Electromagnetic Biology and Medicine最新文献

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Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue. 脉冲电磁场和n -乙酰半胱氨酸对玻璃化小鼠卵巢组织移植的影响。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2246503
Khadijeh Rasaeifar, Saeed Zavareh, Maryam Hajighasem-Kashani, Meysam Nasiri
{"title":"Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue.","authors":"Khadijeh Rasaeifar,&nbsp;Saeed Zavareh,&nbsp;Maryam Hajighasem-Kashani,&nbsp;Meysam Nasiri","doi":"10.1080/15368378.2023.2246503","DOIUrl":"https://doi.org/10.1080/15368378.2023.2246503","url":null,"abstract":"<p><p>In this experimental study, adult female NMRI mice were randomly assigned to five groups: control ;(fresh ovarian transplantation, OT); sham ;(vitrified OT); NAC ;(vitrified OT treated with N-acetyl cysteine, NAC); EMF ;(vitrified OT treated with pulsed electromagnetic fields, PEMF); and NAC+EMF ;(vitrified OT combined with NAC and PEMF). We conducted histological assessments to evaluate follicle reservation and vascularization. Furthermore, we examined the relative expression of <i>Fgf-2, Vegf, Tnf-α, Il-6, Il-1</i>, and <i>Cd31</i> genes on days 2 and 7 after OT. Additionally, we measured total antioxidant capacity (TAC), malondialdehyde (MDA) levels, as well as the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). Our results demonstrated that NAC, PEMF, and NAC+PEMF treatments significantly increased the number of follicles. Moreover, we observed a more pronounced development of vascularization in the NAC, PEMF, and PEMF+NAC groups. The relative expression levels of <i>Fgf-2, Vegf, Tnf-α, Il-1β</i>, and <i>Il-6</i> were significantly elevated in the NAC, PEMF, and NAC+PEMF groups. Notably, TAC levels decreased significantly in the NAC group compared to the control group. Additionally, the MDA level showed a significant decrease in the PEMF+NAC group when compared to the other groups. Overall, the combination of NAC and PEMF exhibited a synergistic effect in promoting angiogenesis and protecting against oxidative stress and inflammation during OT.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"67-80"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10066169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice. 脉冲电磁场对老年小鼠行为、免疫功能、氧化和炎症状态的积极影响。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2243994
Estefanía Díaz-Del Cerro, Mónica De la Fuente
{"title":"Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice.","authors":"Estefanía Díaz-Del Cerro,&nbsp;Mónica De la Fuente","doi":"10.1080/15368378.2023.2243994","DOIUrl":"https://doi.org/10.1080/15368378.2023.2243994","url":null,"abstract":"<p><p>The establishment of chronic oxidative and inflammatory stress with aging leads to the deterioration of the nervous and immune systems and, consequently, to the loss of health. The aim of this work was to study the effect of exposure to low-frequency pulsed electromagnetic fields (PEMFs) produced by the NEURALTER® system (15 min/day for 4 weeks) in the behavior, immune functions, and oxidative and inflammatory state of old mice. Female old CD1 mice were divided into three groups: control group, handling control group and Neuralter group. Then, behavioral tests were performed, and peritoneal leukocytes were extracted to analyze function, oxidative and inflammatory parameters. In peritoneal leukocytes from old mice, the effects <i>in vitro</i> of 15 min with NEURALTER® were studied on function and oxidative parameters. The results show that after this type of treatment, old mice had greater coordination and locomotion, better immune function, and an oxidative-inflammatory state. Similarly, the immune function and oxidative state of leukocytes showed an improvement when these cells were exposed directly to the NEURALTER® system. In conclusion, the exposure to low-frequency PEMFs produced by the NEURALTER® system has beneficial effects on health in aging. In addition, this effect is direct, at least in part, on immune cells.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"51-66"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative proteomics reveals effects of environmental radiofrequency electromagnetic fields on embryonic neural stem cells. 定量蛋白质组学揭示了环境射频电磁场对胚胎神经干细胞的影响。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2243980
Guangzhou An, Yuntao Jing, Tao Zhao, Wei Zhang, Ling Guo, Juan Guo, Xia Miao, Junling Xing, Jing Li, Junye Liu, Guirong Ding
