Electromagnetic Biology and Medicine最新文献_第6页

Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers. 毫米波对健康志愿者痛觉减退和副交感神经的影响。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2022.2162919

Laure Minier, Jean-Claude Debouzy, Michaël Foerster, Virginie Pierre, Caroline Maindet, David Crouzier

{"title":"Hypoalgesia and parasympathetic effects of millimeter waves on experimentally induced pain in healthy volunteers.","authors":"Laure Minier, Jean-Claude Debouzy, Michaël Foerster, Virginie Pierre, Caroline Maindet, David Crouzier","doi":"10.1080/15368378.2022.2162919","DOIUrl":"https://doi.org/10.1080/15368378.2022.2162919","url":null,"abstract":"In humans, exposure to electromagnetic millimeter waves (MMW) has a hypoalgesic effect. In animals, this effect has been shown to depend on innervation density of the area exposed. This study aims to assess hypoalgesic and parasympathetic effects of MMW applied on the palmar side of the wrist in healthy participants. In a within-subject design, 10 healthy participants had the palmar side of their wrist exposed to MMW (61.25 GHz, 17 mW/cm2) for 30 minutes, 1 h, & 1 h30, and 30 minutes of sham exposure. Experimental pain was induced after the exposure sessions with the Cold Pressor Test, and pain threshold and pain tolerance values were compared to that of the sham condition. Participants' heart rate and blood pressure were measured before and after exposures. Finally, innocuity of the exposure system was controlled with a pre-post exposure visual examination scale and skin temperature measured by a thermal camera. Exposure to 30 minutes, but not 1 h or 1 h30, of MMW led to significant increases in pain thresholds compared to the sham condition, but no increase of pain tolerance. All conditions led to decreased heart rate, while no change in blood pressure was observed. No change in skin state or temperature was observed for any of the conditions. MMW applied on the inner part of the wrist diminish pain sensations more effectively than placebo, and seem to increase parasympathetic activities, while remaining innocuous. Building a miniaturized MMW emission system to be worn on the wrist would provide access to ambulatory MMW therapy for pain management.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"3-11"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multi-criterion optimization of invasive antenna applicators for Au@Fe₃O4, Au@-Fe₂O₃ and Au@-Fe₂O₃ mediated microwave ablation treatment. Au@Fe3O4, Au@-Fe2O3和Au@-Fe2O3介导的微波消融治疗中有创天线应用器的多准则优化。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2184381

Alka Singla, Anupma Marwaha, Sanjay Marwaha

{"title":"Multi-criterion optimization of invasive antenna applicators for Au@Fe3O4, Au@-Fe2O3 and Au@-Fe2O3 mediated microwave ablation treatment.","authors":"Alka Singla, Anupma Marwaha, Sanjay Marwaha","doi":"10.1080/15368378.2023.2184381","DOIUrl":"https://doi.org/10.1080/15368378.2023.2184381","url":null,"abstract":"Magnetic nanoparticle (MNP) mediated microwave ablation has the great potential at present to address challenges associated with treatment planning such as maximum heat generation in the vicinity of targeted tissues in lesser penetration time. Further, the antenna applicators injected in human phantom must be rigid and thin. The derivative-free optimization algorithms are carried out for optimum design of monopole, slot, dipole, and tapered slot antenna applicators for ablation of tumour tissues invasively. It is found that in terms of input impedance matching, the used multi-criterion Nelder-Mead optimization performs efficiently for tapered slot applicator achieving S11 value of -40 dB with much reduced antenna dimensions. In order to further escalate the performance of tapered slot antenna, gold (Au)-coated iron-based MNPs are suggested for tumor infusion. Spherical gold-coated shell material is preferrable for more sphericity of ablation zone, biocompatibility and due to high conductivity, heat generated in MNPs can be transferred to biological tissues more rapidly. The size, type, and shape of MNPs also influence the heat generation in tumor tissues. Thus, three different types of MNPs having high magnetization properties, Au@Fe3O4, Au@<math><mi>α</mi></math>-Fe2O3 and Au@<math><mi>γ</mi></math>-Fe2O3 have been employed to study the performance in terms of maximum rise in temperature, specific absorption rate (SAR), and area of ablation zone by varying core size radius of MNPs. Results demonstrate that increase in radius of MNP core helps in increasing the temperature distribution and reduction in ablation zone. The optimized lesion is achieved for 20 nm core radius of Au@Fe3O4.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"42 1","pages":"21-40"},"PeriodicalIF":1.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9245782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Memorium. 在记忆中。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2023-01-02 DOI: 10.1080/15368378.2023.2180090

