{"title":"Estimation of Tear Film Concentration of Oral Ciprofloxacin in Patients With Bacterial Keratitis.","authors":"Virendra Kumar Bagraniya, Manasi Tripathi, Nishat Hussain Ahmed, Rajesh Sinha, Namrata Sharma, Manpreet Kaur, Jeewan Singh Titiyal, Tushar Agarwal, Prafulla Maharana","doi":"10.1097/ICL.0000000000001212","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001212","url":null,"abstract":"<p><strong>Aims: </strong>To estimate the tear film concentration of oral ciprofloxacin in patients with bacterial keratitis and evaluate its correlation with various clinical factors.</p><p><strong>Method: </strong>This prospective intraindividual study enrolled 52 patients (104 eyes), each with unilateral, microbiologically confirmed bacterial keratitis (n=52 eyes); the fellow eye (n=52 eyes) served as the healthy control. The etiology of keratitis was confirmed by corneal scraping followed by detection of bacteria on Gram stain and bacterial culture. In addition to empirical therapy with topical fortified cefazolin 5% and tobramycin 1.3%, changing drugs if necessary, according to the antibiotic sensitivity report, these patients received oral ciprofloxacin 500 mg BD for 5 days. Tear samples were collected from infected and noninfected eyes, respectively, 3 hr after the morning dose of day 5. These samples underwent liquid chromatography and mass spectrometry to estimate concentration of ciprofloxacin in tear film.</p><p><strong>Result: </strong>Staphylococcus epidermidis was the most prevalent organism in our study (28.85%). The median ulcer area was 24 (4, 72) mm2. The median concentration of ciprofloxacin in tear samples from infected eyes was 547 (10.9, 3,490) ng/mL. In the noninfected eyes, the median concentration was 461 (3.86, 1730) ng/mL. The median concentration of ciprofloxacin in infected eyes was comparable with the minimum inhibitory concentration (MIC) for Staphylococcus species. Drug concentration in tear film had a strong positive correlation with ulcer area (Spearman rho=0.957; P=0.02) but weak positive correlation with the presence of infection (Spearman rho=0.245; P=0.08).</p><p><strong>Conclusion: </strong>Oral ciprofloxacin reaches tear concentration similar to the reported MIC of staphylococcus species, therefore is a promising adjuvant to topical therapy in staphylococcal keratitis. Further larger scale, comparative studies are warranted to ascertain the same.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yaohua Zhang, Jing Li, Shengsheng Wei, Zhiqing Wu, Yong Li, Yan Wang
{"title":"Characteristics of Anterior and Posterior Ocular Biometric Parameters in Nonamblyopic Myopic Anisometropia.","authors":"Yaohua Zhang, Jing Li, Shengsheng Wei, Zhiqing Wu, Yong Li, Yan Wang","doi":"10.1097/ICL.0000000000001213","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001213","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to quantify the differences in the anterior and posterior segment parameters between both eyes of individuals with nonamblyopic myopic anisometropia of ≥2 diopters (D).</p><p><strong>Methods: </strong>This study enrolled 141 adults (mean age: 24.3±6.0 years; 48.3% men) with myopic anisometropia (binocular refractive difference of ≥2.0 D in spherical power). Bilateral measurements included refractive error (spherical equivalent, SE), mean keratometry, intraocular pressure, axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), peripapillary retinal nerve fiber layer (RNFL) thickness, optic nerve head (ONH) parameters, and macular thickness in Early Treatment Diabetic Retinopathy Study (ETDRS)-defined regions. Linear associations between variables and interocular differences in ocular parameters were statistically evaluated.</p><p><strong>Results: </strong>The right eyes of the 68 men and 73 women enrolled in this study had significantly high myopia (P<0.05). The mean interocular difference in the SE was 2.72±0.93 D. The AL, ACD, and ACV were significantly greater for the more myopic eyes than for the contralateral eyes (all P<0.05). The CCT, ETDRS thickness, and ONH parameters (excluding average RNFL thickness) were lower for the more myopic eyes than for the contralateral eyes (all P<0.05). The superior quadrant RNFL thickness decreased with age (P<0.05). The refractive difference was significantly correlated with interocular differences in AL (r=0.735, P<0.001).</p><p><strong>Conclusions: </strong>Interocular differences in anterior chamber parameters, macular thickness, and ONH structures were identified in adult patients with nonamblyopic myopic anisometropia. The more myopic eyes had thinner CCT, greater corneal curvatures, and specific ONH and macular layer alterations.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Trinh, Ashlie A Bernhisel, Cherie B Nau, Muriel M Schornack
