{"title":"Retinal diseases: Current medical and surgical updates and a look to the future.","authors":"Jayanth Sridhar, Ajay E Kuriyan","doi":"10.1097/ICU.0000000000001214","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001214","url":null,"abstract":"","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":"37 3","pages":"141-142"},"PeriodicalIF":2.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Cappellani, Martin Snyder, Jose S Pulido, Allen C Ho
{"title":"AI-driven, low-cost aids for people with visual impairment.","authors":"Francesco Cappellani, Martin Snyder, Jose S Pulido, Allen C Ho","doi":"10.1097/ICU.0000000000001215","DOIUrl":"10.1097/ICU.0000000000001215","url":null,"abstract":"<p><strong>Purpose of review: </strong>The rapid integration of artificial intelligence (AI) into mainstream consumer devices has created new opportunities for accessible, low-cost support for individuals with visual impairment. This review examines emerging AI-driven tools that repurpose common hardware - such as smartphones and smart glasses - to deliver assistive functions traditionally reliant on costly, specialized devices.</p><p><strong>Recent findings: </strong>Three representative technologies illustrate this shift: Ray-Ban × Meta smart glasses offering hands-free scene interpretation; Apple's iPhone Magnifier app with LiDAR-based Detection Mode providing spatial awareness and text recognition; and the Be My Eyes platform with its AI-powered virtual assistant enabling autonomous image interpretation. These tools emphasize affordability, discreet design, and seamless integration into daily life. Although widely adopted in real-world settings, formal clinical evaluation remains limited, with gaps in evidence regarding functional outcomes, safety, and performance across diverse environments. Online user-generated content has become a prominent source of practical guidance, often outpacing peer-reviewed research.</p><p><strong>Summary: </strong>AI-enabled consumer devices are reshaping assistive technology by lowering financial barriers and enhancing usability. Clinicians should be aware of these rapidly evolving tools as patients increasingly adopt them independently. Rigorous studies are needed to assess their clinical impact, guide safe use, and inform integration into vision rehabilitation practice.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"197-204"},"PeriodicalIF":2.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Martin, Trisha Ortiz, Sidra Zafar, Ajay E Kuriyan
{"title":"Review of current management of submacular hemorrhage.","authors":"Jonathan Martin, Trisha Ortiz, Sidra Zafar, Ajay E Kuriyan","doi":"10.1097/ICU.0000000000001210","DOIUrl":"10.1097/ICU.0000000000001210","url":null,"abstract":"<p><strong>Purpose of review: </strong>Subretinal hemorrhage (SRH) is most commonly associated with neovascular age-related macular degeneration (nAMD) and can cause profound vision loss in the macula through mechanical, toxic, and inflammatory mechanisms. Submacular hemorrhage (SMH) lacks consensus on management. This review summarizes current treatment options, key comparative studies, and ongoing challenges, with emphasis on SMH management.</p><p><strong>Recent findings: </strong>Antivascular endothelial growth factor (anti-VEGF) therapy remains central to SMH management, with outcomes comparable to surgery in small to moderate hemorrhages. Pneumatic displacement (PD) with or without recombinant tissue plasminogen activator (rtPA) shows the greatest comparative benefit in more extensive SMH. Adjunctive rtPA improves hemorrhage displacement rates, and meta-analyses support its efficacy with anti-VEGF therapy. Pars plana vitrectomy (PPV) remains an option for large or refractory hemorrhages but has not consistently shown superior visual outcomes compared to less invasive modalities.</p><p><strong>Summary: </strong>Early intervention is consistently associated with improved outcomes, but there is no universally accepted treatment algorithm. Ongoing randomized trials and advances in multimodal imaging have the potential to refine patient selection and treatment strategies. Future efforts should focus on balancing efficacy, safety, and cost-effectiveness to establish evidence-based guidelines for SMH management.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"187-196"},"PeriodicalIF":2.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical coherence tomography angiography in retinal vascular disease: transformative tool or expensive gimmick?","authors":"Maxwell S Mayeda, Talisa E de Carlo Forest","doi":"10.1097/ICU.0000000000001223","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001223","url":null,"abstract":"<p><strong>Purpose of review: </strong>Optical coherence tomography angiography (OCTA) has rapidly evolved from an experimental imaging technique into a routine component of many retina practices. By providing noninvasive, depth-resolved visualization of retinal and choroidal vasculature without dye injection, OCTA promises safer, faster, and more detailed assessment of retinal vascular disease than fluorescein angiography. However, there is still debate about its clinical applicability and its role in everyday ophthalmology practice, which we review in this article.