Joseph R Salvatore, Henry Lai

引用次数: 0

Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice. 旋转振荡磁场无创刺激小鼠全身的方法及其安全性。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-09-26 DOI: 10.1080/15368378.2022.2127108

Shashank Hambarde, Lisa Nguyen, Jeanne Manalo, Blessy John, David S Baskin, Santosh A Helekar

{"title":"Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice.","authors":"Shashank Hambarde, Lisa Nguyen, Jeanne Manalo, Blessy John, David S Baskin, Santosh A Helekar","doi":"10.1080/15368378.2022.2127108","DOIUrl":"https://doi.org/10.1080/15368378.2022.2127108","url":null,"abstract":"We recently reported shrinkage of untreatable recurrent glioblastoma (GBM) in an end-stage patient using noninvasive brain stimulation with a spinning oscillating magnetic field (sOMF)-generating device called the Oncomagnetic device. Our in vitro experiments demonstrated selective cancer cell death while sparing normal cells by sOMF-induced increase in intracellular reactive oxygen species (ROS) levels due to magnetic perturbation of mitochondrial electron transport. Here, we describe the results of an in vivo study assessing the toxicity of chronic sOMF stimulation in mice using a newly constructed apparatus comprised of the sOMF-generating active components of the Oncomagnetic device. We chronically stimulated 10 normal 60-day old female C57BL/6 mice in their housing cages for 2 h 3 times a day, as in the patient treatment protocol, over 4 months. We also studied the effects of 2-h acute sOMF stimulation. Our observations and those of blinded independent veterinary staff observers, indicated no significant adverse effects of chronic or acute sOMF stimulation on the health, behavior, electrocardiographic and electroencephalographic activities, hematologic profile, and brain and other tissue and organ morphology of treated mice compared to age-matched untreated control mice. These findings suggest that short- and long-term therapies with the Oncomagnetic device are safe and well tolerated.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"41 4","pages":"419-428"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33481172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pain reduction in validated rat pain models: radio frequency spectrum targeted at the low and ultra-low ends using the emulate® delivery system. 在经过验证的大鼠疼痛模型中减少疼痛:使用仿真®传递系统针对低和超低端的射频频谱。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-10-14 DOI: 10.1080/15368378.2022.2131568

Xavier A Figueroa, Lucas Lacambra, B Michael Butters

引用次数: 0

Environment-dependent fluctuations of potentiometric pH dynamics in geomagnetic field. 地磁场中pH电位动力学的环境依赖性波动。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-10-06 DOI: 10.1080/15368378.2022.2125527

S Kernbach, O Kernbach

{"title":"Environment-dependent fluctuations of potentiometric pH dynamics in geomagnetic field.","authors":"S Kernbach, O Kernbach","doi":"10.1080/15368378.2022.2125527","DOIUrl":"https://doi.org/10.1080/15368378.2022.2125527","url":null,"abstract":"This work explores fluctuations of potentiometric pH dynamics in environments with different configurations of geomagnetic fields. High-resolution pH measurements of test liquids are conducted in electromagnetically shielded and thermally stabilized conditions. External measurement environment in two laboratories is modulated by non-conducting/non-magnetic objects of organic and inorganic origins. Totally, 88 experiments in three groups have been conducted during 4 months. The affected pH dynamics at the level of 10-2-10-5 pH is detected in 93.5%, 82.2% and 74.4% depending on dielectric permittivity of environmental objects. Reaction of potentiometric system has a typical delay of 30-180 minutes. Experiments in both laboratories demonstrated 19% difference of reproducibility rate caused by different background fluctuations. To explain the obtained results, the paper discusses the effects of the Earth's electric and magnetic fields in the form of magnetospheric Poynting vectors or spin-spin forces in geomagnetic field, which affects the productivity of ionic and free-radical reactions. Since the pH level of aqueous solutions controls various biochemical reactions, this mechanism can explain several biological effects with non-contact signal transmission observed in environmental biology and electromagnetic biophysics.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"41 4","pages":"409-418"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to elf magnetic fields. 电磁场作用下大鼠糖尿病形成中胎儿素a通路的研究。