{"title":"Intracorneal Hemorrhage Associated With Scleral Lens Wear.","authors":"Jessica Trinh, Ashlie A Bernhisel, Cherie B Nau, Muriel M Schornack","doi":"10.1097/ICL.0000000000001215","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001215","url":null,"abstract":"<p><strong>Abstract: </strong>Scleral lenses have been shown to provide improved visual acuity and ocular surface protection in patients with corneal irregularities and ocular surface disease. However, scleral lens (SL) wear may lead to anterior ocular pathology owing to metabolic or mechanical stress. Most reports of SL-related complications have described microbial keratitis or hypoxia-related issues. There is limited literature describing complications caused by mechanical interactions, such as suction between the SL and ocular surface. This case report describes a patient with long-standing keratoconjunctivitis and keratoconus who developed intracorneal hemorrhage within 4 hr of completing application and removal training on the first day of SL wear.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing the Effect of 2 Artificial Tear Formulations on Daytime Ocular Surface Parameters After Orthokeratology Contact Lenses Wearing.","authors":"Chih-Ying Lin, Wen-Ling Liao, Hui-Ju Lin, Chun-Chi Chiang, Yi-Yu Tsai, Ning-Yi Hsia, Yi-Ching Hsieh","doi":"10.1097/ICL.0000000000001207","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001207","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the ocular comfort and tear film stability of low viscous and medium viscous lubricant eye drops in orthokeratology lens users.</p><p><strong>Method: </strong>This is a prospective, two-arm, randomized, crossover trial. After a 7±2 day run-in and washout period, subjects were assigned to apply one of two eye drops to the orthokeratology lens bow every night before inserting their lenses. Low viscosity eye drops with sodium chloride 5.5 mg (AIM Artificial Tears, Aimedicine) and medium viscosity eye drops with 0.4% polyethylene glycol (Systane ULTRA Unit dose, Alcon) were used.</p><p><strong>Results: </strong>The study included 40 subjects with a mean age of 10.40±2.64 years and an averaged spherical equivalent of-3.43±1.31 diopters. There were no significant differences in Ocular Surface Disease Index (OSDI), Schirmer,noncontact tear film break-up time (NiTBUT), corneal staining score (NEI), or topographic decentration between the two treatment groups.</p><p><strong>Conclusion: </strong>Despite the disparity in viscosity, the difference in visual acuity, OSDI, Schirmer, NiTBUT, NEI, and topographic decentration failed to reach statistical significance. Therefore, wearing orthokeratology lenses with low or medium viscosity artificial tears did not significantly impact daily visual acuity, ocular surface parameters, or contact lens centration.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuzhuo Fan, Xuewei Li, Sitong Chen, Yan Li, Mingwei Zhao, Kai Wang
{"title":"Factors Influencing Ortho-K Treatment in Low Myopia and Management Approaches.","authors":"Yuzhuo Fan, Xuewei Li, Sitong Chen, Yan Li, Mingwei Zhao, Kai Wang","doi":"10.1097/ICL.0000000000001208","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001208","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify the key demographic, biometric, and behavioral factors that impact the treatment effect of Ortho-K in low myopia and to discover the management ideas for low myopes undergoing Ortho-K treatment.</p><p><strong>Methods: </strong>A 12-month retrospective study examined 380 individuals who received Ortho-K treatment. Stratification and multinomial logistic regression were conducted to identify biometric features and behavioral indicators associated with Ortho-K treatment outcomes in low myopes.</p><p><strong>Results: </strong>The 12-month axial length growth was significantly longer in the low myopia group than in the moderate myopia group (P<0.0001). Multivariate logistic regression analysis showed that Ortho-K only was 2.23 times more likely to have rapid axial growth than Ortho-K combined with 0.01% atropine in patients with low myopia (P=0.01; odds ratio [OR]=2.23; 95% confidence interval [CI], 1.19-4.20). Multinomial logistic regression analyses showed that in patients with low myopia, female sex (P<0.0001; OR=0.4; 95% CI, 0.22-0.72), young age (P=0.01; OR=0.79; 95% CI, 0.66-0.93), flatter K mean (P=0.004; OR=0.74; 95% CI, 0.61-0.91), and having two myopic parents (P=0.03; OR=0.18; 95% CI, 0.05-0.71) were associated with worse treatment outcomes. A diet rich in white meats, such as fish and duck (P=0.01; OR=0.06; 95% CI, 0.01-0.54), was protective behavioral factors associated with slower axial length growth in children with low myopia.</p><p><strong>Conclusions: </strong>Patients with low myopia who exhibit one or more of the demographic and biometric risk factors (young age, female, flat mean K, and two myopic parents) require heightened attention in clinic settings because of their increased risk of myopia progression. Ortho-K combined with 0.01% atropine may achieve better efficacy than Ortho-K only in low myopes. A diet rich in white meat is protective and controlled behavioral factors for these patients.