Current Opinion in Ophthalmology最新文献_第2页

Pediatric blepharokeratoconjunctivitis: review of epidemiology, pathophysiology, and current treatments. 儿童眼睑角化结膜炎：流行病学、病理生理学和当前治疗的综述。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/ICU.0000000000001141

Rija Awan, Shama Khan, Wajid Ali Khan

{"title":"Pediatric blepharokeratoconjunctivitis: review of epidemiology, pathophysiology, and current treatments.","authors":"Rija Awan, Shama Khan, Wajid Ali Khan","doi":"10.1097/ICU.0000000000001141","DOIUrl":"10.1097/ICU.0000000000001141","url":null,"abstract":"Purpose of review: This review aims to provide a comprehensive overview of the epidemiology and clinical features of pediatric blepharokeratoconjunctivitis (BKC), with a focus on elucidating the underlying pathophysiology and evaluating new therapeutic strategies.Recent findings: Ongoing research continues to refine the management of pediatric BKC. Recent evidence suggests that disease remission can be achieved in approximately 95% of cases through an integrated approach involving topical or systemic antibiotics, corticosteroids, topical immunosuppressants, and lid hygiene. Notably, a significant advancement in the treatment of Demodex blepharitis is the FDA approval of 0.25% lotilaner ophthalmic solution, which has demonstrated safety and efficacy with twice-daily application over six weeks.Summary: Pediatric blepharokeratoconjunctivitis is a chronic inflammatory condition affecting the eyelids, conjunctiva, and cornea. It is underdiagnosed and associated with significant vision-threatening complications. While there is no established consensus on the most effective therapeutic strategy, management currently includes lid hygiene, topical/systemic antibiotics, corticosteroids, immunosuppressants, lubricants, and dietary supplements. Challenges arise from its chronicity, recurrence, and lack of standardized treatment protocols. This underscores the importance of early diagnosis, education, and continued research on treatment methods to prevent severe outcomes.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"314-321"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in procedural management of dry eye disease. 干眼病的程序性治疗进展。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1097/ICU.0000000000001144

Colleen Podd, Salma Fleifil

{"title":"Advances in procedural management of dry eye disease.","authors":"Colleen Podd, Salma Fleifil","doi":"10.1097/ICU.0000000000001144","DOIUrl":"10.1097/ICU.0000000000001144","url":null,"abstract":"Purpose of review: The purpose of this article is to provide a summary of in-office procedures available for dry eye treatment. Dry eye is a multifactorial condition of the ocular surface with increasing prevalence among patients. There have been advances in nonpharmacological treatment options for patients in recent years. Most of these new treatments are geared towards evaporative dry eye due to meibomian gland deficiency.Recent findings: Standard treatment of dry eye usually starts with topical treatments, such as artificial tears and inflammation modulators. However, options have now broadened to in-office procedural treatments. Most devices and procedures available for dry eye syndrome focus on the health of the lid structures involved in tear secretion, specifically the meibomian glands. There are fewer procedural options that address aqueous deficiency dry eye cases. The recent recall in over-the-counter eye drops may have caused patients to research nonpharmacological alternatives.Summary: There are now numerous nonpharmacological options for dry eye therapy. A range of thermal devices are used for the purpose of assisting in meibomian gland expression. Intense pulsed light (IPL) is also a popular therapy option. In addition to thermal properties to melt the meibum, it also has the benefit of an anti-inflammatory effect. Radiofrequency can be used in combination with IPL. Meibomian gland probing is an option as a rejuvenator for improving meibomian gland function. Treating aqueous deficiency dry eye still favors topical treatments, but the surgical procedure of salivary gland transplantation is occasionally used.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"308-313"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical importance of retinal displacement in planning retinal detachment repair and evaluating outcomes. 视网膜移位在视网膜脱离修复计划和疗效评估中的临床意义。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-06-23 DOI: 10.1097/ICU.0000000000001156

