Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques最新文献

{"title":"Three-Dimensional Left Atrial Strain in Hypertensive Disorders of Pregnancy: A New Prognostic Frontier?","authors":"Andrea Sonaglioni, Gian Luigi Nicolosi","doi":"10.1111/echo.70292","DOIUrl":"https://doi.org/10.1111/echo.70292","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning-Driven Automated Assessment of Left Ventricular Diastolic Function in Echocardiography","authors":"Arnas Karužas,&nbsp;Laurynas Miščikas,&nbsp;Antanas Kiziela,&nbsp;Karolis Šablauskas,&nbsp;Ieva Kažukauskienė,&nbsp;Dovydas Verikas,&nbsp;Karolis Naskauskas,&nbsp;Gintarė Šakalytė,&nbsp;Gediminas Jaruševičius,&nbsp;Jurgita Plisienė,&nbsp;Vaiva Lesauskaitė","doi":"10.1111/echo.70290","DOIUrl":"https://doi.org/10.1111/echo.70290","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study sought to evaluate the feasibility, accuracy, and diagnostic performance of a fully automated deep learning model for assessing left ventricular diastolic function (LVDF) using 2D transthoracic echocardiography (TTE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>In this prospective observational study, 302 patients underwent 2D TTE for suspected diastolic dysfunction. Diastolic parameters, such as mitral inflow velocities, tissue Doppler indices, left atrial volumes, and tricuspid regurgitation velocity, were automatically analyzed using AI-based software (Ligence Heart) and compared with expert manual measurements. The AI achieved a maximal measurement success rate for spectral and tissue Doppler parameters. Strong correlation was observed for key variables such as E velocity (<i>r</i> = 0.93), A velocity (<i>r</i> = 0.88), E/A ratio (<i>r</i> = 0.94), and LAVi (<i>r</i> = 0.92), while lower agreement was noted for TR velocity. Classification of diastolic dysfunction showed high accuracy in identifying normal and severe grades, with more variability in intermediate categories. No consistent bias or directional error was observed across measured parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Automated AI-based evaluation of diastolic function using 2D TTE is feasible and provides accurate, guideline-based measurements with strong correlation to expert interpretation. The software demonstrated promising results in classifying LVDF grades, particularly in distinguishing normal and severe dysfunction. This approach shows potential to enhance diagnostic consistency and efficiency in clinical practice, although further validation is needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Imaging of Mitral Annular Disjunction: Where Are We?","authors":"Silvia Pradella,&nbsp;Giulia Grazzini,&nbsp;Rocco Pio Basile,&nbsp;Federica De Litteris,&nbsp;Valeria Rende,&nbsp;Martina Bevilacqua,&nbsp;Vittorio Miele","doi":"10.1111/echo.70286","DOIUrl":"https://doi.org/10.1111/echo.70286","url":null,"abstract":"<div>\u0000 \u0000 <p>Mitral annular disjunction (MAD) is a structural abnormality characterized by the separation of the mitral valve annulus from the left ventricular myocardium, often in association with mitral valve prolapse (MVP). Initially identified in the 1980s, MAD was not considered clinically significant at the time. However, recent advancements in imaging techniques have renewed interest in its potential role in mitral valve dysfunction and arrhythmias. Several studies have suggested a possible association with arrhythmogenic events, including non-sustained ventricular tachycardia. Nonetheless, its independent role in arrhythmogenesis remains a subject of debate. Advanced imaging techniques, particularly cardiac magnetic resonance (CMR), have proven valuable for diagnosing MAD and evaluating its implications, especially by detecting myocardial fibrosis.</p>\u0000 <p>This review aims to provide a comprehensive overview of the current literature on MAD, with a focus on its diagnosis, clinical significance, and the application of advanced imaging modalities such as cardiac computed tomography (CCT) and CMR.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Effect of Left Atrial Function by Three-Dimensional Speckle-Tracking Echocardiography on Adverse Pregnancy Outcomes in Patients With Hypertensive Disorders of Pregnancy: A Preliminary Study","authors":"Lan Tingyu,&nbsp;Zhang Meng,&nbsp;Zhang Huiqin,&nbsp;Lv Yifei,&nbsp;Zhou Yixi,&nbsp;He Wen,&nbsp;Du Lijuan,&nbsp;Zhang Wei","doi":"10.1111/echo.70287","DOIUrl":"https://doi.org/10.1111/echo.70287","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the left atrial function in pregnant women with hypertension versus those with normotension using three-dimensional speckle tracking echocardiography (3D-STE) and investigate the association between left atrial dysfunction and adverse pregnancy outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 94 pregnant women registered at the Tiantan Hospital between August 2023 and October 2024 who underwent comprehensive prenatal exams were enrolled. They were divided into three groups according to their blood pressure: gestational hypertension (GH), preeclampsia (PE), and normotensive control groups. The left atrial function was evaluated using two-dimensional speckle tracking echocardiography (2D-STE) and three-dimensional speckle tracking echocardiography (3D-STE). Demographic and echocardiographic parameters were analyzed and compared across the three groups. Maternal births were also documented. The primary adverse pregnancy outcomes included iatrogenic preterm delivery, admission to the neonatal intensive care unit, and infants with small for gestational age. The cohort of pregnant women with hypertensive disorders were stratified into two groups based on the occurrence of adverse pregnancy outcomes: those with adverse outcomes and those without. Comparative analyses were performed to evaluate the differences in demographic and echocardiographic parameters between these groups. Subsequently, regression analyses were performed to identify potential prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pregnant women with GH and PE exhibited increased maximum left atrial volume and decreased left atrial deformation during the reservoir (LASr) and conduit (LAScd) phases compared to those in the control group (<i>p</i> &lt; 0.05). 