Clinica Terapeutica最新文献

{"title":"The effects of laser therapy on pain, functionality and biomechanical parameters in patients suffering from gonarthrosis: an observational study.","authors":"F Agostini, F Capuano, C Sebastiani, V Santilli, G Santilli, M Damanti, M Isola, M Paoloni, M Mangone","doi":"10.7417/CT.2025.5230","DOIUrl":"10.7417/CT.2025.5230","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) consists of a heterogeneous pathology of the peripheral joints, characterized by a complex, multifactorial nature and with multiple risk factors. The aim of this study was to evaluate the effects of laser therapy on pain and biomechanical parameters in patients with KOA.</p><p><strong>Methods: </strong>A retrospective study was carried out for patients with KOA (I-II Kellgren-Lawrence). All patients underwent 10 sessions of Laser therapy (three/week). Patients were evaluated at T0 and 22 days later-T1. At T0, before the treatment and at T1 pain (Visual Analogue Scale-VAS), symptoms (Knee Injury and Osteoarthritis Outcome Score-KOOS and Western Ontario and McMaster Universities Osteoarthritis Index-WOMAC) and instrumental assessment (gait analysis) were assessed.</p><p><strong>Results: </strong>Twelve patients were included. A significant difference was found in all three scales between T0-T1, VAS decreased by three points (p=0.002), KOOS increased by fifteen points (p=0.008) and WOMAC decreased by 8.5 (p=0.003). For gait analysis parameters, we detected a significant decrease in stance duration (p=0.04), a marked increase in speed normalized to height (p=0.01), an increase in knee ROM (p=0.01) and an increase in maximum knee moment (p=0.02).</p><p><strong>Conclusions: </strong>Laser therapy is an effective intervention in the management of KOA. Our study showed that laser therapy is effective in relieving pain and improving symptoms as well as gait parameters.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"330-335"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Gastrointestinal Deaths of a Child due to a Fecaloma: a Multilevel Forensic Pathological Approach.","authors":"G V Lacasella, S De Simone, M Karaboue, A Montana, F Orsini, E Dimauro, L Cipolloni, A Cioffi, C Cecannecchia","doi":"10.7417/CT.2025.5221","DOIUrl":"10.7417/CT.2025.5221","url":null,"abstract":"<p><strong>Background: </strong>Sudden gastrointestinal deaths refer to unexpected fatalities that occure due severe gastrointestinal conditions. They are rare, especially when compared to sudden deaths caused by cardiovascular, respiratory or neurological events. It is even more rare that a sudden death due to gastrointestinal causes occurs in a child.</p><p><strong>Results: </strong>We presented a unique case of sudden death of a 9-year-old child with no pertinent medical history, presenting abdominal pain and diarrhea and deceased shortly after the onset of symptoms. The autopsy showed a severe intestinal obstruction due to a rectosigmoid fecaloma. In addition, the immunohistochemical evaluation revealed an inflammation of the intestine.</p><p><strong>Conclusion: </strong>In case of sudden deaths, forensic pathological investigation is essential to determine the cause of death. Diagnosis can only be made through a rigorous and multi-level post-mortem approach in which immunostochemical investigation can also make an important contribution.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"271-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical legal evaluations on the radiological error: has the use of PACS introduced changes in cognitive errors?","authors":"M Salducci, V Martines, M S Simonelli","doi":"10.7417/CT.2025.5239","DOIUrl":"https://doi.org/10.7417/CT.2025.5239","url":null,"abstract":"<p><strong>Abstract: </strong>The introduction of PACS (Picture Archiving and Communication System) digital image archiving systems has changed the way radiologists work. We refer to a new typology of cognitive error that we can define as confirmation compulsion. It is a behavior that includes components of emotional influence, contour influence and the tendency to alliteration. The frequent possibility of comparing previous exams on the same reporting console leads radiologists to automatically compare with the latest exam being viewed. This operational methodology is not suitable for the identification of slowly evolving pathologies whose changes can only be appreciated through comparative evaluation considering time intervals longer than 6-12 months and equal, for example, to 24 months. This type of error is avoided by comparing with exams from two or three previous years.