Eye & Contact Lens-Science and Clinical Practice最新文献

The Effect of Scleral Lens Reservoir Solution on Post-lens Fluid Turbidity and Settling in Patients With Keratoconus. 巩膜晶状体积液对圆锥角膜患者晶状体后液体混浊和沉淀的影响。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-16 DOI: 10.1097/ICL.0000000000001231

Elif Bagatur Vurgun, Gamze Ozkan, Semra Akkaya Turhan, Ayşe Ebru Toker

{"title":"The Effect of Scleral Lens Reservoir Solution on Post-lens Fluid Turbidity and Settling in Patients With Keratoconus.","authors":"Elif Bagatur Vurgun, Gamze Ozkan, Semra Akkaya Turhan, Ayşe Ebru Toker","doi":"10.1097/ICL.0000000000001231","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001231","url":null,"abstract":"Objectives: To evaluate the impact of using a high-viscosity hyaluronate solution in the fluid reservoir (FR) on post-lens fluid turbidity and the settling of scleral lenses (SLs).Methods: Forty-four eyes of 22 keratoconus patients were fitted SLs. SLs applied to the right eye were filled with preservative-free sodium hyaluronate solution, whereas those applied to the left eye were filled with preservative-free saline. After SL fitting, high- and low-contrast visual acuities (VAs) were measured at 0, 4, and 8 hr. The optical density of the post-lens fluid was calculated using Scheimpflug tomography and graded from anterior-segment optical coherence (AS-OCT) images. Central corneal clearance and lens settling were measured with AS-OCT.Results: High-contrast VA showed no significant change over time in either group. Low-contrast VA remained stable during 8 hr of SL wear in the right eyes, but low-contrast VA decreased at 4th and 8th hours in the left eyes. AS-OCT-based turbidity grading and the optical density increased over time, with no difference between the two solutions. The rate and amount of settling did not differ between the groups.Conclusions: High-viscosity sodium hyaluronate may sustain improved low-contrast vision in keratoconus patients compared with saline, without adversely affecting post-lens fluid turbidity or lens settling.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

l-Cysteine Graphene Oxide Deposition on Contact Lenses. 隐形眼镜上的l-半胱氨酸氧化石墨烯沉积。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-13 DOI: 10.1097/ICL.0000000000001230

Krupa Mukkaragari, Pratap Kollu, Nagaraju Konda

{"title":"l-Cysteine Graphene Oxide Deposition on Contact Lenses.","authors":"Krupa Mukkaragari, Pratap Kollu, Nagaraju Konda","doi":"10.1097/ICL.0000000000001230","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001230","url":null,"abstract":"Objective: l-cysteine graphene oxide (CysGO) was synthesized and deposited onto the hydrogel and silicone hydrogel contact lenses (CLs) to study the surface characterization.Methods: A cysteine graphene oxide composite was synthesized, characterized, and deposited on commercially available soft CLs. Characterization techniques such as FESEM, Fourier Transform Infrared, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and Ultraviolet-Visible spectroscopy were employed to analyze CysGO deposited lens surface characterisation. Swelling and transmission percentages were calculated.Results: Raman spectra revealed an increased Id/Ig ratio of 2.5 for CysGO compared with GO (2.25), indicating reduced layer stacking due to cysteine interaction. IR spectra confirmed the presence of amide groups, and XPS spectra exhibited a distinct s2p peak at 164eV and N2 spectrum at 399 eV exclusively in CysGO, confirming its deposition on the lens substrate. The deposited CLs showed a uniform coating of CysGO, an increase in the swelling percentage (P<0.001), and no difference in transmittance percentage when compared with the control.Conclusion: This study presents the inaugural investigation of CysGO deposition applied to CL, revealing its advantageous properties, including uniformity and enhanced wettability. The potential of this coating extends beyond these characteristics, prompting further exploration of its diverse properties and applications in subsequent studies.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Management of a Rare Keratitis Caused by Mycobacterium Immunogenum After a Series of Misdiagnoses. 一例罕见的由免疫原分枝杆菌引起的角膜炎误诊后的成功治疗。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-02 DOI: 10.1097/ICL.0000000000001228

