Clinica Terapeutica最新文献

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Cannabis-based medicines and medical fitness-to-drive: current legal issues in Switzerland. 以大麻为基础的药物和医疗适合驾驶:瑞士当前的法律问题。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5096
C Palmiere, M P Scarpelli
{"title":"Cannabis-based medicines and medical fitness-to-drive: current legal issues in Switzerland.","authors":"C Palmiere, M P Scarpelli","doi":"10.7417/CT.2024.5096","DOIUrl":"https://doi.org/10.7417/CT.2024.5096","url":null,"abstract":"<p><strong>Background: </strong>Interest in cannabis-based medicines has risen importantly in recent years due to the wide range of potential uses. On the other hand, delta-9-tetrahydrocannabinol (THC) impairs driving performance and other safety-sensitive tasks. Under the Swiss law, use of cannabis with a THC content of at least 1% is generally prohibited. However, the Swiss Parliament has decided to lift the ban on cannabis-based medicines from 1 August 2022. Hence, exceptional authorisation from the Federal Office of Public Health is no longer required for cannabis-based medicine prescription. Accordingly, general practitioners may prescribe these medicines (e.g. 'magistral preparations', i.e. a medicinal preparation prepared on prescription by a pharmacist). On the other hand, prescribing physicians must inform their patients that cannabis-based medicines may affect momentary ability to drive and general fitness-to-drive.</p><p><strong>Materials and methods: </strong>The positioning of cannabis as a legitimate medical treatment produces some tensions with other regulatory frameworks. A notable example of this is the so-called 'zero tolerance' drug driving legal frameworks, which criminalise the presence of THC in a driver's bodily fluids irrespective of impairment. On the other hand, it has been observed that there is little evidence to justify the differential treatment of patients taking cannabis-based medicines compared with those taking other medications potentially impairing driving performances.</p><p><strong>Conclusions: </strong>The aim of this paper is to briefly discuss current Swiss legal issues concerning drivers who are prescribed medicines containing cannabis, as well as to update prescribing physicians on relevant issues and the best guidance to offer their patients.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of the microbiome in forensic investigations on pediatric deaths. 儿科死亡法医调查中的微生物组研究。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5107
S Gualtieri, M A Sacco, P Tarzia, A P Tarallo, R La Russa, I Aquila
{"title":"The study of the microbiome in forensic investigations on pediatric deaths.","authors":"S Gualtieri, M A Sacco, P Tarzia, A P Tarallo, R La Russa, I Aquila","doi":"10.7417/CT.2024.5107","DOIUrl":"https://doi.org/10.7417/CT.2024.5107","url":null,"abstract":"<p><strong>Background: </strong>Sudden infant death syndrome (SIDS) is a tragic and devastating condition whose causes remain largely unknown. Recent studies have shown that the composition of a child's gut flora can play a significant role in the development of SIDS.</p><p><strong>Methods: </strong>This work aims to research those factors that influence the composition of the intestinal flora, the role they have in the development of SIDS and the new strategies for preventing SIDS showing a new interpretation through a detailed review of the literature. The gut in physiological conditions is mainly composed of Bacteroidetes, Firmicutes, Actinobacteria, and Proteobacteria, but when there is the presence of dysbiotic or different microbial communities, the onset of the disease is more likely as an altered microbial community can lead to an interruption of the gut-brain axis and an increased risk of SIDS.</p><p><strong>Conclusions: </strong>All this implies that the composition of the microbiome can be modified to reduce the risk of sudden death in newborns. The results of the literature provide valuable information on the potential role of the intestinal microbiome in SIDS even if not all mechanisms are yet clear, especially in the mechanisms of death. Therefore, it is necessary in cases of SIDS when carrying out an autopsy to also investigate this area; to this end, we suggest a questionnaire to be administered to family members to understand the eating habits of the newborn and the family and integrate with microbiological investigations to explore every possible hypothesis.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of suicide of psychiatric patient in the Sicilian hospital: accidental or professional liability of "top management"? 西西里医院精神病人自杀案:是意外还是 "高层管理者 "的职业责任?
