S I Elshennawy, F G Yehia, H Elhakeem, L A Gad, A A Eldamanhory, A M Attia, I R Alsawy, A M I Ghit, M A Mohamed, A A Elboghdady, E G Rezk, M F I Mosa, M R Zohri, M A M El Kholy, W A Ayad, A A H Emam, M Y M Ahmed
{"title":"一种新的子痫前期诊断生物标志物：与正常孕妇相比，子痫前期妇女外周血白细胞中的microrna。","authors":"S I Elshennawy, F G Yehia, H Elhakeem, L A Gad, A A Eldamanhory, A M Attia, I R Alsawy, A M I Ghit, M A Mohamed, A A Elboghdady, E G Rezk, M F I Mosa, M R Zohri, M A M El Kholy, W A Ayad, A A H Emam, M Y M Ahmed","doi":"10.7417/CT.2025.5216","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim of the work.: </strong>The purpose of this study is to compare the expression levels of miR-21-3p and miR-155-5p in leukocytes from preeclampsia (PE) patients to healthy controls.</p><p><strong>Patients and methods: </strong>The miR-21-3p and miR-155-5p that have been linked to PE were our choices. In comparison to 50 healthy controls, the expression levels of miR-21-3p and miR-155-5p were examined in PE (n = 50). Quantitative PCR in real-time is used for this. Relative quantification values were produced by comparing the target miR's relative expression in the samples to that of the calibrator in the lab.</p><p><strong>Results: </strong>There was a significant decrease in the expression levels of miR-21-3p and miR-155-5p in PE group. The mean expression levels of miR-21-3p and miR-155-5p in PE were 1.12 ± 0.6 and 0.82 ±0.5, respectively compared to 1.52 ± 0.8 and 1.44 ± 0.9 in normal individuals.</p><p><strong>Conclusion: </strong>Our findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE. A significant part of the pathophysiology of PE is played by miRNAs. Findings differentially expressed miRNAs in mother blood presents a chance to identify a simple-to-use PE biomarker.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":"176 2","pages":"255-260"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Novel Diagnostic Biomarker of Preeclampsia: MicroRNAs in Maternal Blood Leukocytes in Preeclamptic Women Compared to Normal Pregnant Women.\",\"authors\":\"S I Elshennawy, F G Yehia, H Elhakeem, L A Gad, A A Eldamanhory, A M Attia, I R Alsawy, A M I Ghit, M A Mohamed, A A Elboghdady, E G Rezk, M F I Mosa, M R Zohri, M A M El Kholy, W A Ayad, A A H Emam, M Y M Ahmed\",\"doi\":\"10.7417/CT.2025.5216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim of the work.: </strong>The purpose of this study is to compare the expression levels of miR-21-3p and miR-155-5p in leukocytes from preeclampsia (PE) patients to healthy controls.</p><p><strong>Patients and methods: </strong>The miR-21-3p and miR-155-5p that have been linked to PE were our choices. In comparison to 50 healthy controls, the expression levels of miR-21-3p and miR-155-5p were examined in PE (n = 50). Quantitative PCR in real-time is used for this. Relative quantification values were produced by comparing the target miR's relative expression in the samples to that of the calibrator in the lab.</p><p><strong>Results: </strong>There was a significant decrease in the expression levels of miR-21-3p and miR-155-5p in PE group. The mean expression levels of miR-21-3p and miR-155-5p in PE were 1.12 ± 0.6 and 0.82 ±0.5, respectively compared to 1.52 ± 0.8 and 1.44 ± 0.9 in normal individuals.</p><p><strong>Conclusion: </strong>Our findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE. A significant part of the pathophysiology of PE is played by miRNAs. Findings differentially expressed miRNAs in mother blood presents a chance to identify a simple-to-use PE biomarker.</p>\",\"PeriodicalId\":50686,\"journal\":{\"name\":\"Clinica Terapeutica\",\"volume\":\"176 2\",\"pages\":\"255-260\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinica Terapeutica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7417/CT.2025.5216\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica Terapeutica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7417/CT.2025.5216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
A Novel Diagnostic Biomarker of Preeclampsia: MicroRNAs in Maternal Blood Leukocytes in Preeclamptic Women Compared to Normal Pregnant Women.
Aim of the work.: The purpose of this study is to compare the expression levels of miR-21-3p and miR-155-5p in leukocytes from preeclampsia (PE) patients to healthy controls.
Patients and methods: The miR-21-3p and miR-155-5p that have been linked to PE were our choices. In comparison to 50 healthy controls, the expression levels of miR-21-3p and miR-155-5p were examined in PE (n = 50). Quantitative PCR in real-time is used for this. Relative quantification values were produced by comparing the target miR's relative expression in the samples to that of the calibrator in the lab.
Results: There was a significant decrease in the expression levels of miR-21-3p and miR-155-5p in PE group. The mean expression levels of miR-21-3p and miR-155-5p in PE were 1.12 ± 0.6 and 0.82 ±0.5, respectively compared to 1.52 ± 0.8 and 1.44 ± 0.9 in normal individuals.
Conclusion: Our findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE. A significant part of the pathophysiology of PE is played by miRNAs. Findings differentially expressed miRNAs in mother blood presents a chance to identify a simple-to-use PE biomarker.
期刊介绍：
La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