{"title":"Quantitative proteomics reveals effects of environmental radiofrequency electromagnetic fields on embryonic neural stem cells.","authors":"Guangzhou An,&nbsp;Yuntao Jing,&nbsp;Tao Zhao,&nbsp;Wei Zhang,&nbsp;Ling Guo,&nbsp;Juan Guo,&nbsp;Xia Miao,&nbsp;Junling Xing,&nbsp;Jing Li,&nbsp;Junye Liu,&nbsp;Guirong Ding","doi":"10.1080/15368378.2023.2243980","DOIUrl":"https://doi.org/10.1080/15368378.2023.2243980","url":null,"abstract":"<p><p>The effects of environmental radiofrequency electromagnetic fields (RF-EMF) on embryonic neural stem cells have not been determined, particularly at the proteomic level. This study aims to elucidate the effects of environmental levels of RF-EMF radiation on embryonic neural stem cells. Neuroectodermal stem cells (NE-4C cells) were randomly divided into a sham group and an RF group, which were sham-exposed and continuously exposed to a 1950 MHz RF-EMF at 2 W/kg for 48 h. After exposure, cell proliferation was determined by a Cell Counting Kit-8 (CCK8) assay, the cell cycle distribution and apoptosis were measured by flow cytometry, protein abundance was detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and mRNA expression was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). We did not detect differences in cell proliferation, cell cycle distribution, and apoptosis between the two groups. However, we detected differences in the abundance of 23 proteins between the two groups, and some of these differences were consistent with alterations in transcript levels determined by qRT-PCR (<i>P</i> < 0.05). A bioinformatics analysis indicated that the differentially regulated proteins were mainly enriched in 'localization' in the cellular process category; however, no significant pathway alterations in NE-4C cells were detected. We conclude that under the experimental conditions, low-level RF-EMF exposure was not neurotoxic but could induce minor changes in the abundance of some proteins involved in neurodevelopment or brain function.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"41-50"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse effects of 900, 1800 and 2100 MHz radiofrequency radiation emitted from mobile phones on bone and skeletal muscle. 移动电话发出的900、1800及2100兆赫射频辐射对骨骼及骨骼肌的不利影响。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2179065
Hava Bektas, Asrin Nalbant, Mahmut Berat Akdag, Canan Demir, Servet Kavak, Suleyman Dasdag
{"title":"Adverse effects of 900, 1800 and 2100 MHz radiofrequency radiation emitted from mobile phones on bone and skeletal muscle.","authors":"Hava Bektas,&nbsp;Asrin Nalbant,&nbsp;Mahmut Berat Akdag,&nbsp;Canan Demir,&nbsp;Servet Kavak,&nbsp;Suleyman Dasdag","doi":"10.1080/15368378.2023.2179065","DOIUrl":"https://doi.org/10.1080/15368378.2023.2179065","url":null,"abstract":"<p><p>The goal of this study was to biomechanically and morphologically research both the impact of mobile phone like radiofrequency radiations (RFR) on the tibia and the effects on skeletal muscle through oxidative stress parameters. Fifty-six rats (200-250 g) were put into groups: healthy sham (n = 7), healthy RFR (900, 1800, 2100 MHz) (n = 21), diabetic sham (n = 7) and diabetic RFR (900, 1800, 2100 MHz) (n = 21). Over a month, each group spent two hours/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, the right tibia bones and skeletal muscle tissue were removed. The three-point bending test and radiological evaluations were performed on the bones, and CAT, GSH, MDA, and IMA in muscles were measured. There were differences in biomechanics properties and radiological evaluations between the groups (p < .05). In the measurements in the muscle tissues, significant differences were statistically found (p < .05). The average whole-body SAR values for GSM 900, 1800 and 2100 MHz were 0.026, 0.164, and 0.173 W/kg. RFRs emitted from mobile phone may cause adverse effects on tibia and skeletal muscle health, though further studies are needed.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"12-20"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9246387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers. 毫米波对健康志愿者痛觉减退和副交感神经的影响。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2022.2162919
Laure Minier, Jean-Claude Debouzy, Michaël Foerster, Virginie Pierre, Caroline Maindet, David Crouzier
{"title":"Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers.","authors":"Laure Minier,&nbsp;Jean-Claude Debouzy,&nbsp;Michaël Foerster,&nbsp;Virginie Pierre,&nbsp;Caroline Maindet,&nbsp;David Crouzier","doi":"10.1080/15368378.2022.2162919","DOIUrl":"https://doi.org/10.1080/15368378.2022.2162919","url":null,"abstract":"<p><p>In humans, exposure to electromagnetic millimeter waves (MMW) has a hypoalgesic effect. In animals, this effect has been shown to depend on innervation density of the area exposed. This study aims to assess hypoalgesic and parasympathetic effects of MMW applied on the palmar side of the wrist in healthy participants. In a within-subject design, 10 healthy participants had the palmar side of their wrist exposed to MMW (61.25 GHz, 17 mW/cm<sup>2</sup>) for 30 minutes, 1 h, & 1 h30, and 30 minutes of sham exposure. Experimental pain was induced after the exposure sessions with the Cold Pressor Test, and pain threshold and pain tolerance values were compared to that of the sham condition. Participants' heart rate and blood pressure were measured before and after exposures. Finally, innocuity of the exposure system was controlled with a pre-post exposure visual examination scale and skin temperature measured by a thermal camera. Exposure to 30 minutes, but not 1 h or 1 h30, of MMW led to significant increases in pain thresholds compared to the sham condition, but no increase of pain tolerance. All conditions led to decreased heart rate, while no change in blood pressure was observed. No change in skin state or temperature was observed for any of the conditions. MMW applied on the inner part of the wrist diminish pain sensations more effectively than placebo, and seem to increase parasympathetic activities, while remaining innocuous. Building a miniaturized MMW emission system to be worn on the wrist would provide access to ambulatory MMW therapy for pain management.