Current Opinion in Ophthalmology最新文献_第10页

A review of posterior chamber phakic intraocular lenses. 后房型晶状体人工晶状体的研究进展。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-12-06 DOI: 10.1097/ICU.0000000000001018

Dan Z Reinstein, Cheryl MacGregor, Timothy J Archer, Ruchi Gupta, Joseph G Potter

{"title":"A review of posterior chamber phakic intraocular lenses.","authors":"Dan Z Reinstein, Cheryl MacGregor, Timothy J Archer, Ruchi Gupta, Joseph G Potter","doi":"10.1097/ICU.0000000000001018","DOIUrl":"10.1097/ICU.0000000000001018","url":null,"abstract":"Purpose of review: Posterior chamber phakic intraocular lenses (pIOLs) are increasing in popularity as a viable alternative to laser refractive surgery. The purpose of this review is to evaluate the recent updates to pIOLs and to assess the advancements and safety of the procedure.Recent findings: Accurate lens sizing is the key determinant to suitable vault prediction, advancements to sizing formulae including the use of very high frequency (VHF) digital ultrasound and the application of artificial intelligence and machine learning has led to improved vault prediction and safety. The introduction of the central aquaport has been shown to reduce the formation of cataract and is now adopted in most myopic pIOLs. Recently published studies have demonstrated that pIOLs have an excellent safety profile with no increased risk of retinal detachment or endothelial cell loss. Advancements have led to the introduction of extended depth of focus pIOLs for the correction of presbyopia, further research is required to evaluate the efficacy of new lens designs.Summary: pIOL surgery is experiencing traction with improved lens design and increased lenses choices such as larger optical zone and presbyopic options. Accuracy of implantable collamer lens sizing is paramount to the safety and clinical outcomes, greater predictability is likely to encourage more posterior chamber pIOL users due to fewer sizing related complications.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"138-146"},"PeriodicalIF":3.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cataract surgery in setting of ocular surface disease. 眼表疾病的白内障手术。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-11-27 DOI: 10.1097/ICU.0000000000001024

Enrica Sarnicola, Caterina Sarnicola, Maddalena De Bernardo, Nicola Rosa, Vincenzo Sarnicola

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2024-02-08 DOI: 10.1097/ICU.0000000000001027

引用次数: 0

Recent developments of telemedicine in glaucoma. 青光眼远程医疗的最新发展。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2024-02-08 DOI: 10.1097/ICU.0000000000001019

Jason J Jo, Louis R Pasquale

{"title":"Recent developments of telemedicine in glaucoma.","authors":"Jason J Jo, Louis R Pasquale","doi":"10.1097/ICU.0000000000001019","DOIUrl":"10.1097/ICU.0000000000001019","url":null,"abstract":"Purpose of review: Telemedicine has an increasingly significant role in the fields of ophthalmology and glaucoma. This review covers recent advancements in the development and optimization of teleglaucoma techniques and applications.Recent findings: Glaucoma monitoring and diagnosis via remote tonometry, perimetry, and fundus imaging have become a possibility based on recent developments. Many applications work in combination with smart devices, virtual reality, and artificial intelligence and have been tested in patient populations against conventional \"reference-standard\" measurement tools, demonstrating promising results. Of note, there is still much progress to be made in teleglaucoma and telemedicine at large, such as accessibility to internet, broadband, and smart devices, application affordability, and reimbursement for remote services. However, continued development and optimization of these applications suggest that the implementation of remote monitoring will be a mainstay for glaucoma patient care.Summary: Especially since the beginning of the COVID-19 pandemic, remote patient care has taken on an important role in medicine and ophthalmology. Remote versions of tonometry, perimetry, and fundus imaging may allow for a more patient-centered and accessible future for glaucoma care.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"116-123"},"PeriodicalIF":3.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future directions of glaucoma treatment: emerging gene, neuroprotection, nanomedicine, stem cell, and vascular therapies. 青光眼治疗的未来方向：新兴基因、神经保护、纳米医学、干细胞和血管治疗。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-11-01 DOI: 10.1097/ICU.0000000000001016

