Eye & Contact Lens-Science and Clinical Practice最新文献

{"title":"Exploring New and Global Therapeutic Options for Dry Eye Disease: What You Need to Know.","authors":"Shizuka Koh","doi":"10.1097/ICL.0000000000001171","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001171","url":null,"abstract":"<p><strong>Abstract: </strong>Dry eye disease (DED) is a complex condition characterized by the loss of tear film homeostasis, resulting in ocular symptoms, inflammation, and damage. Managing DED involves a diverse range of therapies aimed at alleviating symptoms and addressing underlying causes. This review provides a comprehensive update on current DED treatments, focusing on medications approved by the United States (US) Food and Drug Administration and notable treatments available outside the United States. Differences in treatment approaches between Asian and Western countries have been explored, highlighting the need for a nuanced understanding of regional variations. The Asia Dry Eye Society offers a new perspective on dry eye, further elucidating these regional distinctions. This review emphasizes the importance of staying informed about evolving treatment guidelines and advancements in DED therapeutics. As the field progresses with new and innovative therapies, there is increased potential for improved patient management and enhanced quality of life for individuals affected by DED.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Insulin in Artificial Tears Stability Study: Short-term Physical, Chemical and Microbiological Stability Study of 0.5 Units (25 IU/mL) of Topical Insulin in Artificial Tears.","authors":"Mae-Lynn Catherine Bastion, Wan Haslina Wan Abdul Halim, Mazlina Mohd Said, Birinder Kaur Sadu Singh, Azura Abdul Ghani","doi":"10.1097/ICL.0000000000001175","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001175","url":null,"abstract":"<p><strong>Objectives: </strong>Topical insulin (TI) at 25 IU/mL effectively normalizes healing of corneal epithelium and dry eye in diabetic patients. We aim to determine physicochemical stability and sterility of TI in sodium hyaluronate 0.18% (TI-artificial tears [AT]) in an eye drop formulation.</p><p><strong>Methods: </strong>The physicochemical stability of TI-AT at 5°C±3°C and 30°C±2°C in sterile low-density polyethylene bottles was studied. Samples were put in conditions of simulated use and analyzed weekly for stability parameters (visual inspection, turbidity, ultraviolet spectral absorption, osmolality, and pH) and culture growth. Insulin was quantified using the stability-indicating high-performance liquid chromatographic method with diode-array detection with RP-C18 column, o-nitrophenol as an internal standard, and ultraviolet detection at 214 nm. Stability was set according to British Pharmacopoeia with 90% to 110% of initial concentration (with 95% confidence interval) considered acceptable.</p><p><strong>Results: </strong>All tested physicochemical and sterility parameters remained stable for 1 month in both temperature conditions with stable TI concentrations.</p><p><strong>Conclusion: </strong>Topical insulin-artificial tears is stable in both room temperature and refrigeration. Topical insulin-artificial tears can be prescribed with a 1-month shelf life.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Safety and Efficacy of Orthokeratology Contact Lenses With Toric Peripheral Curves: A Review of the Literature.","authors":"Langis Michaud, Jennifer Harthan, Ayda Shahidi, Marjorie Rah, William Reindel","doi":"10.1097/ICL.0000000000001174","DOIUrl":"https://doi.org/10.1097/ICL.0000000000001174","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical safety and efficacy of orthokeratology (OK) lenses with toric peripheral curves (TPCs), based on a review of published literature.</p><p><strong>Methods: </strong>A literature search on OK lenses with TPCs using 11 relevant search term combinations was conducted. Databases included PubMed, Cochrane Online Library, Prospero International Prospective Register of Systematic Reviews, and Embase. The period covered was January 1, 2012, to May 1, 2024.