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5106
P Tarzia, G Baldino, G Trapuzzano, C Genovese, G Genovese, A Asmundo, E Ventura Spagnolo
{"title":"A case of suicide of psychiatric patient in the Sicilian hospital: accidental or professional liability of \"top management\"?","authors":"P Tarzia, G Baldino, G Trapuzzano, C Genovese, G Genovese, A Asmundo, E Ventura Spagnolo","doi":"10.7417/CT.2024.5106","DOIUrl":"https://doi.org/10.7417/CT.2024.5106","url":null,"abstract":"<p><strong>Background: </strong>In the hospital environment, any liability for organizational inadequacy and/or inefficiency, or again for defects in the facilities, or inadequacy of health equipment may be found in the work of the apex professional figures: Medical Director, the General Manager, and/or others. The responsibility for the internal organization of the department falls on the figure of the Director of the Complex Structure where the deficiencies have not been promptly and adequately reported to the top figures.</p><p><strong>Case report: </strong>A woman 61-year-old, was admitted on a voluntary basis to the Department of Psychiatry. On the third day, in the early morning hours, the patient was found on the ground floor, lying on the floor near the entrance door of the ward with a lacerated contusion wound to the head. The woman underwent total body CT examination with findings of fractured polytrauma as well as subarachnoid hemorrhage and complete fracture of the spleen, which was surgically removed. Three days later, despite the care given, death occurred. The injuries ascertained were consistent with voluntary precipitation from the second-floor stairwell window. The investigations conducted by the police and the checks carried out by the head of the Internal Prevention and Protection Service and the company's Risk Manager, highlighted multiple critical issues.</p><p><strong>Conclusion: </strong>The case allows for numerous considerations relating to liability profiles in the determinism of the patient's death, the hospital's company failure to implement measures to prevent the patient's suicide in the hospital was influential.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homicide by drowning: a literature review and analysis of three cases. 溺水杀人:文献综述和三起案件的分析。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5103
F Orsini, C A D'Amato, L Cipolloni, M Aromatario, S De Simone
{"title":"Homicide by drowning: a literature review and analysis of three cases.","authors":"F Orsini, C A D'Amato, L Cipolloni, M Aromatario, S De Simone","doi":"10.7417/CT.2024.5103","DOIUrl":"https://doi.org/10.7417/CT.2024.5103","url":null,"abstract":"<p><strong>Background: </strong>Homicide by drowning in adults is rare. Usually, marks of violence are found on both the victim and the perpetrator, unless the victim was under the influence of alcohol, drugs, or was unexpectedly forced or dragged into the water. Indeed, many cases of drowning in adults are believed to be accidental, but they may be the result of drunken fights or attempts to make the death appear ac-cidental. In order to define the manner of death, cooperation between the forensic pathologist and the investigators is mandatory. Indeed, the autopsy is important to distinguish homicide by drowning from other kinds of drowning. The purpose of this study is to highlight the features of homicide by drowning.</p><p><strong>Materials and methods: </strong>Literature search was conducted using PubMed databases, using the following keywords: \"(homicide) and (drowning)\". 3 articles were included in the systematic review, in addition to 3 cases observed in our institute.</p><p><strong>Conclusions: </strong>Both external examination and autopsy findings and the results of the investigation are essential to differentiate a homicide by drowning from accidental ones. The low specificity and variability of external and internal findings, the possibility of atypical asphyctic and nonasphyctic pathophysiological mechanisms, whose nature is not detectable at postmortem examinations, makes the diagnosis of cause of death difficult and often based on exclusion criteria only. In complex cases only using a strict forensic method allows to use the essential tools to identify the real manner of death.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Primary Synovial Chondromatosis of the Hip: An Integrated Perspective on Physiotherapeutic Support. 髋关节同步原发性滑膜软骨瘤病:物理治疗支持的综合视角。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5066
G Basile, L Bianco Prevot, L P Tronconi, M Basile, A Ciccarelli, V Bolcato
{"title":"Synchronous Primary Synovial Chondromatosis of the Hip: An Integrated Perspective on Physiotherapeutic Support.","authors":"G Basile, L Bianco Prevot, L P Tronconi, M Basile, A Ciccarelli, V Bolcato","doi":"10.7417/CT.2024.5066","DOIUrl":"https://doi.org/10.7417/CT.2024.5066","url":null,"abstract":"<p><strong>Abstract: </strong>Primary synovial chondromatosis of the hip is a rare joint condition characterized by the abnormal proliferation of cartilaginous tissue within the synovial membrane, which leads to the formation of clusters of chondrocytes floating in the joint space. This commentary provides a comprehensive overview of the pathology, including symptoms, diagnosis, treatment options and long-term management. Patients with primary synovial chondromatosis complaint pain and functional impairment, together with a peculiar joint popping sensation during movement, so determining early disability. The early treatment can lead to better clinical outcomes, with increased preservation of joint function and reduced risk of long-term disability, but strictly depend on symptoms acknowledgement and proper imaging interpretation. As a chronic pathology, surgical approach must necessarily be part of a larger medical and rehabilitative care planning, with long period follow-up. Multidisciplinary team management, with the active involvement of the patient is pivotal in improving the clinical outcomes and quality of life.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple suicidal gunshot wounds. Case reports and mini-review of literature. 多处自杀性枪伤。病例报告和文献综述。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5073
