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Current Opinion in Genetics & Development最新文献

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A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models 神经肌肉接头研究的新时代：自组织和组装体外模型的最新进展。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102229
Aylin Nebol , Mina Gouti
{"title":"A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models","authors":"Aylin Nebol ,&nbsp;Mina Gouti","doi":"10.1016/j.gde.2024.102229","DOIUrl":"10.1016/j.gde.2024.102229","url":null,"abstract":"<div><p>Understanding the development and function of the human neuromuscular system is crucial for deciphering the mechanisms of neuromuscular disorders and developing effective therapies. However, limitations of animal models necessitate the development of human-specific <em>in vitro</em> models to study such complex diseases effectively. Here, we discuss different approaches for <em>in vitro</em> neuromuscular junction (NMJ) modeling: complex self-organized models that rely on the inherent abilities of cells to form NMJs based on embryonic developmental principles and assembled models that depend on integrating different cell types for controlled NMJ formation. Finally, we discuss the advantages and limitations of these models and the need for continued advancements enhanced by bioengineering approaches to deepen our understanding of human NMJ biology and pave the way for personalized medicine.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102229"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000789/pdfft?md5=e7d8062d3ddf2d4871eec8b8b38e5075&pid=1-s2.0-S0959437X24000789-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements 边缘增强子--核膜如何控制基因调控元件。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102234
Rafal Czapiewski , Eric C Schirmer
{"title":"Enhancers on the edge — how the nuclear envelope controls gene regulatory elements","authors":"Rafal Czapiewski ,&nbsp;Eric C Schirmer","doi":"10.1016/j.gde.2024.102234","DOIUrl":"10.1016/j.gde.2024.102234","url":null,"abstract":"<div><p>Precise temporal and sequential control of gene expression during development and in response to environmental stimuli requires tight regulation of the physical contact between gene regulatory elements and promoters. Current models describing how the genome folds in 3D space to establish these interactions often ignore the role of the most stable structural nuclear feature — the nuclear envelope. While contributions of 3D folding within/between topologically associated domains (TADs) have been extensively described, mechanical contributions from the nuclear envelope can impact enhancer–promoter interactions both directly and indirectly through influencing intra/inter-TAD interactions. Importantly, these nuclear envelope contributions clearly link this mechanism to development and, when defective, to human disease. Here, we discuss evidence for nuclear envelope regulation of tissue-specific enhancer–promoter pairings, potential mechanisms for this regulation, exciting recent findings that other regulatory elements such as microRNAs and long noncoding RNAs are under nuclear envelope regulation, the possible involvement of condensates, and how disruption of this regulation can lead to disease.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102234"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000832/pdfft?md5=a0fd774b7022a001af67060d5c2cbce7&pid=1-s2.0-S0959437X24000832-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of RNA modifications in cancer metastasis RNA 修饰在癌症转移中的作用
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102232
Nofar Malka-Tunitsky , Aldema Sas-Chen
{"title":"Role of RNA modifications in cancer metastasis","authors":"Nofar Malka-Tunitsky ,&nbsp;Aldema Sas-Chen","doi":"10.1016/j.gde.2024.102232","DOIUrl":"10.1016/j.gde.2024.102232","url":null,"abstract":"<div><p>The epitranscriptome encompasses over 170 post-transcriptional modifications found in various RNA species. RNA modifications play pivotal roles in regulating gene expression by shaping RNA structure and function, implicating the epitranscriptome in diverse biological processes, including pathology progression. This review focuses on research elucidating the roles of the epitranscriptome in cancer metastasis. Metastasis, a primary cause of solid tumor patient mortality, involves a multistep process whereby tumor cells migrate from a primary tumor to distant secondary organs. We discuss RNA modifications found on rRNA, tRNA, and mRNA, highlighting their roles in different stages of metastasis. Understanding mechanisms by which modifications regulate molecular and cellular processes during metastasis is crucial for leveraging epitranscriptomic signatures in cancer diagnosis and treatment.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102232"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell genomic profiling to study regeneration 研究再生的单细胞基因组剖析。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102231
Ashley Maynard , Mateja Soretić , Barbara Treutlein
