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mRNA translational control of regeneration 再生的mRNA翻译控制
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-06-07 DOI: 10.1016/j.gde.2025.102367
Mehdi Amiri , Nahum Sonenberg , Soroush Tahmasebi
{"title":"mRNA translational control of regeneration","authors":"Mehdi Amiri ,&nbsp;Nahum Sonenberg ,&nbsp;Soroush Tahmasebi","doi":"10.1016/j.gde.2025.102367","DOIUrl":"10.1016/j.gde.2025.102367","url":null,"abstract":"<div><div>mRNA translation is rapidly upregulated after injury to supply proteins required for tissue regeneration. Augmented protein synthesis during regeneration has long been associated with increases in ribosome biogenesis and mTORC1 activity. Emerging evidence highlights the roles of multiple signaling pathways, RNA-binding proteins, and RNA modifications in tissue repair. Here, we review recent research on the molecular mechanisms underlying translational control in response to tissue damage. The findings underscore the importance of mRNA translation in regeneration and its potential therapeutic applications in tissue repair.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102367"},"PeriodicalIF":3.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways 减数分裂前期运动的重新布线：调节因子，角色和进化途径
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-06-07 DOI: 10.1016/j.gde.2025.102366
Wenxin Xie , Manjunath Gowder , Dominic Bazzano , Morgan DeSantis , Saher S Hammoud
{"title":"Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways","authors":"Wenxin Xie ,&nbsp;Manjunath Gowder ,&nbsp;Dominic Bazzano ,&nbsp;Morgan DeSantis ,&nbsp;Saher S Hammoud","doi":"10.1016/j.gde.2025.102366","DOIUrl":"10.1016/j.gde.2025.102366","url":null,"abstract":"<div><div>Meiotic prophase movement and chromosome bouquet formation are highly conserved processes and essential features of meiosis, yet their functional components and dependencies vary among organisms. A key feature of meiotic prophase is that chromosome regions like telomeres or centromeres become physically tethered to the inner nuclear membrane through a hierarchical and sequential arrangement of proteins. Telomeres or their analogs further interact with the cytoskeletal machinery, which provides the necessary mechanical force to execute the chromosomal movements that enable homologous pairing, synapsis, and meiotic recombination. Despite decades of research, our understanding of these processes, their interdependencies, and their precise role remains incomplete. Here, we summarize the current mechanistic understanding and describe avenues for further exploration.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102366"},"PeriodicalIF":3.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in interspecies chimeras and organogenesis 种间嵌合和器官发生的最新进展
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-06-04 DOI: 10.1016/j.gde.2025.102368
Jia Huang , Bingbing He , Jun Wu
{"title":"Recent advances in interspecies chimeras and organogenesis","authors":"Jia Huang ,&nbsp;Bingbing He ,&nbsp;Jun Wu","doi":"10.1016/j.gde.2025.102368","DOIUrl":"10.1016/j.gde.2025.102368","url":null,"abstract":"<div><div>Interspecies chimeras have served as a crucial tool for understanding the mechanisms of tissue regeneration and repair, offering promising potential to address the global organ shortage crisis. Through a technique known as interspecies blastocyst complementation, researchers can cultivate tissues and organs of one species within the body of another species. This approach involves injecting donor pluripotent stem cells into a host blastocyst that lacks critical developmental genes, allowing the donor cells to compensate for the missing organs or tissues in the host and thereby produce organs derived from the donor species. This review consolidates key findings from studies published in the past 2 years, highlighting advancements in techniques that enable the development of functional organs across species, as well as the remaining challenges.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102368"},"PeriodicalIF":3.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-homologous sequence interactions during meiosis: meiotic challenges and evolutionary opportunities 减数分裂过程中的非同源序列相互作用：减数分裂的挑战和进化机会
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-23 DOI: 10.1016/j.gde.2025.102365
Beth L Dumont, Mary Ann Handel