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Evaluation of 26-Gauge Needle Versus Kimura Spatula for Corneal Scraping in Infective Keratitis: A Randomized Controlled Trial.","authors":"Prafulla Kumar Maharana, Aafreen Bari, Sohini Mandal, Sarath Sukumara Pillai, Nishat Hussain, Rajesh Sinha, Tushar Agarwal, Namrata Sharma, Jeewan Singh Titiyal","doi":"10.1097/ICL.0000000000001203","DOIUrl":"10.1097/ICL.0000000000001203","url":null,"abstract":"<p><strong>Purpose: </strong>Microbial keratitis accounts for significant proportion of corneal blindness. To know the underlying etiological micro-organism, performing corneal scraping is important for initiating the correct antibiotic therapy. A study was conducted to compare the efficacy and safety of 26-gauge needle and Kimura spatula for the same.</p><p><strong>Methods: </strong>A prospective, comparative randomized pilot study was conducted to compare Kimura spatula (group 1) to 26-gauge needle (group 2). In total, 115 patients were recruited in the 2 groups-67 in group 1 and 48 in group 2.</p><p><strong>Results: </strong>Both the groups were comparable in adequacy of sample, microbiological staining and culture, and safety ( P >0.05). However, in subgroup analysis, the number of fully adequate samples was higher and nonadequate samples was lower in the 26-gauge needle group ( P =0.004).</p><p><strong>Conclusion: </strong>Both Kimura spatula and 26-gauge needle are safe and effective tools for corneal scraping. However, in adequacy, cost-effectiveness, easy availability, disposable nature, and nondependency on sterilization unit, 26-gauge needle is superior to Kimura spatula.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"343-347"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer Swingle Fogt, Muriel Schornack, Cherie Nau, Jennifer S Harthan, Amy Nau, Ellen Shorter
{"title":"Slit Lamp Findings in Scleral Lens Wearers With and Without Subjective Fogging.","authors":"Jennifer Swingle Fogt, Muriel Schornack, Cherie Nau, Jennifer S Harthan, Amy Nau, Ellen Shorter","doi":"10.1097/ICL.0000000000001204","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001204","url":null,"abstract":"<p><strong>Purpose: </strong>The term \"midday fogging\" is used to describe visual blur, which some scleral lens wearers experience during use. The purpose of this study was to determine whether fit characteristics and biomicroscopic findings in habitual scleral lens wearers contribute to symptoms of fogging.</p><p><strong>Methods: </strong>This prospective, observational study analyzed 48 habitual scleral lens wearers who wore lenses in one or both eyes from five clinical sites. Participants indicated whether they experienced fogging. Slit Lamp biomicroscopy was performed to evaluate fluid reservoir (FR) depth and presence or absence of limbal clearance, edge lift or impingement, conjunctival prolapse, and front surface nonwetting. Presence or absence of mucous strands, fine particulate debris, and diffuse haze in the FR were also noted. Backward elimination binomial logistic regression using one eye per participant compared the findings of eyes with and without subjective fogging.</p><p><strong>Results: </strong>Fogging was reported by 58% participants (28/48). Statistical analysis found no significant differences in scleral lens fitting characteristics of eyes with and without reported fogging. The presence of front surface nonwetting and diffuse haze were statistically higher in eyes with fogging.</p><p><strong>Conclusion: </strong>In this study, front surface nonwetting and diffuse haze observed with Slit Lamp biomicroscopy were associated with patient-reported scleral lens fogging.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does Corneal Tattooing Improve Psychosocial Functioning in Patients With Corneal Leukoma? A Pilot Study.","authors":"Omer Faruk Yilmaz, Ebubekir Durmus, Fehim Esen, Alperen Bikmazer, Adnan Berkay Kisakurek, Esma Ecem Ersoy, Oguzhan Koyuncu, Vahdettin Gormez, Halit Oguz","doi":"10.1097/ICL.0000000000001202","DOIUrl":"10.1097/ICL.0000000000001202","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to investigate the psychosocial effects of corneal tattooing in patients with corneal leukoma.</p><p><strong>Materials and methods: </strong>Aesthetic pigmentation was applied to patients with corneal leukomas. The Hospital Anxiety and Depression Scale (HADS), Social Appearance Anxiety Scale (SAAS), and the International Brief Version of the Fear of Negative Evaluation Scale, which were validated by Turkish speakers, were performed before and 3 months after corneal tattooing for aesthetic purposes. A review and interpretation of questionnaire scores was conducted under the supervision of authors from psychiatric departments. For demographic and clinical data, 20 questions were asked of patients before tattooing and 14 questions were asked 3 months after tattooing.</p><p><strong>Results: </strong>According to all tests, all scores drastically decreased after corneal tattooing. In the HADS test, the mean preoperative depression score was 8.80, while the postoperative was 4.39 ( P <0.001). The mean preoperative anxiety score was 7.52, and the postoperative score was 4.41 ( P <0.001). The mean preoperative SAAS score was 50.64, with the postoperative score equaling 33.68 ( P <0.001). Finally, the mean preoperative BNFES score was 35.14, and the postoperative was 24.57 ( P <0.001). All values are statistically strongly significant ( P <0.001).