Elizabeth C Ciociola, Elise Fernandez, Mary Kaufmann, Meredith R Klifto

{"title":"Future directions of glaucoma treatment: emerging gene, neuroprotection, nanomedicine, stem cell, and vascular therapies.","authors":"Elizabeth C Ciociola, Elise Fernandez, Mary Kaufmann, Meredith R Klifto","doi":"10.1097/ICU.0000000000001016","DOIUrl":"10.1097/ICU.0000000000001016","url":null,"abstract":"Purpose of review: The aim of this article is to summarize current research on novel gene, stem cell, neuroprotective, nanomedicine, and vascular therapies for glaucoma.Recent findings: Gene therapy using viral vectors and siRNA have been shown to reduce intraocular pressure by altering outflow and production of aqueous humor, to reduce postsurgical fibrosis with few adverse effects, and to increase retinal ganglion cell (RGC) survival in animal studies. Stem cells may treat glaucoma by replacing or stimulating proliferation of trabecular meshwork cells, thus restoring outflow facility. Stem cells can also serve a neuroprotective effect by differentiating into RGCs or preventing RGC loss via secretion of growth factors. Other developing neuroprotective glaucoma treatments which can prevent RGC death include nicotinamide, the NT-501 implant which secretes ciliary neurotrophic factor, and a Fas-L inhibitor which are now being tested in clinical trials. Recent studies on vascular therapy for glaucoma have focused on the ability of Rho Kinase inhibitors and dronabinol to increase ocular blood flow.Summary: Many novel stem cell, gene, neuroprotective, nanomedicine, and vascular therapies have shown promise in preclinical studies, but further clinical trials are needed to demonstrate safety and efficacy in human glaucomatous eyes. Although likely many years off, future glaucoma therapy may take a multifaceted approach.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"89-96"},"PeriodicalIF":3.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence for glaucoma: state of the art and future perspectives. 青光眼的人工智能治疗:现状和未来展望。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-11-29 DOI: 10.1097/ICU.0000000000001022

Rafael Correia Barão, Ruben Hemelings, Luís Abegão Pinto, Marta Pazos, Ingeborg Stalmans

引用次数: 0

Impact of smoking on glaucoma. 吸烟对青光眼的影响。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-11-27 DOI: 10.1097/ICU.0000000000001023

Golnoush Mahmoudinezhad, Leo Meller, Sasan Moghimi

{"title":"Impact of smoking on glaucoma.","authors":"Golnoush Mahmoudinezhad, Leo Meller, Sasan Moghimi","doi":"10.1097/ICU.0000000000001023","DOIUrl":"10.1097/ICU.0000000000001023","url":null,"abstract":"Purpose of review: Assessing whether lifestyle related factors play a role in causing primary open-angle glaucoma (POAG) is of great value to clinicians, public health experts and policy makers. Smoking is a major global public health concern and contributes to ocular diseases such as cataracts, and age-related macular degeneration through ischemic and oxidative mechanisms. Recently, smoking has been investigated as a modifiable risk factor for glaucoma. In the presence of an association with glaucoma, provision of advice and information regarding smoking to patients may help reduce the burden of disease caused by POAG. Therefore, the aim of this review is to summarize the current evidence regarding the effect of smoking in the pathogenesis of glaucoma and its incidence, progression as well as the benefits of smoking cessation.Recent findings: While the association between glaucoma development and smoking history is controversial, in the last decade, several recent studies have helped to identify possible effects of smoking, especially heavy smoking, in regard to glaucomatous progression. Smoking cessation may possibly be protective against glaucoma progression.Summary: Smoking may play a role in glaucoma progression and long-term smoking cessation may be associated with lower glaucoma progression. The dose-response relationship between smoking and glaucoma as well as therapeutic potential of smoking cessation needs to be further validated with both preclinical and rigorous clinical studies.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"124-130"},"PeriodicalIF":3.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding racial disparities of glaucoma. 了解青光眼的种族差异。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-03-01 Epub Date: 2023-11-03 DOI: 10.1097/ICU.0000000000001017

