Clinica Terapeutica最新文献

{"title":"Pre-operative total neoadjuvant therapy in locally advanced rectal cancer patients: Initial results of Vietnamese patients.","authors":"H H Nguyen, H H Nguyen, T H Nguyen, Q B Bui, H T Vu","doi":"10.7417/CT.2024.5149","DOIUrl":"10.7417/CT.2024.5149","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the initial results of neoadjuvant chemoradiation followed by consolidation chemotherapy (total neoadjuvant therapy - TNT) in locally advanced rectal cancer (LARC) and its side effects.</p><p><strong>Material and method: </strong>A prospective study in 75 patients with stage II and III rectal cancer at 108 Military Central Hospital and Nghe An Oncology Hospital from April 2022 to January 2024 who received total neoadjuvant therapy (preoperative chemoradiation of 50.4 Gy concurrent with Capecitabine 825 mg/m², twice a day for 5 days per week, then added neoadjuvant chemotherapy with the mFOLFOX6 or CAPEOX regimen) and subsequently underwent surgery.</p><p><strong>Results: </strong>The median age was 60.07. Males accounted for 58.7%. Most patients in the study group exhibited tumor stage T3, accounting for 88.0% of the total. The percentages for lymph node stages N0, N1, and N2 were 14.7%, 40.0%, and 45.3%, respectively. 20.09% of patients exhibited a positive result for CRM on magnetic resonance imaging. CEA levels measured before and after using TNT were stati-stically significantly lower than before TNT. After treatment, 25 out of 75 patients (33.3%) had a pathological complete response (pCR). Side effects were mainly grade 1 or 2. Leukopenia was the most common side effect in both neoadjuvant chemoradiotherapy and consolidation chemotherapy. The patients underwent TME (60%), Miles (26.7%), LAR-RAR (12%), and ISR (1.3%). 10.6% of the patients experienced postoperative complications.</p><p><strong>Conclusion: </strong>Total neoadjuvant therapy is an effective and safe treatment and results in acceptable rates of pathological complete response.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"422-429"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate Influence on Blood Pressure Rhythms and Left Ventricular Parameters in Hypertensive Patients: Comparative Study.","authors":"A Sivkov, N Chernus, T Sakharova, Y Tikhonova, I Vasileva","doi":"10.7417/CT.2024.5152","DOIUrl":"10.7417/CT.2024.5152","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a prevalent condition that significantly impacts cardiovascular health. The rhythmicity of arterial blood pressure (BP) can vary based on climatic conditions, potentially influencing the severity and outcomes of hypertensive complications. The study aims to assess the characteristics of arterial blood pressure rhythmicity in hypertensive patients and their influence on the structural parameters of the left ventricle of the heart in both temperate and subarctic regions of Russia.</p><p><strong>Methods: </strong>The study encompassed 600 randomly selected patients with arterial hypertension, categorized into two groups based on their geographic location: Group 1 comprised patients from Moscow and the Moscow region, while Group 2 included patients from the Kamchatka region. Comprehensive assessments, including cardiovascular ultra-sound, Systematic Coronary Risk Evaluation (SCORE 2 2), and the Framingham Risk Scale, were conducted for all participants. Statistical analyses included descriptive statistics, Student's t-test for comparing means, Mann-Whitney U test for non-parametric data, and Pearson and Spearman correlation analyses. P-values were calculated to assess statistical significance, with a threshold set at P < 0.05.</p><p><strong>Results: </strong>Notably, 49% of patients residing in the subarctic region exhibited an inadequate nocturnal BP reduction (<10%). These non-dipping ABPM patterns were associated with increased diastolic BP variability and elevated Double Product (systolic BP x heart rate) compared to those with normal dipping. Furthermore, the non-dipping ABPM pattern observed in subarctic region residents demonstrated notable correlations with cardiovascular risk factors.</p><p><strong>Conclusions: </strong>The study reveals that patients in the subarctic region exhibit a higher prevalence of non-dipping blood pressure patterns, which is associated with increased diastolic blood pressure variability, higher nighttime blood pressure levels, and a greater incidence of left ventricular hypertrophy. These findings highlight the need for tailored diagnostic and treatment approaches to address the unique cardiovascular risks associated with different climatic conditions.