Current Opinion in Ophthalmology最新文献_第4页

Treatment approaches for refractory full-thickness macular holes. 难治性全层黄斑孔的治疗方法。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI: 10.1097/ICU.0000000000001131

Nikhil Bommakanti, Roselind Ni, Ajay E Kuriyan

{"title":"Treatment approaches for refractory full-thickness macular holes.","authors":"Nikhil Bommakanti, Roselind Ni, Ajay E Kuriyan","doi":"10.1097/ICU.0000000000001131","DOIUrl":"10.1097/ICU.0000000000001131","url":null,"abstract":"Purpose of review: Full-thickness macular holes (FTMH) can result in significant visual impairment if untreated. Although conventional treatment achieves high closure rates, FTMH can persist or reopen in some cases. This review examines recent advances in surgical approaches for managing refractory FTMH and highlights their effectiveness and limitations.Recent findings: Approaches to refractory FTMH aim to relieve traction, encourage glial cell proliferation, improve RPE pump efficiency, increase retinal compliance, and/or provide replacement tissue. A variety of techniques targeting these mechanisms, including various autologous or allogeneic transplants such as internal limiting membrane (ILM) or human amniotic membrane grafts, or surgical manipulations such as macular detachment or relaxing retinotomies, have been proposed. These techniques are reviewed here.Summary: Multiple techniques have shown promise for refractory FTMH. Choice of technique should be guided by characteristics of the FTMH, including size and chronicity, availability of desired tissue or instrumentation, and surgeon familiarity.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"219-226"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial. 社论。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1097/ICU.0000000000001122

Sunir J Garg, Jason Hsu

引用次数: 0

Promising therapeutic targets for neuroprotection in retinal disease. 视网膜疾病神经保护的有前景的治疗靶点。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.1097/ICU.0000000000001123

Warren W Pan, Thomas J Wubben, David N Zacks

{"title":"Promising therapeutic targets for neuroprotection in retinal disease.","authors":"Warren W Pan, Thomas J Wubben, David N Zacks","doi":"10.1097/ICU.0000000000001123","DOIUrl":"10.1097/ICU.0000000000001123","url":null,"abstract":"Purpose of review: Neurodegeneration is a common endpoint of various blinding retinal diseases. Yet, despite exciting advances in disease treatment, there continues to exist a critical need for the development of neuroprotective strategies to prevent retinal cell death. Here, we summarize the recent advances in neuroprotective strategies.Recent findings: From laboratory deciphering of the mechanisms involved in disease, many novel neuroprotective strategies have emerged and are currently under investigation for the treatment of various retinal and ocular diseases such as inherited retinal degeneration, retinal detachment, diabetic retinopathy, age-related macular degeneration, macular telangiectasia type 2, and glaucoma. These strategies include gene therapies, Fas inhibition, and targeting inflammatory, metabolic and reduction-oxidation abnormalities. Interestingly, investigation of several treatments across different diseases suggests shared neuroprotection mechanisms that can be targeted regardless of the particular disease.Summary: Retinal neuroprotection can improve treatment of different retinal diseases. Fortunately, the current landscape, with a plethora of novel neuroprotective therapies, portends a better future for patients.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"247-252"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements in optic disc pit maculopathy management. 视盘斑窝病治疗的最新进展。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-12 DOI: 10.1097/ICU.0000000000001130

Tadashi Yokoi, Roselind L Ni, Meera D Sivalingam, Yoshihiro Yonekawa

{"title":"Recent advancements in optic disc pit maculopathy management.","authors":"Tadashi Yokoi, Roselind L Ni, Meera D Sivalingam, Yoshihiro Yonekawa","doi":"10.1097/ICU.0000000000001130","DOIUrl":"10.1097/ICU.0000000000001130","url":null,"abstract":"Purpose of review: Optic disc pit maculopathy (ODPM) is a rare yet serious condition that can lead to visual impairment. While pars plana vitrectomy (PPV) remains the gold standard for ODPM that requires treatment, there is ongoing debate regarding adjunctive surgical techniques. This review explores the latest surgical advancements and innovations in the management of ODPM from the past few years.Recent findings: Vitrectomy remains an effective procedure for ODPM management, achieving high success rates. Adjunctive techniques, including internal limiting membrane (ILM) peeling, gas tamponade, and juxtapapillary laser photocoagulation, have demonstrated efficacy, though their roles remain debated. Novel approaches using ILM plugging, amniotic membrane grafts, and autologous platelet concentrate offer promise, especially in refractory cases. High-level evidence remains scarce, and most recent publications are relatively small case series. Therefore, it remains unclear whether the additional techniques confer additional benefit beyond vitrectomy alone, although the novel approaches can be effective options for refractory cases. Larger comparative studies are required to provide better evidence.Summary: Vitrectomy with or without additional maneuvers is an effective treatment for ODPM. Emerging adjunctive surgical techniques provide new possibilities, but further research is required to assess for comparative efficacy and optimize outcomes.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"210-218"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide-1 receptor agonists and the eye. 胰高血糖素样肽-1受体激动剂与眼睛。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-27 DOI: 10.1097/ICU.0000000000001137

