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Current Opinion in Genetics & Development最新文献

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R-loop homeostasis in genome dynamics, gene expression and development
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-03-04 DOI: 10.1016/j.gde.2025.102325
Paula Aguilera , Andrés Aguilera
{"title":"R-loop homeostasis in genome dynamics, gene expression and development","authors":"Paula Aguilera ,&nbsp;Andrés Aguilera","doi":"10.1016/j.gde.2025.102325","DOIUrl":"10.1016/j.gde.2025.102325","url":null,"abstract":"<div><div>R-loops are double-edge swords with functional roles that in many cases constitute a threat to genome integrity and gene expression with relevant consequences in cell physiology and development. A number of factors have evolved to control R-loop homeostasis by acting at the levels of R-loop prevention, resolution, or the repair of the R-loop-induced DNA lesion. Deciphering the role of R-loops generated under different stresses and the plethora of processes controlling their homeostasis has become crucial to evaluate their impact in cell physiology and the biological significance of their association with development and disease. Here, we review publications of the last 2 years that help understand their biological role.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"92 ","pages":"Article 102325"},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-24 DOI: 10.1016/j.gde.2025.102326
Jason L Stein , Alex A Pollen
{"title":"Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution","authors":"Jason L Stein ,&nbsp;Alex A Pollen","doi":"10.1016/j.gde.2025.102326","DOIUrl":"10.1016/j.gde.2025.102326","url":null,"abstract":"","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"92 ","pages":"Article 102326"},"PeriodicalIF":3.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling forebrain regional development and connectivity by human brain organoids
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-20 DOI: 10.1016/j.gde.2025.102324
Mu Seog Choe , Cynthia Lo , In-Hyun Park
{"title":"Modeling forebrain regional development and connectivity by human brain organoids","authors":"Mu Seog Choe ,&nbsp;Cynthia Lo ,&nbsp;In-Hyun Park","doi":"10.1016/j.gde.2025.102324","DOIUrl":"10.1016/j.gde.2025.102324","url":null,"abstract":"<div><div>The forebrain is one of the most important brain structures for modern human existence, which houses the uniquely sophisticated social and cognitive functions that distinguish our species. Therefore, modeling the forebrain development by using human cells is especially critical for our understanding of the intricacies of human development and devising treatments for related diseases. Recent advancements in brain organoid fields have offered unprecedented tools to investigate forebrain development from studies on specific regions to exploring tract formation and connectivity between different regions of the forebrain. In this review, we discuss the developmental biology of the forebrain and diverse methods for modeling its development by using organoids.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"91 ","pages":"Article 102324"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of long-range gene regulation
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-13 DOI: 10.1016/j.gde.2025.102323
Sanyami Zunjarrao, Maria Cristina Gambetta
{"title":"Principles of long-range gene regulation","authors":"Sanyami Zunjarrao,&nbsp;Maria Cristina Gambetta","doi":"10.1016/j.gde.2025.102323","DOIUrl":"10.1016/j.gde.2025.102323","url":null,"abstract":"<div><div>Transcription from gene promoters occurs in specific spatiotemporal patterns in multicellular organisms, controlled by genomic regulatory elements. The communication between a regulatory element and a promoter requires a certain degree of physical proximity between them; hence, most gene regulation occurs locally in the genome. However, recent discoveries have revealed long-range gene regulation strategies that enhance interactions between regulatory elements and promoters by overcoming the distances between them in the linear genome. These new findings challenge the traditional view of how gene expression patterns are controlled. This review examines long-range gene regulation strategies recently reported in Drosophila and mammals, offering insights into their mechanisms and evolution.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"91 ","pages":"Article 102323"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the connection between RNA splicing and intellectual disability