</p><p><strong>Results: </strong>In total, 600 publications were identified in the search databases using the search criteria. Based on titles and abstracts, 52 distinct articles were identified for further review; of these, 16 were determined related to clinical evaluation of OK lenses with TPCs. The published studies involved five different lens models from five different manufacturers: Menicon Z Night Toric (Menicon Co, Ltd, Nagoya, Japan), Euclid Emerald Toric (Euclid Systems Corporation, Herndon, VA), Lucid Night Ortho-K Toric (Lucid Korea, Seoul, Korea), Dual Axis Corneal Refractive Therapy (Paragon Vision Sciences, Gilbert, AZ), and Eyebright Base Curve Aspheric Ortho-K (Eyebright Medical Technology Co, Ltd, Beijing, China).</p><p><strong>Conclusions: </strong>Published literature suggests that OK lenses with TPCs are effective in treating patients with both myopia and astigmatism, with favorable safety profiles.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Survey Using NEI VFQ-25 in Japanese Patients With Fuchs Endothelial Corneal Dystrophy.","authors":"Keiko Yamada, Yoshinori Oie, Nozomi Nishida, Sayo Maeno, Chifune Kai, Masahiro Kitao, Reiko Kobayashi, Takeshi Soma, Shizuka Koh, Ryo Kawasaki, Kohji Nishida","doi":"10.1097/ICL.0000000000001159","DOIUrl":"10.1097/ICL.0000000000001159","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the quality of life in Japanese patients with Fuchs endothelial corneal dystrophy (FECD) using The National Eye Institute Visual Function Questionnaire.</p><p><strong>Methods: </strong>Here, 34 patients with FECD (FECD group) and 13 healthy individuals (control group) completed the National Eye Institute Visual Function Questionnaire Japanese version by interview format. The association between dominant eye corrected distance visual acuity and composite score (component 11) or subscales in the FECD group was evaluated using Spearman rank correlation coefficient.</p><p><strong>Results: </strong>The average age was 65.8±11.9 and 60.1±7.9 years in the FECD and control groups, respectively. Corrected distance visual acuity was significantly lower in the FECD group (0.021±0.21 logarithm of the minimum angle of resolution) than in the control group (-0.61±0.055 logarithm of the minimum angle of resolution) ( P <0.0001). Composite scores were significantly lower in the FECD group (77.6±11.0) than in the control group (89.2±7.0) ( P =0.0006). All subscale scores were lower in the FECD group, particularly for distance vision and mental health (81.4±13.1 and 84.0±15.6, respectively) than in the control group (90.7±12.0 and 95.7±5.7) ( P =0.022 and P =0.0046, respectively). Corrected distance visual acuity in the dominant eye did not significantly correlate with composite scores or subscales in the FECD group.</p><p><strong>Conclusions: </strong>Quality of life is lower in patients with FECD than in healthy individuals, particularly regarding distance vision and mental health.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e135-e141"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piggyback Scleral Contact Lens to Enhance Cosmesis and Comfort in Uniocular Stevens-Johnson Syndrome.","authors":"Madhumathi Subramanian, Janani Balaji","doi":"10.1097/ICL.0000000000001143","DOIUrl":"10.1097/ICL.0000000000001143","url":null,"abstract":"<p><strong>Abstract: </strong>Stevens-Johnson syndrome often results in a significant reduction in vision, dryness, and photophobia based on severity. Scleral lenses are well-considered visual interventions that enhance vision and comfort, resulting in an increased quality of life for patients. This case report describes the enhancement of comfort, cosmesis, and reduction of photophobia using a piggyback system (scleral contact lenses over a prosthetic contact lens), whereas the other modalities were unsatisfactory.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e157-e159"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Responses to Questions About Keratoconus Using ChatGPT-4.0, Google Gemini and Microsoft Copilot: A Comparative Study of Large Language Models on Keratoconus.","authors":"Suleyman Demir","doi":"10.1097/ICL.0000000000001158","DOIUrl":"10.1097/ICL.0000000000001158","url":null,"abstract":"<p><strong>Objectives: </strong>Large language models (LLMs) are increasingly being used today and are becoming increasingly important for providing accurate clinical information to patients and physicians. This study aimed to evaluate the effectiveness of generative pre-trained transforme-4.0 (ChatGPT-4.0), Google Gemini, and Microsoft Copilot LLMs in responding to patient questions regarding keratoconus.