Humza Zaidi, Priya S Vakharia

{"title":"The clinical importance of retinal displacement in planning retinal detachment repair and evaluating outcomes.","authors":"Humza Zaidi, Priya S Vakharia","doi":"10.1097/ICU.0000000000001156","DOIUrl":"10.1097/ICU.0000000000001156","url":null,"abstract":"Purpose of review: Retinal displacement is an occasional yet underrecognized sequela of rhegmatogenous retinal detachment (RRD) repair that can cause postoperative visual distortions and anisekonia. While retinal surgeons strive to achieve single-surgery success, more emphasis and understanding should also be placed on optimizing visual outcomes following RRD repair, including minimizing retinal distortions. This review explores the pathophysiology, clinical manifestations, imaging modalities, risk factors, and preventive strategies associated with retinal displacement.Recent findings: Retinal displacement is associated with significant visual disturbances - most notably metamorphopsia, aniseikonia, and spatial mislocalization - despite preserved visual acuity. Imaging advances, particularly optical coherence tomography (OCT) overlays and OCT homography, have improved detection over traditional fundus autofluorescence. Risk factors for displacement include macula-off detachments, extensive detachment area, use of a complete intraocular gas fill, and surgical modality, with pneumatic retinopexy and scleral buckling associated with lower displacement rates. Computer modeling has suggested biomechanical forces contributing to displacement.Summary: Retinal displacement significantly affects postoperative visual quality following RRD repair. Although often missed on standard examination, improved imaging and surgical refinement offer opportunities for early detection and prevention. Continued research into the mechanisms and outcomes of displacement is critical for optimizing both anatomical and functional success in retinal detachment surgery.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation: evidence and applications in ophthalmology. 光生物调节：证据及其在眼科中的应用。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-06-06 DOI: 10.1097/ICU.0000000000001154

Natania Rae XiangQin Tan, Kai En Chan, Blanche Xiao Hong Lim, Giuseppe Giannaccare, Raymond P Najjar, Chris Hong Long Lim

{"title":"Photobiomodulation: evidence and applications in ophthalmology.","authors":"Natania Rae XiangQin Tan, Kai En Chan, Blanche Xiao Hong Lim, Giuseppe Giannaccare, Raymond P Najjar, Chris Hong Long Lim","doi":"10.1097/ICU.0000000000001154","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001154","url":null,"abstract":"Purpose of review: Photobiomodulation (PBM) is a noninvasive therapy utilising low-level light energy to stimulate cellular processes, modulate inflammatory pathways, enhance mitochondrial activity, promote tissue regeneration. With growing interest in PBM as a potential treatment modality, this review synthesises current evidence and highlights challenges of implementing PBM across various ophthalmic conditions.Recent findings: Current ophthalmic applications of PBM can be categorised into established and exploratory therapies, differentiated primarily by the attainment of regulatory approval. Established applications of PBM include the treatment of dry eye disease and nonexudative age-related macular degeneration, while the use of PBM is still largely exploratory in conditions such as diabetic macular oedema and retinopathy of prematurity. Regardless of the level of regulatory authorisation, the application of PBM in each ophthalmic condition presents with distinct challenges requiring further research for comprehensive validation.Summary: While PBM holds promise as a novel therapeutic option, its long-term efficacy and safety remains to be fully established. Standardised treatment guidelines and larger randomised controlled trials are essential to optimise its use in future clinical practice.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing retinoblastoma in 2025. 2025年视网膜母细胞瘤的治疗。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-06-06 DOI: 10.1097/ICU.0000000000001155

Eugenia M Ramos-Dávila, Basil K Williams, Maura Di Nicola

{"title":"Managing retinoblastoma in 2025.","authors":"Eugenia M Ramos-Dávila, Basil K Williams, Maura Di Nicola","doi":"10.1097/ICU.0000000000001155","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001155","url":null,"abstract":"Purpose of review: The management of retinoblastoma is an evolving field, with ongoing research focused on novel diagnostic techniques and therapeutic interventions. This review aims to summarize the current treatment options for retinoblastoma and explore future directions in the field.Recent findings: Early diagnosis remains crucial for improving prognosis in retinoblastoma, as prompt identification significantly enhances treatment success. New diagnostic imaging strategies as well as prenatal testing are being developed to detect subclinical disease in high-risk patients, allowing for earlier intervention. Recurrent or refractory disease remains a challenge, but encouraging results have been observed with intravenous chemotherapy, intra-arterial chemotherapy, and intravitreal chemotherapy as salvage therapies. Other strategies, including anterior chamber chemotherapy, novel drug formulations, and advanced delivery methods like sustained release chemotherapy in the form of a chemoplaque, are being explored to address these persistent challenges.Summary: Significant progress in retinoblastoma treatment has led to a dramatic improvement in globe salvage rates. Nevertheless, challenges remain. Delayed diagnosis, particularly in low-income and middle-income regions, continues to contribute to reduced survival rates. Additionally, the management of advanced disease, as well as recurrent or refractory tumors, remain critical issues. The development of new drugs and delivery methods as well as modified treatment strategies offer promise in overcoming these obstacles.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optometry co-management of preoperative and postoperative cataract surgery patients. 验光在白内障手术患者术前和术后的联合管理。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-06-06 DOI: 10.1097/ICU.0000000000001153

