Electromagnetic Biology and Medicine最新文献_第9页

Enhancing the antibacterial effect of iron oxide and silver nanoparticles by extremely low frequency electric fields (ELF-EF) against S. aureus. 通过极低频电场（ELF-EF）增强氧化铁和银纳米颗粒对金黄色葡萄球菌的抗菌作用。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-07-03 Epub Date: 2023-05-08 DOI: 10.1080/15368378.2023.2208610

Ebtesam A Mohamad, Marwa A Ramadan, Marwa M Mostafa, Mona S Elneklawi

{"title":"Enhancing the antibacterial effect of iron oxide and silver nanoparticles by extremely low frequency electric fields (ELF-EF) against S. aureus.","authors":"Ebtesam A Mohamad, Marwa A Ramadan, Marwa M Mostafa, Mona S Elneklawi","doi":"10.1080/15368378.2023.2208610","DOIUrl":"10.1080/15368378.2023.2208610","url":null,"abstract":"Staphylococcus aureus is the cause of many infectious and inflammatory diseases and a lot of studies aim to discover alternative ways for infection control and treatment rather than antibiotics. This work attempts to reduce bacterial activity and growth characteristics of Staphylococcus aureus using nanoparticles (iron oxide nanoparticles and silver nanoparticles) and extremely low frequency electric fields (ELF-EF). Bacterial suspensions of Staphylococcus aureus were used to prepare the samples, which were evenly divided into groups. Control group, 10 groups were exposed to ELF-EF in the frequency range (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 1 Hz), iron oxide NPs treated group, iron oxide NPs exposed to 0.8 Hz treated group, silver NPs treated group and the last group was treated with silver NPs and 0.8 Hz. Antibiotic sensitivity testing, dielectric relaxation, and biofilm development for the living microbe were used to evaluate morphological and molecular alterations. Results showed that combination of nanoparticles with ELF-EF at 0.8 Hz enhanced the bacterial inhibition efficiency, which may be due to structural changes. These were supported by the dielectric measurement results which indicated the differences in the dielectric increment and electrical conductivity for the treated samples compared with control samples. This was also confirmed by biofilm formation measurements obtained. We may conclude that the exposure of Staphylococcus aureus bacteria to ELF-EF and NPs affected its cellular activity and structure. This technique is nondestructive, safe and fast and could be considered as a mean to reduce the use of antibiotics.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"99-113"},"PeriodicalIF":1.7,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Assessing the effect of selenium on cyclin D1 level and nuclear factor kappa b activity in NIH/3T3 fibroblast cells at 2100 MHz electromagnetic field exposure. 评估硒在2100MHz电磁场暴露下对NIH/3T3成纤维细胞中细胞周期蛋白D1水平和核因子κb活性的影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-07-03 Epub Date: 2023-08-28 DOI: 10.1080/15368378.2023.2252457

Dilek Duzgun Ergun, Nural Pastaci Ozsobaci, Tuba Yilmaz, Dervis Ozcelik, Mustafa Tunaya Kalkan

{"title":"Assessing the effect of selenium on cyclin D1 level and nuclear factor kappa b activity in NIH/3T3 fibroblast cells at 2100 MHz electromagnetic field exposure.","authors":"Dilek Duzgun Ergun, Nural Pastaci Ozsobaci, Tuba Yilmaz, Dervis Ozcelik, Mustafa Tunaya Kalkan","doi":"10.1080/15368378.2023.2252457","DOIUrl":"10.1080/15368378.2023.2252457","url":null,"abstract":"Although there are numerous studies on the health impacts of electromagnetic field (EMF) of mobile phone operation frequency 2100 MHz, the published works present contradicting results. Long-term exposure to mobile phone frequencies has unclear health hazards. Therefore, it is important to investigate the molecular mechanism of possible biological effects in mobile phone exposure and to determine the corresponding biological markers. Towards this end, this study was designed to assess the effect of 200 nM selenium (Se) on cell viability% [trypan blue], cell cycle biomarker [cyclin D1] and the transcription factor [nuclear factor kappa b (NF-κB)] in NIH/3T3 fibroblast cells when exposed to 2100 MHz mobile phone frequency. When 2100 MHz EMF was exposed to NIH/3T3 fibroblast cells, the cell viability% was reduced, whereas cyclin D1 level and NF-kB activity increased. Also we show that Se supplementation decreases the effects of 2100 MHz EMF on these parameters. Although future studies will be required to investigate the biological effects of EMF emitted by mobile phones, the results obtained here provide an insight into the molecular mechanisms and specifically underlying selenium's protective effect against 2100 MHz EMF exposure.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"123-132"},"PeriodicalIF":1.7,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10466143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electromagnetic field exposure to human head model with various metal objects at sub-6 GHz frequencies. 在低于6GHz的频率下，暴露于具有各种金属物体的人类头部模型的电磁场。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-07-03 Epub Date: 2023-06-04 DOI: 10.1080/15368378.2023.2220736