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"391-393"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Observational Study on the Prediction of Cardiovascular Events and Mortality from Cardiovascular Diseases in Patients from Different Socio-Demographic and Ethnic Groups.","authors":"A Sivkov, N Chernus, A Spaska, M Kubareva","doi":"10.7417/CT.2025.5162","DOIUrl":"10.7417/CT.2025.5162","url":null,"abstract":"<p><strong>Background: </strong>Currently, additional risk factors for cardiovascular diseases (CVD), including nationality, psychological characteristics, and social status, are under consideration. Therefore, there is a need for the exploration and assessment of the contribution and consideration of the aforementioned factors to determine patient-oriented management strategies.</p><p><strong>Methods: </strong>Participants underwent a survey using the \"social determinants\" questionnaire, which was developed and initially utilized in the context of the extensive American MESA study. Based on the identified set of adverse socio-demographic factors during the survey, an assessment of their cumulative impact on major cardiovascular risk factors, systemic inflammation, subclinical atherosclerosis, and cardiovascular diseases was conducted.</p><p><strong>Results: </strong>An association was established between increasing social adversity and an elevated likelihood of developing all cardiovascular risk factors, except for dyslipidemia. Smoking exhibited the most significant association with deteriorating health-related social determinants (odds ratio [OR], 2.67 for quartile 4 versus quartile 1 [95% CI, 2.13-3.34]). Compared to patients in quartile 1 of health-related social determinants, those in quartile 4 had a one-third increased risk of elevated C-reactive protein (OR, 1.33 [95% CI, 1.11-1.60]) and a 31% increased risk of all cardiovascular diseases (risk ratio, 1.31 [95% CI, 1.03-1.67]).</p><p><strong>Conclusions: </strong>The risk of cardiovascular diseases was higher in immigrants from the North Caucasus republics and Central Asia compared to the indigenous population and immigrants from Eastern Asia. For representatives of the mentioned ethnic groups, the prevalence was significantly higher in quartile 4 than in quartile 1: 43.0% versus 29.2%, respectively (p < 0.001).</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"27-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCL footprints are potential predictor of ACL graft size or the femoral footprint of the anterior cruciate ligament changes with aging?","authors":"R Gupta, A K Nayyar","doi":"10.7417/CT.2025.5158","DOIUrl":"10.7417/CT.2025.5158","url":null,"abstract":"<p><strong>Objective: </strong>In spite of the advancement to anatomic ACL recon-struction (ACLR), approximation of the native ACL size in pre-op conditions is a challenging task. Therefore, a method was developed for using an intact posterior cruciate ligament (PCL) as an interpreter of anterior cruciate ligament (ACL) graft size.</p><p><strong>Material and method: </strong>Fifty embalmed knees of known gender and age (15 male/10 female) were dissected. The length of ACL and PCL, as well as the size and shape of femoral and tibial footprints of both cruciate ligaments, were measured, and evaluate the correlation. Linear regression models were used to identify the relationship between ACL and PCL measurement.</p><p><strong>Result: </strong>PCL femoral and tibial footprints were statistically signi-ficant predictors of ACL femoral and tibial footprints. The following equations were developed to calculate ACL femoral and tibial foot-print measurements from an intact PCL measurement: ACL femoral footprint = 67.03 + 0.046*PCL femoral footprint, ACL tibial footprint = 240.23 - 0.77* PCL tibial footprint. A significant difference was observed between the frequency rates of the morphologies of femoral and tibial footprints of the younger and older groups (p < 0.001 for both genders). However, no differences were observed between males and females of the same age group.</p><p><strong>Conclusion: </strong>Associations be present in between ACL and PCL measurements. The length of ligaments was higher in male than female. There was a strong correlation between height and length of ligaments but no correlation with age.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Asana and Pranayama on Heart Rate Variability and Cardiac Autonomic Functions in Young Femaleswith Premenstrual Syndrome: An Interventional Clinical Trial.","authors":"A Pai, L Shetty, G Bhasin, K Vasanthalaxmi, A K Nayanatara, G Shyamala, K Annapoorna, S D Manjula","doi":"10.7417/CT.2025.5171","DOIUrl":"10.7417/CT.2025.5171","url":null,"abstract":"<p><strong>Background: </strong>Premenstrual syndrome (PMS) is known to be a prevalent health concern affecting a significant number of women globally and yoga is found to be beneficial in such psychosocial disorders.