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"441-449"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on bisphenol induce renal damage and role of vitamin c as an antioxidant on bisphenol induced renal damage in wistar rats. A case control study.","authors":"Rekha D Kini, S Kumar, A K Nayanatara, G Megha","doi":"10.7417/CT.2024.5153","DOIUrl":"10.7417/CT.2024.5153","url":null,"abstract":"<p><strong>Introduction: </strong>Bisphenol A (BPA) is considered one of the most common industrial manufactured chemicals and a pollutant. oxidative stress has been induced by bisphenol by dysregulate the cytokines. Oxidative stress induced by BPA is known to affect the brain, liver, and kidneys. Vitamin C is an important dietary antioxidant which is known decreases the oxidative stress induced by reactive oxygen species. Hence the current study was focused to evaluate the damaging effect of BPA on kidney and the role of ascorbic acid on BPA induced kidney toxicity.</p><p><strong>Material & methods: </strong>There were four groups of rats(6 rats in each); Group 1: Control Group (Olive oil treated) Group 2:(Vitamin C treated), Group 3: (Bispenol treated), Group 4: (Vitamin C + Bispenol treated). One kidney homogenized to measure Melonaldihyde level and glutathione and other kidney was used to study the histopathlogical parmeters. Biochemical estimation of serum electrolyte was done by commercially available kits using spectrophotometer.</p><p><strong>Results: </strong>Animals exposed to Bisphenol showed fall in the level of GSH and increase in MDA level as well as fall in serum sodium and potassium level. Biochemical results were supported by histo-pathalogical changes. Pre-treatment with Vitamin C showed an rise in the level of GSH, sodium and potassium level and fall in MDA. Vitamin C pre-treatment also showed some beneficial changes in histology of kidney also.</p><p><strong>Conclusion: </strong>Our result demonstrated that exposure to Bisphenol induced oxidative stress in rat kidney and vitamin C could act as an antioxidant protecting against BPA induced oxidative stress.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"450-454"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passionate Homicides and Overkilling. A Forensic Case Series of Overkill in Rome (Italy) from 1999 to 2015.","authors":"B Baldari, A Cioffi, C Cecannecchia, M A Bosco, L Cipolloni, S De Simone","doi":"10.7417/CT.2024.5142","DOIUrl":"10.7417/CT.2024.5142","url":null,"abstract":"<p><strong>Background: </strong>In forensics, the term overkill refers to the modus operandi of the offender that goes beyond the immediate need to kill the victim, but not beyond the borders of cruelty. The killer - unable to stop his murderous impulse - seems to want to make sure the victim is dead, repeatedly hitting the corpse. From a forensic point of view, this type of murder is characterized by bloody crime scenes and the discovery of brutal wounds on the victim's body.</p><p><strong>Aims: </strong>Through an examination of suggestive cases, we aim to identify and analyse the forensic aspects of overkill. The study aims to provide a framework of the findings in this type of murder to guide forensic assessment and allow differential diagnosis with others type of homicide.</p><p><strong>Methods: </strong>In our study, we examined all the murders occurred in Rome between 1999 to 2015, closed with a final sentence and/or archived. We have therefore selected 18 cases where the crime has degenerated into overkill, because characterized by repeated and several signs of aggression on the body of the victim. For each case, there were analyzed the crime scenes and there were performed complete autopsies.</p><p><strong>Results: </strong>Only in one case the killer was a woman. In most cases victim and killer were partners. As for the motive, in 38.8% of the cases there was a passionate motive, followed by a neighborhood problem (22.2%) and money motive (17%). The sharps were the most used weapons; only in two cases firearms were used. The 39% of our cases had < 10 wounds on the victim's body; only in one case were more than 40 wounds.