Current Opinion in Ophthalmology最新文献_第2页

Prevention and management of postcataract cystoid macular edema.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI: 10.1097/ICU.0000000000001127

Satya S Paruchuri, Raziyeh Mahmoudzadeh, Sydney Wheeler, Jessica Randolph

引用次数: 0

Tissue engineering of the vitreous body: recent progress and future trends.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-07 DOI: 10.1097/ICU.0000000000001125

André Schulz, Stefaniya K Boneva, Clemens Lange, J Sebag

{"title":"Tissue engineering of the vitreous body: recent progress and future trends.","authors":"André Schulz, Stefaniya K Boneva, Clemens Lange, J Sebag","doi":"10.1097/ICU.0000000000001125","DOIUrl":"10.1097/ICU.0000000000001125","url":null,"abstract":"Purpose of review: In contrast to current clinically used tamponades including oils and gases, hydrogels offer a vitreous replacement that has the potential to present a niche for vitreous cells and elevate vitreous substitutes to the level of tissue engineering. This article, therefore, highlights and discusses recent hydrogel-based vitreous replacement strategies as well as the latest progress on vitreous cells, towards the development of a cellularized vitreous substitute.Recent findings: A variety of different crosslinked hydrogel systems have been recently investigated as preformed and in situ forming vitreous substitutes, based on biopolymers and/or synthetic polymers. In addition, a comprehensive understanding of the precise function and immunological significance of hyalocytes as vitreous macrophages has recently emerged using advanced imaging techniques and high-throughput transcriptional and protein analyses.Summary: Tissue engineering offers transformative potential for vitreous replacement by combining advanced hydrogel systems with hyalocytes as vitreous cells to further replicate the versatile characteristics and functions of the native vitreous.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"262-269"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of diabetic tractional retinal detachments: surgical experiences from a large tertiary academic institution.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-14 DOI: 10.1097/ICU.0000000000001124

Albert Liao, Blake Fortes, Adrian Au, Kirk Hou

{"title":"Management of diabetic tractional retinal detachments: surgical experiences from a large tertiary academic institution.","authors":"Albert Liao, Blake Fortes, Adrian Au, Kirk Hou","doi":"10.1097/ICU.0000000000001124","DOIUrl":"10.1097/ICU.0000000000001124","url":null,"abstract":"Purpose of review: Management of diabetic tractional retinal detachments (TRDs) remains technically challenging. The purpose of this review is to provide an updated overview of current surgical techniques and important considerations when treating this condition.Recent findings: Recent advances in imaging have provided critical insights into hyaloid status and tractional forces in diabetic TRDs, greatly aiding surgical planning. Updates in vitrectomy instruments have also greatly improved anatomic success rates. However, a comprehensive preoperative evaluation and plan remains key in optimizing visual outcomes for this difficult condition.Summary: The surgical management of diabetic TRDs requires several key elements for successful outcomes. Timely intervention and presurgical planning are crucial, particularly in rapidly progressing cases. The use of advanced imaging and instruments enhances visualization and precision during surgery. Finally, a collaborative multispecialty approach with clear communication with patients about their prognosis is fundamental to effective care. These strategies collectively improve patient outcomes and promote visual recovery in those affected by diabetic TRDs.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"177-181"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment approaches for refractory full-thickness macular holes.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI: 10.1097/ICU.0000000000001131

Nikhil Bommakanti, Roselind Ni, Ajay E Kuriyan

{"title":"Treatment approaches for refractory full-thickness macular holes.","authors":"Nikhil Bommakanti, Roselind Ni, Ajay E Kuriyan","doi":"10.1097/ICU.0000000000001131","DOIUrl":"10.1097/ICU.0000000000001131","url":null,"abstract":"Purpose of review: Full-thickness macular holes (FTMH) can result in significant visual impairment if untreated. Although conventional treatment achieves high closure rates, FTMH can persist or reopen in some cases. This review examines recent advances in surgical approaches for managing refractory FTMH and highlights their effectiveness and limitations.Recent findings: Approaches to refractory FTMH aim to relieve traction, encourage glial cell proliferation, improve RPE pump efficiency, increase retinal compliance, and/or provide replacement tissue. A variety of techniques targeting these mechanisms, including various autologous or allogeneic transplants such as internal limiting membrane (ILM) or human amniotic membrane grafts, or surgical manipulations such as macular detachment or relaxing retinotomies, have been proposed. These techniques are reviewed here.Summary: Multiple techniques have shown promise for refractory FTMH. Choice of technique should be guided by characteristics of the FTMH, including size and chronicity, availability of desired tissue or instrumentation, and surgeon familiarity.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"219-226"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1097/ICU.0000000000001122

Sunir J Garg, Jason Hsu

引用次数: 0

Promising therapeutic targets for neuroprotection in retinal disease.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.1097/ICU.0000000000001123