Niyazi İl, Kayhan Ateş, Şükrü Özen

{"title":"Electromagnetic field exposure to human head model with various metal objects at sub-6 GHz frequencies.","authors":"Niyazi İl, Kayhan Ateş, Şükrü Özen","doi":"10.1080/15368378.2023.2220736","DOIUrl":"10.1080/15368378.2023.2220736","url":null,"abstract":"In recent years, the interactions of metal objects in human body with electromagnetic fields caused by devices working at fifth-generation (5G) frequencies have been studied by various researchers. A motivation behind this research was to evaluate the human body absorption of electromagnetic energy operating at sub-6 GHz 5G applications. According to this, the specific absorption rate (SAR) caused by new generation mobile phones was investigated in human heads wearing metal-framed spectacles and having metallic implants or earrings to analyse electromagnetic field exposure. A realistic human head model, including some metal objects, was numerically calculated, and analysed in terms of non-ionizing dosimetry. Simulations were carried out with the finite integration technique (FIT) based commercial software in the frequencies of 0.9, 1.8, 2.1, 2.45, 3.5 and 5 GHz, respectively. The maximum SAR of 14 × 10-5 W/kg for 10 g average tissue was calculated at 2.45 GHz frequency in the head model with earrings. The highest electric field strength of 0.52 V/m was observed at a 1.8 GHz frequency in the head model with all metal objects equipped. Results show that metal objects such as spectacles, dental implants and earrings can cause an increase in the SAR values for external biological tissues, and metal objects can behave as a kind of shield for deeper tissues. However, the obtained values are below the limits of international organisations.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":" ","pages":"114-122"},"PeriodicalIF":1.7,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K_Ca1.1 channel expression. 磁场作用可抑制癫痫发作时c-fos表达的增加，但不抑制KCa1.1通道的表达。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2247027

Mehmet Zülkif Akdağ, Emrah Oğraş, Züleyha Doğanyiğit, Enes Akyüz, Mahmut Berat Akdag, Aslı Okan, Veysi Akpolat, I Rem Küllü

{"title":"The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression.","authors":"Mehmet Zülkif Akdağ, Emrah Oğraş, Züleyha Doğanyiğit, Enes Akyüz, Mahmut Berat Akdag, Aslı Okan, Veysi Akpolat, I Rem Küllü","doi":"10.1080/15368378.2023.2247027","DOIUrl":"https://doi.org/10.1080/15368378.2023.2247027","url":null,"abstract":"The aim of this study was to understand the expression of big potassium (BK, KCa1.1) channels in epileptic seizures under magnetic field application. Forty Wistar albino adult male rats were divided into five groups (n = 8). First group rats were control group. Pentylenetetrazole (PTZ) administrated to second group rats to induce the seizures with 35 mg/kg intraperitoneally injection every two days. Levetiracetam (LEV) i.p. at a dose of 108 mg/kg was given to third group rats as positive control group (PC) before 20 minutes PTZ administration. Pulsed magnetic field with 1.5 mT was exposed to the fourth group rats for 3 hours a day for 1 month as magnetic field (MF) group. 1.5 mT pulsed magnetic field was exposed to the fifth group rats for 3 hours a day for 1 month in addition to PTZ administration (PTZ+MF). KCa1.1 not changed in hippocampus of PTZ rats while increased in frontal cortex and pons for PTZ group but not changed with magnetic field exposure. KCa1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the KCa1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"81-97"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue. 脉冲电磁场和n -乙酰半胱氨酸对玻璃化小鼠卵巢组织移植的影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2246503

