带有滑动宽带扼流圈的腔内单极的多频操作,用于提供可变覆盖范围的热疗。

IF 1.6 4区 生物学 Q3 BIOLOGY
Shabeeb Ahamed Kp,Kavitha Arunachalam
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引用次数: 0

摘要

据报道,用于腔内热疗(HT)的微波应用器以单一频率运行,并在肿瘤靶点提供固定的治疗覆盖范围。在这项工作中,我们报告了带有滑动宽带铁氧体扼流圈的水冷单极天线的多频工作情况,该天线可对宫颈进行空间覆盖可变的腔内热疗。通过使用机械滑动装置改变扼流圈相对于单极子的位置,并以修改后的谐振频率激励天线,可实现不同空间覆盖范围的治疗。天线原型的多频操作是通过一个直的宫颈内涂抹器在 700-1000 兆赫范围内进行演示的。数字模拟证实,通过控制滑动扼流圈和耦合水温,能够提供轴向范围在 35.4 至 62.0 毫米之间的定向高温热疗。在组织模拟模型中进行的涂抹器原型测量证实了该天线的多频工作能力,以及使用单个涂抹器诱导轴向变化的腔内 HT 覆盖范围以匹配肿瘤大小的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multifrequency operation of an intracavitary monopole with sliding broadband choke for delivering hyperthermia treatment with variable coverage.
Microwave applicators reported for intracavitary hyperthermia (HT) operate at single frequency and deliver fixed treatment coverage at the tumor target. In this work, we report multifrequency operation of a water-cooled monopole antenna with a sliding broadband ferrite choke for delivering intracavitary HT to the cervix with variable spatial coverage. Spatially varying treatment coverage is achieved by varying the choke position with respect to the monopole using a mechanical sliding arrangement and exciting the antenna at the modified resonant frequency. Multifrequency operation of the antenna prototype is demonstrated over 700-1000 MHz using a straight intrauterine cervix applicator. Numerical simulations confirm the ability to deliver targeted HT with axial extent varying between 35.4 and 62.0 mm by controlling the sliding choke and coupling water temperature. Applicator prototype measurements in tissue mimicking phantoms confirm multifrequency operation of the antenna and its ability to induce axially varying intracavitary HT coverage to match the tumor size using a single applicator.
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来源期刊
CiteScore
3.60
自引率
11.80%
发文量
33
审稿时长
>12 weeks
期刊介绍: Aims & Scope: Electromagnetic Biology and Medicine, publishes peer-reviewed research articles on the biological effects and medical applications of non-ionizing electromagnetic fields (from extremely-low frequency to radiofrequency). Topic examples include in vitro and in vivo studies, epidemiological investigation, mechanism and mode of interaction between non-ionizing electromagnetic fields and biological systems. In addition to publishing original articles, the journal also publishes meeting summaries and reports, and reviews on selected topics.
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