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"3-11"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multi-criterion optimization of invasive antenna applicators for Au@Fe3O4, Au@-Fe2O3 and Au@-Fe2O3 mediated microwave ablation treatment. Au@Fe3O4, Au@-Fe2O3和Au@-Fe2O3介导的微波消融治疗中有创天线应用器的多准则优化。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2184381
Alka Singla, Anupma Marwaha, Sanjay Marwaha
{"title":"Multi-criterion optimization of invasive antenna applicators for Au@Fe<sub>3</sub>O4, Au@-Fe<sub>2</sub>O<sub>3</sub> and Au@-Fe<sub>2</sub>O<sub>3</sub> mediated microwave ablation treatment.","authors":"Alka Singla,&nbsp;Anupma Marwaha,&nbsp;Sanjay Marwaha","doi":"10.1080/15368378.2023.2184381","DOIUrl":"https://doi.org/10.1080/15368378.2023.2184381","url":null,"abstract":"<p><p>Magnetic nanoparticle (MNP) mediated microwave ablation has the great potential at present to address challenges associated with treatment planning such as maximum heat generation in the vicinity of targeted tissues in lesser penetration time. Further, the antenna applicators injected in human phantom must be rigid and thin. The derivative-free optimization algorithms are carried out for optimum design of monopole, slot, dipole, and tapered slot antenna applicators for ablation of tumour tissues invasively. It is found that in terms of input impedance matching, the used multi-criterion Nelder-Mead optimization performs efficiently for tapered slot applicator achieving <i>S</i><sub>11</sub> value of -40 dB with much reduced antenna dimensions. In order to further escalate the performance of tapered slot antenna, gold (Au)-coated iron-based MNPs are suggested for tumor infusion. Spherical gold-coated shell material is preferrable for more sphericity of ablation zone, biocompatibility and due to high conductivity, heat generated in MNPs can be transferred to biological tissues more rapidly. The size, type, and shape of MNPs also influence the heat generation in tumor tissues. Thus, three different types of MNPs having high magnetization properties, Au@Fe<sub>3</sub>O<sub>4</sub>, Au@<math><mi>α</mi></math>-Fe<sub>2</sub>O<sub>3</sub> and Au@<math><mi>γ</mi></math>-Fe<sub>2</sub>O<sub>3</sub> have been employed to study the performance in terms of maximum rise in temperature, specific absorption rate (SAR), and area of ablation zone by varying core size radius of MNPs. Results demonstrate that increase in radius of MNP core helps in increasing the temperature distribution and reduction in ablation zone. The optimized lesion is achieved for 20 nm core radius of Au@Fe<sub>3</sub>O4.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"21-40"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9245782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Memorium. 在记忆中。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2180090
Joseph R Salvatore, Henry Lai
{"title":"In Memorium.","authors":"Joseph R Salvatore,&nbsp;Henry Lai","doi":"10.1080/15368378.2023.2180090","DOIUrl":"https://doi.org/10.1080/15368378.2023.2180090","url":null,"abstract":"","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10364811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated irreversible electroporated region prediction using deep neural network, a preliminary study for treatment planning. 基于深度神经网络的不可逆电穿孔区自动预测,为治疗方案的初步研究。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-08-22 DOI: 10.1080/15368378.2022.2114493
Amir Khorasani
{"title":"Automated irreversible electroporated region prediction using deep neural network, a preliminary study for treatment planning.","authors":"Amir Khorasani","doi":"10.1080/15368378.2022.2114493","DOIUrl":"https://doi.org/10.1080/15368378.2022.2114493","url":null,"abstract":"<p><p>The primary purpose of cancer treatment with irreversible electroporation (IRE) is to maximize tumor damage and minimize surrounding healthy tissue damage. Finite element analysis is one of the popular ways to calculate electric field and cell kill probability in IRE. However, this method also has limitations. This paper will focus on using a deep neural network (DNN) in IRE to predict irreversible electroporated regions for treatment planning purposes. COMSOL Multiphysics was used to simulate the IRE. The electric conductivity change during IRE was considered