Eye & Contact Lens-Science and Clinical Practice最新文献

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Supervised Machine Learning Models for Ocular Sagittal Height Prediction Incorporating Corneoscleral Profile Data. 基于角膜巩膜剖面数据的有监督机器学习模型用于眼矢状高度预测。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 DOI: 10.1097/ICL.0000000000001277
Timoteo González-Cruces, Miriam Carrillo-Pulido, Francisco Javier Aguilar-Salazar, Antonio Cano-Ortiz, Razvan Ionut Ghinea, Sonia Ortiz-Peregrina
{"title":"Supervised Machine Learning Models for Ocular Sagittal Height Prediction Incorporating Corneoscleral Profile Data.","authors":"Timoteo González-Cruces, Miriam Carrillo-Pulido, Francisco Javier Aguilar-Salazar, Antonio Cano-Ortiz, Razvan Ionut Ghinea, Sonia Ortiz-Peregrina","doi":"10.1097/ICL.0000000000001277","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001277","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop supervised machine learning (ML) models to predict ocular sagittal height (OC-SAG), using anterior eye data derived from topography and tomography.</p><p><strong>Method: </strong>ology: A retrospective cohort of 100 eyes provided data such as keratometry, eccentricity, white-to-white distance, and corneoscleral junction (CSJ) metrics through anterior segment optical coherence tomography (CASIA 2). Four supervised ML models were developed to predict OC-SAG at 10 mm and 14 mm chord lengths, using either topographical data alone or both topographical and tomographical data.</p><p><strong>Results: </strong>The model with the strongest predictive accuracy for the validation sample was the Random Forest, both for the 10-mm chord (r=0.88; MAE=28.16±26.81 μm) and the 14-mm chord (r=0.77; MAE=73.56±61.31 μm; flat corneal meridian, topography-based model). The inclusion of tomographic data, such as measurements related to the CSJ, did not significantly improve the performance of the models compared with using topographic data alone.</p><p><strong>Conclusions: </strong>Adding tomographic predictors did not significantly improve model performance. Despite reduced performance for longer chords, the observed error could be considered clinically acceptable for soft contact lens fitting. The study demonstrated the potential of ML in predicting OC-SAG, providing an accessible estimation method for all clinicians to support decision-making.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial Keratoplasty with Amniotic Membrane Transplantation for Corneal Perforation in the Setting of Severe Ocular Surface Disease. 角膜内皮移植术联合羊膜移植治疗严重眼表疾病患者角膜穿孔。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-04-03 DOI: 10.1097/ICL.0000000000001270
Grace Tu, Maria Soledad Cortina
{"title":"Endothelial Keratoplasty with Amniotic Membrane Transplantation for Corneal Perforation in the Setting of Severe Ocular Surface Disease.","authors":"Grace Tu, Maria Soledad Cortina","doi":"10.1097/ICL.0000000000001270","DOIUrl":"10.1097/ICL.0000000000001270","url":null,"abstract":"<p><strong>Abstract: </strong>Corneal perforation can significantly undermine corneal integrity in patients with severe ocular surface disease (OSD) and escalate to serious ocular sequelae and vision loss. The primary objective of this study is to report the technique and outcomes of non-Descemet stripping automated endothelial keratoplasty using the suture pull-through insertion method for the treatment of perforation in the setting of severe OSD rather than traditional penetrating keratoplasty. Three patients with corneal perforation complicated by severe OSD who underwent non-Descemet stripping automated endothelial keratoplasty at the Illinois Eye and Ear Infirmary between May 2023 and January 2025 were reviewed retrospectively. Information about preoperative patient's characteristics, surgical technique, and postoperative outcomes was extracted. All three patients achieved structural integrity with successful sealing of the perforation at the last follow-up. Postoperatively, all grafts remained attached in the area of perforation. No signs of infection or rejection were observed in any operative eye. Best-corrected visual acuity significantly improved in most cases. Endothelial keratoplasty with amniotic membrane transplantation offers an alternative approach for the treatment of perforation in patients with severe OSD and can be considered in selected cases to avoid further compromise to corneal nerves and epithelial complications that are frequent with full-thickness grafting in these patients.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"210-213"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral Lattice Corneal Dystrophy Associated With c.1864A>T Variant in the Transforming Growth Factor Beta-Induced Gene: A Rare Case Report. 单侧晶格状角膜营养不良与转化生长因子β诱导基因c.1864A >t变异相关:一例罕见病例报告。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-24 DOI: 10.1097/ICL.0000000000001268