</p><p><strong>Methods: </strong>The LLMs' responses to the 25 most common questions about keratoconus asked by real-life patients were blindly rated by two ophthalmologists using a 5-point Likert scale. In addition, the DISCERN scale was used to evaluate the responses of the language models in terms of reliability, and the Flesch reading ease and Flesch-Kincaid grade level indices were used to determine readability.</p><p><strong>Results: </strong>ChatGPT-4.0 provided more detailed and accurate answers to patients' questions about keratoconus than Google Gemini and Microsoft Copilot, with 92% of the answers belonging to the \"agree\" or \"strongly agree\" categories. Significant differences were observed between all three LLMs on the Likert scale ( P <0.001).</p><p><strong>Conclusions: </strong>Although the answers of ChatGPT-4.0 to questions about keratoconus were more complex for patients than those of other language programs, the information provided was reliable and accurate.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e107-e111"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact on Distance and Near Contrast Sensitivity of Multifocal Contact Lenses: A Systematic Review.","authors":"Kevin J Mena-Guevara, Dolores de Fez, David P Piñero","doi":"10.1097/ICL.0000000000001149","DOIUrl":"10.1097/ICL.0000000000001149","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact on distance and near contrast sensitivity (CS) after fitting multifocal contact lenses (MFCLs) for presbyopia correction according to the scientific evidence already published.</p><p><strong>Methods: </strong>Three bibliographic search was conducted on PubMed, Web of Sciences, and Scopus. Inclusion criteria were articles written in English evaluating distance and/or near CS in presbyopic patients using MFCLs, controlled clinical trials, and articles published from 2000 to 2024. After reading and analyzing carefully the articles that were finally included, the Critical Appraisal Skills Programme (CASP) tool for clinical trials was used to evaluate the quality of the research.</p><p><strong>Results: </strong>A total of eight articles were considered. One study did not find significant changes in binocular contrast sensitivity function (CSF) after fitting center-distance MFCL (CD) in the dominant eye and a center-near (CN) in the nondominant eye. Another research did not detect significant differences comparing CN MFCLs with monovision. However, another study found significant differences when comparing CN MFCL with spectacles. Half of studies only reported the comparison in CSF among different MFCL designs, with two studies confirming worse visual performance with MFCLs compared to pinhole contact lenses. Concerning the CASP analysis, some level of variability in the quality scores was found, with 5/13 in three studies, 6/13 in three studies, 7/13 in one study, and 8/13 in one study.</p><p><strong>Conclusions: </strong>The limited evidence on the impact on CS of using MFCLs does not allow to extract consistent generalizable conclusions, with only three studies suggesting a variable impact and no evidence of the real clinical benefit of using this metric for the evaluation and optimization of MFCL fitting. More research is needed on this topic.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e117-e122"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Contact Lens Regulations in the Asia Pacific Region.","authors":"Jie Rong Jerome Lee, Ting Hui Yee, David Levitz, Blanche Xiao Hong Lim, Jodhbir Singh Mehta, Fiona Stapleton, Chris Hong Long Lim","doi":"10.1097/ICL.0000000000001150","DOIUrl":"10.1097/ICL.0000000000001150","url":null,"abstract":"<p><strong>Abstract: </strong>The increased usage of nonrefractive cosmetic contact lenses in Asia and a trend toward increased online purchasing of both refractive and cosmetic contact lenses poses unique challenges in the management of contact lens-related complications. However, regulations have lagged behind this increased uptake in the community. This paper reviews regulations surrounding the manufacturing, import, and distribution of contact lenses in the Asia Pacific region and compares them with international regulations from the European Union and United States. It found a need for more specific regulations and closer surveillance targeted at new trends in contact lens purchasing and usage. This paper also found a need for more effective enforcement of current regulations.