Clinica Terapeutica最新文献

{"title":"Bioinformatics tool in Identification of the Structural and Functional Impact Of ACE Isoform 1 precursor gene.","authors":"D Pai, U Adiga, S Adiga, D Chaitra, A Shetty, L Krishna","doi":"10.7417/CT.2025.5229","DOIUrl":"10.7417/CT.2025.5229","url":null,"abstract":"<p><strong>Background: </strong>The genetic variations in human genome causes considerable in the phenotype which is influenced by single nucleotide polymorphism. It is very challenging to determine which SNP in a candidate gene is responsible for a given phenotype, and requires testing hundreds or thousands of SNPs. The SNPs are utilized to map the susceptibility of genes involved in complex diseases and to connect the genetic variants that determine an individual's reaction to different medications. The hardest part of the mapping is deciding which set of SNPs to use. Only those SNPs with functional significance may be included in the set of SNPs selected for a given study after screening. One such prediction tool that helps to distinguish between SNPs with functional significance and neutral SNPs is the tool called \"Bioinfor-matics.\". One of the microvascular complications of diabetes mellitus is diabetic nephropathy. As the nephropathy advances, the patients depend on the renal replacement therapy. Angiotensin converting enzyme is a part of Renin-angiotensin system that plays an important role in maintaining the blood pressure and renal hemodynamics.</p><p><strong>Aim: </strong>To analyze and extract the ACE isoform 1 precursor gene's functional SNP by the bioinformatic tool and analysis of ACE rs267604983 gene by SIFT and PROVEAN tool and performing HOPE modelling.</p><p><strong>Methods: </strong>SIFT and PROVEAN bioinformatics tools were applied to extract the functional SNP's of ACE isoform precursor 1 gene.</p><p><strong>Results: </strong>The database yielded about 9,680 single nucleotide polymorphisms. Coding variations were 100%, according to SIFT analysis of the ACE precursor gene. 94% of those projected were met. 30% were destructive, and were tolerated. Merely 6% were synonymous, while the remaining 94% were not. According to PROVEAN, 25% of the samples were harmful and 65% were tolerable.</p><p><strong>Conclusion: </strong>In conclusion, new information about the complexities of diabetic nephropathy may be revealed by combining in silico analysis with wet laboratory research. For those who are at risk of diabetic nephropathy, customized medicine techniques and targeted medicines may become possible if the predictions made by bioinformatics tools match the results of experiments.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"324-329"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution Of Postmortem Computed Tomography in evaluation of fatal work accidents: A Case Study During The Covid-19 Pandemic State.","authors":"V Cianci, C Mondello, C Pitrone, D Iannello, A Messina, A Cianci, A Cracò, A Bottari, P Gualniera, A Asmundo, C Giorgianni, D Sapienza","doi":"10.7417/CT.2025.5235","DOIUrl":"10.7417/CT.2025.5235","url":null,"abstract":"<p><strong>Introduction: </strong>Workplace safety is continually improving in many developed countries, but, despite this, work-related injuries, including fatal ones, are on the rise. Furthermore, in all cases of serious non-fatal accidents, a high morbidity rate for workers has been documented, burdened by an equally large expense that the State will have to sustain as damage compensation. Often, in case of fatal accidents, it is necessary to reconstruct the dynamics that caused the death, which makes it necessary to analyze all the lesions detectable on corpses. In this perspective, postmortem computed tomography (PMCT) has become essential to increase the speed and diagnostic accuracy, especially in case of lesions affecting the bone structures.</p><p><strong>Methods: </strong>A retrospective analysis aimed at evaluating the data collected from judicial autopsies performed between January 2019 and the recent month of March 2023 was carried out, focusing on those related to fatal accidents occurred at work.</p><p><strong>Results: </strong>According to the inclusion criteria, 18 out of the 204 autopsies carried out during the pre-established time frame were included, as certainly classifiable as \"occupational deaths\". Among the 18 enrolled corpses, 16 were male and 2 female subjects. The traumatic events responsible of the death were analysed: 40% were related to falls from heights greater than 2 meters, 28% to explosion, 22% to accidental crush, 5% to electrocution and 5% to semi-truncation.