G Baldino, P Tarzia, S Roccuzzo, A Bottari, G Burrascano, A Asmundo, D Sapienza, E Ventura Spagnolo
{"title":"Multiple suicidal gunshot wounds. Case reports and mini-review of literature.","authors":"G Baldino, P Tarzia, S Roccuzzo, A Bottari, G Burrascano, A Asmundo, D Sapienza, E Ventura Spagnolo","doi":"10.7417/CT.2024.5073","DOIUrl":"https://doi.org/10.7417/CT.2024.5073","url":null,"abstract":"<p><strong>Background: </strong>To determine the manner of death (MOD) and, there-fore, to classify the event as natural, suicidal, homicidal, or accidental is an essential and routine task in forensic medicine. The evaluation of MOD presents numerous difficulties due to unusual anamnestic and circumstantial data, in addition to autopsy findings and postmortem findings.</p><p><strong>Materials and methods: </strong>A mini review of the literature on the topic was performed. Here we report two cases of uncommon self-inflicted multiple GWs (SMGWs) to the head and thorax, suspected of killing. The presence of more than one gunshot wound is suggestive of homi-cide, especially when they involve the head. A review of the literature on the topic was performed on PubMed's database, showing, although considered infrequent, cases documenting SMGWs are not rare.</p><p><strong>Conclusion: </strong>In the cases reported, the initial suspicion of involvement of third persons was excluded through the examination of the death scene, post-mortem (CT and autopsy) findings and clinical-circumstantial data. The analysis derived from the review of the related literature allowed us to highlight the presence of common findings which should be considered in the evaluation of such cases.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postmortem or Perimortem Injury? Presentation of an incredible court case in which flames are the protagonists of a murder. 死后伤害还是死前伤害?介绍一起令人难以置信的法庭案件,其中火焰是谋杀案的主角。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5087
P Tarzia, F Introna, A Leggio
{"title":"Postmortem or Perimortem Injury? Presentation of an incredible court case in which flames are the protagonists of a murder.","authors":"P Tarzia, F Introna, A Leggio","doi":"10.7417/CT.2024.5087","DOIUrl":"https://doi.org/10.7417/CT.2024.5087","url":null,"abstract":"<p><strong>Background: </strong>Establishing the cause of death when analysing burnt human remains is limiting due to thermal degradation. The heat generated by high combustion degrades the bone structure, definitively hiding the perimortem trauma in most cases, which is crucial for solving a court case.</p><p><strong>Case report: </strong>In November 2019, a completely burnt corpse was found inside a car set on fire near a location in Reggio Calabria, Italy. The corpse was subsequently subjected to an initial radiodiagnostic examination and an anthropological/medico-legal investigation, in order to confirm the biological profile of the unidentified subject, define the cause of death and assess the presence of perimortal lesions through macroscopic analysis of skull fragments subjected to fleshing.</p><p><strong>Conclusions: </strong>The soft tissue fleshing of the burnt skull fragments allowed the reconstruction of a partial calotte. Macroscopic analysis of the consolidated shell identified in the left fronto-parietal region a clear linear fracture, perimortal in nature, compatible with blunt trauma. Autopsy examination revealed the presence of carbonaceous residues within the larynx and especially the trachea, confirming ante-mortem combustion.The results of the autopsy examination and the anthropological analysis allowed us to state that the net linear fracture, perimortal in nature, caused the subject a complex encephalic trauma, resulting in loss of consciousness and subsequent death due to carbon monoxide inhalation. This result not only confirms the malicious hypothesis, but reveals a deliberate burning of the victim in order to conceal the evidence necessary to solve the forensic case.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supermarket shopping death: the role of forensic investigations in plastic bag suffocation. 超市购物死亡:法医调查在塑料袋窒息中的作用。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5077
F Cordasco, C Scalise, M A Sacco, P Tarzia, S Gualtieri, F Ranno, I Aquila
