{"title":"带有滑动宽带扼流圈的腔内单极的多频操作,用于提供可变覆盖范围的热疗。","authors":"Shabeeb Ahamed Kp,Kavitha Arunachalam","doi":"10.1080/15368378.2024.2389068","DOIUrl":null,"url":null,"abstract":"Microwave applicators reported for intracavitary hyperthermia (HT) operate at single frequency and deliver fixed treatment coverage at the tumor target. In this work, we report multifrequency operation of a water-cooled monopole antenna with a sliding broadband ferrite choke for delivering intracavitary HT to the cervix with variable spatial coverage. Spatially varying treatment coverage is achieved by varying the choke position with respect to the monopole using a mechanical sliding arrangement and exciting the antenna at the modified resonant frequency. Multifrequency operation of the antenna prototype is demonstrated over 700-1000 MHz using a straight intrauterine cervix applicator. Numerical simulations confirm the ability to deliver targeted HT with axial extent varying between 35.4 and 62.0 mm by controlling the sliding choke and coupling water temperature. Applicator prototype measurements in tissue mimicking phantoms confirm multifrequency operation of the antenna and its ability to induce axially varying intracavitary HT coverage to match the tumor size using a single applicator.","PeriodicalId":50544,"journal":{"name":"Electromagnetic Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifrequency operation of an intracavitary monopole with sliding broadband choke for delivering hyperthermia treatment with variable coverage.\",\"authors\":\"Shabeeb Ahamed Kp,Kavitha Arunachalam\",\"doi\":\"10.1080/15368378.2024.2389068\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Microwave applicators reported for intracavitary hyperthermia (HT) operate at single frequency and deliver fixed treatment coverage at the tumor target. In this work, we report multifrequency operation of a water-cooled monopole antenna with a sliding broadband ferrite choke for delivering intracavitary HT to the cervix with variable spatial coverage. Spatially varying treatment coverage is achieved by varying the choke position with respect to the monopole using a mechanical sliding arrangement and exciting the antenna at the modified resonant frequency. Multifrequency operation of the antenna prototype is demonstrated over 700-1000 MHz using a straight intrauterine cervix applicator. Numerical simulations confirm the ability to deliver targeted HT with axial extent varying between 35.4 and 62.0 mm by controlling the sliding choke and coupling water temperature. Applicator prototype measurements in tissue mimicking phantoms confirm multifrequency operation of the antenna and its ability to induce axially varying intracavitary HT coverage to match the tumor size using a single applicator.\",\"PeriodicalId\":50544,\"journal\":{\"name\":\"Electromagnetic Biology and Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Electromagnetic Biology and Medicine\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/15368378.2024.2389068\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electromagnetic Biology and Medicine","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/15368378.2024.2389068","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
Multifrequency operation of an intracavitary monopole with sliding broadband choke for delivering hyperthermia treatment with variable coverage.
Microwave applicators reported for intracavitary hyperthermia (HT) operate at single frequency and deliver fixed treatment coverage at the tumor target. In this work, we report multifrequency operation of a water-cooled monopole antenna with a sliding broadband ferrite choke for delivering intracavitary HT to the cervix with variable spatial coverage. Spatially varying treatment coverage is achieved by varying the choke position with respect to the monopole using a mechanical sliding arrangement and exciting the antenna at the modified resonant frequency. Multifrequency operation of the antenna prototype is demonstrated over 700-1000 MHz using a straight intrauterine cervix applicator. Numerical simulations confirm the ability to deliver targeted HT with axial extent varying between 35.4 and 62.0 mm by controlling the sliding choke and coupling water temperature. Applicator prototype measurements in tissue mimicking phantoms confirm multifrequency operation of the antenna and its ability to induce axially varying intracavitary HT coverage to match the tumor size using a single applicator.
期刊介绍:
Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.