</p><p><strong>Discussion and conclusions: </strong>Among fatal accidents, those related to falls from great heights and crushing are described as the most common, while among the least common are deaths due to electrocution. With reference to the location of injuries, those involving the head are considered the most fatal, while rib fractures are considered as the most common. In this context, postmortem computed tomography can be very helpful, not only for the two- and three-dimensional reconstruction of fractures, but also for understanding the dynamics with which fatal accidents develop in the workplace. This can both ensure a better assessment of the responsibilities of workers and/or the employer, and lead to the evaluation of the suitability of protective devices, also allowing to make them safer.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"363-370"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasculature and External Surface Variations of the Cadaveric Liver: Embryological Perspective with Clinical Relevance.","authors":"N Bhardwaj, H Krishna, S Ghatak, S Gupta","doi":"10.7417/CT.2025.5228","DOIUrl":"10.7417/CT.2025.5228","url":null,"abstract":"<p><strong>Background: </strong>The liver, a highly vascular organ, receives its nourishment from the dual supply of the hepatic artery and portal vein. Variations in this vascular supply of the liver often emerge serendipitously during abdominal surgeries and radiological procedures, revealing the organ's complex anatomy. While many of these vascular and morpho-logical variations remain asymptomatic, a sound knowledge of these variations of the liver is of utmost importance for ensuring successful outcomes in hepatobiliary surgeries. Awareness of these vascular variations can be a safeguard against intraoperative injuries and complications such as hemorrhages, necrosis, postoperative thrombosis, and liver failure. Recognizing and anticipating these variations can significantly enhance surgical precision and patient safety.</p><p><strong>Methods: </strong>The present study was conducted on 110 formalinfixed cadaveric livers aged 60-90 years in the Department of Anatomy, AIIMS Jodhpur. We observed the variations in the hepatic artery and portal vein, including branching patterns and aberrant branches. We also observed surface variations in the liver.</p><p><strong>Results: </strong>Variations in arterial supply were found in 25.45% (28/110) of the liver specimens. The most prevalent arterial variation was the trifurcation of the hepatic artery proper, which was observed in 21.81% (24/110) of specimens. Trifurcation of the portal vein was observed in 4.55% (5/110) specimens. Additionally, 16.36% (18) of specimens exhibited arterial and surface variations. The surface variations were noted in 80.9% (89/110) of liver specimens, with 34.55% having multiple surface variations. Vascular and surface morphological variations were observed in 1.8% (2/110) of specimens.</p><p><strong>Conclusion: </strong>Understanding these vascular and surface variations is crucial for planning and executing hepatobiliary surgeries such as liver transplantation, pancreatoduodenectomy, biliary reconstruction, portal vein embolization, and portosystemic shunts. This knowledge can help minimize complications during these procedures.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"317-323"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of survival in patients with advanced non-small cell lung cancer treated with tyrosine-kinase inhibitors: Value of SUVmax or value of other factor?","authors":"T Pham-Van, T C Bui, C P Pham, L T Le, T K Mai, B D Nguyen, H T Vo-Thi, Q H Nguyen","doi":"10.7417/CT.2025.5165","DOIUrl":"10.7417/CT.2025.5165","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the role of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and other factors in prediction of response and survival following epithelial growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy in patients with advanced lung adeno-carcinomas and EGFR mutations.</p><p><strong>Methods: </strong>Patients having a diagnosis of non-small cell lung cancer (NSCLC) who received 18F-FDG PET/CT imaging for staging before therapy between November of 2018 and May of 2023 at the Nuclear Medicine and Oncology Centre, Bach Mai Hospital.