Vincenzo Barone, Daniele Petrini, Pier Luigi Surico, Sebastiano Nunziata, Claudia Scarani, Francesco Offi, Valentina Villani, Marco Coassin, Antonio Di Zazzo
{"title":"Profilometry-Guided Scleral Lenses Improve Visual Acuity and Reduce Ocular Aberrations in Irregular Corneas: A Retrospective Case Series.","authors":"Vincenzo Barone, Daniele Petrini, Pier Luigi Surico, Sebastiano Nunziata, Claudia Scarani, Francesco Offi, Valentina Villani, Marco Coassin, Antonio Di Zazzo","doi":"10.1097/ICL.0000000000001199","DOIUrl":"10.1097/ICL.0000000000001199","url":null,"abstract":"<p><strong>Objectives: </strong>Scleral lenses (SLs) represent a key treatment for visual rehabilitation in patients with irregular corneas, such as keratoconus (KC), pellucid marginal degeneration (PMD), and postlaser in situ keratomileusis (LASIK) ectasia. This study evaluates the impact of profilometry-guided SLs on visual acuity (VA) and ocular aberrations in these patients.</p><p><strong>Methods: </strong>Medical records of 23 eyes from 23 patients with KC, PMD, and post-LASIK ectasia were reviewed. All patients were fitted with profilometry-guided SLs. High-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA), and aberrometry parameters (Strehl ratio, higher-order root mean square (HO-RMS), coma, spherical aberration, and trefoil) were analyzed before and during SL wear.</p><p><strong>Results: </strong>HCVA improved significantly from 0.62±0.09 logMAR at baseline to 0.03±0.01 logMAR with SL wear ( P <0.05). LCVA also showed significant improvements ( P <0.05). HO-RMS decreased from 2.70±0.54 D to 1.00±0.20 D ( P <0.05), with notable reductions in coma (1.31±0.21 D to 0.49±0.04 D) and trefoil (1.26±0.29 D to 0.34±0.09 D).</p><p><strong>Conclusions: </strong>Profilometry-guided SLs significantly improve VA and reduce higher-order aberrations in patients with irregular corneas, offering an effective nonsurgical solution for enhancing vision quality in these complex cases.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"445-449"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimation of Tear Film Concentration of Oral Ciprofloxacin in Patients With Bacterial Keratitis.","authors":"Virendra Kumar Bagraniya, Manasi Tripathi, Nishat Hussain Ahmed, Rajesh Sinha, Namrata Sharma, Manpreet Kaur, Jeewan Singh Titiyal, Tushar Agarwal, Prafulla Maharana","doi":"10.1097/ICL.0000000000001212","DOIUrl":"10.1097/ICL.0000000000001212","url":null,"abstract":"<p><strong>Aims: </strong>To estimate the tear film concentration of oral ciprofloxacin in patients with bacterial keratitis and evaluate its correlation with various clinical factors.</p><p><strong>Method: </strong>This prospective intraindividual study enrolled 52 patients (104 eyes), each with unilateral, microbiologically confirmed bacterial keratitis (n=52 eyes); the fellow eye (n=52 eyes) served as the healthy control. The etiology of keratitis was confirmed by corneal scraping followed by detection of bacteria on Gram stain and bacterial culture. In addition to empirical therapy with topical fortified cefazolin 5% and tobramycin 1.3%, changing drugs if necessary, according to the antibiotic sensitivity report, these patients received oral ciprofloxacin 500 mg BD for 5 days. Tear samples were collected from infected and noninfected eyes, respectively, 3 hr after the morning dose of day 5. These samples underwent liquid chromatography and mass spectrometry to estimate concentration of ciprofloxacin in tear film.</p><p><strong>Result: </strong>Staphylococcus epidermidis was the most prevalent organism in our study (28.85%). The median ulcer area was 24 (4, 72) mm 2 . The median concentration of ciprofloxacin in tear samples from infected eyes was 547 (10.9, 3,490) ng/mL. In the noninfected eyes, the median concentration was 461 (3.86, 1730) ng/mL. The median concentration of ciprofloxacin in infected eyes was comparable with the minimum inhibitory concentration (MIC) for Staphylococcus species. Drug concentration in tear film had a strong positive correlation with ulcer area (Spearman rho=0.957; P =0.02) but weak positive correlation with the presence of infection (Spearman rho=0.245; P =0.08).</p><p><strong>Conclusion: </strong>Oral ciprofloxacin reaches tear concentration similar to the reported MIC of staphylococcus species, therefore is a promising adjuvant to topical therapy in staphylococcal keratitis. Further larger scale, comparative studies are warranted to ascertain the same.