Khushi Saigal, Shalini Shah, Zubair Ansari

{"title":"Optometry co-management of preoperative and postoperative cataract surgery patients.","authors":"Khushi Saigal, Shalini Shah, Zubair Ansari","doi":"10.1097/ICU.0000000000001153","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001153","url":null,"abstract":"Purpose of review: As the prevalence of cataracts continues to rise, the increasing demand for cataract surgery may surpass the availability of ophthalmologists. This review examines the role of optometry in the co-management of patients with cataracts, including preoperative and postoperative care, and discusses the implications of expanding optometric scope-of-practice laws.Recent findings: Collaboration between optometrists and ophthalmologists occurs through two primary models: referral-based and integrated management. Studies indicate that direct referrals from optometrists to ophthalmologists improve surgical listing rates and streamline patient care. Integrated models enhance efficiency by incorporating optometrists into ophthalmology practices, allowing ophthalmologists to focus on surgical interventions. Postoperative care co-managed by optometrists has demonstrated mostly favorable visual outcomes, with 86% of patients achieving 20/40 vision or better and low postoperative complication rates. However, legislative changes expanding optometric surgical privileges remain controversial due to concerns about training adequacy and patient safety. Sharing clinical responsibilities can lead to a \"slippery slope\" phenomenon encroaching on the surgeon's role and threatening patient care.Summary: Optometry-ophthalmology co-management can enhance surgical efficiency, improve patient access, and alleviate workforce shortages. While co-management may be effective for routine cases, the expansion of optometric surgical privileges raises debate regarding clinical competency and regulatory oversight. Future efforts should focus on creating best practice guidelines for standardizing training, shared ethical responsibility, and ensuring high-quality, patient-centered care.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of endophthalmitis: to culture or not to culture? 眼内炎的处理：培养还是不培养？

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-21 DOI: 10.1097/ICU.0000000000001152

Annika G Samuelson, Samir N Patel, Sunir J Garg

{"title":"Management of endophthalmitis: to culture or not to culture?","authors":"Annika G Samuelson, Samir N Patel, Sunir J Garg","doi":"10.1097/ICU.0000000000001152","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001152","url":null,"abstract":"Purpose: To review the role of microbial cultures in managing endophthalmitis following cataract surgery and intravitreal injections.Recent findings: The endophthalmitis vitrectomy study (EVS) continues to guide the management of endophthalmitis including its recommendation for intraocular vitreous sampling. Vitreous cultures have better diagnostic yield than aqueous cultures. Advances in culture techniques have improved the efficiency and sensitivity of pathogen identification. While culture results are useful for prognostication, microbiology data rarely changes management in endophthalmitis following cataract surgery or intravitreal injections. Endophthalmitis managed without microbial cultures had similar outcomes to eyes managed with microbial cultures.Summary: Despite advances in culture techniques, most institutions still rely on gram stain and microbial cultures, often requiring several days for results. Initial administration of empiric antibiotics occurs before microbiology data becomes available, limiting the utility of cultures in clinical management. Despite concerns for antibiotic resistance, the large majority of postcataract surgery and postintravitreal injection endophthalmitis pathogens are susceptible to vancomycin and ceftazidime. Given this, obtaining intraocular specimens can be deferred if it poses a delay to prompt treatment with intravitreal antibiotics. Emerging culture techniques hold promise for more rapid and sensitive pathogen identification, which could change the landscape of culture guidelines and improve clinical usefulness.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical and surgical management of neovascular glaucoma. 新生血管性青光眼的内科和外科治疗。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-05 DOI: 10.1097/ICU.0000000000001151