</p><p><strong>Results: </strong>67 patients diagnosed with advanced EGFR-mutated adenocarcinoma, 25 (37.3%) were male, and 42 (62.7%) were female. During the following observation period, there were 42 cases (62.7%) of mortality attributed to cancer. We verified that the remaining 25 patients (37.3%) were still alive when writing this report. The mean SUVmax is 9.12 (±3.81), ranging from 1 to 18. The mean Progression-Free Survival (PFS) is 18.22 months (±13.38), ranging from 0 to 51 months. The mean overall survival (OS) is 27.43 months (±15.773), ranging from 2 to 59 months. SUVmax was not associated with survival status. The area under the curve = 0.624 with p-value =0.092. OS was higher in age < 70 years old and in patients with adverse events. PFS was higher in age < 70 years old and in female patients.</p><p><strong>Conclusion: </strong>SUVmax was not associated with survival status. OS was higher in age < 70 years old and in patients with adverse events. PFS was higher in age < 70 years old and in female patients.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Cerebral Ventricular Dimensions in the Adult Population of Northern India: A Cross-Sectional Study Using Magnetic Resonance Imaging.","authors":"A Patra, H Kaur, P Chaudhary, K S Ravi, A Asghar, J Walocha, T Iskra, M Blaszczyk","doi":"10.7417/CT.2025.5160","DOIUrl":"10.7417/CT.2025.5160","url":null,"abstract":"<p><strong>Purpose: </strong>This primary aim of the study was to establish the normative values of brain ventricles and indices in the adult North Indian population. Secondary aims were to evaluate sex and age-related differences, assess the applicability of widely cited normal ventricle size ranges in the study population, and explore the correlation between ventricular dimensions and anthropometric parameters.</p><p><strong>Methods: </strong>Magnetic resonance imaging (MRI) of 142 healthy individuals, aged between 18 to 72 years, was conducted and sagittal and axial images were utilized for brain ventricles measurements.</p><p><strong>Results: </strong>The study revealed following mean values for brain ventricles and indices in males: frontal horn width (FHW), third ventricle width (TVW), fourth ventricle anteroposterior width (FVWAP), fourth ventricle transverse width (FVWT) and the transverse inner diameter of the skull (TIDS) were 33.07 mm, 4.20 mm, 8.62 mm, 13.12 mm, and 117.6 mm respectively. In females, the corresponding dimensions were 30.20 mm, 3.65 mm, 8.20 mm, 12.62 mm, and 116.05 mm, respectively. Statistically significant differences between the sexes were observed only in TVW. The mean values of Evans' index were 0.25 ± 0.020 in females and 0.26 ± 0.024 in males.</p><p><strong>Conclusion: </strong>The findings contribute valuable insights into the normal values of brain ventricles and indices among healthy adult individuals of North Indian origin, as determined by MRI. The exploration of sex and age-related differences holds significance for facilitating the diagnosis and management of hydrocephalic patients. The calculated mean values of Evans' index provide a reliable metric for aiding the diagnosis of various neurological disorders, including the early detection of hydrocephalus and cerebral atrophy, and offer crucial follow-up information for affected patients.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-colonoscopy pancreatitis: a case report and a systematic review of the literature.","authors":"I D Gkegkes, A P Stamatiadis","doi":"10.7417/CT.2025.5164","DOIUrl":"10.7417/CT.2025.5164","url":null,"abstract":"<p><strong>Background: </strong>Colonoscopy represents a commonly performed endoscopic procedure for the study of large bowel. Even though, colonoscopy is considered a safe and well-tolerated procedure, in the literature, it has also been related with in a few cases of acute pancreatitis.</p><p><strong>Methods: </strong>A systematic PubMed and Scopus search was conducted, a propos of a case report.</p><p><strong>Results: </strong>Twelve patients were included from 11 case reports. The mean age of the patients was 57.4 years (range: 25 - 84). None of the included patients had a history of cholelithiasis or alcoholism. The principal indication for colonoscopy was cancer/polyp surveillance (7 out of 12, 58.3%). Polypectomy was performed in 9 patients (75%). In 4 out of 12 cases (33.3%) the procedure of colonoscopy was characterised as difficult and external manipulation was necessitated. The mean onset of symptoms was 8 hours after colonoscopy (range: 2 - >24). Hospitalization was necessary in 9 out of 12 patients (75%). Regarding the location of the pancreatitis, body/tail (3 out of 12, 25%), body (4 out of 12, 33.3%) and tail (4 out of 12, 33.3%) were most affected. The median duration of symptoms was 7 days (range: 3-12). No complications were reported. The mean follow-up period of the included patients was 15 months (range: 3-36). No fatalities were reported.