to create accurate data sets of electric field distribution and cell kill probability distributions. We used eight pulses with a pulse width of 100 μs, frequency of 1 Hz, and different voltages. To create masks for DNN training, a 90% cell kill probability contour was used. After data set creation, U-Net architecture was trained to predict irreversible electroporated regions. In this study, the average U-Net DICE coefficient on test data was 0.96. Also, the average accuracy of U-Net for predicting irreversible electroporated regions was 0.97. As far as we are aware, this is the first time that U-Net was used to predict an irreversible electroporated region in IRE. The present study provides significant evidence for U-Net's use for predicting an irreversible electroporated region in treatment planning.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"379-388"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile phone induced EMF stress is reversed upon the use of protective devices: results from two experiments testing different boundary conditions. 在使用保护装置后,手机引起的EMF应力被逆转:来自测试不同边界条件的两个实验的结果。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-10-03 DOI: 10.1080/15368378.2022.2129380
Rainer Schneider
{"title":"Mobile phone induced EMF stress is reversed upon the use of protective devices: results from two experiments testing different boundary conditions.","authors":"Rainer Schneider","doi":"10.1080/15368378.2022.2129380","DOIUrl":"https://doi.org/10.1080/15368378.2022.2129380","url":null,"abstract":"<p><p>This work examines (a) the impact of electromagnetic fields (EMF) on heart rate variability (HRV), saliva cortisol, arterial blood oxygenation, and tympanic temperature, and (b) the potential effect of protective devices developed to counter EMF-induced stress. In a pilot study, recordings were taken during a 15-min mobile phone call emitting a high burden of EMF (electric, magnetic, high frequency) after a baseline measurement at rest with very low EMF. In a second visit, this was repeated with participants using three protective devices (insoles, pendant, mobile phone chip). In the main study, four experimental arms were employed, two of which replicated the experimental setup of the pilot study, and two of which examined the effect of only one mobile phone chip in an open-hidden-paradigm. In both experiments, exposure to EMF decreased HRV and increased salivary cortisol. In the protective experimental condition, HRV increased above and cortisol decreased below the level of the baseline measures. All differences were large and specific and not modulated by non-specific effects like placebo effects.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"429-438"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice. 旋转振荡磁场无创刺激小鼠全身的方法及其安全性。
IF 1.7 4区 生物学
Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-09-26 DOI: 10.1080/15368378.2022.2127108
Shashank Hambarde, Lisa Nguyen, Jeanne Manalo, Blessy John, David S Baskin, Santosh A Helekar
{"title":"Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice.","authors":"Shashank Hambarde,&nbsp;Lisa Nguyen,&nbsp;Jeanne Manalo,&nbsp;Blessy John,&nbsp;David S Baskin,&nbsp;Santosh A Helekar","doi":"10.1080/15368378.2022.2127108","DOIUrl":"https://doi.org/10.1080/15368378.2022.2127108","url":null,"abstract":"<p><p>We recently reported shrinkage of untreatable recurrent glioblastoma (GBM) in an end-stage patient using noninvasive brain stimulation with a spinning oscillating magnetic field (sOMF)-generating device called the Oncomagnetic device. Our <i>in vitro</i> experiments demonstrated selective cancer cell death while sparing normal cells by sOMF-induced increase in intracellular reactive oxygen species (ROS) levels due to magnetic perturbation of mitochondrial electron transport. Here, we describe the results of an <i>in vivo</i> study assessing the toxicity of chronic sOMF stimulation in mice using a newly constructed apparatus comprised of the sOMF-generating active components of the Oncomagnetic device. We chronically stimulated 10 normal 60-day old female C57BL/6 mice in their housing cages for 2 h 3 times a day, as in the patient treatment protocol, over 4 months. We also studied the effects of 2-h acute sOMF stimulation. Our observations and those of blinded independent veterinary staff observers, indicated no significant adverse effects of chronic or acute sOMF stimulation on the health, behavior, electrocardiographic and electroencephalographic activities, hematologic profile, and brain and other tissue and organ morphology of treated mice compared to age-matched untreated control mice. These findings suggest that short- and long-term therapies with the Oncomagnetic device are safe and well tolerated.</p>","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"41 4","pages":"419-428"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33481172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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