A Novel Diagnostic Biomarker of Preeclampsia: MicroRNAs in Maternal Blood Leukocytes in Preeclamptic Women Compared to Normal Pregnant Women.

Q2 Medicine

Clinica Terapeutica Pub Date : 2025-03-01 DOI:10.7417/CT.2025.5216

S I Elshennawy, F G Yehia, H Elhakeem, L A Gad, A A Eldamanhory, A M Attia, I R Alsawy, A M I Ghit, M A Mohamed, A A Elboghdady, E G Rezk, M F I Mosa, M R Zohri, M A M El Kholy, W A Ayad, A A H Emam, M Y M Ahmed

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引用次数: 0

Abstract

Aim of the work.: The purpose of this study is to compare the expression levels of miR-21-3p and miR-155-5p in leukocytes from preeclampsia (PE) patients to healthy controls.

Patients and methods: The miR-21-3p and miR-155-5p that have been linked to PE were our choices. In comparison to 50 healthy controls, the expression levels of miR-21-3p and miR-155-5p were examined in PE (n = 50). Quantitative PCR in real-time is used for this. Relative quantification values were produced by comparing the target miR's relative expression in the samples to that of the calibrator in the lab.

Results: There was a significant decrease in the expression levels of miR-21-3p and miR-155-5p in PE group. The mean expression levels of miR-21-3p and miR-155-5p in PE were 1.12 ± 0.6 and 0.82 ±0.5, respectively compared to 1.52 ± 0.8 and 1.44 ± 0.9 in normal individuals.

Conclusion: Our findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE. A significant part of the pathophysiology of PE is played by miRNAs. Findings differentially expressed miRNAs in mother blood presents a chance to identify a simple-to-use PE biomarker.

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来源期刊

Clinica Terapeutica PHARMACOLOGY & PHARMACY-

CiteScore

2.50

自引率

0.00%

发文量

124

审稿时长

6-12 weeks

期刊介绍： La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.