Ayse Merve Ekincikli, Ece Turan-Vural, Filiz Ozen
{"title":"Unilateral Lattice Corneal Dystrophy Associated With c.1864A>T Variant in the Transforming Growth Factor Beta-Induced Gene: A Rare Case Report.","authors":"Ayse Merve Ekincikli, Ece Turan-Vural, Filiz Ozen","doi":"10.1097/ICL.0000000000001268","DOIUrl":"10.1097/ICL.0000000000001268","url":null,"abstract":"<p><strong>Abstract: </strong>We describe a patient with unilateral lattice corneal dystrophy (LCD) associated with a previously unreported pathogenic transforming growth factor beta-induced (TGFBI) variant (c.1864A>T, p.(Asn622Tyr)), contributing to the expanding phenotypic spectrum of non-R124C TGFBI-related LCD. A 58-year-old male patient presented with complaints of recurrent epithelial erosions and progressive vision loss in his right eye for the past 20 years. On slitlamp biomicroscopic examination of the patient's right eye, thick, branched lattice lines extended from the limbus to the central cornea. The lesions extended from the anterior to midstroma. Genetic analysis identified a heterozygous c.1864A>T (p.(Asn622Tyr)) TGFBI variant, classified as likely pathogenic based on the American College of Medical Genetics criteria. Importantly, this variant has not been reported in gnomAD, ClinVar, dbSNP, or the scientific literature, and it is therefore considered a novel TGFBI variant. This case represents a novel TGFBI variant (LCD-N622Y) associated with unilateral LCD, further underscoring the phenotypic variability of non-R124C TGFBI-related LCD. Recognition of unilateral or asymmetric presentations is essential to avoid misdiagnosis and to ensure appropriate genetic evaluation and family counseling.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"214-216"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-Orthokeratology Changes in the Corneal Epithelium Induced by an Orthokeratology Lens: An Anterior-Segment Optical Coherence Tomography Assessment. Menicon α晶状体诱导的角膜上皮术后角膜变化:前段光学相干断层扫描评估。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-27 DOI: 10.1097/ICL.0000000000001267
Kaoru Nemoto, Kazutaka Kamiya, Seiichiro Hata, Manabu Kobayashi
{"title":"Post-Orthokeratology Changes in the Corneal Epithelium Induced by an Orthokeratology Lens: An Anterior-Segment Optical Coherence Tomography Assessment.","authors":"Kaoru Nemoto, Kazutaka Kamiya, Seiichiro Hata, Manabu Kobayashi","doi":"10.1097/ICL.0000000000001267","DOIUrl":"10.1097/ICL.0000000000001267","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate detailed regional changes in corneal epithelial thickness after orthokeratology treatment according to the targeted refractive power.</p><p><strong>Methods: </strong>This retrospective study included a total of 63 eyes of 44 patients who underwent overnight orthokeratology for the correction of myopia. Corneal epithelial thickness was segmentally measured using anterior segment optical coherence tomography before and after treatment.</p><p><strong>Results: </strong>In the central zone (0-2 mm), the corneal epithelial thickness was significantly decreased by 7.54±5.46 μm ( P <0.05). In the paracentral zone (2-4 mm), it was also significantly decreased in all sectors, with the greatest thinning found in the temporal area. In the midperipheral zone (4-6 mm), it was significantly increased especially in the superior superonasal area, whereas in the peripheral zone (6-7 mm), it was also significantly increased especially in the inferior temporal area. The changes in the epithelial thickness within the central 4-mm area was significantly correlated with the amount of the target refractive power in both low- and high-correction groups. The geography pattern of corneal epithelial redistribution was in accordance with the overall trend of the orthokeratology lens fitting decentration.</p><p><strong>Conclusions: </strong>Orthokeratology induces central epithelial thinning and peripheral thickening with an asymmetric redistribution, presumably due to inferior temporal lens decentration. Eyes with higher refractive correction showed greater changes in the corneal epithelial thickness.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"198-202"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should Daily Disposable Silicone Hydrogel Contact Lens Use be Considered as the First Choice Among Soft Contact Lens Options for Pediatric Myopia Control? 在控制儿童近视的软性隐形眼镜选择中,每日使用一次性硅胶水凝胶隐形眼镜是否应被视为首选?