{"title":"Single-cell genomic profiling to study regeneration","authors":"Ashley Maynard ,&nbsp;Mateja Soretić ,&nbsp;Barbara Treutlein","doi":"10.1016/j.gde.2024.102231","DOIUrl":"10.1016/j.gde.2024.102231","url":null,"abstract":"<div><p>Regenerative capacities and strategies vary dramatically across animals, as well as between cell types, organs, and with age. In recent years, high-throughput single-cell transcriptomics and other single-cell profiling technologies have been applied to many animal models to gain an understanding of the cellular and molecular mechanisms underlying regeneration. Here, we review recent single-cell studies of regeneration in diverse contexts and summarize key concepts that have emerged. The immense regenerative capacity of some invertebrates, exemplified by planarians, is driven mainly by the differentiation of abundant adult pluripotent stem cells, whereas in many other cases, regeneration involves the reactivation of embryonic or developmental gene-regulatory networks in differentiated cell types. However, regeneration also differs from development in many ways, including the use of regeneration-specific cell types and gene regulatory networks.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102231"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000807/pdfft?md5=812b152d9ba58af1f133e9ddbf185605&pid=1-s2.0-S0959437X24000807-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation X染色体结构在哺乳动物X染色体剂量补偿中的关键作用
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102235
Iris Dror , Tiao Tan , Kathrin Plath
{"title":"A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation","authors":"Iris Dror ,&nbsp;Tiao Tan ,&nbsp;Kathrin Plath","doi":"10.1016/j.gde.2024.102235","DOIUrl":"10.1016/j.gde.2024.102235","url":null,"abstract":"<div><p>To regulate gene expression, the macromolecular components of the mammalian interphase nucleus are spatially organized into a myriad of functional compartments. Over the past decade, increasingly sophisticated genomics, microscopy, and functional approaches have probed this organization in unprecedented detail. These investigations have linked chromatin-associated noncoding RNAs to specific nuclear compartments and uncovered mechanisms by which these RNAs establish such domains. In this review, we focus on the long non-coding RNA Xist and summarize new evidence demonstrating the significance of chromatin reconfiguration in creating the inactive X-chromosome compartment. Differences in chromatin compaction correlate with distinct levels of gene repression on the X-chromosome, potentially explaining how human XIST can induce chromosome-wide dampening and silencing of gene expression at different stages of human development.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102235"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000844/pdfft?md5=970f1b4b826ea87648c064627cff6be6&pid=1-s2.0-S0959437X24000844-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals 刺鼠再生的奇迹：哺乳动物恢复组织结构的细胞参与者及其相互作用。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI: 10.1016/j.gde.2024.102228
Antonio Tomasso , Vanessa Disela , Michael T Longaker , Kerstin Bartscherer
{"title":"Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals","authors":"Antonio Tomasso ,&nbsp;Vanessa Disela ,&nbsp;Michael T Longaker ,&nbsp;Kerstin Bartscherer","doi":"10.1016/j.gde.2024.102228","DOIUrl":"10.1016/j.gde.2024.102228","url":null,"abstract":"<div><p>Understanding the cellular and molecular determinants of mammalian tissue regeneration and repair is crucial for developing effective therapies that restore tissue architecture and function. In this review, we focus on the cell types involved in scarless wound response and regeneration of spiny mice (<em>Acomys</em>). Comparative -omics approaches with scar-prone mammals have revealed species-specific peculiarities in cellular behavior during the divergent healing trajectories. We discuss the developing views on which cell types engage in restoring the architecture of spiny mouse tissues through a co-ordinated spatiotemporal response to injury. While yet at the beginning of understanding how cells interact in these fascinating animals to regenerate tissues, spiny mice hold great promise for scar prevention and anti-fibrotic treatments.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102228"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000777/pdfft?md5=ed573c4c7732df00c19905ff9bb98fa3&pid=1-s2.0-S0959437X24000777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the role of tRNA modifications in cancer progression 解码 tRNA 修饰在癌症进展中的作用。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-07-31 DOI: 10.1016/j.gde.2024.102238
Riley O Hughes , Hannah J Davis , Leona A Nease , Elena Piskounova
{"title":"Decoding the role of tRNA modifications in cancer progression","authors":"Riley O Hughes ,&nbsp;Hannah J Davis ,&nbsp;Leona A Nease ,&nbsp;Elena Piskounova","doi":"10.1016/j.gde.2024.102238","DOIUrl":"10.1016/j.gde.2024.102238","url":null,"abstract":"<div><p>Epitranscriptomic modification of tRNA has recently gained traction in the field of cancer biology. The presence of such modifications on tRNA appears to allow for translational control of processes central to progression and malignant transformation. Methyltransferase Like 1 protein (METTL1), along with other epitranscriptomic writers (e.g. NSUN3, NAT10, ELP3, etc.), has recently been investigated in multiple cancer types. Here, we review the impact of such tRNA modifications in tumorigenesis and the progression of cancer toward drug resistance and metastasis. Regulation of central cellular processes relied upon by malignant cancer cells through modulation of the tRNA epitranscriptome represents an area with great potential to bring novel first-in-class therapies to the clinic.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"88 ","pages":"Article 102238"},"PeriodicalIF":3.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic strategies to target the epitranscriptomic machinery 针对表转录组机制的治疗策略