Khadijeh Rasaeifar, Saeed Zavareh, Maryam Hajighasem-Kashani, Meysam Nasiri

{"title":"Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue.","authors":"Khadijeh Rasaeifar, Saeed Zavareh, Maryam Hajighasem-Kashani, Meysam Nasiri","doi":"10.1080/15368378.2023.2246503","DOIUrl":"https://doi.org/10.1080/15368378.2023.2246503","url":null,"abstract":"In this experimental study, adult female NMRI mice were randomly assigned to five groups: control ;(fresh ovarian transplantation, OT); sham ;(vitrified OT); NAC ;(vitrified OT treated with N-acetyl cysteine, NAC); EMF ;(vitrified OT treated with pulsed electromagnetic fields, PEMF); and NAC+EMF ;(vitrified OT combined with NAC and PEMF). We conducted histological assessments to evaluate follicle reservation and vascularization. Furthermore, we examined the relative expression of Fgf-2, Vegf, Tnf-α, Il-6, Il-1, and Cd31 genes on days 2 and 7 after OT. Additionally, we measured total antioxidant capacity (TAC), malondialdehyde (MDA) levels, as well as the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). Our results demonstrated that NAC, PEMF, and NAC+PEMF treatments significantly increased the number of follicles. Moreover, we observed a more pronounced development of vascularization in the NAC, PEMF, and PEMF+NAC groups. The relative expression levels of Fgf-2, Vegf, Tnf-α, Il-1β, and Il-6 were significantly elevated in the NAC, PEMF, and NAC+PEMF groups. Notably, TAC levels decreased significantly in the NAC group compared to the control group. Additionally, the MDA level showed a significant decrease in the PEMF+NAC group when compared to the other groups. Overall, the combination of NAC and PEMF exhibited a synergistic effect in promoting angiogenesis and protecting against oxidative stress and inflammation during OT.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"67-80"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10066169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice. 脉冲电磁场对老年小鼠行为、免疫功能、氧化和炎症状态的积极影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2243994

Estefanía Díaz-Del Cerro, Mónica De la Fuente

{"title":"Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice.","authors":"Estefanía Díaz-Del Cerro, Mónica De la Fuente","doi":"10.1080/15368378.2023.2243994","DOIUrl":"https://doi.org/10.1080/15368378.2023.2243994","url":null,"abstract":"The establishment of chronic oxidative and inflammatory stress with aging leads to the deterioration of the nervous and immune systems and, consequently, to the loss of health. The aim of this work was to study the effect of exposure to low-frequency pulsed electromagnetic fields (PEMFs) produced by the NEURALTER® system (15 min/day for 4 weeks) in the behavior, immune functions, and oxidative and inflammatory state of old mice. Female old CD1 mice were divided into three groups: control group, handling control group and Neuralter group. Then, behavioral tests were performed, and peritoneal leukocytes were extracted to analyze function, oxidative and inflammatory parameters. In peritoneal leukocytes from old mice, the effects in vitro of 15 min with NEURALTER® were studied on function and oxidative parameters. The results show that after this type of treatment, old mice had greater coordination and locomotion, better immune function, and an oxidative-inflammatory state. Similarly, the immune function and oxidative state of leukocytes showed an improvement when these cells were exposed directly to the NEURALTER® system. In conclusion, the exposure to low-frequency PEMFs produced by the NEURALTER® system has beneficial effects on health in aging. In addition, this effect is direct, at least in part, on immune cells.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"51-66"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative proteomics reveals effects of environmental radiofrequency electromagnetic fields on embryonic neural stem cells. 定量蛋白质组学揭示了环境射频电磁场对胚胎神经干细胞的影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-04-03 DOI: 10.1080/15368378.2023.2243980