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 DOI: 10.1097/ICL.0000000000001269
Fiona Stapleton, Mark Willcox, Xu Cheng, Monica Jong
{"title":"Should Daily Disposable Silicone Hydrogel Contact Lens Use be Considered as the First Choice Among Soft Contact Lens Options for Pediatric Myopia Control?","authors":"Fiona Stapleton, Mark Willcox, Xu Cheng, Monica Jong","doi":"10.1097/ICL.0000000000001269","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001269","url":null,"abstract":"","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":"52 5","pages":"177-179"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Binocular Diplopia With Prism Incorporated Ocular Impression-Based Scleral Lenses With and Without Wavefront-Guided Optics. 带波前导光学与不带波前导光学的棱镜结合眼印象巩膜透镜治疗双眼复视。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 DOI: 10.1097/ICL.0000000000001275
John D Gelles, Angelina Weng, Victoria Vought, Rita Vought, Isis Zhang, Larry P Frohman, Steven A Greenstein
{"title":"Management of Binocular Diplopia With Prism Incorporated Ocular Impression-Based Scleral Lenses With and Without Wavefront-Guided Optics.","authors":"John D Gelles, Angelina Weng, Victoria Vought, Rita Vought, Isis Zhang, Larry P Frohman, Steven A Greenstein","doi":"10.1097/ICL.0000000000001275","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001275","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to report the efficacy of prism-incorporated impression-based scleral lenses (pibSL) in the management of binocular diplopia.</p><p><strong>Methods: </strong>This case series includes seven patients with various etiologies of binocular diplopia, including congenital and acquired conditions, that were managed with pibSLs. Of the seven patients, two had corneal irregularity. Visual acuity (VA), diplopia resolution, and subjective patient reports on comfort and cosmetics were assessed. Wavefront-guided (wfg) optics were incorporated in select cases where poor visual quality was reported.</p><p><strong>Results: </strong>All patients experienced resolution of diplopia with VA improving to 20/20 or better with pibSLs. Wfg optics reduced residual higher-order aberrations, resulting in subjective improvement in vision quality and balanced VA. Patients reported high levels of satisfaction with pibSL.</p><p><strong>Conclusions: </strong>PibSLs are an effective, well-tolerated alternative to traditional prism spectacles for managing binocular diplopia and can address multiple comorbidities. The addition of wfg optics further improved visual quality in patients with complex visual needs.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Orthokeratology Affects Accommodative Response and Binocular Vision: A Systematic Review and Meta-Analysis. 角膜塑形术如何影响调节反应和双眼视力:系统回顾和荟萃分析。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-11 DOI: 10.1097/ICL.0000000000001263
Carlos Eduardo de Menezes E Souza Filho, Mariana Tosato Zinher, Andres Bravo-Gonzalez, Claudia Avilés Covarrubias, Larissa Maria Ferrarez Faria, Sara Hira, Juliana Dias Moreira Penna, Carlos Eduardo de Menezes E Souza, Izabela Fernandes Godinho
{"title":"How Orthokeratology Affects Accommodative Response and Binocular Vision: A Systematic Review and Meta-Analysis.","authors":"Carlos Eduardo de Menezes E Souza Filho, Mariana Tosato Zinher, Andres Bravo-Gonzalez, Claudia Avilés Covarrubias, Larissa Maria Ferrarez Faria, Sara Hira, Juliana Dias Moreira Penna, Carlos Eduardo de Menezes E Souza, Izabela Fernandes Godinho","doi":"10.1097/ICL.0000000000001263","DOIUrl":"10.1097/ICL.0000000000001263","url":null,"abstract":"<p><strong>Purpose: </strong>Orthokeratology (OK) has been recognized as an effective intervention for slowing myopia progression. However, its effects on the accommodative response and its role in myopia control remain controversial. This systematic review and meta-analysis aimed to provide a comprehensive evaluation of the OK influence on accommodation.</p><p><strong>Methods: </strong>Cochrane, Embase, and PubMed were searched for studies published up to April, 2024. All eligible studies that compared OK with a neutral control and reported measurements related to accommodative response in myopic patients were included. The outcomes evaluated were accommodation lag (AL), positive relative accommodation, and accommodation amplitude (AA). The mean difference [MD] and 95% confidence interval were used for continuous outcomes. Heterogeneity was assessed using I 2 statistics. The analysis was performed using R software version 4.4.1.