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e149-e156"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Doctors: Performance of Chatbots as a Tool for Patient Education on Keratoconus.","authors":"Zeynep Özer Özcan, Levent Doğan, Ibrahim Edhem Yilmaz","doi":"10.1097/ICL.0000000000001160","DOIUrl":"10.1097/ICL.0000000000001160","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to compare the answers given by ChatGPT, Bard, and Copilot and that obtained from the American Academy of Ophthalmology (AAO) website to patient-written questions related to keratoconus in terms of accuracy, understandability, actionability, and readability to find out whether chatbots can be used in patient education.</p><p><strong>Methods: </strong>Twenty patient-written questions obtained from the AAO website related to keratoconus were asked to ChatGPT, Bard, and Copilot. Two ophthalmologists independently assessed the answers obtained from chatbots and the AAO website in terms of accuracy, understandability, and actionability according to the Structure of Observed Learning Outcome taxonomy, Patient Education Materials Assessment Tool-Understandability, and Patient Education Materials Assessment Tool-Actionability tests, respectively. The answers were also compared for readability according to the Flesch Reading Ease scores obtained through the website.</p><p><strong>Results: </strong>Bard had significantly higher scores compared with ChatGPT-3.5, Copilot, and AAO website according to Structure of Observed Learning Outcome taxonomy and Patient Education Materials Assessment Tool-Understandability ( P <0.001 for each), whereas there was no significant difference between the other groups. Bard and ChatGPT achieved significantly higher scores than the AAO website according to the Patient Education Materials Assessment Tool-Actionability scale ( P =0.001). The AAO website achieved significantly higher scores than the Bard on the Flesch Reading Ease scale, whereas there was no significant difference between the other groups ( P =0.017).</p><p><strong>Conclusion: </strong>Chatbots are promising to provide accurate, understandable, and actionable answers. Chatbots can be a valuable aid in the education of patients with keratoconus under clinician supervision. In this way, unnecessary hospital visits can be prevented, and the burden on the health care system can be alleviated, while patient awareness can be raised.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e112-e116"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Meibomian Gland Dysfunction by Classical Eyelid Hygiene Measures With and Without Additional Lipid Substitution for Tear Film Stabilization.","authors":"Isabel Weinstein, Augustin Kelava, Dieter Dausch, Berthold Seitz","doi":"10.1097/ICL.0000000000001155","DOIUrl":"10.1097/ICL.0000000000001155","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to document the treatment success of eyelid hygiene with liposomal suspension using new diagnostic tools and to determine whether additional lipid substitution provided measurable benefits in meibomian gland dysfunction.</p><p><strong>Methods: </strong>A single-center controlled, partially single masked study was conducted. Group A used eyelid hygiene only, whereas group B additionally applied a liposomal eye spray. Subjective perception using the Ocular Surface Disease Index (OSDI) questionnaire, measurement of tear film osmolarity, noninvasive tear film break-up time, assessment of the lipid layer, meibography, inspection of lid margins, assessment of the meibomian glands, and measurement of matrix-metallopeptidase-9 were collected at baseline and after 12 weeks.</p><p><strong>Results: </strong>Eighty-two patients were included and randomized into two groups. Both groups showed a decrease in OSDI score ( P <0.001), an increase in lipid layer thickness ( P <0.001), significant improvement in the degree of loss of meibomian glands ( P <0.001), in the damage pattern of the eyelid margins ( P <0.001), in the quality of meibomian gland secretion, and in matrix-metallopeptidase-9 after 12 weeks.</p><p><strong>Conclusions: </strong>Our study confirms the success of treatment with eyelid hygiene measures using a liposomal suspension. The additional benefit of lipid substitution was not significant after 12 weeks of treatment.</p>","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":"e123-e128"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}