David L Zhang, Avni P Finn

{"title":"Glucagon-like peptide-1 receptor agonists and the eye.","authors":"David L Zhang, Avni P Finn","doi":"10.1097/ICU.0000000000001137","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001137","url":null,"abstract":"Purpose of review: Glucagon-like peptide-1 receptor agonists (GLP-1RA) have gained popularity as an antidiabetic and weight loss agent with protective cardiovascular outcomes, but attention to the potential ocular side effects has grown. This review aims to consolidate the existing evidence on the effects of GLP-1RA on conditions such as diabetic retinopathy (DR), nonarteritic ischemic optic neuropathy (NAION), glaucoma, age-related macular degeneration (AMD), idiopathic intracranial hypertension (IIH), and dry eye disease (DED).Recent findings: The effect of GLP-1RA on DR is controversial but likely linked to rapid correction of hemoglobin A1c levels. GLP-1RA may be associated with increased risk of NAION, although the mechanism remains elusive. Protective effects have been shown against glaucoma, AMD, and DED possibly due to its anti-inflammatory properties, and these medications may decrease intracranial pressure in IIH.Summary: As the usage of GLP-1RA increases, further dedicated ocular safety trials are key to determining the risk of eye-related complications. Given the limited prospective evidence available and the proven systemic benefits of the medication, as well as its potential protective effects on certain eye diseases, GLP-1RA use should generally not be discouraged in most patients. Regular ophthalmologic follow up is important in patients considered at higher risk of ocular adverse events.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the necessity of topical and subconjunctival antibiotic prophylaxis in ocular surgery. 评估眼科手术中局部和结膜下抗生素预防的必要性。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-27 DOI: 10.1097/ICU.0000000000001136

Kareena Chawla, Prashant D Tailor, Jayanth Sridhar

{"title":"Evaluating the necessity of topical and subconjunctival antibiotic prophylaxis in ocular surgery.","authors":"Kareena Chawla, Prashant D Tailor, Jayanth Sridhar","doi":"10.1097/ICU.0000000000001136","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001136","url":null,"abstract":"Purpose of review: The role of topical and subconjunctival antibiotics in reducing infection risk in major ocular surgeries remains unclear despite their widespread use. This review discusses the efficacy of both administration routes across various forms of surgery, underscoring evidence-based recommendations for quality practice patterns and limitations in current research.Recent findings: Although intracameral antibiotics consistently result in low infection rates in phacoemulsification procedures, there may be some role for topical and subconjunctival antibiotic use, also influenced by regional preferences. Topical antibiotics may prove to be more beneficial in cases of pars plana vitrectomy and keratoprosthesis, but subconjunctival may be more beneficial in trabeculotomies.Summary: Despite substantial data on infection incidence in ocular surgeries, gaps remain in the evaluation of specific antibiotic regimens, particularly for lesser studied procedures, such as minimally invasive glaucoma surgeries (MIGS) and ocular surface surgeries. Further research is needed to address these disparities and explore novel antimicrobial approaches.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction. 编辑介绍。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-02-02 DOI: 10.1097/ICU.0000000000001114

引用次数: 0

Implications of myopia in diagnosis and screening of open angle glaucoma. 近视在开角型青光眼诊断和筛查中的意义。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1097/ICU.0000000000001116