</p><p><strong>Results: </strong>A total of 14 studies comprising 1,404 patients met the inclusion criteria. Single vision spectacles was the control group in 12 articles, soft single vision contact lenses in one, and no intervention in one. The OK group showed a significant reduction in AL compared with control groups at 3 months follow-up (MD: -0.38D; confidence interval [CI]: -0.54 to -0.22D; P <0.00001; I 2 =0%). At 12 months, OK significantly increased AA compared with controls (MD: 0.64D; CI: 0.25 to 1.03D; P =0.001; I 2 =69%), which was not observed at 3 months (MD: 0.26D; CI: -0.16 to 0.70D; P =0.21; I 2 =80%). Positive relative accommodation did not differ significantly at 3 months (MD: -0.53D; CI: -1.08 to 0.02D; P =0.06; I 2 =83%).</p><p><strong>Conclusion: </strong>This meta-analysis demonstrates that OK significantly reduces AL and, in the long-term, increases AA compared with controls. These findings suggest that OK does improve the accommodation response, which may contribute to one of the mechanisms underlying its effectiveness in slowing myopia progression.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"180-190"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benoxinate-Induced Keratopathy: Clinical Patterns and Management, a Cairo University Residents' Report. 苯氧辛酸诱发的角膜病变:临床模式和管理,开罗大学居民报告。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-20 DOI: 10.1097/ICL.0000000000001265
Maryam Massoud, Rawan Hosny, Rana Shebl, Maha Saad, Bassant Yasser, Fayrouz Aboalazayem, Ahmed Rashad Ashor, Mohamed Hosny, Yehia Salah Mostafa
{"title":"Benoxinate-Induced Keratopathy: Clinical Patterns and Management, a Cairo University Residents' Report.","authors":"Maryam Massoud, Rawan Hosny, Rana Shebl, Maha Saad, Bassant Yasser, Fayrouz Aboalazayem, Ahmed Rashad Ashor, Mohamed Hosny, Yehia Salah Mostafa","doi":"10.1097/ICL.0000000000001265","DOIUrl":"10.1097/ICL.0000000000001265","url":null,"abstract":"<p><strong>Purpose: </strong>To describe clinical characteristics, patterns, and management options in benoxinate-induced keratopathy.</p><p><strong>Methods: </strong>Retrospective single-center study in which patients using benoxinate hydrochloride 0.4% for greater than 1 month and present with keratopathy and/or corneal complications were enrolled.</p><p><strong>Results: </strong>A total of 36 eyes were included, 90.5% belonged to welders. Median corrected distance visual acuity (CDVA) was 2.3 logMAR (hand motion). Secondary corneal abscess was present in 47.2% of eyes and 66.7% of eyes showed ring-shaped corneal deposits. Approximately 13.9% had corneal perforation at presentation and 22.3% had marked corneal thinning. All eyes except one had varying degrees of epithelial defects, mean defect 50.7±38.1 mm 2 . Approximately 47.2% received medical treatment and 52.7% were treated surgically. Size of epithelial defect was correlated to CDVA and presence of abscess ( P =0.007 and 0.041). Choice of management was affected by size of epithelial defect and CDVA ( P <0.001 and=0.006). CDVA did not improve after reepithelialization ( P =0.157).</p><p><strong>Conclusion: </strong>Benoxinate-induced keratopathy is a potentially blinding and preventable disease. Stricter laws preventing over the counter availability is needed.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"203-209"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Toric and Spherical Orthokeratology Lenses on High-Order Aberrations and Axial Length Elongation in Patients With Astigmatism. 环形和球形角膜塑形镜对散光患者高阶像差和轴长延伸的影响比较。
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-25 DOI: 10.1097/ICL.0000000000001266
Wenjie Jiang, Zhiyu Du, Zhangbing Mou, Xiaoyu Chen
{"title":"Comparison of Toric and Spherical Orthokeratology Lenses on High-Order Aberrations and Axial Length Elongation in Patients With Astigmatism.","authors":"Wenjie Jiang, Zhiyu Du, Zhangbing Mou, Xiaoyu Chen","doi":"10.1097/ICL.0000000000001266","DOIUrl":"10.1097/ICL.0000000000001266","url":null,"abstract":"<p><strong>Purpose: </strong>To compare ocular high-order aberrations (HOAs) and axial length (AL) change between spherical and toric orthokeratology (ortho-k) lenses in the treatment of patients with moderate to high corneal astigmatism.