Viviana Barquet-Pizá, Carla J Siegfried

{"title":"Understanding racial disparities of glaucoma.","authors":"Viviana Barquet-Pizá, Carla J Siegfried","doi":"10.1097/ICU.0000000000001017","DOIUrl":"10.1097/ICU.0000000000001017","url":null,"abstract":"Purpose of review: Increased prevalence, earlier onset, and more rapid progression to vision loss from glaucoma has demonstrated racial disparity in numerous studies over decades. Precise etiologies of these important differences among patients of African and Hispanic ancestral background have not been elucidated. This review focuses on currently available epidemiologic/population, genetic, socioeconomic and physiologic studies of racial disparities in this blinding disease.Recent findings: In depth reviews of several landmark studies of glaucoma prevalence in various racial groups have highlighted potential challenges of lack of recruitment of diverse populations in genetic studies and clinical trials, challenges of racial stratification of subjects, and the impact of socioeconomic variables.Summary: Through a more comprehensive analysis of racial disparities of glaucoma, both clinicians and researchers may provide more effective population screening and management with a holistic approach for individualized patient care to provide improved outcomes. Future studies of interventions in sociodemographic factors and genetic/physiologic variables that influence the prevalence, access, and consequential vision loss from glaucoma will be crucial to minimize/eliminate racial disparities and improve outcomes for all.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"97-103"},"PeriodicalIF":3.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71434828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of geographic atrophy: an update on data related to pegcetacoplan. 地理性萎缩的治疗：聚乙二醇乙酮普兰相关数据的更新。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-01-01 Epub Date: 2023-10-10 DOI: 10.1097/ICU.0000000000000845

Sagar B Patel, Jeffrey S Heier, Varun Chaudhary, Charles C Wykoff

{"title":"Treatment of geographic atrophy: an update on data related to pegcetacoplan.","authors":"Sagar B Patel, Jeffrey S Heier, Varun Chaudhary, Charles C Wykoff","doi":"10.1097/ICU.0000000000000845","DOIUrl":"10.1097/ICU.0000000000000845","url":null,"abstract":"Purpose of review: Geographic atrophy is an advanced and currently untreatable form of age-related macular degeneration (AMD), which leads to significant compromise of visual function and quality of life. Dysregulation of the complement cascade has been directly implicated in AMD pathogenesis. Pegcetacoplan is a pegylated highly selective bicyclic peptide that inhibits the cleavage of complement component 3 (C3), which represents a key step in propagation of the complement cascade. The phase 2 FILLY trial as well as the phase 3 OAKS and DERBY trials have evaluated the safety and efficacy of pegcetacoplan for the treatment of GA.Recent findings: The FILLY, OAKS and DERBY trials have demonstrated that local inhibition of C3 cleavage with pegcetacoplan can reduce geographic atrophy lesion growth compared with sham with an effect size of approximately 11-35% depending on the specific trial and specific geographic atrophy phenotype considered. Overall pegcetacoplan has appeared to be well tolerated with the notable side effect of a dose-dependent increase in the rate of exudative AMD development in treated eyes.Summary: The FILLY, OAKS and DERBY trials have demonstrated that pegcetacoplan is a potentially viable treatment for geographic atrophy. Additional data from the 2-year outcomes of DERBY and OAKS as well as data from the ongoing 3-year GALE extension study will provide additional insights into the potential therapeutic benefit of pegcetacoplan. Future studies assessing complement inhibition at earlier stages of AMD, with the goal of preventing geographic atrophy formation, are warranted.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"64-72"},"PeriodicalIF":3.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient experiences and satisfaction with cataract surgery. 患者对白内障手术的体验和满意度。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.1097/ICU.0000000000001008

Alexander C Lieu, Natalie A Afshari

引用次数: 0