{"title":"Supermarket shopping death: the role of forensic investigations in plastic bag suffocation.","authors":"F Cordasco, C Scalise, M A Sacco, P Tarzia, S Gualtieri, F Ranno, I Aquila","doi":"10.7417/CT.2024.5077","DOIUrl":"https://doi.org/10.7417/CT.2024.5077","url":null,"abstract":"<p><strong>Background: </strong>Plastic bag suffocation may represent a very complex enigma for the forensic pathologist. The aim of this work is to highlight how the resolution of plastic bag suffocation cases is possible through the use of various forensic investigations, including psychological one (psychological autopsy) and toxicological examinations, in order to be able to define the manner of death.</p><p><strong>Case report: </strong>A 70-year-old man was found by his daughter lying on the bed, with his head inside a plastic bag knotted around his neck. The daughter claimed to have immediately removed the bag, but the father was already dead. An autopsy was performed. The clinical history of the victim was analysed in search of reason that could lead to suicide. The statements of the people on the death scene were examined. Results were compared with the scientific literature: a literature review was performed on the search engine Pubmed, Scopus and Google Scholar using the keywords \"plastic bag suffocation\" and \"death\". The autopsy showed no typical signs of asphyxial death. Toxicological examinations revealed benzodiazepines in the urine. Investigations revealed that the victim had been suffering from severe depression.</p><p><strong>Conclusions: </strong>The literature review confirmed that the most used wrapper is the supermarket shopping bag. We emphasize that plastic bag suffocation is a very quick event that does not leave any evident sign: this rapidity does not allow to appreciate the typical elements of asphyxiated death (petechiae, cyanosis). It seems that the fatal mechanism is a cardio-inhibitory, rather than a hypoxic process.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ritual male circumcision: a case of fatal hemorrhagic shock in a 28-day-old infant. 男性包皮环切术:一例 28 天大婴儿致命的失血性休克。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5104
I Caristo, F Caputo, R Barranco, F Ventura
{"title":"Ritual male circumcision: a case of fatal hemorrhagic shock in a 28-day-old infant.","authors":"I Caristo, F Caputo, R Barranco, F Ventura","doi":"10.7417/CT.2024.5104","DOIUrl":"https://doi.org/10.7417/CT.2024.5104","url":null,"abstract":"<p><strong>Background: </strong>Male circumcision (MC) is a practice involving the surgical excision of the foreskin to expose the glans and it is often performed for religious reasons. Ritual circumcision is frequently carried out by unqualified practitioners in inadequate settings, which can also lead to the death of the individual.</p><p><strong>Case report: </strong>A 28-day-old infant was undergoing circumcision by a man that performed the circumcision using a razor blade. During the same day, the child experienced continuous bleeding from the wound and, finally, died after about 20 hours. At autopsy, a cutaneous sharp injury was revealed with ablation of the foreskin and part of the penile body. The lesion had irregular and jagged margins, with diffuse hemorrhagic infiltration. The glans and upper fascia of the penis appeared edematous and hyperemic and there were abundant hemorrhagic infiltrations in the frenulum area. The child's death was attributed to hemorrhagic shock in a child undergoing genital mutilation surgery. The finding of a significant hemorrhagic infiltration of the frenulum region indicated that the frenular artery had been severed.</p><p><strong>Conclusions: </strong>Around 35% of ritual male circumcisions are performed clandestinely in Italy, and typically by unqualified practitioners. In such events, the forensic investigation of the injuries inflicted on the victim allows for determining whether the procedure was performed appropriately or not, to verify the existence of a causal link between the procedure itself and the death of the individual.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of suicide by bleach fatal ingestion: a case report and a literature overview. 一例罕见的摄入漂白剂致死自杀病例:病例报告和文献综述。
Clinica Terapeutica Pub Date : 2024-07-01 DOI: 10.7417/CT.2024.5122
U Baggio, V Tortorella, L De Paola, T Berloco, G D'Antonio, T Mangiulli
{"title":"A rare case of suicide by bleach fatal ingestion: a case report and a literature overview.","authors":"U Baggio, V Tortorella, L De Paola, T Berloco, G D'Antonio, T Mangiulli","doi":"10.7417/CT.2024.5122","DOIUrl":"https://doi.org/10.7417/CT.2024.5122","url":null,"abstract":"<p><strong>Background: </strong>Nowadays it is estimated that worldwide more than 700 000 people die by suicide every year and a greater amount attempt this practice. Suicide is the fourth cause of death among 15-29 years old people. Sodium Hypochlorite (NaOCl) is used in household and com-mercial bleaches and due to its easy availability, accidental exposure to or intentional ingestion of NaOCl occurs frequently. In most cases health effects are only transient but if the subject ingests a large amount of this substance, this can generate severe consequences as oesophageal or stomach lesions and electrolytic imbalance. In the present study we analyse a rare case of suicide by fatal ingestion of bleach.</p><p><strong>Case report: </strong>Case of a caucasic 47 years old woman with a background of several suicide attempts by exogenous substance ingestion that was found death alone in her apartment. The purpose of our investigation was identifying the cause of death. A rigorous and multidisciplinary methodological approach was adopted, including an accurate judicial inspection of the environment, an anamnestic collection, an autoptic procedure completed by macro and microscopic examinations of internal organs and a toxicological examination of biological fluids. Furthermore, a literature overview of similar cases was carried out. The resulting evidence demonstrates that woman's death occurred after a massive bleach ingestion.</p><p><strong>Conclusions: </strong>This case report highlights the importance of forensic methodology in investigating the ingestion of exogenous substances. Crime scene investigation, a detailed post-mortem examination, toxicology and a complete histopathological study are mandatory to solve the enigma.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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