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-08 DOI: 10.1016/j.gde.2025.102322
Anthony Caputo, Ashleigh E Schaffer
{"title":"Exploring the connection between RNA splicing and intellectual disability","authors":"Anthony Caputo,&nbsp;Ashleigh E Schaffer","doi":"10.1016/j.gde.2025.102322","DOIUrl":"10.1016/j.gde.2025.102322","url":null,"abstract":"<div><div>Intellectual disability (ID) is a broad diagnostic category that encompasses individuals with impaired cognitive ability. While these disorders have heterogeneous causes, recent developments in next-generation sequencing (NGS) are revealing the prevalence of genetic etiologies. In particular, germline mutations in genes that affect RNA splicing are increasingly common causes of ID disorders. Research to elucidate the functional relationship between splicing and neurodevelopment is critical since molecular therapeutics require a nuanced understanding of the pathological mechanism. In this review, we first summarize the trends that have led to the discovery of the RNA splicing–ID relationship, then discuss recent progress and future directions for research surrounding RNA splicing in neurodevelopment. Finally, we speak on how these results may serve as the foundation for burgeoning therapies.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"91 ","pages":"Article 102322"},"PeriodicalIF":3.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-04 DOI: 10.1016/j.gde.2025.102311
Lei Yang , Mingli Ma , Yawei Gao , Jun Liu
{"title":"Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions","authors":"Lei Yang ,&nbsp;Mingli Ma ,&nbsp;Yawei Gao ,&nbsp;Jun Liu","doi":"10.1016/j.gde.2025.102311","DOIUrl":"10.1016/j.gde.2025.102311","url":null,"abstract":"<div><div><em>N</em><sup>6</sup>-methyladenosine (m<sup>6</sup>A), a reversible and dynamic RNA modification, plays pivotal roles in regulating stem cell pluripotency and early embryogenesis. Disruptions in m<sup>6</sup>A homeostasis lead to profound developmental defects, impairing processes such as stem cell self-renewal, lineage specification, oocyte maturation, zygotic genome activation, and maternal RNA degradation after fertilization. Beyond its well-recognized roles in mRNA transport, stability, and translation, recent studies have highlighted m<sup>6</sup>A’s critical role in transcriptional regulation through intricate RNA–chromatin interactions, notably involving chromatin-associated regulatory RNAs (carRNAs) and retrotransposon RNAs. This review delves into the dynamic regulatory landscape of m<sup>6</sup>A, highlighting its critical interplay with chromatin modifications, and explores its broader implications in stem cell biology and early embryonic development.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"91 ","pages":"Article 102311"},"PeriodicalIF":3.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tile by tile: capturing the evolutionary mosaic of human conditions 一砖一瓦：捕捉人类环境的进化马赛克。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-01 DOI: 10.1016/j.gde.2024.102297
Nicolò Caporale , Oliviero Leonardi , Carlo Emanuele Villa , Alessandro Vitriolo , Cedric Boeckx , Giuseppe Testa
{"title":"Tile by tile: capturing the evolutionary mosaic of human conditions","authors":"Nicolò Caporale ,&nbsp;Oliviero Leonardi ,&nbsp;Carlo Emanuele Villa ,&nbsp;Alessandro Vitriolo ,&nbsp;Cedric Boeckx ,&nbsp;Giuseppe Testa","doi":"10.1016/j.gde.2024.102297","DOIUrl":"10.1016/j.gde.2024.102297","url":null,"abstract":"<div><div>The collection of <em>Homo sapiens</em> anatomical hallmarks hypothesized to support the ‘human condition’ did not appear at one specific time and place, but gradually, creating a reticulate evolutionary trajectory. The recent reconstruction of migration patterns and gene flows across different hominin species and populations draws a mosaic that we contend can be illuminated by genomic comparisons and specific experiments. Here, we first review key discoveries that could allow this experimental endeavor by describing recent advances in a variety of fields, stressing the importance of charting the current human neurodiversity as an interpretive substrate for evolutionary changes. Then, we identify key cellular and molecular observables. Finally, given the vast amount of possible variants, we focus the discussion on technologies that could allow their interrogation in a way that is compatible with the staggering amount of contemporary genomic and phenotypic characterization.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"90 ","pages":"Article 102297"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear remodeling during cell fate transitions 细胞命运转变过程中的核重塑。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-01 DOI: 10.1016/j.gde.2024.102287
