Clinica Terapeutica最新文献

{"title":"Overview and potential role of omega-3 in COVID-19.","authors":"M A Gammone, N D'Orazio","doi":"10.7417/CT.2024.5124","DOIUrl":"https://doi.org/10.7417/CT.2024.5124","url":null,"abstract":"<p><strong>Abstract: </strong>Obesity is a modifiable inflammatory commodity that has been linked to higher morbidity and mortality to those that contract novel viruses, such as H1N1 and SARS-CoV-2. Loss of life and the high cost of obesity highlights the need to focus on preventative measures. This article will discuss obesity as a crucial comorbid inflammatory condition during COVID-19 pandemic, focus on the mechanisms that may contribute to the likely benefits of omega-3 and provide potential recommendations to promote strategies for wellness.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"346-351"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vietnam Association of Gastroenterology consensus for the diagnosis and treatment of functional dyspepsia.","authors":"K-T T Tran, B H Mai, L Ta, L V Dao, H V Tran, M K Tran, D T Quach, K T Vu, Q D D Ho, K V Vu, T T Tran, T-H T Pham, D T Trinh, V T Nguyen, T V Tran, T H Duong, H H Bui, V-H T Nguyen, T T Nguyen, T D Nguyen, B C Nguyen, H Q Phan, L C Nguyen, T L Nguyen, H V Dao, K D Thai, N T Phan, N V Le, L T Le, M-C H Vo, T-P T Le, P T Ho, Q D Le, P-T P Tran, Q-L Dau","doi":"10.7417/CT.2024.5135","DOIUrl":"10.7417/CT.2024.5135","url":null,"abstract":"<p><strong>Abstract: </strong>Functional dyspepsia (FD) is a common disorder in clinical practice. It is necessary to rule out physical causes to diagnose this condition. However, the diagnosis is challenging particularly in resource-limited areas. The aim of this consensus is to update international and regional guidelines on the management of FD. The consensus panel included 32 experts from major Vietnamese universities and institutes. This consensus study was conducted using the Delphi method. The grade of recommendation and level of evidence were assessed using the Grading of Recommendations, Assessment, Development, and Evalua-tion system. The consensus level was defined as ≥80% for agreement on the proposed statements. The expert panel approved 14 statements after two rounds of voting, which were related to two sections: (1) diagnostic tests for FD and (2) treatment of FD. This consensus is expected to help physicians in identifying and managing FD appropriately in daily clinical practice and to contribute FD data to Asian regions.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"307-317"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helical PHILOS plating in shaft humeral fractures with proximal extension: a safe choice using an anterior approach.","authors":"G Touloupakis, E Ruberto, E Pernigotti, E Theodorakis, A Gilli, M Messori, S Ghirardelli, P Pozzi, G Antonini","doi":"10.7417/CT.2024.5136","DOIUrl":"10.7417/CT.2024.5136","url":null,"abstract":"<p><strong>Abstract: </strong>Helical plating for humeral shaft fractures has gained popularity in recent years as it avoids iatrogenic nerve damage. A total of 16 patients with humeral shaft fracture involving the metaphyseal proximal part were treated between Dicembrer 2016 and January 2023. Complications such as pseudarthrosis, infections and nerve lesions were investigated during the postoperative period. Functional outcome was quantified using the Italian version of the DASH 30 quality of life assessment item. Healing of the fracture was achie-ved at the last follow-up with good clinical recovery and no pain. The self-contoured Philos-Helix plate for humeral shaft fractures with proximal extension in combination with an anterior window approach is a safe procedure with good functional results at a follow-up of at least one year.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"318-322"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal-assisted intervention for geriatric well-being: A comprehensive review.","authors":"L K Bernhardt, A Vashe, G V Bernhardt, J Pinto","doi":"10.7417/CT.2024.5126","DOIUrl":"https://doi.org/10.7417/CT.2024.5126","url":null,"abstract":"<p><strong>Background: </strong>In recent years, the size of geriatric population seems to have grown larger than that of younger children and is expected to grow even larger in few years from now. As older individuals are more vulnerable to health concerns and loneliness, it is necessary to focus on providing them opportunities for healthy ageing. Animal-assisted therapy (AAT) has emerged as one of the simple yet effective approach to enhance physical, psychological, and social well-being in older adults.</p><p><strong>Methods: </strong>This review article presents collective information from various experiments on AAT's effectiveness in promoting healthy ageing.</p><p><strong>Results: </strong>The physiological impacts of AAT, on cardiovascular health, mobility, and day to day activities have been discussed. The psychological benefits of AAT, such as improvement of mood, cognition, and alleviation of anxiety, loneliness, and depression, are explored. This review also presents the possible mechanisms underlying the effective-ness of AAT, such as release of oxytocin, dopamine, and endorphins, which contribute to emotional well-being along with reduction of stress. The human-animal bond established during AAT sessions is discussed as a significant factor in promoting positive outcomes. Challenges faced and limitations involved in employing therapy animals within ageing populations are also discussed.