</p><p><strong>Methods: </strong>This was a prospective study involving 80 adolescents with myopia and moderate to high corneal astigmatism (≥1.50 diopters). These participants underwent consecutive ortho-k treatment at the Department of Ophthalmology of 363 Hospital between July 2021 and June 2023. The spherical group consisted of 41 subjects (41 eyes, 19 male and 22 female subjects; mean age: 11.15±2.09 years), who were fitted with traditional spherical ortho-k lenses. The toric group included 39 subjects (39 eyes, 15 male and 24 female subjects; mean age: 11.21±1.79 years), who were fitted with toric ortho-k lenses. All participants were followed up at 1 week, 1 month, and 3 months after wearing lenses. Uncorrected visual acuity (UCVA), lens decentration based on corneal topography, total ocular HOA, spherical aberrations (SA), coma aberrations (CA), and slitlamp microscopy were measured and compared between the two groups. Additionally, AL was assessed and compared between the groups after 12 months of lens wear.</p><p><strong>Results: </strong>At 1 week, 1 month, and 3 months after wearing ortho-k lenses, the mean lens decentration in the toric group was (0.56±0.20) mm, (0.58±0.22) mm, and (0.56±0.24) mm, respectively, which were lower than those in the spherical group [(0.68±0.22) mm, (0.73±0.30) mm, and (0.72±0.27) mm, respectively], with statistically significant differences ( P <0.05). The CA values in the toric group were (0.27±0.17) μm, (0.30±0.24) μm, and (0.28±0.24) μm, which were lower than those in the spherical group [(0.39±0.24) μm, (0.44±0.33) μm, and (0.45±0.33) μm, respectively], with all differences being statistically significant ( P <0.05). No significant differences were observed between the two groups in terms of UCVA, total ocular HOA, SA, or corneal fluorescein staining ( P >0.05). Additionally, after 12 months of lens wear, no statistically significant difference in AL change between the two groups (spherical group: 0.25±0.18 mm; toric group: 0.24±0.12 mm; P >0.05).</p><p><strong>Conclusion: </strong>For myopic adolescents with moderate to high corneal astigmatism (≥1.50 D), toric ortho-k lenses can reduce lens decentration compared with traditional spherical ortho-k lenses and induce less CA. However, toric and spherical ortho-k lenses demonstrate comparable outcomes in terms of UCVA, total ocular HOA, SA, safety profiles, and efficacy in myopia control.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"191-197"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Scleral Contact Lenses Affect Pupillary Light Response in Patients With Keratoconus? 巩膜隐形眼镜对圆锥角膜患者瞳孔光反应有影响吗?
IF 2.1 4区 医学
Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-04-21 DOI: 10.1097/ICL.0000000000001273
Büşra Dilara Yıldırım Erdal, Burcu Kazancı
{"title":"Do Scleral Contact Lenses Affect Pupillary Light Response in Patients With Keratoconus?","authors":"Büşra Dilara Yıldırım Erdal, Burcu Kazancı","doi":"10.1097/ICL.0000000000001273","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001273","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of scleral lenses on ocular aberrations, static and dynamic pupil functions in patients with keratoconus.</p><p><strong>Methods: </strong>Thirty-nine eyes from 31 patients diagnosed with moderate to severe keratoconus. Ocular aberration measurements (Pentacam AXL wave) and pupillometry measurements using automated pupillometry were recorded for all patients, both before and after the wearing of scleral lenses.</p><p><strong>Results: </strong>After the application of scleral lenses, considerable improvements were noted in best-corrected visual acuity (BCVA), lower-order aberration (LOA), higher-order aberration (HOA), vertical coma, horizontal coma, and spherical aberration values in ocular aberration (P<0.05). In static and dynamic pupillometry, significant decreases were observed in high photopic pupil diameter (PD), low photopic PD, mesopic PD, scotopic PD, contraction velocity, and dilation velocity (P=0.039, P<0.001, P<0.001, P=0.023, P=0.001, and P=0.016, respectively). The change in BCVA after scleral lenses correlated with the change in LOA, HOA, vertical coma, spherical aberration, low photopic PD, and mesopic PD values (P<0.05).</p><p><strong>Conclusions: </strong>Scleral lenses cause notable changes in static and dynamic pupil functions. Besides neutralizing LOA and HOA, the decrease in low-photopic and mesopic PD might contribute to improved BCVA and enhanced visual quality after the use of scleral lenses.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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