Xinyi Liu, Xiaoru Ling, Qi Tian, Zibin Huang, Junjun Ding
{"title":"Nuclear remodeling during cell fate transitions","authors":"Xinyi Liu,&nbsp;Xiaoru Ling,&nbsp;Qi Tian,&nbsp;Zibin Huang,&nbsp;Junjun Ding","doi":"10.1016/j.gde.2024.102287","DOIUrl":"10.1016/j.gde.2024.102287","url":null,"abstract":"<div><div>Totipotent stem cells, the earliest cells in embryonic development, can differentiate into complete embryos and extra-embryonic tissues, making them essential for understanding both development and regenerative medicine. This review examines recent advances in the dynamic remodeling of nuclear structures during the transition between totipotency and pluripotency, as well as other cell fate transition processes. Additionally, we highlight innovative experimental and computational methods that elucidate the relationship between nuclear architecture and cell fate decisions. By integrating these insights, we aim to enhance our understanding of how nuclear remodeling influences totipotency and other cell fate transitions, paving the way for future research in this critical field.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"90 ","pages":"Article 102287"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early central nervous system development and neuron regeneration 早期中枢神经系统发育和神经元再生。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-01 DOI: 10.1016/j.gde.2024.102286
Runhua Yang, Fen Ji, Jianwei Jiao
{"title":"Early central nervous system development and neuron regeneration","authors":"Runhua Yang,&nbsp;Fen Ji,&nbsp;Jianwei Jiao","doi":"10.1016/j.gde.2024.102286","DOIUrl":"10.1016/j.gde.2024.102286","url":null,"abstract":"<div><div>The nervous system is the most complex system in the human body, and the normal development of the central nervous system (CNS) is essential for maintaining the healthy life activities of the individual. CNS development requires the orchestration of multiple internal or external or direct or indirect factors to regulate neural stem cell fate specification. Here, we provide a broad overview of the regulatory system of nerve cell fate decisions and discuss the latest technological approaches to achieve neural regeneration. Understanding the CNS development and regeneration mechanisms has shifted the paradigm from traditional experiments to high-throughput sequencing.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"90 ","pages":"Article 102286"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interphase chromatin biophysics and mechanics: new perspectives and open questions 间期染色质生物物理学和力学：新观点和开放问题。
IF 3.7 2区 生物学
Current Opinion in Genetics & Development Pub Date : 2025-02-01 DOI: 10.1016/j.gde.2024.102296
Antoine Coulon
{"title":"Interphase chromatin biophysics and mechanics: new perspectives and open questions","authors":"Antoine Coulon","doi":"10.1016/j.gde.2024.102296","DOIUrl":"10.1016/j.gde.2024.102296","url":null,"abstract":"<div><div>The physical organization and properties of chromatin within the interphase nucleus are intimately linked to a wide range of functional DNA-based processes. In this context, interphase chromatin mechanics — that is, how chromatin, physically, responds to forces — is gaining increasing attention. Recent methodological advances for probing the force–response of chromatin <em>in cellulo</em> open new avenues for research, as well as new questions. This review discusses emerging views from these approaches and others, including recent <em>in vitro</em> single-molecule studies of cohesin and condensin motor activities, providing insights into physical and material aspects of chromatin, its plasticity in the context of functional processes, its nonequilibrium or ‘active matter’ properties, and the importance of factors such as chromatin fiber tension and stiffness. This growing field offers exciting opportunities to better understand the interplay between interphase chromosome structure, dynamics, mechanics, and functions.</div></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"90 ","pages":"Article 102296"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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