</p><p><strong>Conclusion: </strong>Post-colonoscopy pancreatitis is an extremely rare complication of colonoscopy. After having excluded a surgical emergency, acute pancreatitis should be taken into consideration, especially when endoscopy is technically challenging. Conservative management is indicated in these cases, while no serious sequels have been reported in the literature.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey on Twenty Years of Robotic Surgery in Italy: Evaluating Distribution, Bioetic Impact, and Future Directions.","authors":"F Guzzi, U G Falagario, A Mari, L Napolitano, A Fanelli, M Karaboue, G V Lacasella, V Mirone, A Salonia, V Ficarra, A Minervini, G Carrieri","doi":"10.7417/CT.2025.5237","DOIUrl":"10.7417/CT.2025.5237","url":null,"abstract":"<p><strong>Aim: </strong>The Italian Society of Urology conducted a comprehensive survey across Italy's urology specialists to assess the prevalence and integration of robotic surgery in the country's medical landscape. The survey aimed to examine the diffusion and acceptance of robotic surgical platforms and to ascertain surgeons' preferences regarding the most frequently performed urological procedures.</p><p><strong>Materials and methods: </strong>The Italian Society of Urology surveyed Italian urologists via SURVEYMONKEY. Emails were sent to society members and clinic heads, covering geographic location, robotic practices, and procedures. The 44-question survey, open from March to June 2023, gathered data on clinic location, equipment, cases, and techniques. Descriptive statistics were used, reporting median and inter-quartile range for continuous variables, and rates for categorical ones. Analysis included respondent characteristics, robotic surgery availability, applications, and technical modifications. Stata 16 conducted statistical analyses (StataCorp LP, College Station, TX, USA).</p><p><strong>Results: </strong>The study included 339 urologists with varied institutional and professional backgrounds, investigating aspects like the availability of robotic technology, preferences in procedures, surgical methodologies, and training programs. Participants included 50% affiliated with university hospitals, 25% with non-university hospitals, and 25% with IRCCS institutions and accredited private hospitals. The survey showcased significant geographic diversity, receiving responses from urologists across all regions of Italy, with Lombardy being the most represented (19.7%), followed by Lazio (12.9%) and Veneto (11.2%). Notably, 93.7% of respondents associated robotic surgery with economic benefits, attributing to reduced hospital stays and increased facility attractiveness. Among urological procedures, robotic-assisted techniques were preferred for Radical Prostatectomies (88%), partial nephrectomy (87%), and pyeloplasty (79%), while cystectomies and radical nephrectomy were commonly performed using open or lap-aroscopic approaches.</p><p><strong>Conclusion: </strong>The survey findings highlight the widespread use and influence of robotic surgery in Italian urology, showcasing enhanced patient care but also indicating technique discrepancies and restricted access in certain facilities. Standardization, accessibility, and ongoing training are vital for maximizing robotic surgery's potential across specialties.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"376-385"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Era of Pandemics and the Need for Readjustment of National Health Systems.","authors":"M Karaboue, C Cecannecchia, E Dimauro, S De Simone, F Orsini, L Cipolloni, G V Lacasella, A Cioffi","doi":"10.7417/CT.2025.5238","DOIUrl":"https://doi.org/10.7417/CT.2025.5238","url":null,"abstract":"<p><strong>Abstract: </strong>The last few years have been marked by true upheavals in the organization of both public and private healthcare systems. These upheavals have had their epicenter in the impact that the COVID-19 pandemic has had on the organization of healthcare systems. Additionally, the