{"title":"Non-homologous sequence interactions during meiosis: meiotic challenges and evolutionary opportunities","authors":"Beth L Dumont,&nbsp;Mary Ann Handel","doi":"10.1016/j.gde.2025.102365","DOIUrl":"10.1016/j.gde.2025.102365","url":null,"abstract":"<div><div>A hallmark of meiosis is pairing of homologous chromosomes, an event that ensures proper segregation into the gametes. Homology pairing is crucial to the formation of normal gametes, the maintenance of genomic integrity, and avoidance of aneuploidy. However, chromosomes are not completely homologous. Here we discuss two notable exceptions to homology: the mammalian sex chromosomes and centromeres. In themselves, these exceptions illustrate meiotic adaptations that both ensure correct chromosome segregation and present evolutionary opportunities. More broadly, such examples of non-homology provide a window for viewing normal mechanisms of meiotic pairing and chromosome modifications. Current analyses of mammalian meiotic chromosome dynamics suggest that the basis for the initial recognition of homology early in meiosis may be based in epigenetic chromatin modifications. Chromatin units may both form pairing sites and provide the modifications that allow non-homologous sequences to be tolerated. Despite recent research progress, we have yet to understand why some non-homologies are tolerated, while others lead to aneuploidy. Understanding how genomes evolve strategies to subvert the usual rules of meiosis will benefit from studies focused on the identification and characterization of meiosis in species with recently acquired non-homology. Looking forward, we are now armed with technologies and tools suited to precisely measure the extent of nonhomology across mammalian chromosomes and to probe the molecular and biophysical steps required for the initiation of homologous chromosome recognition and pairing. These goals are important for elucidating an essential mechanism of meiosis and ultimately for advancing the clinical diagnosis of gametic and embryo aneuploidy.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102365"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological roles of nonsense-mediated RNA decay: insights from the nervous system 无义介导的RNA衰变的生物学作用：来自神经系统的见解
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-22 DOI: 10.1016/j.gde.2025.102356
Kun Tan , Miles F Wilkinson
{"title":"Biological roles of nonsense-mediated RNA decay: insights from the nervous system","authors":"Kun Tan ,&nbsp;Miles F Wilkinson","doi":"10.1016/j.gde.2025.102356","DOIUrl":"10.1016/j.gde.2025.102356","url":null,"abstract":"<div><div>Nonsense-mediated RNA decay (NMD) is a highly selective and conserved RNA turnover pathway. The discovery that NMD is not only a quality control pathway that degrades aberrant mRNAs but also degrades subsets of normal mRNAs has led to the hypothesis that NMD influences and controls normal biological events. In this review, we lay out the support for this hypothesis, with a focus on NMD’s roles in the nervous system. Studies have demonstrated roles for NMD in several aspects of nervous system development, including neural cell generation and differentiation. Studies in mice have provided evidence that NMD inhibits neural inflammation and promotes mature neuron functions, including dendritic spine maturation and synaptic plasticity, providing a potential explanation for why NMD deficiency leads to cognitive and behavioral dysfunction in mice and humans.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102356"},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell models of human embryo implantation and trophoblast invasion 人胚胎着床和滋养细胞侵袭的干细胞模型
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-20 DOI: 10.1016/j.gde.2025.102357
Peiheng Liu , Serene Mattis , Thorold W Theunissen
{"title":"Stem cell models of human embryo implantation and trophoblast invasion","authors":"Peiheng Liu ,&nbsp;Serene Mattis ,&nbsp;Thorold W Theunissen","doi":"10.1016/j.gde.2025.102357","DOIUrl":"10.1016/j.gde.2025.102357","url":null,"abstract":"<div><div>Stem cell–based embryo models have taken the scientific community by storm as they enable investigation of previously inaccessible stages of human development. Here, we discuss how stem cell–based embryo and placenta models can shine a light on two elusive and intertwined aspects of human development that are critical for successful pregnancy: the implantation of the blastocyst into the endometrium and the subsequent invasion of placental villi deep inside the maternal tissues. Both of these processes are mediated by the trophoblast lineage, which is specified in the preimplantation embryo and can be modeled using naïve pluripotent stem cells. We review how embryo and placenta models built from naïve stem cells can be leveraged to obtain mechanistic insights into human implantation and trophoblast invasion.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102357"},"PeriodicalIF":3.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spliceosome complex and neurodevelopmental disorders 剪接体复合体与神经发育障碍
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-15 DOI: 10.1016/j.gde.2025.102358
Hannah M Deutsch , Yuanquan Song , Dong Li