</p><p><strong>Recent findings: </strong>Over the past decade, OCTA has been extensively applied to diabetic retinopathy, retinal vein occlusion, sickle cell retinopathy, and other ischemic disorders, generating a growing body of literature linking OCTA-derived metrics to disease severity and visual outcomes. Despite this enthusiasm, significant limitations remain, including susceptibility to artifacts, restricted field of view, inability to demonstrate vascular leakage, and uncertain impact on management decisions.</p><p><strong>Summary: </strong>We critically evaluate the current role of OCTA in retinal vascular disease by reviewing recently published literature. This review examines OCTA's technical foundations, clinical applications, strengths, limitations, and future directions. We argue that OCTA is neither a replacement for conventional angiography nor a mere technological novelty, but rather a powerful complementary imaging modality whose value depends on appropriate interpretation and thoughtful clinical integration.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Acaba-Berrocal, Omesh P Gupta, Brandon D Ayres, Ajay E Kuriyan
{"title":"Secondary intraocular fixation: anterior vs. posterior segment approaches, middle segment surgery, and emerging artificial capsule technologies.","authors":"Luis Acaba-Berrocal, Omesh P Gupta, Brandon D Ayres, Ajay E Kuriyan","doi":"10.1097/ICU.0000000000001220","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001220","url":null,"abstract":"<p><strong>Purpose of review: </strong>To review current and emerging advances in secondary intraocular lens (IOL) fixation in the absence of capsular support, emphasizing contemporary techniques, surgical outcomes, complication, and decision making across anterior segment-based, posterior segment-based, and iris-based approaches, while discussing the growing role of middle segment surgery.</p><p><strong>Recent findings: </strong>Practice patterns have shifted away from anterior chamber IOLs toward posterior chamber fixation, driven by advances in small-gauge vitrectomy, improved suture materials, refined scleral-fixation strategies, and dedicated fixation IOL designs. Contemporary options include anterior chamber IOLs, iris-sutured and iris-claw lenses, sutured scleral fixation using polypropylene or expanded polytetrafluoroethylene (Gore-Tex), and sutureless intrascleral haptic fixation techniques such as the Yamane method. Comparative evidence suggests that no single technique is universally superior, rather, procedures demonstrate broadly similar visual outcomes but distinct complication profiles. Middle segment surgery, proposing pars plana-based management of lens and capsular pathology by anterior segment surgeons has gained recent attention. In parallel, early clinical experience with artificial capsule technologies suggests a potential pathway to restore a capsular-like scaffold, expand IOL options, and improve refractive predictability.</p><p><strong>Summary: </strong>Modern techniques have improved safety and outcomes of secondary IOL fixation. Surgical choice should be individualized, and emerging technologies may further redefine posterior chamber reconstruction.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in cataract surgery: is a new era on the horizon?","authors":"Xiaobo Zhang, Yibo Yu, Ke Yao","doi":"10.1097/ICU.0000000000001219","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001219","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarize recent technological, procedural and material advances that are reshaping cataract surgery and to appraise their implications for visual outcomes, safety and global accessibility.</p><p><strong>Recent findings: </strong>Phacoemulsification remains the gold-standard technique, yet refinements in fluidics, ultrasound modulation and heads-up 3-D visualization continue to enhance efficiency and surgeon ergonomics. Femtosecond laser assistance yields measurable benefits in dense or unstable lenses but offers comparable long-term vision to modern phaco in routine cases. Presbyopia-correcting optics have diversified: trifocal and extended-depth-of-focus lenses deliver high rates of spectacle independence, light-adjustable lenses permit postoperative power customization, and early fluid-based or dual-optic accommodative models show 2-2.5 D of true accommodation. Intraoperative tool, digital overlays, aberrometry, microscope-integrated optical coherence tomography, and artificial intelligence-driven video analytics increase refractive precision and aid training. Drug-eluting and nanopatterned intraocular lenses, portable low-cost equipment and sustainability initiatives address comorbidity management, access and environmental impact.