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-10-02 Epub Date: 2022-09-08 DOI: 10.1080/15368378.2022.2117189

Cemil Sert, Murat Delin, Mehmet Ali Eren, Yusuf Çakmak

{"title":"Investigation of Fetuin-A pathway in diabetes mellitus formation in rats exposed to elf magnetic fields.","authors":"Cemil Sert, Murat Delin, Mehmet Ali Eren, Yusuf Çakmak","doi":"10.1080/15368378.2022.2117189","DOIUrl":"https://doi.org/10.1080/15368378.2022.2117189","url":null,"abstract":"The presence of technological devices in our lives has increased exposure to environmental electromagnetic fields. As a result of this, especially Cancer and Diabetes are increasing.Rats were divided into 3 groups with 12 rats in each group. The 1st experimental group (n = 12) was exposed to a 50 Hz ELF magnetic field of 0.4 mT for 6 hours a day for 5 days, the 2nd experimental group (n = 12) was exposed for 10 days, and the control group (n = 12) was never exposed to a magnetic field. After completing the applications, blood collection from the rats was performed under appropriate conditions, measurements were made in the laboratory, and statistical analysis was performed between the groups. There was no significant difference between the groups in the results of transaminases and lipid profiles and C-Peptide. There was no significant difference in insulin, urea, creatinine, Na, K, Ca, and uric acid parameters between the groups. However, there was a significant increase in glucose, HbA1c, and Hba1 IFCC values between the control group and the experimental groups (p < .001). There was a significant increase in the level of Fetuin-A between the control group and the experimental groups (p < .05). There was an increase in the Fetuin-A, Glucose, HbA1c, and Hba1c IFCC values in both of the experimental groups compared to the control group. We believe that an increase in these values may cause Type 3 diabetes.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"41 4","pages":"402-408"},"PeriodicalIF":1.7,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimulation of human bone marrow mesenchymal stem cells by electromagnetic transduction therapy - EMTT 电磁转导疗法对人骨髓间充质干细胞的刺激

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-06-07 DOI: 10.1080/15368378.2022.2079672

L. Gerdesmeyer, Paula Zielhardt, T. Klüter, Fanlu Wang, H. Gollwitzer, L. Gerdesmeyer, J. Hausdorf, M. Ringeisen, Karsten Knobloch, A. Saxena, S. Fuchs, André Krath

{"title":"Stimulation of human bone marrow mesenchymal stem cells by electromagnetic transduction therapy - EMTT","authors":"L. Gerdesmeyer, Paula Zielhardt, T. Klüter, Fanlu Wang, H. Gollwitzer, L. Gerdesmeyer, J. Hausdorf, M. Ringeisen, Karsten Knobloch, A. Saxena, S. Fuchs, André Krath","doi":"10.1080/15368378.2022.2079672","DOIUrl":"https://doi.org/10.1080/15368378.2022.2079672","url":null,"abstract":"ABSTRACT Many different pulsed electromagnetic field (PEMF) devises have been clinically used to stimulate healing processes, but many procedures are still without supporting basic research data. The aim of this study was to investigate a new modified pulsed electromagnetic field therapy: electromagnetic transduction therapy (EMTT). EMTT is technically based on high-intensive PEMFs with a magnetic field strength between 80 and 150 mT. The effect of EMTT for a 10-min session three times a week on human bone marrow mesenchymal stem cells (MSCs) was evaluated by assessing cell viability, gene expression of bone regenerative factors and VEGF-A (vascular endothelial growth factor) secretion after 7 and 14 days of treatment. No negative or toxic effects of EMTT on MSCs in vitro were observed in the applied test frame. The VEGF-ELISA at day 7 of EMTT treatment with 80 mT showed a significant higher VEGF concentration compared to untreated control group. In conclusion, high-intensive electromagnetic impulses showed no harmful effects on MSC cultures in our study. The enhancement of the proangiogenic factor VEGF in MSCs on day 7 indicates a substantial role in cell-stimulating effect of EMTT. Further in vitro and in vivo studies should differentiate specific stimulating and regenerating effects of EMTT impulses in soft tissue engineering. Specific electromagnetic characteristics have to be determined to optimize electromagnetic treatment options in orthopedic surgery and traumatology and soft tissue treatment options.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"9 1","pages":"304 - 314"},"PeriodicalIF":1.7,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78225718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of pre and postnatal 2450 MHz continuous wave (CW) radiofrequency radiation on thymus: Four generation exposure 产前和产后2450mhz连续波(CW)射频辐射对胸腺的影响:四代暴露