Guangzhou An, Yuntao Jing, Tao Zhao, Wei Zhang, Ling Guo, Juan Guo, Xia Miao, Junling Xing, Jing Li, Junye Liu, Guirong Ding

{"title":"Quantitative proteomics reveals effects of environmental radiofrequency electromagnetic fields on embryonic neural stem cells.","authors":"Guangzhou An, Yuntao Jing, Tao Zhao, Wei Zhang, Ling Guo, Juan Guo, Xia Miao, Junling Xing, Jing Li, Junye Liu, Guirong Ding","doi":"10.1080/15368378.2023.2243980","DOIUrl":"https://doi.org/10.1080/15368378.2023.2243980","url":null,"abstract":"The effects of environmental radiofrequency electromagnetic fields (RF-EMF) on embryonic neural stem cells have not been determined, particularly at the proteomic level. This study aims to elucidate the effects of environmental levels of RF-EMF radiation on embryonic neural stem cells. Neuroectodermal stem cells (NE-4C cells) were randomly divided into a sham group and an RF group, which were sham-exposed and continuously exposed to a 1950 MHz RF-EMF at 2 W/kg for 48 h. After exposure, cell proliferation was determined by a Cell Counting Kit-8 (CCK8) assay, the cell cycle distribution and apoptosis were measured by flow cytometry, protein abundance was detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and mRNA expression was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). We did not detect differences in cell proliferation, cell cycle distribution, and apoptosis between the two groups. However, we detected differences in the abundance of 23 proteins between the two groups, and some of these differences were consistent with alterations in transcript levels determined by qRT-PCR (P < 0.05). A bioinformatics analysis indicated that the differentially regulated proteins were mainly enriched in 'localization' in the cellular process category; however, no significant pathway alterations in NE-4C cells were detected. We conclude that under the experimental conditions, low-level RF-EMF exposure was not neurotoxic but could induce minor changes in the abundance of some proteins involved in neurodevelopment or brain function.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 2","pages":"41-50"},"PeriodicalIF":1.7,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse effects of 900, 1800 and 2100 MHz radiofrequency radiation emitted from mobile phones on bone and skeletal muscle. 移动电话发出的900、1800及2100兆赫射频辐射对骨骼及骨骼肌的不利影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2179065

Hava Bektas, Asrin Nalbant, Mahmut Berat Akdag, Canan Demir, Servet Kavak, Suleyman Dasdag

{"title":"Adverse effects of 900, 1800 and 2100 MHz radiofrequency radiation emitted from mobile phones on bone and skeletal muscle.","authors":"Hava Bektas, Asrin Nalbant, Mahmut Berat Akdag, Canan Demir, Servet Kavak, Suleyman Dasdag","doi":"10.1080/15368378.2023.2179065","DOIUrl":"https://doi.org/10.1080/15368378.2023.2179065","url":null,"abstract":"The goal of this study was to biomechanically and morphologically research both the impact of mobile phone like radiofrequency radiations (RFR) on the tibia and the effects on skeletal muscle through oxidative stress parameters. Fifty-six rats (200-250 g) were put into groups: healthy sham (n = 7), healthy RFR (900, 1800, 2100 MHz) (n = 21), diabetic sham (n = 7) and diabetic RFR (900, 1800, 2100 MHz) (n = 21). Over a month, each group spent two hours/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, the right tibia bones and skeletal muscle tissue were removed. The three-point bending test and radiological evaluations were performed on the bones, and CAT, GSH, MDA, and IMA in muscles were measured. There were differences in biomechanics properties and radiological evaluations between the groups (p < .05). In the measurements in the muscle tissues, significant differences were statistically found (p < .05). The average whole-body SAR values for GSM 900, 1800 and 2100 MHz were 0.026, 0.164, and 0.173 W/kg. RFRs emitted from mobile phone may cause adverse effects on tibia and skeletal muscle health, though further studies are needed.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"12-20"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9246387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers. 毫米波对健康志愿者痛觉减退和副交感神经的影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2022.2162919

Laure Minier, Jean-Claude Debouzy, Michaël Foerster, Virginie Pierre, Caroline Maindet, David Crouzier