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-07-17 DOI: 10.1016/j.gde.2024.102230
Denise Sighel , Eliana Destefanis , Alessandro Quattrone
{"title":"Therapeutic strategies to target the epitranscriptomic machinery","authors":"Denise Sighel ,&nbsp;Eliana Destefanis ,&nbsp;Alessandro Quattrone","doi":"10.1016/j.gde.2024.102230","DOIUrl":"10.1016/j.gde.2024.102230","url":null,"abstract":"<div><p>Altered RNA modification patterns and dysregulated expression of epitranscriptomic machinery proteins (EMPs) have been causatively correlated with several diseases. Modulation of EMP gene expression has shown promise in reversing disease-associated phenotypes, making EMPs attractive therapeutic targets.</p><p>Various therapeutic strategies, including small-molecule modulators, proteolysis-targeting chimeras, and molecular tools for site-specific engineering of RNA modifications, have been introduced to modulate EMPs and RNA modifications themselves and are currently being investigated to enrich the physician’s armamentarium. At the forefront of research are small-molecule inhibitors of the key players involved in the N<sup>6</sup>-methyladenosine RNA modification, with an inhibitor of methyltransferase 3 in clinical trials. Preclinical studies have also demonstrated proof-of-concept for the other approaches, raising expectations for this exciting new frontier of therapy.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102230"},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000790/pdfft?md5=15e405d00c3e7e256a13a4d02d8605fd&pid=1-s2.0-S0959437X24000790-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of N6-methyladenosine writers, readers and erasers in the mammalian germline 哺乳动物种系中 N6-甲基腺苷的书写者、阅读者和擦除者的作用
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-07-08 DOI: 10.1016/j.gde.2024.102224
Graeme R Wells, Ramesh S Pillai
{"title":"Roles of N6-methyladenosine writers, readers and erasers in the mammalian germline","authors":"Graeme R Wells,&nbsp;Ramesh S Pillai","doi":"10.1016/j.gde.2024.102224","DOIUrl":"10.1016/j.gde.2024.102224","url":null,"abstract":"<div><p><em>N</em><sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant internal modification of mRNAs in eukaryotes. Numerous studies have shown that m<sup>6</sup>A plays key roles in many biological and pathophysiological processes, including fertility. The factors involved in m<sup>6</sup>A-dependent mRNA regulation include writers, which deposit the m<sup>6</sup>A mark, erasers, which remove it, and readers, which bind to m<sup>6</sup>A-modified transcripts and mediate the regulation of mRNA fate. Many of these proteins are highly expressed in the germ cells of mammals, and some have been linked to fertility disorders in human patients. In this review, we summarise recent findings on the important roles played by proteins involved in m<sup>6</sup>A biology in mammalian gametogenesis and fertility. Continued study of the m<sup>6</sup>A pathway in the mammalian germline will shed further light on the importance of epitranscriptomics in reproduction and may lead to effective treatment of human fertility disorders.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102224"},"PeriodicalIF":3.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X2400073X/pdfft?md5=4de1f1689adeff156763f246bafdf392&pid=1-s2.0-S0959437X2400073X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial metabolomics in tissue injury and regeneration 组织损伤和再生中的空间代谢组学
IF 4 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2024-06-19 DOI: 10.1016/j.gde.2024.102223
Rosalie GJ Rietjens , Gangqi Wang , Bernard M van den Berg, Ton J Rabelink
{"title":"Spatial metabolomics in tissue injury and regeneration","authors":"Rosalie GJ Rietjens ,&nbsp;Gangqi Wang ,&nbsp;Bernard M van den Berg,&nbsp;Ton J Rabelink","doi":"10.1016/j.gde.2024.102223","DOIUrl":"https://doi.org/10.1016/j.gde.2024.102223","url":null,"abstract":"<div><p>Tissue homeostasis is intricately linked to cellular metabolism and metabolite exchange within the tissue microenvironment. The orchestration of adaptive cellular responses during injury and repair depends critically upon metabolic adaptation. This adaptation, in turn, shapes cell fate decisions required for the restoration of tissue homeostasis. Understanding the nuances of metabolic processes within the tissue context and comprehending the intricate communication between cells is therefore imperative for unraveling the complexity of tissue homeostasis and the processes of injury and repair. In this review, we focus on mass spectrometry imaging as an advanced platform with the potential to provide such comprehensive insights into the metabolic instruction governing tissue function. Recent advances in this technology allow to decipher the intricate metabolic networks that determine cellular behavior in the context of tissue resilience, injury, and repair. These insights not only advance our fundamental understanding of tissue biology but also hold implications for therapeutic interventions by targeting metabolic pathways critical for maintaining tissue homeostasis.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"87 ","pages":"Article 102223"},"PeriodicalIF":4.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000728/pdfft?md5=c94475248a825a6dadd8f9593cc3ab77&pid=1-s2.0-S0959437X24000728-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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