Binghong Wang, Ying Fu, Dingwen Xu, Jia Liu, Tian Tian, Wenjia Xie

{"title":"Successful Management of a Rare Keratitis Caused by Mycobacterium Immunogenum After a Series of Misdiagnoses.","authors":"Binghong Wang, Ying Fu, Dingwen Xu, Jia Liu, Tian Tian, Wenjia Xie","doi":"10.1097/ICL.0000000000001228","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001228","url":null,"abstract":"Abstract: This case report presents the successful diagnosis and management of a rare case of Mycobacterium immunogenum keratitis. A 34-year-old immunocompetent female presented with a 6-month history of recurrent right eye redness and blurred vision. Previous treatment at other hospitals with oral antivirals, topical corticosteroids, and ganciclovir ointment for presumed herpetic keratitis had failed, with progressive vision decline from 20/20 to 20/50. The causative pathogen identification revealed Mycobacterium immunogenum through comprehensive diagnostic workup including microbiological culture, acid-fast staining, and metagenomic next-generation sequencing (mNGS). Initial therapy with topical amikacin proved ineffective and caused significant ocular toxicity, whereas adjunctive oral azithromycin showed no clinical benefit. Subsequent treatment with 0.3% gatifloxacin eye gel resulted in dramatic improvement. During the healing phase, 0.02% fluorometholone was added to control scarring. Complete resolution was achieved within 4 months, with only mild residual scarring and final uncorrected visual acuity of 20/30. The patient remained recurrence-free throughout 4 years of follow-up. This case demonstrates that Mycobacterium immunogenum keratitis does not necessarily occur in immunocompromised individuals or those with a history of trauma or surgery. It is easily misdiagnosed in the early stages, whereas mNGS can aid in pathogen identification. Treatment with 0.3% gatifloxacin eye gel suggests potentially superior efficacy and safety in such condition.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractive and Topographical Analyses After Wavefront-Optimized Photorefractive Keratectomy With 75% Angle Kappa Compensation for Myopia. 75%角Kappa补偿的波前优化光屈光性角膜切除术治疗近视后的屈光和地形分析。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-02 DOI: 10.1097/ICL.0000000000001226

Burak Tanriverdi, Nurullah Cagil

{"title":"Refractive and Topographical Analyses After Wavefront-Optimized Photorefractive Keratectomy With 75% Angle Kappa Compensation for Myopia.","authors":"Burak Tanriverdi, Nurullah Cagil","doi":"10.1097/ICL.0000000000001226","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001226","url":null,"abstract":"Objective: To evaluate refractive and topographic outcomes following photorefractive keratectomy (PRK) with 75% angle kappa (P-Dist) compensation in myopic eyes.Methods: This retrospective study included 127 right eyes of patients with myopia and/or myopic astigmatism, who underwent wavefront-optimized PRK, incorporating 75% P-Dist compensation. Visual, refractive, topographic, aberrometric, and point-spread function (PSF) measurements were recorded preoperatively and at 1, 3, and 6 months postoperatively.Results: The mean P-Dist was 232.13±121.78 μm (range: 31.69-769.84 μm). Eyes were grouped by mean P-Dist: group-1 (<232.13 μm, small-angle kappa, n=67) and group-2 (>232.13 μm, large-angle kappa, n=60). Preoperative P-Dist correlated with root-mean-square of higher-order aberrations (RMS-HOAs) (r=0.24, P=0.01) and coma (r=0.381, P<0.001). Group-2 had higher preoperative coma (P=0.001). At 6 months, the percentage of eyes within ±0.50 diopters (D) spherical equivalent and≤0.50 D astigmatism, visual acuity, asphericity, mean pupil power, HOAs, and PSF were similar between the groups (P>0.05 for all). No correlation was found between preoperative P-Dist and postoperative HOAs or PSF changes (P>0.05 for all).Conclusions: PRK with 75% angle kappa compensation yields comparable refractive and topographical outcomes in myopic eyes with small- and large-angle kappa. In eyes with a significant angle kappa, aligning ablation with P-Dist may not induce additional corneal refractive or topographical changes.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic Cost Analysis of Acanthamoeba Keratitis Among Contact Lens Wearers. 隐形眼镜佩戴者棘阿米巴角膜炎的经济成本分析。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI: 10.1097/ICL.0000000000001216

Dereje Hayilu Anbesse, Stephanie Yeo, Bryan Chong, Blake Angell, Fiona Stapleton, Constantinos Petsoglou, Nicole Ann Carnt