3D-STE revealed significantly larger left atrial volumes in both the GH and PE groups (<i>p</i> &lt; 0.05), and compared to the control group, the absolute value of LASr, LAScd, left atrial contractile strain (LASct), and the circumferential strain of the left atrial reservoir (LASrc) demonstrated a significant reduction in the GH and PE groups (<i>p</i> &lt; 0.05). Multivariate logistic regression analysis determined the systolic blood pressure and LASr (3D-STE) as independent predictors of adverse pregnancy outcomes. The LASr (3D-STE) predictive cutoff was ≤27%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>3D-STE can detect early reduced left atrial function in patients with hypertensive disorders of pregnancy, and LASr can predict adverse pregnancy outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality Imaging of Left Coronary Artery Complete Occlusion With Thrombosis Secondary to Kawasaki Disease","authors":"Minjie Wan,&nbsp;Wei Li,&nbsp;Fengjuan Yao,&nbsp;Donghong Liu,&nbsp;Cuiling Li","doi":"10.1111/echo.70289","DOIUrl":"https://doi.org/10.1111/echo.70289","url":null,"abstract":"<p>Giant coronary artery aneurysms caused by Kawasaki disease (KD) are rare but can result in substantial morbidity and mortality due to the risk of thrombosis, stenosis, and myocardial infarction. This was the first report of KD causing complete occlusion and thrombus formation of the entire left coronary artery.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coconut Left Atrium: Causes and Management","authors":"Gisou Erabi,&nbsp;Sarmad Karimi,&nbsp;Assal Behkar,&nbsp;Diba Allafi,&nbsp;Reyhaneh Shahveghar,&nbsp;Araz Pooryai,&nbsp;Bashir Najafabadian,&nbsp;Shayan Mirshafiee,&nbsp;Mohaddeseh Behjati","doi":"10.1111/echo.70282","DOIUrl":"https://doi.org/10.1111/echo.70282","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cardiac calcification has multiple etiologies, including previous myocardial infarction, sepsis, and myocarditis. An imbalance between plasma calcium and phosphorus levels can also lead to cardiac calcification. Patients with pre-existing conditions such as rheumatic heart disease or those who have undergone mitral valve replacement (MVR) are at risk of developing left atrium (LA) calcification. Complications may include pulmonary hypertension and heart failure. The objective of this study is to summarize left atrial calcification, its causes, complications, and therapeutic guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study reviewed relevant literature from Google Scholar and PubMed databases until October 2024, including case series, observational studies, and randomized controlled trials (RCTs). The American Psychological Association (APA) seventh edition guidelines were followed for data presentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Coconut LA can arise from various diseases, including rheumatic heart disease, congenital pulmonic valve disease, and MVR. Pathological studies indicate that atrial calcification results from collagen-rich matrices, macrophages, and lymphocytes. Radiological imaging plays a crucial role in assessing disease severity and localization. Treatment options include surgical intervention or resynchronization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In summary, calcification can affect nearly every part of the heart, with diverse underlying reasons and etiologies such as rheumatic heart disease and congenital pulmonic valve disease. Both surgical and resynchronization methods are available for patient management. However, further research is necessary to enhance our understanding of the coconut LA (calcification of the LA).</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Stroke Work Index as a Predictor of Aortic Stenosis After Transcatheter Aortic Valve Implantation","authors":"Hiroyuki Iwano,&nbsp;Kimi Sato,&nbsp;Noor Albakaa,&nbsp;Shingo Tsujinaga,&nbsp;Suguru Ishizaka,&nbsp;Yasuyuki Chiba,&nbsp;Hisao Nishino,&nbsp;Sanae Kaga,&nbsp;Tomoko Ishizu,&nbsp;Yoshihiro Seo,&nbsp;JSE-TAVI investigators","doi":"10.1111/echo.70281","DOIUrl":"https://doi.org/10.1111/echo.70281","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Evaluation of left ventricular (LV) myocardial contractility to predict outcome in aortic stenosis (AS) is challenging because global longitudinal strain (GLS) does not take afterload into account. We thus tested prognostic value of an echocardiographic index of LV external work, stroke work index (SWI) in AS patients undergoing transcatheter aortic valve implantation (TAVI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We evaluated 1583 patients who underwent TAVI from database of a multicenter retrospective study. As an index of LV external work, echocardiographic LV SWI was calculated as 0.0136 × [stroke volume index × (mean aortic pressure + mean transvalvular pressure gradient—LV end-diastolic pressure)] [g × min/m²], where LV end-diastolic pressure was estimated as 4.9 + (0.62 × <i>E</i>/<i>e</i>′) [mmHg]. GLS data was available in 902 patients. Primary endpoint was defined as cardiac death or worsening heart failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During a median follow-up period of 725 days, 262 patients experienced primary endpoint. Kaplan–Meyer analysis showed that patients having lower LV SWI had lower event-free survival. Furthermore, Cox regression analysis showed that LV SWI was associated with primary endpoint independently of other clinically relevant factors. When influence of LV SWI on outcome was tested in preserved and reduced GLS groups respectively, LV SWI discriminated event-free survival in patients showing reduced GLS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Reduced LV SWI before TAVI was associated with poorer outcomes in AS patients. Furthermore, combined assessment of LV SWI and GLS is expected to improve prognostic risk stratification in AS patients undergoing TAVI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 4D Flow MRI-Derived Aortic Hemodynamics and Their Relationships With Left Ventricular Remodeling in Patients With Moderate Aortic Stenosis: A Preliminary Study","authors":"Jeong-Eun Yi,&nbsp;Sungho Park,&nbsp;Osung Kwon,&nbsp;Dongyeop Han,&nbsp;Hyungkyu Huh,&nbsp;Bae Young Lee","doi":"10.1111/echo.70280","DOIUrl":"https://doi.org/10.1111/echo.70280","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Identifying factors associated with left ventricular (LV) remodeling is important for risk stratification of patients with moderate aortic stenosis (AS). The aim of this preliminary study was to explore aortic hemodynamics in these patients and assess their relationships with LV remodeling using four-dimensional (4D) flow magnetic resonance imaging (MRI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Data from 17 patients with moderate AS involving the tricuspid aortic valves and normal LV ejection fraction (EF &gt; 55%) were analyzed. All patients underwent 4D flow MRI of the ascending aorta and cardiac magnetic resonance (CMR) on the same day within 1 month of being diagnosed with moderate AS by transthoracic Doppler echocardiography. 4D flow MRI aortic parameters, including turbulent kinetic energy (TKE), both total and peak; peak wall shear stress (WSS); and the vortex and helix flow severity, were assessed. CMR measures comprised LV structure and function, late gadolinium enhancement (LGE), myocardial native T1 mapping, and extracellular volume fraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The minimum and maximum values of total TKE, peak TKE, and peak WSS were 39.4/160.3 mJ, 876.6/2059.6 J/m³, and 2.0/4.9 Pa, respectively. More than 50% of the patients had vortex and helix flow of Grade 2. Peak TKE significantly correlated with LV end-diastolic volume index (<i>r</i> = 0.675, <i>p</i> = 0.003), LV end-systolic volume index (<i>r</i> = 0.666, <i>p</i> = 0.003), and LV mass index (<i>r</i> = 0.653, <i>p</i> = 0.004). LGE was not observed, and peak TKE also showed an inverse correlation with native T1 value (<i>r</i> = −0.571, <i>p</i> = 0.017).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among patients with moderate AS, 4D flow MRI revealed heterogeneous aortic hemodynamic profiles and peak TKE was a significant hemodynamic parameter related to early LV remodeling. However, these findings need to be confirmed in further studies with larger sample sizes and a long-term serial follow-up data.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/echo.70280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in Assessing Left Atrial Dysfunction in Hypertensive Patients With Diabetes Mellitus","authors":"Macit Kalçik","doi":"10.1111/echo.70276","DOIUrl":"https://doi.org/10.1111/echo.70276","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Gadolinium Enhancement on Cardiac MRI and the Prognosis of Patients With Pulmonary Hypertension: A Meta-Analysis","authors":"Wenjuan Han,&nbsp;Qijun Ban,&nbsp;Deyin Zhai,&nbsp;Yujie Zhai","doi":"10.1111/echo.70278","DOIUrl":"https://doi.org/10.1111/echo.70278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (MRI) is indicative of myocardial fibrosis and has been proposed as a prognostic marker in patients with pulmonary hypertension (PH). However, the strength and consistency of this association remain uncertain. This meta-analysis aims to evaluate the relationship between LGE and adverse clinical outcomes in patients with PH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Embase, and Web of Science were systematically searched from the inception of each database through March 28, 2025, for longitudinal observational studies reporting on the prognostic value of LGE detected by cardiac MRI in PH. Risk ratios (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model to account for between-study heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten studies involving 733 patients were included. The presence of LGE on cardiac MRI was associated with a nonsignificant trend toward increased risk of adverse clinical outcomes (RR = 1.23, 95% CI: 0.99–1.54; <i>p</i> = 0.07; I² = 40%). A similar result was observed in the sensitivity analysis restricted to high-quality studies (RR = 1.15, 95% CI: 0.98–1.36; <i>p</i> = 0.10; I² = 14%). Subgroup analyses showed consistent trends across all stratifications, with no significant differences (all <i>p</i> &gt; 0.05). No evidence of publication bias was detected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LGE on cardiac MRI may be associated with adverse outcomes in patients with PH; however, the current evidence remains inconclusive. Further large-scale, prospective studies are warranted to clarify its prognostic value.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 9","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}