{"title":"Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers.","authors":"Laure Minier, Jean-Claude Debouzy, Michaël Foerster, Virginie Pierre, Caroline Maindet, David Crouzier","doi":"10.1080/15368378.2022.2162919","DOIUrl":"https://doi.org/10.1080/15368378.2022.2162919","url":null,"abstract":"In humans, exposure to electromagnetic millimeter waves (MMW) has a hypoalgesic effect. In animals, this effect has been shown to depend on innervation density of the area exposed. This study aims to assess hypoalgesic and parasympathetic effects of MMW applied on the palmar side of the wrist in healthy participants. In a within-subject design, 10 healthy participants had the palmar side of their wrist exposed to MMW (61.25 GHz, 17 mW/cm2) for 30 minutes, 1 h, & 1 h30, and 30 minutes of sham exposure. Experimental pain was induced after the exposure sessions with the Cold Pressor Test, and pain threshold and pain tolerance values were compared to that of the sham condition. Participants' heart rate and blood pressure were measured before and after exposures. Finally, innocuity of the exposure system was controlled with a pre-post exposure visual examination scale and skin temperature measured by a thermal camera. Exposure to 30 minutes, but not 1 h or 1 h30, of MMW led to significant increases in pain thresholds compared to the sham condition, but no increase of pain tolerance. All conditions led to decreased heart rate, while no change in blood pressure was observed. No change in skin state or temperature was observed for any of the conditions. MMW applied on the inner part of the wrist diminish pain sensations more effectively than placebo, and seem to increase parasympathetic activities, while remaining innocuous. Building a miniaturized MMW emission system to be worn on the wrist would provide access to ambulatory MMW therapy for pain management.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"3-11"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multi-criterion optimization of invasive antenna applicators for Au@Fe₃O4, Au@-Fe₂O₃ and Au@-Fe₂O₃ mediated microwave ablation treatment. Au@Fe3O4, Au@-Fe2O3和Au@-Fe2O3介导的微波消融治疗中有创天线应用器的多准则优化。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2184381

Alka Singla, Anupma Marwaha, Sanjay Marwaha

{"title":"Multi-criterion optimization of invasive antenna applicators for Au@Fe3O4, Au@-Fe2O3 and Au@-Fe2O3 mediated microwave ablation treatment.","authors":"Alka Singla, Anupma Marwaha, Sanjay Marwaha","doi":"10.1080/15368378.2023.2184381","DOIUrl":"https://doi.org/10.1080/15368378.2023.2184381","url":null,"abstract":"Magnetic nanoparticle (MNP) mediated microwave ablation has the great potential at present to address challenges associated with treatment planning such as maximum heat generation in the vicinity of targeted tissues in lesser penetration time. Further, the antenna applicators injected in human phantom must be rigid and thin. The derivative-free optimization algorithms are carried out for optimum design of monopole, slot, dipole, and tapered slot antenna applicators for ablation of tumour tissues invasively. It is found that in terms of input impedance matching, the used multi-criterion Nelder-Mead optimization performs efficiently for tapered slot applicator achieving S11 value of -40 dB with much reduced antenna dimensions. In order to further escalate the performance of tapered slot antenna, gold (Au)-coated iron-based MNPs are suggested for tumor infusion. Spherical gold-coated shell material is preferrable for more sphericity of ablation zone, biocompatibility and due to high conductivity, heat generated in MNPs can be transferred to biological tissues more rapidly. The size, type, and shape of MNPs also influence the heat generation in tumor tissues. Thus, three different types of MNPs having high magnetization properties, Au@Fe3O4, Au@<math><mi>α</mi></math>-Fe2O3 and Au@<math><mi>γ</mi></math>-Fe2O3 have been employed to study the performance in terms of maximum rise in temperature, specific absorption rate (SAR), and area of ablation zone by varying core size radius of MNPs. Results demonstrate that increase in radius of MNP core helps in increasing the temperature distribution and reduction in ablation zone. The optimized lesion is achieved for 20 nm core radius of Au@Fe3O4.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"21-40"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9245782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0