</p><p><strong>Conclusions: </strong>Avenues for future research and potential applications of AAT in diverse healthcare settings are proposed, emphasizing the need for further empirical investigation to fully elucidate the mechanisms and benefits of AAT for healthy ageing. Through this comprehensive review, we aim to highlight the potential of AAT as a holistic intervention to enhance the well-being of older adults, providing valuable insights for healthcare practitioners, researchers, and policymakers invested in promoting healthy ageing strategies.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"362-369"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain: are there effective therapeutic exercises in rehabilitation treatment? A narrative review.","authors":"F Camerota, G Petronelli, A Savina, M G Parlangeli, A Truini, C Celletti","doi":"10.7417/CT.2024.5139","DOIUrl":"10.7417/CT.2024.5139","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain has been investigated in pathophysiology and different mechanisms underlying this condition has been described. Despite the plentiful literature regarding this topic and the different pharmacological treatments proposed, patients often referred inadequate relief from medication. The aim of this narrative review was to investigate the different rehabilitative approach in the management of chronic pain and their efficacy.</p><p><strong>Methods: </strong>A systematic narrative review has been conducted considering randomize controlled trials and systematic reviews published within the past 5 years.</p><p><strong>Results: </strong>13 papers on chronic pain and 6 papers on nociplastic pain has been described in the main aspects analyzed.</p><p><strong>Conclusions: </strong>No one treatment appears to be more effective than another but often it is the combination of several treatments that gives the best results. More studies, evaluating in particular specific exercises with clear proprioceptive elements, should be conducted to best analyzed their role in the management of chronic pain.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"337-345"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of histogram analysis in distinguishing between low-grade and high-grade brainstem glioma.","authors":"D V Anh, T V Lam, N T H Anh, D V He, N D Hung, N Minh Duc","doi":"10.7417/CT.2024.5134","DOIUrl":"10.7417/CT.2024.5134","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study was designed to evaluate the value of histogram analysis on the apparent diffusion coefficient (ADC) map in distinguishing between low-grade and high-grade brainstem glioma (BSG). In this article, we used the two VOI (volume of interest) placements of the entire tumour method and the entire solid part method, thus aiming to compare the diagnostic value between these two performances.</p><p><strong>Methods: </strong>A total of 28 patients (8 low-grade BSGs and 20 high-grade BSGs) with histological diagnosis of BSG. All victims underwent contrast-enhanced magnetic resonance imaging (MRI). We measured ADC histogram parameters (mean, median, SD, max, min, Kurtosis, Skewness, Entropy, Uniformity, and Variance) and calculated the ratios between tumour and normal brain parenchyma parameters in two methods. Independent samples test, Mann-Whitney U test, and ROC curve were used to determine each value's cut-off point, sensitivity, and specificity.</p><p><strong>Results: </strong>Among the method of VOI placing the entire tumour, the values of ADC_min, rADC_mean, rADC_median, and rADC_min are significantly different between these two neoplasms with cut-off values (sensitivity %, specificity %) of 776 x10-6 m2/s (62.5%, 90%), 2.1765 (62.5%, 95%), 2.1588 (50%, 100%), 1.0535 (100%, 50%), respectively. On the other hand, the method of VOI placing the entire solid part of the tumour showed significantly different in ADC_mean, ADC_median, ADC_min, rADC_mean, rADC_median, rADC_min at the cut-off values (sensitivity%, specificity %) of 1491 x10-6 m2/s (62.5%, 95%), 1438.9 x10-6 m2/s (62.5%, 90%), 862.5 x10-6 m2/s (75%, 100%), 2,112 (62.5%, 95%), 1.9748 (62.5%, 90%), 1.3735 (87.5%, 90%), respectively.</p><p><strong>Conclusions: </strong>The ADC histogram analysis is a promising approach to distinguishing low-grade BSG and high-grade BSG. The entire solid part VOI placement has a superior value compared to the whole tumour VOI placement. The rADC_mean showed the best performance in differentiating between these two entities, followed by ADC_min, rADC_mean, rADC_median, ADC_mean, and ADC_median.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"296-306"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical and Experimental study of Liquid chromatography-mass spectrometry (LC-MS) profiling of the dehydrated Allium sativum and Allium cepa extracts; a gateway to therapeutic drug development.","authors":"N Shyamala, S Naresh, A K Nayanatara, H Anupama, D Shivananda","doi":"10.7417/CT.2024.5131","DOIUrl":"10.7417/CT.2024.5131","url":null,"abstract":"<p><strong>Purpose: </strong>Practice of medicinal plants for the treatment of various ailments is a history for several decades. Occurrence of active compounds in these plants makes it significant in the era of modern medicine. Garlic and onion a monocotyledonous bulbous flowering plant belonging to the genus Allium has an extensive tradition for being used as anti-inflammatory, anti-cancer, anti-hyperepidemic, anti-diabetic, anti-bacterial, neuroprotective agent against various disorders. Modern day synthetic formulations have reduced efficacy and rendered with side effects that channelled the exploration for alternate source in plants for dealing with various disorders. The present study aims to explore the bioactive compounds present in Allium sativum (Garlic) and Allium cepa (Red Onion).