Warren W Pan, Thomas J Wubben, David N Zacks

{"title":"Promising therapeutic targets for neuroprotection in retinal disease.","authors":"Warren W Pan, Thomas J Wubben, David N Zacks","doi":"10.1097/ICU.0000000000001123","DOIUrl":"10.1097/ICU.0000000000001123","url":null,"abstract":"Purpose of review: Neurodegeneration is a common endpoint of various blinding retinal diseases. Yet, despite exciting advances in disease treatment, there continues to exist a critical need for the development of neuroprotective strategies to prevent retinal cell death. Here, we summarize the recent advances in neuroprotective strategies.Recent findings: From laboratory deciphering of the mechanisms involved in disease, many novel neuroprotective strategies have emerged and are currently under investigation for the treatment of various retinal and ocular diseases such as inherited retinal degeneration, retinal detachment, diabetic retinopathy, age-related macular degeneration, macular telangiectasia type 2, and glaucoma. These strategies include gene therapies, Fas inhibition, and targeting inflammatory, metabolic and reduction-oxidation abnormalities. Interestingly, investigation of several treatments across different diseases suggests shared neuroprotection mechanisms that can be targeted regardless of the particular disease.Summary: Retinal neuroprotection can improve treatment of different retinal diseases. Fortunately, the current landscape, with a plethora of novel neuroprotective therapies, portends a better future for patients.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"247-252"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements in optic disc pit maculopathy management.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-12 DOI: 10.1097/ICU.0000000000001130

Tadashi Yokoi, Roselind L Ni, Meera D Sivalingam, Yoshihiro Yonekawa

{"title":"Recent advancements in optic disc pit maculopathy management.","authors":"Tadashi Yokoi, Roselind L Ni, Meera D Sivalingam, Yoshihiro Yonekawa","doi":"10.1097/ICU.0000000000001130","DOIUrl":"10.1097/ICU.0000000000001130","url":null,"abstract":"Purpose of review: Optic disc pit maculopathy (ODPM) is a rare yet serious condition that can lead to visual impairment. While pars plana vitrectomy (PPV) remains the gold standard for ODPM that requires treatment, there is ongoing debate regarding adjunctive surgical techniques. This review explores the latest surgical advancements and innovations in the management of ODPM from the past few years.Recent findings: Vitrectomy remains an effective procedure for ODPM management, achieving high success rates. Adjunctive techniques, including internal limiting membrane (ILM) peeling, gas tamponade, and juxtapapillary laser photocoagulation, have demonstrated efficacy, though their roles remain debated. Novel approaches using ILM plugging, amniotic membrane grafts, and autologous platelet concentrate offer promise, especially in refractory cases. High-level evidence remains scarce, and most recent publications are relatively small case series. Therefore, it remains unclear whether the additional techniques confer additional benefit beyond vitrectomy alone, although the novel approaches can be effective options for refractory cases. Larger comparative studies are required to provide better evidence.Summary: Vitrectomy with or without additional maneuvers is an effective treatment for ODPM. Emerging adjunctive surgical techniques provide new possibilities, but further research is required to assess for comparative efficacy and optimize outcomes.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"210-218"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide-1 receptor agonists and the eye.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-27 DOI: 10.1097/ICU.0000000000001137

David L Zhang, Avni P Finn

{"title":"Glucagon-like peptide-1 receptor agonists and the eye.","authors":"David L Zhang, Avni P Finn","doi":"10.1097/ICU.0000000000001137","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001137","url":null,"abstract":"Purpose of review: Glucagon-like peptide-1 receptor agonists (GLP-1RA) have gained popularity as an antidiabetic and weight loss agent with protective cardiovascular outcomes, but attention to the potential ocular side effects has grown. This review aims to consolidate the existing evidence on the effects of GLP-1RA on conditions such as diabetic retinopathy (DR), nonarteritic ischemic optic neuropathy (NAION), glaucoma, age-related macular degeneration (AMD), idiopathic intracranial hypertension (IIH), and dry eye disease (DED).Recent findings: The effect of GLP-1RA on DR is controversial but likely linked to rapid correction of hemoglobin A1c levels. GLP-1RA may be associated with increased risk of NAION, although the mechanism remains elusive. Protective effects have been shown against glaucoma, AMD, and DED possibly due to its anti-inflammatory properties, and these medications may decrease intracranial pressure in IIH.Summary: As the usage of GLP-1RA increases, further dedicated ocular safety trials are key to determining the risk of eye-related complications. Given the limited prospective evidence available and the proven systemic benefits of the medication, as well as its potential protective effects on certain eye diseases, GLP-1RA use should generally not be discouraged in most patients. Regular ophthalmologic follow up is important in patients considered at higher risk of ocular adverse events.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the necessity of topical and subconjunctival antibiotic prophylaxis in ocular surgery.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-27 DOI: 10.1097/ICU.0000000000001136

Kareena Chawla, Prashant D Tailor, Jayanth Sridhar

{"title":"Evaluating the necessity of topical and subconjunctival antibiotic prophylaxis in ocular surgery.","authors":"Kareena Chawla, Prashant D Tailor, Jayanth Sridhar","doi":"10.1097/ICU.0000000000001136","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001136","url":null,"abstract":"Purpose of review: The role of topical and subconjunctival antibiotics in reducing infection risk in major ocular surgeries remains unclear despite their widespread use. This review discusses the efficacy of both administration routes across various forms of surgery, underscoring evidence-based recommendations for quality practice patterns and limitations in current research.Recent findings: Although intracameral antibiotics consistently result in low infection rates in phacoemulsification procedures, there may be some role for topical and subconjunctival antibiotic use, also influenced by regional preferences. Topical antibiotics may prove to be more beneficial in cases of pars plana vitrectomy and keratoprosthesis, but subconjunctival may be more beneficial in trabeculotomies.Summary: Despite substantial data on infection incidence in ocular surgeries, gaps remain in the evaluation of specific antibiotic regimens, particularly for lesser studied procedures, such as minimally invasive glaucoma surgeries (MIGS) and ocular surface surgeries. Further research is needed to address these disparities and explore novel antimicrobial approaches.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction.

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-02-02 DOI: 10.1097/ICU.0000000000001114

引用次数: 0