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"378-386"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesthetic Facial Surgery: a Systematic Review.","authors":"D Poojary, Naresh Y Shetty, A Dubey, Y Lakshmisha Rao, A Sugathan, K S Rashmi","doi":"10.7417/CT.2024.5156","DOIUrl":"10.7417/CT.2024.5156","url":null,"abstract":"<p><strong>Abstract: </strong>The field of facial cosmetic surgery is rapidly expanding and becoming more well-known worldwide. Over the past century, there have been notable developments in medical technology, accessibility to resources, and patient demand for facial plastic surgery in India, a country that has become a global leader in this sector. This study aims to perform a thorough evaluation of current trends and past practises in aesthetic operations and facial plastic surgery in India. In order to do this, common nonsurgical treatments including threaded processes, Botox injections Kybella, filler substances, micro-focused ultrasound, and pharmacologic hair transplantation will be examined in contrast to common surgical treatments like face lifts, blepharoplasty, rhinoplasty procedure and transplantation of hair. In addition, the goal of this study is to give a more complete look at the future trends in the field and make facial beauty tips. A thorough search of the literature was done using several databases, including Cochrane, PubMed, MEDLINE, and EMBASE. A scoping review and an evidence-based synthesis came next. The initial search yielded 703 publications in all; 53 of these were deemed relevant to the subject at hand, after which they were investigated and discussed. The poll indicates that there has been a noticeable increase of India has seen a rise in the number of people getting plastic surgery on their faces and a clear change in how patients feel about painless cosmetic procedures. This study examines the latest advancements and patterns in medical practitioners' methods to bolster the expansion of cosmetic face surgery in India. It also seeks to solve the inadequacies in the current administration and close the gaps that can be found in the realm of cosmetic surgery.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"467-478"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological analysis of coronary arteries with emphasis on myocardial bridges and triangle of Brocq and Mouchet.","authors":"V Rajanigandha, M T Bhavana, S R Vikram, B V Murlimanju","doi":"10.7417/CT.2024.5151","DOIUrl":"10.7417/CT.2024.5151","url":null,"abstract":"<p><strong>Background: </strong>Goals of this study include observing the origin, course, termination, dominance and branching outline of the coro-nary arteries with emphasis on Brocq and Mouchet's triangle. The objectives were to determine the prevalence of Kugel's artery, third coronary artery and myocardial bridges in formalin fixed cadavers of Indian population.</p><p><strong>Methods: </strong>This cross-sectional anatomical study utilized 30 formalin fixed cadaveric hearts. The length of the trunk is measured for both the right and left coronary arteries with the help of measuring tape and width was determined by using the digital vernier calliper (Mitutoyo Corporation, Kawasaki, Japan).</p><p><strong>Results: </strong>The 25 hearts (83%) were right dominant, 4 heart specimens (14%) were left dominant and 1 heart specimen (3%) was co-dominant. Kugel's artery was observed in 12 hearts (30%), in this study. The third coronary artery was observed in 4 hearts (14%) of this study. The myocardial bridges were observed in only 4 hearts (7%) of this study. The presence of median artery (one artery) as Brocq and Mouchet's triangle content was observed in 16 specimens (53%), while the 11 specimens (37%) had presence of two arteries (median and diagonal) as its contents, 2 specimens (7%) showed 3 arteries (median, diagonal and one extra artery) as its contents and 1 specimen (3%) didn't have any artery as its content. In the present study, LCA exhibited more variations as in 12 specimens (40%), there was bifur-cation, 9 specimens (30%), there was trifurcation and in 7 specimens (23%), there was tetrafurcation (Fig. 7) and in only 2 specimens (7%), there was pentafurcation of the LCA.</p><p><strong>Conclusions: </strong>We believe that the present research has provided detailed morphology of the coronary arteries with emphasis on myocardial bridges and Brocq and Mouchet's triangle. However, the data can be still better interpreted with a larger sample size.