</p><p><strong>Objective: </strong>To evaluate the effectiveness of a structured yoga intervention by comparing pre-and post-intervention changes in the severity of PMS symptoms and cardiac autonomic functions in young, healthy female students over the course of three menstrual cycles.</p><p><strong>Methods: </strong>The present study is a trial conducted in the Department of Physiology, Kasturba Medical College, Manipal which consists of 49 young, healthy female volunteers suffering from moderate PMS. Heart rate variability (HRV) and autonomic functions were assessed via PowerLab, after which yoga training was provided for a 12-week duration in the Division of Yoga, CIMR. HRV and other autonomic function tests were again repeated postintervention.</p><p><strong>Results: </strong>Student's t-test was used to analyze the different parameters, and significant improvements were observed in the time domains of the HRV (i.e. SDNN). There was a significant decrease in the SBP and heart rate. Cardiac autonomic function tests revealed reduced sympathetic drive.</p><p><strong>Conclusion: </strong>This study revealed that significant alterations were seen in HRV and autonomic functions during the regular practice of yoga in young healthy females in the premenstrual phase. These findings suggest that regular yoga practice can have beneficial effects on parasympathetic dominance as well as overall well-being by creating a balance in the neuro-endocrinal axis.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel potassium channel opener for spontaneous preterm birth prevention: Bringing the concepts together.","authors":"A A Awd, A A Elboghdady, M M Metwally, A R El Makawy, R E Elsayed, M I Mohamed, M A A Elhawary, M R M Elsharkawy, Y M S Diab, B E E Mohamed, E M Taha, S K Galal, M A Abdelmoaty, A Shaaban, W S T Soliman, E E K Sultan, S H M Kamal, M R Mohamed, A A Elhamid, M Saleh, A M Elshorbagy, A F Sherif","doi":"10.7417/CT.2025.5222","DOIUrl":"10.7417/CT.2025.5222","url":null,"abstract":"<p><strong>Aim: </strong>Its goal is to evaluate nicorandil, a potassium channel opener, for tocolysis in premature labor patients in a tertiary care facility.</p><p><strong>Patients and methods: </strong>We evaluated 100 pregnant women who were given nicorandil (study group n= 50 cases) and nifedipine (control group n= 50 cases) for tocolysis in established preterm labour between 24 and 33+6 weeks of gestation. The effectiveness of tocolysis in extending pregnancy for more than 48 hours and 7 days, adverse effects on the mother and fetus, and admission to the neonatal critical care unit were compared across the groups.</p><p><strong>Results: </strong>The number of births at 24 0/7- 33 6/7 weeks did not differ significantly between the two groups when pregnancy was prolonged for more than 48 hours or 7 days (P > 0.05). Negative effects on the mother and fetus were lower in the nicorandil group (< P 0.05), although both groups' rates of newborn ICU hospitalization were comparable (P > 0.05).</p><p><strong>Conclusion: </strong>Nicorandil has the benefit of having less harmful effects on the mother and fetus than nifedipine in situations of established preterm labor for inhibiting labor.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"278-283"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life and health rights for italy's disabled without caregivers.","authors":"P Bailo, M Cennamo, A M Caraffa, F Gibelli, G Pesel, G Ricci","doi":"10.7417/CT.2025.5167","DOIUrl":"10.7417/CT.2025.5167","url":null,"abstract":"<p><strong>Background: </strong>Individuals with severe disabilities face significant challenges when left without parental or familial support. Italian Law 112 of 2016, commonly referred to as the \"After Us\" law, was introduced to address these issues by ensuring long-term care and economic security for disabled individuals. Eight years after its enactment, there is a need to assess the law's effectiveness and whether the allocated resources meet the needs of the intended beneficiaries.</p><p><strong>Methods: </strong>This study provides a detailed examination of the \"After Us\" law, focusing on key protective measures designed to prevent the institutionalization of disabled individuals and support independent living. The analysis includes a review of co-housing options, accessible living facilities, and training programs aimed at fostering autonomy. Additionally, a thorough investigation into the law's application is conducted, incorporating an analysis of relevant decrees, state funding mechanisms, regional implementation strategies, and the financial audit conducted by the Court of Auditors.