonomy. Additionally, a thorough investigation into the law's application is conducted, incorporating an analysis of relevant decrees, state funding mechanisms, regional implementation strategies, and the financial audit conducted by the Court of Auditors.</p><p><strong>Results: </strong>The analysis reveals both the strengths and limitations of the \"After Us\" law. While the law provides essential protective measures, such as housing options and independent living support, regional disparities in implementation and varying levels of state funding have affected its overall impact. Furthermore, the financial review suggests that the allocated funds may not be sufficient to ensure the law's full and equitable application across Italy.</p><p><strong>Conclusions: </strong>The study underscores the importance of consistent and comprehensive social policies in safeguarding the welfare of individuals with severe disabilities. While the \"After Us\" law represents a significant step forward, uniform implementation across Italy remains a challenge. Additionally, comparisons with similar regulations in other European countries suggest that further improvements are necessary to ensure long-term care and economic security for disabled individuals throughout the European Union.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-operative total neoadjuvant therapy in locally advanced rectal cancer patients: Initial results of Vietnamese patients.","authors":"H H Nguyen, H H Nguyen, T H Nguyen, Q B Bui, H T Vu","doi":"10.7417/CT.2024.5149","DOIUrl":"10.7417/CT.2024.5149","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the initial results of neoadjuvant chemoradiation followed by consolidation chemotherapy (total neoadjuvant therapy - TNT) in locally advanced rectal cancer (LARC) and its side effects.</p><p><strong>Material and method: </strong>A prospective study in 75 patients with stage II and III rectal cancer at 108 Military Central Hospital and Nghe An Oncology Hospital from April 2022 to January 2024 who received total neoadjuvant therapy (preoperative chemoradiation of 50.4 Gy concurrent with Capecitabine 825 mg/m², twice a day for 5 days per week, then added neoadjuvant chemotherapy with the mFOLFOX6 or CAPEOX regimen) and subsequently underwent surgery.</p><p><strong>Results: </strong>The median age was 60.07. Males accounted for 58.7%. Most patients in the study group exhibited tumor stage T3, accounting for 88.0% of the total. The percentages for lymph node stages N0, N1, and N2 were 14.7%, 40.0%, and 45.3%, respectively. 20.09% of patients exhibited a positive result for CRM on magnetic resonance imaging. CEA levels measured before and after using TNT were stati-stically significantly lower than before TNT. After treatment, 25 out of 75 patients (33.3%) had a pathological complete response (pCR). Side effects were mainly grade 1 or 2. Leukopenia was the most common side effect in both neoadjuvant chemoradiotherapy and consolidation chemotherapy. The patients underwent TME (60%), Miles (26.7%), LAR-RAR (12%), and ISR (1.3%). 10.6% of the patients experienced postoperative complications.</p><p><strong>Conclusion: </strong>Total neoadjuvant therapy is an effective and safe treatment and results in acceptable rates of pathological complete response.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"422-429"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}