Unlocking regeneration: how partial reprogramming resembles tissue healing

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-04-30 DOI:10.1016/j.gde.2025.102351

Melissa T Adams, Heinrich Jasper, Lluc Mosteiro

引用次数: 0

Abstract

Partial reprogramming achieved by the transient expression of the transcription factors (TFs) Oct4, Sox2, Klf4 and C-Myc (abbreviated OSKM) can erase aging and damage features in cells, leading to increased healthspan, lifespan and tissue regeneration. Recent reports suggest that the mechanisms of partial reprogramming may share some similarities with natural dedifferentiation and regeneration. Both processes appear to involve the transient repression of somatic identity through the sequestration of somatic identity TFs to noncanonical sites, which are opened by the high expression of pioneer TFs, leading to transient dedifferentiation into a fetal-like state. Here, we review the reported benefits of partial reprogramming on tissue regeneration and propose a common mechanism of epigenetic remodeling with natural regeneration after tissue injury.

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解锁再生：部分重编程如何类似于组织愈合

通过转录因子Oct4、Sox2、Klf4和C-Myc（简称OSKM）的瞬时表达实现部分重编程，可以消除细胞中的衰老和损伤特征，从而延长健康寿命、寿命和组织再生。最近的报道表明，部分重编程的机制可能与自然去分化和再生有一些相似之处。这两个过程似乎都涉及体细胞身份的短暂抑制，通过将体细胞身份tf隔离到非规范位点，这是由先驱tf的高表达打开的，导致短暂的去分化进入胎儿状态。在此，我们回顾了部分重编程对组织再生的益处，并提出了组织损伤后表观遗传重塑与自然再生的共同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)