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-05-30 DOI: 10.1080/15368378.2022.2079673

Fazile Cantürk Tan, B. Yalçın, A. Yay, B. Tan, K. Yeğin, S. Dasdag

{"title":"Effects of pre and postnatal 2450 MHz continuous wave (CW) radiofrequency radiation on thymus: Four generation exposure","authors":"Fazile Cantürk Tan, B. Yalçın, A. Yay, B. Tan, K. Yeğin, S. Dasdag","doi":"10.1080/15368378.2022.2079673","DOIUrl":"https://doi.org/10.1080/15368378.2022.2079673","url":null,"abstract":"ABSTRACT This study aims to investigate the effects of pre- and postnatal 2450 MHz continuous wave (CW) radiofrequency radiation (RFR) on the thymus of rats spanning four generations. Four groups; sham, irradiated female, irradiated male, irradiated male and female, each consisting of four rats (one male and three females), were created. During the experiment, rats in the exposure groups were whole-body exposed to 2450 MHz CW-RFR for 12 h/day. Irradiation started one month before the fertilization in the experimental group. When the offspring were two months old, four rats, one male and three female, were allocated for the second-generation study. The remaining offspring were sacrificed under general anesthesia, and their thymuses were removed. The same procedure was applied to the next generation. Two months after the second generation gave birth, third-generation rats were decapitated, and their thymuses were removed. In all groups, cortex, medulla and resident cells could be clearly distinguished in the second and third generations. No differences were observed between the control and two experimental groups, defined as irradiated female and irradiated male. In contrast, vascularization was observed in the thymus of the fourth-generation offspring of the group where both males and females were irradiated. The number of offspring and mass of all rats decreased in the third-generation group. Pre-and postnatal 2450 MHz continuous wave radiofrequency radiation exposure may potentially affect the thymus of future generations.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"21 1","pages":"315 - 324"},"PeriodicalIF":1.7,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86638051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Magnetic fields and apoptosis: a possible mechanism 磁场与细胞凋亡:一个可能的机制

IF 1.7 4区生物学

Electromagnetic Biology and Medicine Pub Date : 2022-05-11 DOI: 10.1080/15368378.2022.2073547

S. Tofani

{"title":"Magnetic fields and apoptosis: a possible mechanism","authors":"S. Tofani","doi":"10.1080/15368378.2022.2073547","DOIUrl":"https://doi.org/10.1080/15368378.2022.2073547","url":null,"abstract":"ABSTRACT The potential therapeutic uses of electromagnetic fields (EMF), part of the nonionizing radiation spectrum, increase with time. Among them, those considering the potential antitumor effects exerted by the Magnetic Fields (MFs), part of the EMF entity, have gained more and more interest. A recent review on this subject reports the MFs’ effect on apoptosis of tumor cells as one of the most important breakthroughs. Apoptosis is considered a key mechanism regulating the genetic stability of cells and as such is considered of fundamental importance in cancer initiation and development. According to an atomic/sub-atomic analysis, based on quantum physics, of the complexity of biological life and the role played by oxygen and its radicals in cancer biology, a possible biophysical mechanism is described. The mechanism considers the influence of MFs on apoptosis through an effect on electron spin that is able to increase reactive oxygen species (ROS) concentration. Impacting on the delicate balance between ROS production and ROS elimination in tumor cells is considered a promising cancer therapy, affecting different biological processes, such as apoptosis and metastasis. An analysis in the literature, which allows correlation between MFs exposure characteristics and their influence on apoptosis and ROS concentration, supports the validity of the mechanism.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":"6 2 1","pages":"293 - 303"},"PeriodicalIF":1.7,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85115771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10