近距离的力量:跨气流的机制和生物学作用。

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
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引用次数: 0

摘要

在果蝇许多基因的突变等位基因之间的互补中观察到了转座现象,这种现象被定义为一种依赖于邻近性的等位基因间相互作用。在包括哺乳动物在内的其他物种中也观察到了类似转座现象的案例。然而,转运对野生型基因调控的潜在贡献及其内在机制仍不确定。在此,我回顾了最近的证据,这些证据证明了跨脉流在生理环境中的相关性。这些研究结果表明,转运是基因调控的另一层,它允许细胞根据同源等位基因的接近程度对基因表达进行微调。此外,最近的研究测量了相互作用的等位基因之间的物理距离,发现了意想不到的巨大和可变距离。我将讨论这些距离如何与转录调控的 "中枢 "模型相兼容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The power of proximity: mechanisms and biological roles of transvection
The phenomenon of transvection, defined as a proximity-dependent interallelic interaction, has been observed in the context of complementation between mutant alleles for numerous Drosophila genes. Cases of transvection-like phenomena have also been observed in other species, including mammals. However, the potential contribution of transvection to wild-type gene regulation and the underlying mechanisms remain uncertain. Here, I review recent evidence demonstrating the relevance of transvection in physiological contexts. These findings suggest that transvection represents an additional layer of gene regulation that allows cells to fine-tune gene expression based on the proximity of homologous alleles. In addition, recent studies have measured the physical distance between interacting alleles, revealing unexpectedly large and variable distances. I will discuss how these distances are compatible with the ‘hub’ model of transcriptional regulation.
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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