</p><p><strong>Methods: </strong>Garlic and onion powder was soaked in Methanol, filtered, and concentrated in a vacuum in a rotary evaporator. Fractionation was carried out.LC-MS analysis of aqueous fraction was performed using a Waters Mass Q-TOF Mass Spectrometer with diode array detector.</p><p><strong>Results: </strong>LC-MS analysis revealed the occurrence of 200 compounds in garlic and 184 compounds in onion. 3.53% in garlic and 4.37% in onion were the major chemical constituents based on the number of hits.</p><p><strong>Conclusion: </strong>This study suggests that the Allium sativum and Allium cepa herbal powders being loaded with large number of active compounds would be promising alternative agents due to their richness in antioxidants.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"274-286"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological existence from medicalisation to biomedicalization.","authors":"K Karaboue, D Berritto, G V Lacasella","doi":"10.7417/CT.2024.5128","DOIUrl":"10.7417/CT.2024.5128","url":null,"abstract":"<p><strong>Abstract: </strong>The process of medicalisation began around the end of the 18th century due to the emergence of the bourgeoisie and its values, which included the right to be healthy and carry out one's everyday skills, actions which in turn entailed the creation of a state's wealth. In this period, biopolitics was established, a new form of power administration. This made use of medicine to create behaviour that was useful for social activity, shifting the focus from the administration of the law to bringing subjects back within norms through therapeutic action. This stemmed from the fact that the key issue in governing a population is to maintain the workforce and to establish, through health, modes of behaviour that are valuable in its preservation. Genetic engineering and new forms of biomedicine have changed the paradigm of medicalisation into biomedicalisation, marking a shift from medical control over external nature to the control and transformation of inner nature. Through this optimisation, man regains a natural mode of expression within social norms.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"262-264"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Council Directive 2013/59/Euratom of 5 December 2013 laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation: medico-legal and legal-comparative study.","authors":"M Karaboue, D Berritto, G V Lacasella","doi":"10.7417/CT.2024.5127","DOIUrl":"10.7417/CT.2024.5127","url":null,"abstract":"<p><strong>Abstract: </strong>This paper is a scientific contribution on basic safety standards, related to protection against hazards arising from exposure to ionizing radiation: medico-legal issues resulting from the research of the University of Campania and the study conducted by the Italian Society of Medical and Interventional Radiology are reported.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"259-261"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Biomarkers in Alzheimer's Disease: Insights into Early Detection Through Eye-Based Diagnostics - A Literature Review.","authors":"G Firmani, M Salducci, F Testa, G P Covelli, P Sagnelli, A Lambiase","doi":"10.7417/CT.2024.5125","DOIUrl":"https://doi.org/10.7417/CT.2024.5125","url":null,"abstract":"<p><strong>Abstract: </strong>Alzheimer's Disease (AD) is a significant challenge in neurodegenerative disorders, characterized by a gradual decline in cognitive functions. Diagnosis typically occurs at advanced stages when therapeutic options are less effective, underscoring the importance of early detection. Traditional diagnostic methods are often invasive and costly, spurring interest in more accessible and economical alternatives. The eye, as a direct link to the brain through the optic nerve, suggests that ocular changes could serve as early indicators of AD. This has led to the exploration of non-invasive ocular diagnostic tools. Technologies such as Optical Coherence Tomography (OCT), OCT Angiography (OCT-A), pupillometry, and eye-tracking, along with electrophysiological methods like Electroretinography (ERG) and Pattern Electroretinography (PEV), are being utilized to investigate potential ocular biomarkers. Further, tear fluid analysis has suggested that presence of amyloid-beta (Aβ) protein might reflect neurogenerative processes, providing a non-invasive window into disease progression. Exploring ocular changes as potential early indicators of Alzhei-mer's Disease (AD), we aimed to provide an overview of promising biomarkers for earlier diagnosis and intervention. Our review further investigates the connections between AD and other ocular degenera-tive diseases such as age-related macular degeneration (AMD) and glaucoma, uncovering shared pathogenic pathways that could offer new therapeutic targets. To establish the sensitivity and specificity of these ocular biomarkers, comprehensive studies are required. Moreover, larger, longitudinal studies are essential to confirm the effectiveness of ocular assessments in the preemptive diagnosis of Alzheimer's Disease.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"175 5","pages":"352-361"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}