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"436-440"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Biomarker for Cardiovascular Disease Risk Assessment in Patients With Diabetic Nephropathy.","authors":"D Pai, D Chaitra, H Raghavendra, D Kamath","doi":"10.7417/CT.2024.5154","DOIUrl":"10.7417/CT.2024.5154","url":null,"abstract":"<p><strong>Background & objective: </strong>The objective of this study was to compare serum sirtuin 1 level in diabetic nephropathy patients with or without coronary artery disease. Methods: In this cross-sectional study, 108 diabetic nephropathy patients were included, among which 54 were diagnosed with coronary artery disease based on coronary angioplasty, lipid profile, drug details, and case history, while 54 were without coronary artery disease. Patients above 18 years with nephropathy, as per spot microalbuminuria test, were included. The study excluded patients with any malignancies. Ethical approval was obtained, and consent was acquired from each participant. Serum was obtained from 2ml of whole blood and stored at -20°C before measuring serum sirtuin 1 level using Enzyme Linked Immunosorbent Assay (ELISA).</p><p><strong>Results: </strong>The mean serum sirtuin 1 level was 2.27 ng/ml (2.033, 2.185) in diabetic nephropathy patients with coronary artery disease and 2.55 ng/ml (2.069, 2.372) in those without. Although diabetic nephropathy patients had higher serum sirtuin 1 levels, the difference was not statistically significant (p = 0.063). The ROC curve analysis yielded a cut-off value of 2.30 ng/ml, with an AUC of 0.604, indicating sirtuin 1 level may not be a robust biomarker for predicting coronary artery disease in diabetic nephropathy patients. Furthermore, no significant association was found between serum sirtuin 1 levels and microalbuminuria stages in DN patients with CAD (p = 0.705).</p><p><strong>Conclusion: </strong>In conclusion, serum sirtuin 1 levels showed no significant difference between diabetic nephropathy patients with and without coronary artery disease. The analysis suggests that serum sirtuin 1 level may not strongly indicate the presence or severity of coronary artery disease in diabetic nephropathy patients.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"455-459"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe Integration of Encorafenib plus Binimetinib with Stereotactic Radiosurgery for Melanoma Brain Metastases: a Case Report.","authors":"C Battilotti, I Proietti, F Svara, G Rizzuto, E Tolino, N Bernardini, N Skroza, L Filippi, C Potenza","doi":"10.7417/CT.2024.5141","DOIUrl":"https://doi.org/10.7417/CT.2024.5141","url":null,"abstract":"<p><strong>Background: </strong>Melanoma brain metastases represents a significant clinical challenge, frequently associated with high morbidity and mortality. Recent advancements in neuroimaging, radiation therapy, and targeted systemic therapies, specifically BRAF and MEK inhibitors, have improved the management of this condition. Nevertheless, the optimal therapeutic approach for melanoma brain metastases remains a subject of ongoing debate, with no universally accepted treatment protocol. The combination of stereotactic radiosurgery with targeted therapy using encorafenib and binimetinib in patients harboring BRAF V600E mutation holds therapeutic promise but requires careful toxicity management to ensure both safety and efficacy.</p><p><strong>Case report: </strong>A 61-year-old male with metastatic BRAF V600E-mutated melanoma presented with a 20 mm brain metastasis in the right occipital lobe, manifesting as acute-onset diplopia. The patient was undergoing systemic therapy with encorafenib and binimetinib for metastatic lung involvement. Brain MRI revealed a metastatic lesion with surrounding edema. To minimize the risk of overlapping toxicities, a treatment strategy was devised, combining stereotactic radiosurgery with a temporary cessation of targeted therapy. Stereotactic radiosurgery was administered at a total dose of 27 Gy in three fractions, with enco-rafenib and binimetinib paused 24 hours prior to, and resumed 24 hours following, the radiosurgery. Following treatment, the patient's diplopia resolved completely, and a follow-up MRI two months later demonstrated near-total regression of the brain metastasis. At 30 months post-treatment, the patient remained free from recurrence and continued systemic therapy with excellent tolerance and no reported adverse effects.</p><p><strong>Conclusions: </strong>This case demonstrates the efficacy and safety of combining stereotactic radiosurgery with encorafenib and binimetinib for managing melanoma brain metastases with BRAF V600E mutation. This approach provided effective disease control, as evidenced by symptom resolution, near-complete regression on MRI, and sustained remission at 30 months, with no adverse effects observed. Further studies are needed to establish standardized protocols for optimizing outcomes in this patient population.