management of healthcare resources, the methods of medical-scientific communication, medical professional responsibility, and the maintenance of adequate equity and equality have also been destabilized and questioned. It is crucial to understand how much our healthcare systems have benefited from recent events and how prepared they are for future, potential, and likely new challenges that may arise in the coming years. Unfortunately, many of the issues high-lighted during the pandemic phase have yet to be addressed, and new challenges have likely emerged. This situation inevitably exposes the healthcare systems to the creation of new vulnerabilities, which could lead to serious consequences concerning inequality, the professional responsibility of individual doctors and healthcare structures, and the overall sustainability of national healthcare systems.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"386-390"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case of Kenneth Smith \"The war of a state against a citizen\".","authors":"R Rinaldi, F M Damato, S Libianchi","doi":"10.7417/CT.2025.5161","DOIUrl":"10.7417/CT.2025.5161","url":null,"abstract":"<p><strong>Purpose: </strong>This paper aims to examine the ethical implications of capital punishment, with a focus on the recent use of nitrogen asphyxi-ation in the case of inmate Kenneth Eugene Smith. It seeks to reopen the discussion on the death penalty from a bio-ethical perspective, considering the sensory experience of death and its impact on both inmates and observers.</p><p><strong>Methods: </strong>To analyze the case of Kenneth Eugene Smith, an in-depth search was conducted on scientific databases and international newspapers. Sources were selected to support the analysis of the case, including discussions on previous death penalty debates. Additionally, an overview of nitrogen usage and its physiological effects was provided.</p><p><strong>Results: </strong>he execution of Kenneth Eugene Smith by nitrogen asphyxiation is described, highlighting observations made by witnesses and the prisoner's resistance. Discussion points include the prisoner's suffering, the execution method's lack of scientific study, and transparency.</p><p><strong>Conclusions: </strong>The paper, according to shared ethical principles, criticizes the execution method failure and calls for further research to analyze the psychic and physical distress experienced by the inmates. It advocates for a reevaluation of execution protocols to uphold human dignity and minimize suffering.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary cysts in children with biliary atresia after Kasai procedure.","authors":"T T Tran, T K Phan, L A T Le, P D Ho, N H Au, N T Pham","doi":"10.7417/CT.2025.5170","DOIUrl":"10.7417/CT.2025.5170","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the treatment outcomes of biliary cysts in children with biliary atresia (BA) after undergoing the Kasai procedure.</p><p><strong>Methods: </strong>A case series study on all cases were diagnosed with biliary cysts following the Kasai procedure and treated at Children's Hospital 2 from January 2017 to December 2022.</p><p><strong>Results: </strong>A total of 29 pediatric patients were included in the study, of which 17 were female. The average time of biliary cyst detection post-Kasai procedure was 22.2 months. Solitary cysts accounted for 34.5% of the cases, while multiple cysts accounted for 65.5%. 26/29 patients (89.7%) presented with jaundice. A total of 93.1% (27/29) of cases presented with cholangitis, of which 12 responded well to intravenous antibiotics. 6/27 patients required percutaneous transhe-patic biliary drainage (PTBD) (three of which were successful, one patient underwent cyst-enteric anastomosis, one patient needed liver transplantation, and one case resulted in death due to infection). In total, six patients underwent liver transplantation, and five patients died due to infection-related complications.</p><p><strong>Conclusions: </strong>Biliary cysts after the Kasai procedure are frequently associated with jaundice and cholangitis and require treatment in the majority of cases. PTBD combined with intravenous antibiotics is an effective treatment for simple cysts and can be considered for more complex cysts when liver transplantation is not immediately feasible.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"91-96"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}