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"470-474"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Responses to Questions About Keratoconus Using ChatGPT-4.0, Google Gemini, and Microsoft Copilot: A Comparative Study of Large Language Models on Keratoconus.","authors":"Ibrahim Nagmeldin Hassan","doi":"10.1097/ICL.0000000000001217","DOIUrl":"10.1097/ICL.0000000000001217","url":null,"abstract":"","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"478"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temporal Changes in Tear Film Stability With Four Dry Eye Eyedrops in Healthy Subjects.","authors":"Manabu Suzutani, Hiroki Maehara, Shizuka Koh, Ryo Mukai, Tetsuju Sekiryu","doi":"10.1097/ICL.0000000000001227","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001227","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare temporal changes in tear meniscus height (TMH) and noninvasive tear film break-up time after the instillation of four dry eye treatments: artificial tears (AT), 3% diquafosol sodium long-acting (DQL), 3% diquafosol sodium (DQS), and rebamipide (RB).</p><p><strong>Methods: </strong>Sixty healthy eyes were randomly divided into four treatment groups. The TMH and noninvasive tear film break-up time were measured using a noninvasive tear film analysis device at baseline and 1, 5, 15, 30, 60, 120, and 180 min after instillation.</p><p><strong>Results: </strong>TMH and noninvasive tear film break-up time did not show significant differences among the groups. In the AT and RB groups, TMH increased significantly 1 min after instillation compared with baseline. In the DQS group, TMH remained elevated for up to 60 min, whereas the DQL group showed a more prolonged increase, lasting up to 120 min. For the noninvasive tear film break-up time, significant prolongation was observed only at 5 and 15 min after instillation in the DQL group.</p><p><strong>Conclusions: </strong>Topical instillation of 3% diquafosol ophthalmic solution effectively increased tear volume on the ocular surface, with the long-acting DQL formulation demonstrating a more sustained effect in healthy eyes.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Sport-Tinted Performance Lenses: New? Improved?","authors":"Karl Citek, Alan W Reichow","doi":"10.1097/ICL.0000000000001220","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001220","url":null,"abstract":"","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"OTC: Over the Counter, or Open to Contamination? A Review of Over-the-Counter Lubricating Eye Drops Safety.","authors":"Sarah Y Kim, Kevin Xu, Thomas L Steinemann","doi":"10.1097/ICL.0000000000001224","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001224","url":null,"abstract":"<p><strong>Abstract: </strong>This review examines how gaps within the Food and Drug Administration's|Food and Drug Administration (FDA) regulatory oversight, manufacturing standards, and bottle design requirements contributed to over-the-counter (OTC) eye drop contamination and subsequent product recalls. We also discuss recent growth in the number of patients with dry eye diseases and explosion of electronic commerce (e-commerce) retailers that has created new channels for the widespread circulation of unsafe eye drops. Considering the ongoing FDA recalls, we outline actionable strategies for providers and patients and the role that advocacy organizations play in closing the gaps in OTC eye drop safety.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ngozika Esther Ezinne, Michael Agyemang Kwarteng, Uchechukwu Levi Osuagwu, Khathutshelo Percy Mashige
{"title":"Diagnosis and Management of Keratoconus: A Survey of Trinidad and Tobago Optometrists.","authors":"Ngozika Esther Ezinne, Michael Agyemang Kwarteng, Uchechukwu Levi Osuagwu, Khathutshelo Percy Mashige","doi":"10.1097/ICL.0000000000001222","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001222","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the diagnostic and management practices of optometrists in Trinidad and Tobago (T&T) for keratoconus (KC), and to identify barriers affecting clinical care.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted between July and December 2023 among registered optometrists in T&T using a validated questionnaire. Data were collected on diagnostic approaches, treatment strategies, referral behaviors, and perceived challenges. Descriptive statistics and chi-square tests were used for analysis, with significance set at P<0.05.</p><p><strong>Results: </strong>Of the 108 respondents, 57.4% were women and 50.0% identified as Indo-Trinidadian. While 64.8% reported diagnosing at least five KC cases annually, only 17.6% had access to corneal topography. Most practitioners (78.7%) relied on clinical examination and patient-reported symptoms for the diagnosis of KC. Rigid gas permeable (RGP) lenses were seldomly used for KC management, as 66.7% reported they did not fit RGP lenses, with cost identified as the main barrier (53.7%) to RGP use. Only 36.1% reported co-managing KC cases with ophthalmologists. Regression analysis revealed that Optometrists with ≥5 years of experience were significantly more likely to diagnose KC more frequently compared to those with less than 5 years of practice experience (OR: 4.74; 95% CI: 1.99-11.31; P = 0.001).