{"title":"Economic Cost Analysis of Acanthamoeba Keratitis Among Contact Lens Wearers.","authors":"Dereje Hayilu Anbesse, Stephanie Yeo, Bryan Chong, Blake Angell, Fiona Stapleton, Constantinos Petsoglou, Nicole Ann Carnt","doi":"10.1097/ICL.0000000000001216","DOIUrl":"10.1097/ICL.0000000000001216","url":null,"abstract":"Objectives: This study aimed to estimate direct and indirect economic costs associated with Acanthamoeba keratitis and explore variations in individual and healthcare characteristics.Methods: Patients treated at Moorfields Eye Hospital, UK, between January 2011 and August 2014 were surveyed. Patients were included if they had a confirmed diagnosis and wore contact lenses. Direct costs included healthcare expenses, whereas indirect costs encompassed lost wages for patients and caregivers. The Mann-Whitney U test and generalized linear models were used to analyze cost data and their associated factors, with P <0.05 being considered statistically significant.Results: A total of 73 patients were included, with a mean age of 39.3 years (19-81); 40 patients (54.8%) were female, and 41 (56.2%) had good outcomes. Median direct, indirect, and total costs were £2,966.5 (IQR £5,553.2), £1,776.0 (IQR £3,223.3), and £6,678.6 (IQR £17,268.4), respectively. Higher direct costs were independently associated with multiple medical visits ( P <0.001), steroids before antiamoeba therapy ( P =0.042), and keratoplasty ( P <0.001).Conclusions: The cost of managing Acanthamoeba keratitis is substantial. Future research should focus on optimizing treatment strategies and improving patient outcomes to help alleviate the financial burden on patients and healthcare systems.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"464-469"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letters to the Editor. 给编辑的信。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI: 10.1097/ICL.0000000000001218

Suleyman Demir

引用次数: 0

Bilateral Infectious Keratitis due to Moraxella Nonliquefaciens. 非液化莫拉菌所致双侧感染性角膜炎。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-04 DOI: 10.1097/ICL.0000000000001211

Jorge Salvo Jiménez, Alfredo Vega Estrada, Ezequiel Campos Mollo, Jaime Matarredona Muñoz, Joana Hernández Jiménez, Marta Mifsut Aleixandre

{"title":"Bilateral Infectious Keratitis due to Moraxella Nonliquefaciens.","authors":"Jorge Salvo Jiménez, Alfredo Vega Estrada, Ezequiel Campos Mollo, Jaime Matarredona Muñoz, Joana Hernández Jiménez, Marta Mifsut Aleixandre","doi":"10.1097/ICL.0000000000001211","DOIUrl":"10.1097/ICL.0000000000001211","url":null,"abstract":"Abstract: Gram-negative diplobacilli Moraxella, commonly found on skin and mucous membranes, rarely cause ocular infections, except for Moraxella nonliquefaciens , associated with severe endophthalmitis. We present the case of a patient with common variable immunodeficiency (CVID) who developed bilateral ulcers due to M. nonliquefaciens without local predisposing factors. This case underscores the relevance of considering M. nonliquefaciens as an important ocular pathogen, even in the absence of local predisposition. This case presents a 42-year-old woman with a history of viral conjunctivitis and common variable immunodeficiency presented with pain and blurred vision in her left eye. She was diagnosed with infectious keratitis caused by M. nonliquefaciens , treated with fortified antibiotic eye drops and cycloplegics. Subsequently, she developed similar symptoms in her right eye, also caused by the same microorganism. After several weeks of treatment, both eyes showed improvement, allowing for continued treatment with topical corticosteroids and antibiotics. Two months later, her visual acuity significantly improved, with clear corneas and paracentral leukomas in both eyes. In conclusion, patients with CVID undergoing intravenous immunoglobulin (IVIG) therapy may develop severe ocular infections, even by uncommon microorganisms such as M. nonliquefaciens . Although IVIG therapy is essential for managing CVID, susceptibility to ocular infections may persist due to deficiencies in local immune response, especially in the tear film. It is crucial to consider this risk when treating patients with CVID for proper management and prevention of ocular complications.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"475-477"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracorneal Hemorrhage Associated With Scleral Lens Wear. 角膜内出血与巩膜晶状体磨损有关。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-07-28 DOI: 10.1097/ICL.0000000000001215

