更好地合作：合作性如何影响转录突变

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-11-05 DOI:10.1016/j.gde.2024.102274

Charis Fountas, Tineke L Lenstra

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引用次数: 0

摘要

转录猝发是指启动子在转录活跃和不活跃状态之间的随机转换。这一动态过程受到转录因子与 DNA 结合的动态、转录因子与辅助激活因子的相互作用以及启动子、凝聚子和增强子之间的三维相互作用的高度调控。在这篇微型综述中，我们将讨论转录因子和辅助因子在简单和复杂调控环境中的动力学最新见解，以了解它们对转录猝发的影响。我们研究了转录因子交换的新概念，并将其与不同的合作性模型联系起来。最后，我们讨论了最近关于增强子和转录凝聚物调控转录突变的活细胞成像研究。

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Better together: how cooperativity influences transcriptional bursting

Transcriptional bursting refers to the stochastic transition of a promoter between transcriptionally active and inactive states. This dynamic process is highly regulated by the dynamics of transcription factor binding to DNA, their interactions with coactivators, and the 3D interactions between promoters, condensates, and enhancers. In this mini-review, we discuss recent insights into the kinetics of transcription factors and cofactors in both simple and complex regulatory environments to understand their impact on transcriptional bursting. We examine the novel concept of transcription factor exchange and relate it to different cooperativity models. Finally, we discuss recent live-cell imaging studies on the regulation of transcriptional bursting by enhancers and transcriptional condensates.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)