Aiko Iwase, Makoto Araie

{"title":"Implications of myopia in diagnosis and screening of open angle glaucoma.","authors":"Aiko Iwase, Makoto Araie","doi":"10.1097/ICU.0000000000001116","DOIUrl":"10.1097/ICU.0000000000001116","url":null,"abstract":"Purpose of review: Rapid increase in the prevalence of myopia has been documented worldwide. Myopia, especially high myopia, is not only an important risk factor for having open angle glaucoma (OAG), but also has a strong linking with the progression of OAG. Since myopic axial length (AXL) elongation is associated with nonglaucomatous optic nerve head (ONH) and visual field abnormalities, myopia poses a challenge in differential diagnosis of OAG. This review provides an overview of literature studying relationships between myopic AXL-elongation and diagnosis and prognosis of OAG, and functional and structural changes in the eye.Recent findings: Studies using optical coherence tomography (OCT), OCT-angiography, those using standard automated perimetry (SAP), other perimetric or electrophysiological methods showed dose-dependent effects of myopic AXL elongation on the structural changes in the ONH and parapapillary tissues, and functional abnormalities of an eye. Large cohort studies showed approximately one quarter of eyes with nonpathologic high myopia were complicated with various patterns of visual field defects including glaucoma-like ones.Summary: Findings of cross-sectional and longitudinal studies obtained using various fundus imaging devices must be integrated to perimetric results to improve differential diagnosis of OAG in myopic eyes, in which artificial intelligence technology may be useful.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"107-114"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle modifications and environmental risk factors for glaucoma. 青光眼的生活方式改变和环境风险因素。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1097/ICU.0000000000001098

Abdelrahman M Elhusseiny, Ahmad A Aref

{"title":"Lifestyle modifications and environmental risk factors for glaucoma.","authors":"Abdelrahman M Elhusseiny, Ahmad A Aref","doi":"10.1097/ICU.0000000000001098","DOIUrl":"10.1097/ICU.0000000000001098","url":null,"abstract":"Purpose of review: To summarize recent evidence about the association between different lifestyle modifications and environmental risk factors and glaucoma.Recent findings: Incorporating moderate exercise into the routine of glaucoma patients may help slow the progression of the condition. However, caution should be taken when using swim goggles, and it may be advisable to avoid certain yoga positions and heavy weight-lifting exercises, as they have been linked to intraocular pressure (IOP) spikes and potential risks for glaucoma patients. Various relaxation techniques may lower IOP. The evidence remains inconclusive about the association between vitamins intake and glaucoma. Dietary nitric oxide has been associated with a lower risk of glaucoma. Higher smoking intensity has been linked to faster visual field decline and retinal nerve fiber layer thinning. Additionally, there is currently insufficient evidence to support the use of marijuana in managing glaucoma, with side effects outweighing the proposed benefits. A significant association has been found between air pollutants and ganglion cell layer thinning, as well as a greater burden of glaucoma.Summary: Lifestyle and environmental factors are increasingly recognized as significant contributors to glaucoma development and progression. These modifications should be integrated into a comprehensive treatment approach alongside medications or surgical interventions.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"115-121"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New treatments for glaucoma. 青光眼的新疗法。

IF 3 2区医学

Current Opinion in Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI: 10.1097/ICU.0000000000001110

Anthony P Mai, Tanner J Ferguson, Nathan Radcliffe

{"title":"New treatments for glaucoma.","authors":"Anthony P Mai, Tanner J Ferguson, Nathan Radcliffe","doi":"10.1097/ICU.0000000000001110","DOIUrl":"10.1097/ICU.0000000000001110","url":null,"abstract":"Purpose of review: This review highlights new Federal Drug Administration (FDA) approved glaucoma treatments to familiarize providers with immediately available options.Recent findings: New FDA-approved treatments include the bimatoprost implant, travoprost implant, direct selective laser trabeculoplasty (DSLT), and ocular pressure adjusting pump. The bimatoprost implant is approved for a single administration with effects lasting for about 1 year, as opposed to the nearly 3-year effect for the travoprost implant. Meanwhile, the DSLT lowers intraocular pressure (IOP) by applying a laser through the limbus within 2 s. Lastly, the ocular pressure adjusting pump is a noninvasive, nonpharmaceutical device that lowers IOP with negative pressure within a pair of goggles. Not only do these modalities lower IOP, but they also improve the patient experience by reducing drop burden, decreasing laser duration, or lowering side effects. Although the list of therapies still in development is extensive, another two promising devices under review include a supraciliary stent and an adjustable aqueous tube shunt.Summary: Glaucoma treatment has considerably evolved over the last decade with the introduction of novel topical medications, minimally invasive glaucoma surgeries, sustained-release drug delivery systems, and wearable devices. This expansion in glaucoma has enabled more patient-centric decision-making regarding treatment.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"135-139"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0