Jessica Trinh, Ashlie A Bernhisel, Cherie B Nau, Muriel M Schornack

引用次数: 0

Causal Relationship Between Gut Microbiota and Cataract: A Two-Sample Bidirectional Mendelian Randomization Study. 肠道菌群与白内障的因果关系：一项双样本双向孟德尔随机研究。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1097/ICL.0000000000001209

Han-Dan Xiao, Ji-Ang Li, Chen-Han Zhou, Yi Zhang

{"title":"Causal Relationship Between Gut Microbiota and Cataract: A Two-Sample Bidirectional Mendelian Randomization Study.","authors":"Han-Dan Xiao, Ji-Ang Li, Chen-Han Zhou, Yi Zhang","doi":"10.1097/ICL.0000000000001209","DOIUrl":"10.1097/ICL.0000000000001209","url":null,"abstract":"Purpose: To identify the causal relationship between the gut microbiota and cataracts using a two-sample Mendelian randomization (MR) approach.Methods: Genetic instrumental variables for gut microbiota were derived from a genome-wide association study (GWAS) of 18,340 participants. The aggregated statistics for cataracts, which involved 8,890 cases and 454,120 controls, were also obtained from GWAS. In addition, the inverse variance weighted method served as the primary analysis. Moreover, the weighted median method, MR-Egger regression, and MR Multieffect residual and outlier tests were performed to test the robustness of our results.Results: Ultimately, we found a suggestive association between five bacterial traits and cataract risk: the ChristensenellaceaeR.7 group ( P =0.00175, odds ratio [OR]=0.995, 95% confidence interval [CI]: 0.991-0.998), Sellimonas ( P =0.0309, OR=0.998, 95% CI: 0.997-1.000), and Eubacterium ruminantium group ( P =0.0498, OR=0.998, 95% CI: 0.997-1.000) were negatively correlated with cataract, whereas Eggerthella ( P =0.0157, OR=1.002, 95% CI: 1.000-1.005) and Odoribacter ( P =0.0471, OR=1.004, 95% CI: 1.000-1.007) were positively associated with cataract. Heterogeneity was not observed in any of the five bacteria.Conclusions: Our analysis provides evidence supporting a potential causal relationship between the gut microbiota and cataract risk. However, more research is needed to further elaborate on how gut microbiota affects cataract development.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"454-463"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slit Lamp Findings in Scleral Lens Wearers With and Without Subjective Fogging. 裂隙灯在巩膜晶状体配戴者有无主观雾化中的表现。

IF 2.1 4区医学

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-07-02 DOI: 10.1097/ICL.0000000000001204

Jennifer Swingle Fogt, Muriel Schornack, Cherie Nau, Jennifer S Harthan, Amy Nau, Ellen Shorter

{"title":"Slit Lamp Findings in Scleral Lens Wearers With and Without Subjective Fogging.","authors":"Jennifer Swingle Fogt, Muriel Schornack, Cherie Nau, Jennifer S Harthan, Amy Nau, Ellen Shorter","doi":"10.1097/ICL.0000000000001204","DOIUrl":"10.1097/ICL.0000000000001204","url":null,"abstract":"Purpose: The term \"midday fogging\" is used to describe visual blur, which some scleral lens wearers experience during use. The purpose of this study was to determine whether fit characteristics and biomicroscopic findings in habitual scleral lens wearers contribute to symptoms of fogging.Methods: This prospective, observational study analyzed 48 habitual scleral lens wearers who wore lenses in one or both eyes from five clinical sites. Participants indicated whether they experienced fogging. Slit Lamp biomicroscopy was performed to evaluate fluid reservoir (FR) depth and presence or absence of limbal clearance, edge lift or impingement, conjunctival prolapse, and front surface nonwetting. Presence or absence of mucous strands, fine particulate debris, and diffuse haze in the FR were also noted. Backward elimination binomial logistic regression using one eye per participant compared the findings of eyes with and without subjective fogging.Results: Fogging was reported by 58% participants (28/48). Statistical analysis found no significant differences in scleral lens fitting characteristics of eyes with and without reported fogging. The presence of front surface nonwetting and diffuse haze were statistically higher in eyes with fogging.Conclusion: In this study, front surface nonwetting and diffuse haze observed with Slit Lamp biomicroscopy were associated with patient-reported scleral lens fogging.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"439-444"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0