</p><p><strong>Summary: </strong>Cataract surgery is evolving into a comprehensive, personalized ocular-rehabilitation procedure that corrects refractive error, treats coexisting disease and maximizes visual quality. Parallel efforts to expand workforce capacity, reduce costs and minimize waste are essential to ensure these innovations benefit patients worldwide.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The importance of the microbiome in uveitis.","authors":"Phoebe Lin","doi":"10.1097/ICU.0000000000001197","DOIUrl":"10.1097/ICU.0000000000001197","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review was to summarize the literature on preclinical and clinical studies demonstrating the impact of the intestinal microbiome in noninfectious uveitis.</p><p><strong>Recent findings: </strong>Preclinical studies using the experimental autoimmune uveitis (EAU) model have shown commensals such as Desulfovibrio and Prevotella , as well as Ruminococcaceae , associated with uveitis, which overlap with some clinical studies in uveitis patients. Interventions that target the microbiome that can be developed for the treatment of uveitis include antibiotics, fecal metabolites or metabolite agonists that are protective in uveitis, probiotics, dietary interventions, or fecal microbial transplant.</p><p><strong>Summary: </strong>There is significant data supporting the importance of the intestinal microbiome in noninfectious uveitis through enrichment or depletion of certain gut bacteria as well as their metabolites. Targeting the intestinal microbiome or their metabolites might be a viable option for the treatment of noninfectious uveitis.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"137-140"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of diet and nutrition in glaucoma.","authors":"Danah A Younis, Grace M Richter","doi":"10.1097/ICU.0000000000001193","DOIUrl":"10.1097/ICU.0000000000001193","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to explore the connection between diet and nutritional intake with optic nerve health for patients with glaucoma.</p><p><strong>Recent findings: </strong>Using the AAO Grading Criteria to determine level of evidence, Level 1 and Level 2 studies reviewed here examine associations between nutritional intake and glaucoma. Increasing consumption of dietary nitrates and retinols, incorporating the Mediterranean diet, and reducing intake of ultra-processed foods to lower glaucoma risk are supported by Level 1 evidence. Level 2 evidence suggests that dietary niacin, antioxidants, fruits, and vegetables have potential to improve optic nerve health and are associated with reduced glaucoma risk. Evidence from both Level 1 and Level 2 studies suggest that combining multiple beneficial dietary components may produce more meaningful effects to reduce glaucoma risk than single dietary factors alone.</p><p><strong>Summary: </strong>Although some studies highlight the protective role of single dietary components against glaucoma, adopting a combination of beneficial dietary habits appears to be more effective as an adjunctive treatment to enhance optic nerve health and lower glaucoma risk.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"99-107"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antifibrotics in glaucoma surgery: current practices and future directions.","authors":"Christopher Santilli, Huda Sheheitli","doi":"10.1097/ICU.0000000000001195","DOIUrl":"10.1097/ICU.0000000000001195","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to cover the current landscape of antifibrotics used in glaucoma surgery and discuss developing antifibrotic agents. This review will inform the reader of new antifibrotic agents in development, clinical trials and clinical use that may alter the standard of care in glaucoma surgery in the near future.</p><p><strong>Recent findings: </strong>Mitomycin-C (MMC) remains the most commonly used antifibrotic in glaucoma surgery to date with expanding use beyond trabeculectomy into the world of minimally invasive bleb forming surgeries. MMC continues to cause similar side effects due to toxicity which is a main driver of innovation. Newer antifibrotic agents are under investigation at all stages of drug development from bench research to clinical use. Familiar agents such as bevacizumab, sodium hyaluronate, and matrix metalloproteinases have shown noninferior success rates to MMC when used as adjunct agents with filtration surgery. Many other antifibrotics agents are being investigated with mixed results.</p><p><strong>Summary: </strong>While MMC remains the gold standard antifibrotic agent for glaucoma surgery, there are numerous antifibrotic agents in development with safer side effect profiles and similar success rates that may change the surgical practice of glaucoma.</p>","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"67-75"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}