</p><p><strong>Results: </strong>The analysis reveals both the strengths and limitations of the \"After Us\" law. While the law provides essential protective measures, such as housing options and independent living support, regional disparities in implementation and varying levels of state funding have affected its overall impact. Furthermore, the financial review suggests that the allocated funds may not be sufficient to ensure the law's full and equitable application across Italy.</p><p><strong>Conclusions: </strong>The study underscores the importance of consistent and comprehensive social policies in safeguarding the welfare of individuals with severe disabilities. While the \"After Us\" law represents a significant step forward, uniform implementation across Italy remains a challenge. Additionally, comparisons with similar regulations in other European countries suggest that further improvements are necessary to ensure long-term care and economic security for disabled individuals throughout the European Union.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The yield of using single-nucleotide polymorphism-based chromosomal microarray analysis in diagnosis the genetic etiology of fetal growth restriction.","authors":"P T Nguyen, T N L Hoang, D C Tran, Q T Nguyen","doi":"10.7417/CT.2025.5166","DOIUrl":"10.7417/CT.2025.5166","url":null,"abstract":"<p><strong>Background and objects: </strong>Intrauterine growth restriction (IUGR) is a common and complex obstetricsc condition, especially when accompanied by congenital abnormalities. The aim of this research is to diagnose the genetic abnormalities in IUGR fetuses with malformation on ultrasound.</p><p><strong>Subjects and methods.: </strong>Cross-sectional descriptive study performed from 2021 to 2023 at the Prenatal diagnosis center of National Hos-pital of Obstetric and Gynecology, collected total of 129 cases IUGR suitable for research.</p><p><strong>Results: </strong>The average gestational age at which growth restriction was 25.40 ± 4.86 weeks, IUGR fetuses often accompanied malformations, most of them belong to the cardiovascular system, 75 cases undergoing amniocentesis for karyotyping and SNP Array testing to examine genetic abnormalities. There were 26 cases detected with genetic abnormalities, including 8 cases by both methods, 16 cases with positive Array but negative karyotype, Array SNP can detect twice the number of cases that could be missed, 16 pathogenic copy number variations (CNVs) including gains and deletions, related to some specific clinical syndromes.</p><p><strong>Conclusion: </strong>CMA technology shows quite effective application value in determining genetic causes of IUGR and Array SNP should be recommended for use.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the pharmacokinetics of Ampicillin in newborns' umbilical cord blood and plasma after intrapartum administration for preventing early onset group B streptococcal infection (A prospective study).","authors":"A I M Hasan, I S I Mohamed, M S Mahmoud, A S I Mansour, M M M Saber, M F H Mohammed, M M A M Elfayoumy, M S M Mansour, E N A Mansour, N F Agaba, G N Abd El-Aal, S N Ramdan, S S AbdElgawad, H M Nasr, S A Mohamed, N M Abdalrahim, L A Gad, S A Tahoun, Z N Hamed, M B Yahia, R M Abdelwahed, M M El-Naghi, I A K Mahmoud, A Abady A Ali","doi":"10.7417/CT.2025.5234","DOIUrl":"10.7417/CT.2025.5234","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to determine whether or not ampicillin, following a standard prophylactic dose against group B streptococcal infection, reaches concentrations above the minimum inhibitory concentrations (MIC) in maternal plasma and umbilical cord blood (UCB).</p><p><strong>Patients and methods: </strong>From January 2024 to December 2024, this prospective study was conducted at Al-Azhar and Helwan University Hospitals and included 200 newborns whose moms had received intrapartum ampicillin. There were 200 maternal plasma samples and 200 UCB samples available for examination (between 5 and 75 minutes postpartum).</p><p><strong>Results: </strong>As fast as five minutes after ampicillin infusion, the mean ampicillin concentrations found in maternal and umbilical cord sera all surpassed the lowest bactericidal values documented for group B streptococci (0.25 to 2.0 micrograms/ml).</p><p><strong>Conclusion: </strong>Neonatal quantities of ampicillin over the MIC of GBS are the result of intrapartum dosing.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 3","pages":"358-362"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}