{"title":"Spliceosome complex and neurodevelopmental disorders","authors":"Hannah M Deutsch ,&nbsp;Yuanquan Song ,&nbsp;Dong Li","doi":"10.1016/j.gde.2025.102358","DOIUrl":"10.1016/j.gde.2025.102358","url":null,"abstract":"<div><div>Neurodevelopment requires complex spatiotemporal expression, which heavily relies on proper RNA splicing. The spliceosome is a ribonucleoprotein complex that removes introns from pre-mRNA, joins exons, and produces mature mRNA. Pathogenic variants in genes that code for spliceosome RNAs and proteins cause RNA mis-splicing and spliceosomopathies. Splicing defects during nervous system development upend the tightly controlled neurodevelopmental process, leading to neurodevelopmental disorders (NDDs). Despite the fact that the spliceosome is expressed in every cell, not all spliceosomopathies present as NDDs; spliceosomopathies are often tissue-specific in that a variant has a greater impact on certain cell lineages or cell types. Here we discuss spliceosomopathies whose presentations include NDDs and focus on spliceosome-coding genes.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102358"},"PeriodicalIF":3.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Emerging perspectives in genome architecture and gene regulation 编辑概述：基因组结构和基因调控的新兴观点
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-12 DOI: 10.1016/j.gde.2025.102355
Marcelo Nollmann , Anders S. Hansen
{"title":"Editorial overview: Emerging perspectives in genome architecture and gene regulation","authors":"Marcelo Nollmann ,&nbsp;Anders S. Hansen","doi":"10.1016/j.gde.2025.102355","DOIUrl":"10.1016/j.gde.2025.102355","url":null,"abstract":"","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102355"},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse 脊椎动物受精突触分子调控因子的保存与分化
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-06 DOI: 10.1016/j.gde.2025.102352
Andreas Blaha , Alexander Schleiffer , Andrea Pauli
{"title":"Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse","authors":"Andreas Blaha ,&nbsp;Alexander Schleiffer ,&nbsp;Andrea Pauli","doi":"10.1016/j.gde.2025.102352","DOIUrl":"10.1016/j.gde.2025.102352","url":null,"abstract":"<div><div>Fertilization — the process during which sperm and egg find each other, bind and eventually fuse — marks the beginning of a new individual. Research over the past years in vertebrates has shed new light on conserved and divergent molecular regulators that mediate the formation of the fertilization synapse, the close apposition of the two plasma membranes before fusion. Here, we review the known proteins that are required for sperm–egg interaction in mammals and fish from a phylogenetic perspective. While some sperm factors are only conserved in vertebrates and share phylogenetic and structural features, others have a longer evolutionary history. In contrast, the egg factors have changed even within vertebrates despite recognizing the preserved sperm machinery. Future functional work on these factors will be essential to understand the fusion mechanism of vertebrate sperm and egg.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102352"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular basis of cell fate plasticity — insights from the privileged cells 细胞命运可塑性的分子基础——来自特权细胞的见解
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-05-05 DOI: 10.1016/j.gde.2025.102354
Stephen Maxwell Scalf, Qiao Wu, Shangqin Guo
{"title":"Molecular basis of cell fate plasticity — insights from the privileged cells","authors":"Stephen Maxwell Scalf,&nbsp;Qiao Wu,&nbsp;Shangqin Guo","doi":"10.1016/j.gde.2025.102354","DOIUrl":"10.1016/j.gde.2025.102354","url":null,"abstract":"<div><div>In the post-Yamanaka era, the rolling balls on Waddington’s hilly landscape not only roll downward, but also go upward or sideways. This new-found mobility implies that the tantalizing somatic cell plasticity fueling regeneration, once only known to planarians and newts, might be sparking in the cells of mice and humans, if only we knew how to fully unlock it. The hope for ultimate regeneration was made even more tangible by the observations that partial reprogramming by the Yamanaka factors reverses many hallmarks of aging [76], even though the underlying mechanism remains unclear. We intend to revisit the milestones in the evolving understanding of cell fate plasticity and glean molecular insights from an unusual somatic cell state, the privileged cell state that reprograms in a manner defying the stochastic model. We synthesize our view of the molecular underpinning of cell fate plasticity, from which we speculate how to harness it for regeneration and rejuvenation. We propose that senescence, aging and malignancy represent distinct cell states with definable biochemical and biophysical parameters.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"93 ","pages":"Article 102354"},"PeriodicalIF":3.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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