</p><p><strong>Conclusion: </strong>Patients with corneal leukomas are at higher risk of significant depression and anxiety symptoms for many reasons, such as low vision, trauma, multiple surgery, strabismus, and ptosis. In conclusion, addressing corneal leukoma through appropriate ophthalmological interventions not only improves visual function but also alleviates appearance-related psychological distress. Integrating psychiatric assessment into the care process may further enhance the overall quality of life through a holistic, patient-centered approach.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"368-373"},"PeriodicalIF":2.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seasonal Variation in the Effect of Controlling Myopia Progression Using Orthokeratology.","authors":"Tao Tang, Yan Li, Mingwei Zhao, Kai Wang","doi":"10.1097/ICL.0000000000001205","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001205","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate seasonal variations in the effect of controlling myopia progression using orthokeratology (Ortho-K) in Chinese myopic children.</p><p><strong>Methods: </strong>One hundred sixteen myopic children aged 7 to 12 years who completed 1 year of Ortho-K treatment. Based on initial time wearing Ortho-K, subjects were classified as four groups: spring group (March-May), summer group (June-August), autumn group (September-November), and winter group (December-February). Axial length (AL) was measured every 3 months for 1 year by partial coherence interferometer. Axial elongation over time and between groups was compared.</p><p><strong>Results: </strong>The effect of myopia control using Ortho-K was influenced by seasonal variation. After adjusting study groups (type of Ortho-K), age, AL, spherical equivalent refractive error (SER), and ocular parameters at the baseline, the mean axial elongation over 1 year wearing Ortho-K was 0.33±0.08 mm for spring group, 0.30±0.10 mm for summer group, 0.21±0.08 mm for autumn group, and 0.22±0.09 mm for winter group (P<0.001). Statistically significantly higher mean axial elongation was observed in winter months than that in summer (0.09±0.06 mm vs. 0.05±0.05 mm, P<0.001).</p><p><strong>Conclusions: </strong>In general, axial elongation in myopic children receiving Ortho-K in summer months was approximately 56% of that in winter. Initial time wearing Ortho-K in autumn/winter months, the effect of myopia control is better than in spring/summer. Our results indicated that seasonal variation should be taken into account in studies related to Ortho-K.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in Corneal Epithelial Thickness and Higher-Order Aberrations Treated With a Newly Designed Orthokeratology Lens.","authors":"Tzu-Heng Weng, Wen-Pin Lin, Ting-Yi Lin, Ming-Cheng Tai, Ke-Hung Chien, Yu-Min Chang","doi":"10.1097/ICL.0000000000001201","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001201","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of a new orthokeratology (OrthoK) lens on corneal epithelial thickness and higher-order aberrations (HOAs).</p><p><strong>Methods: </strong>This three-arm, prospective, crossover study randomly assigned participants to the control group, T1 group (1.5× control-group lens-design reverse curve [RC] height), and T2 group (2× control-group lens-design RC height). Participants underwent basic ophthalmological examinations, corneal topography, and corneal epithelial thickness and HOA measurements at each visit. Corneal zones were analyzed based on topographic changes induced by lens wear, corresponding to the central treatment zone and the reverse zone.</p><p><strong>Results: </strong>The spherical equivalent was significantly lower in T1 and T2 than in the control group on days 7 and 28 of lens wear (P<0.001). The corneal curvature was noticeably flatter in T1 and T2 than in the control group. No significant differences were observed among groups in the epithelial thickness of the central treatment zone after OrthoK lens wear. However, epithelial thickness in the reverse zone was significantly greater (P<0.05) in T1 and T2 compared with the control group after 28 days of lens wear. A significant difference in HOA was observed among the three groups after OrthoK lens wear for 1 and 7 days (P<0.01). T2 demonstrated higher levels of HOA than the other groups.</p><p><strong>Conclusions: </strong>This new design of OrthoK can alter the corneal epithelium thickness and stabilize central corneal flattening, thereby achieving a better correction for myopia. However, this design also induces HOAs and is associated with a mild but significant compromise in uncorrected visual acuity compared with conventional designs. Therefore, clinicians should weigh the potential benefits of myopia control against the associated effects on visual quality when selecting OrthoK lens designs.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}