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"374-377"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronal deformity of the knee in childrens and adolescents. A systematic review of current orthopaedics treatments.","authors":"G Cinotti, M Melotto, Y Piccolo, G Giannicola, C Zoccali, F De Maio","doi":"10.7417/CT.2024.5157","DOIUrl":"https://doi.org/10.7417/CT.2024.5157","url":null,"abstract":"<p><strong>Objectives: </strong>Coronal deformities of the knee in skeletally immature patients are often physiological and resolve spontaneously. When this is not the case a surgical correction is required. As limited data are available on the effectiveness of the different surgical procedures to correct coronal deformities in skeletal immature patients, a systematic review was conducted to analyse the surgical outcomes, complications and recurrent deformity rate in idiopathic and pathologic coronal deformities.</p><p><strong>Patients and methods: </strong>A systematic review of articles published between January 1990 and May 2022 was performed. Pub med, Scopus, Google scholar and EMBASE were used for the research. Studies analysing the results of hemiepiphysiodesis for length leg discrepancy were excluded as well as those published in non-english literature. Clinical and radiological parameters before and after surgery were collected.</p><p><strong>Results: </strong>Of the 205 studies initially selected, 47 met the inclusion criteria. There were 3307 patients (2028 men and 1279 women) and 5949 knees. The mean age at surgery was 10.5 years (range 4.1-18 years). Mean length of follow-up was 17 months (range 6-67 mon-ths). Sixty-four per cent of the patients had idiopathic varus-valgus deformity, 36% had secondary deformities. Clinical and radiographic parameters were generally improved after surgery but statistical analy-sis was missing in many studies. Patient satisfaction was 90% or more in 74% of the study.</p><p><strong>Conclusions: </strong>Coronal knee deformity in children and adolescents may be treated successfully with emiepiphysiodesis of the knee. The rate of recurrency appears associated with patients related factors, including deformity secondary to specific pathologies, young age at the time of surgery, severity of the deformity and high BMI. This investigation highlights the need for further studies in which the surgical techniques currently used were compared in a randomized prospective analysis.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"479-486"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiodermatitis lesions and medico-legal implications: a systematic review.","authors":"V Cianci, S Scurria, S Raffo, C Mondello, L Tornese, E Forzese, A Asmundo, P Gualniera, D Sapienza","doi":"10.7417/CT.2024.5155","DOIUrl":"https://doi.org/10.7417/CT.2024.5155","url":null,"abstract":"<p><strong>Background: </strong>The Percutaneous Transluminal Coronary Angio-plasty (PTCA) is an interventional cardiology procedure that allows revascularisation of ischemic myocardial areas both in acute and chronic settings. Over the years, this technique has improved in terms of efficacy, changing the therapeutic approach of myocardial ischemic pathology, with a significant reduction in the mortality rate of myocardial infarction. However, it does not appear free from complications, one of which, although very rare, is radiodermatitis, that is frequently correlated to acute or/and low dose ionizing radiation exposure and oxidative stress.</p><p><strong>Material and methods: </strong>In this regard, the Authors proceeded to a review of the literature concerning the harmful effects of radiation during fluoroscope-guided procedures, underlining in particular the difficulties of univocally determining a \"threshold dose\" beyond which to define the onset of radiodermitic phenomena.</p><p><strong>Results: </strong>It has been highlighted how the onset of radiodermitic manifestations following PTCA is of primary medical-legal interest, since it is possible to recognise the existence of responsibility profiles in the hands of the healthcare professionals, and therefore the occurrence of compensation claims by patients.</p><p><strong>Conclusion: </strong>No specific contribution emerged from the literature consulted, so authors put forward the essential elements for a correct classification of healthcare responsibility and the evaluation of any consequent damage to the person concerned.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 6","pages":"460-466"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}