</p><p><strong>Conclusions: </strong>Optometrists in T&T play a crucial role in KC care despite resource limitations. The development of national guidelines is urgently needed to standardize diagnosis, management, and referral pathways.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two Cases of Polymicrobial Keratitis Involving Distinct and Unusual Anaerobes.","authors":"Erin F Cohn, Thomas L Steinemann","doi":"10.1097/ICL.0000000000001225","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001225","url":null,"abstract":"<p><strong>Abstract: </strong>Corneal infection is a leading cause of blindness globally. Prompt identification of the causative microbe and initiation of appropriate antimicrobial agents is essential for preserving vision. However, diagnosis can be hampered by lengthy microbiological culture and the failure of empiric antibiotic treatment to target rare, aggressive microbes. This case series describes two patients with keratitis, one involving infection with the anaerobic bacteria Eikenella corrodens and the other involving Capnocytophaga species. In both cases, the anaerobes were isolated as a part of polymicrobial infections and required antibiotic treatment tailored to their susceptibility profiles. Despite this effort, both infections resulted in permanent vision loss.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Monitoring of an Intracorneal Bee Stinger Using Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy.","authors":"Banu Bozkurt, Nicat Huseynli, Ayşe Bozkurt Oflaz, Özlem Evren Kemer","doi":"10.1097/ICL.0000000000001223","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001223","url":null,"abstract":"<p><strong>Abstract: </strong>A 19-year-old male patient presented to our clinic with complaints of foreign-body sensation, pain, redness, tearing, and decreased vision in the right eye. One day prior, a bee struck his eye while he was riding a motorcycle. Biomicroscopic examination of the right eye showed periorbital edema, chemosis, ciliary injection, corneal edema with radiating Descemet folds, paracentral corneal infiltrate, and a brown needle-like foreign body resembling a bee stinger. Anterior segment optical coherence tomography (AS-OCT) confirmed corneal edema with Descemet folds, whereas in vivo confocal microscopy (IVCM) revealed multiple hyporeflective, round cyst-like structures within the superficial corneal epithelium, hyperreflective, round inflammatory cells around the subbasal nerves, a honeycomb pattern, and a hyperreflective, needle-like linear opacity in the stroma. The patient was treated with topical moxifloxacin 0.5%, dexamethasone 0.1%, and fluconazole 0.2% eye drops and oral moxifloxacin (400 mg) and cetirizine (10 mg) tablets. The patient's signs and symptoms improved significantly within 1 week. At the 18-month examination, the patient's vision was 20/20, with only a faint stromal opacity remaining. No stinger fragments were detected on biomicroscopic examination, AS-OCT, or IVCM examination. Anterior segment optical coherence tomography and IVCM are highly valuable for monitoring corneal edema, inflammation, cellular changes, and the embedded stinger within the cornea throughout the follow-up period.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah P Ngo, Odette M Houghton, Dharmendra R Patel, Eric R Kawulok, Joanne F Shen
{"title":"Scleral Lens and Suture Erosion in Scleral-Sutured Posterior Chamber Intraocular Lens.","authors":"Hannah P Ngo, Odette M Houghton, Dharmendra R Patel, Eric R Kawulok, Joanne F Shen","doi":"10.1097/ICL.0000000000001221","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001221","url":null,"abstract":"<p><strong>Abstract: </strong>This case series reports two cases of scleral lens (SL)-associated suture erosion of polytetrafluoroethylene CV-8 (Gore-Tex, Newark, DE) in scleral-sutured CZ70BD (Alcon, Fort Worth, TX) posterior chamber intraocular lens (SS-PCIOL). Suture erosion after SS-PCIOL has been reported in two of the patients who were fitted with SL for visual acuity improvement. Erosion was corrected in both cases with suture repositioning and corneal patch graft, with one patient requiring the exchange of the intraocular lens. The other patient was able to transition to an SL of a different size parameter. Scleral lens fitting should consider the position of haptic placement in relation to the suture site and be monitored for suture erosion postoperatively. A scleral flap or corneal tissue patch graft may be needed for patients who have scleral thinning from prior surgery.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}