Justin S Yun, Ahmad Santina, Victoria L Tseng

{"title":"Medical and surgical management of neovascular glaucoma.","authors":"Justin S Yun, Ahmad Santina, Victoria L Tseng","doi":"10.1097/ICU.0000000000001151","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001151","url":null,"abstract":"Purpose of review: Neovascular glaucoma (NVG) is a severe secondary glaucoma precipitated by ocular ischemia and abnormal neovascularization, resulting in elevated intraocular pressure (IOP) and vision loss if not promptly addressed. This study evaluates recent advances in both medical and surgical management of NVG, focusing on strategies that integrate anti-vascular endothelial growth factor (VEGF) therapy, retinal ablation, and evolving surgical techniques.Recent findings: Anti-VEGF agents remain central to NVG treatment, with newer agents and combination regimens showing sustained neovascular suppression, alongside panretinal photocoagulation as an additional cornerstone in reducing neovascular drive. Glaucoma drainage devices continue to have prominence for their ability to bypass fibrotic outflow pathways, while trabeculectomy augmented with mitomycin C continues to offer a viable option in select cases. Cyclodestructive procedures, including micropulse transscleral cyclophotocoagulation and endoscopic cyclophotocoagulation, provide alternative surgical avenues for refractory cases. Novel studies including lipidomic analyses present novel metabolic pathways that are potentially implicated in NVG pathogenesis, suggesting future targets beyond VEGF.Summary: Timely recognition and comprehensive treatment - encompassing IOP control, ischemic drive reduction, and inflammation management - remain critical in the management of NVG. As research illuminates additional molecular targets and refines surgical interventions, the promise of a more personalized, biomarker-driven approach to NVG management continues to grow.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binocular treatment of amblyopia: current state and recent advances. 双眼治疗弱视的现状及最新进展。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-13 DOI: 10.1097/ICU.0000000000001121

Anna Sterkin, Oren Yehezkel

{"title":"Binocular treatment of amblyopia: current state and recent advances.","authors":"Anna Sterkin, Oren Yehezkel","doi":"10.1097/ICU.0000000000001121","DOIUrl":"10.1097/ICU.0000000000001121","url":null,"abstract":"Purpose of review: To provide an overview of research from recent randomized clinical trials (RCTs) on novel binocular treatments for amblyopia, inherently designed to force binocular integration by simultaneous dichoptic stimulation. Second, to present an update on the most recent research.Recent findings: In recent years, binocular treatments as either standalone or adjunct first-line therapies for amblyopia have been gaining acceptance, particularly for older patients and those who are either resistant to or noncompliant with traditional penalization therapy. The findings from a growing body of high-level clinical evidence are highlighted.Summary: Clinically significant improvements in visual acuity and stereopsis can be achieved with binocular therapy. Several of these therapies are commercially available and have consistently shown noninferiority over standard patching treatment or full-time refractive correction. The data suggest binocular treatments should be considered as standalone or adjunct first-line therapy. However, more research is necessary to support some reports of superiority and long-term stability of gains, and to establish specific clinical recommendations with consideration of patient's age and amblyopia etiology.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"237-246"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in pharmacological treatments of proliferative vitreoretinopathy. 增殖性玻璃体视网膜病变的药物治疗进展。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1097/ICU.0000000000001119

Jeysson Sanchez-Suarez, Yoon Jeon Kim, William P Miller, Leo A Kim

{"title":"Recent advances in pharmacological treatments of proliferative vitreoretinopathy.","authors":"Jeysson Sanchez-Suarez, Yoon Jeon Kim, William P Miller, Leo A Kim","doi":"10.1097/ICU.0000000000001119","DOIUrl":"10.1097/ICU.0000000000001119","url":null,"abstract":"Purpose of review: Proliferative vitreoretinopathy (PVR) is a severe complication of retinal detachment and trauma, posing significant challenges to surgical success and visual prognosis. Despite advancements in vitreoretinal surgery, PVR incidence remains unchanged, this review presents a synthesis of the principal clinical and preclinical research findings from recent years.Recent findings: Recent research has focused on anti-inflammatory, antiproliferative, and antifibrotic agents. Corticosteroids, such as triamcinolone and dexamethasone, show promise in reducing inflammation but have inconsistent results. Methotrexate and mitomycin C demonstrate efficacy in preclinical and select clinical scenarios. Anti-vascular endothelial growth factor agents and immunotherapies, like infliximab, have shown limited clinical benefits despite promising preclinical data. Novel approaches, including CB2 receptor agonists, exosome-based drug delivery, and nuclear factor kappa B pathway inhibitors, are gaining traction. Additionally, RNA-based and multitargeted therapies highlight the importance of addressing inflammation, fibrosis, and proliferation simultaneously.Summary: Effective management of PVR requires multifaceted therapies targeting its complex pathogenesis. While current treatments are limited, ongoing research in precision drug delivery and combination therapies offers hope for improved outcomes. Future strategies should focus on translating promising preclinical findings into robust clinical applications.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"253-261"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0