Temporal Changes in Tear Film Stability With Four Dry Eye Eyedrops in Healthy Subjects.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-09-24 DOI:10.1097/ICL.0000000000001227

Manabu Suzutani, Hiroki Maehara, Shizuka Koh, Ryo Mukai, Tetsuju Sekiryu

{"title":"Temporal Changes in Tear Film Stability With Four Dry Eye Eyedrops in Healthy Subjects.","authors":"Manabu Suzutani, Hiroki Maehara, Shizuka Koh, Ryo Mukai, Tetsuju Sekiryu","doi":"10.1097/ICL.0000000000001227","DOIUrl":null,"url":null,"abstract":"Objectives: This study aimed to compare temporal changes in tear meniscus height (TMH) and noninvasive tear film break-up time after the instillation of four dry eye treatments: artificial tears (AT), 3% diquafosol sodium long-acting (DQL), 3% diquafosol sodium (DQS), and rebamipide (RB).Methods: Sixty healthy eyes were randomly divided into four treatment groups. The TMH and noninvasive tear film break-up time were measured using a noninvasive tear film analysis device at baseline and 1, 5, 15, 30, 60, 120, and 180 min after instillation.Results: TMH and noninvasive tear film break-up time did not show significant differences among the groups. In the AT and RB groups, TMH increased significantly 1 min after instillation compared with baseline. In the DQS group, TMH remained elevated for up to 60 min, whereas the DQL group showed a more prolonged increase, lasting up to 120 min. For the noninvasive tear film break-up time, significant prolongation was observed only at 5 and 15 min after instillation in the DQL group.Conclusions: Topical instillation of 3% diquafosol ophthalmic solution effectively increased tear volume on the ocular surface, with the long-acting DQL formulation demonstrating a more sustained effect in healthy eyes.","PeriodicalId":50457,"journal":{"name":"Eye & Contact Lens-Science and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye & Contact Lens-Science and Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ICL.0000000000001227","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study aimed to compare temporal changes in tear meniscus height (TMH) and noninvasive tear film break-up time after the instillation of four dry eye treatments: artificial tears (AT), 3% diquafosol sodium long-acting (DQL), 3% diquafosol sodium (DQS), and rebamipide (RB).

Methods: Sixty healthy eyes were randomly divided into four treatment groups. The TMH and noninvasive tear film break-up time were measured using a noninvasive tear film analysis device at baseline and 1, 5, 15, 30, 60, 120, and 180 min after instillation.

Results: TMH and noninvasive tear film break-up time did not show significant differences among the groups. In the AT and RB groups, TMH increased significantly 1 min after instillation compared with baseline. In the DQS group, TMH remained elevated for up to 60 min, whereas the DQL group showed a more prolonged increase, lasting up to 120 min. For the noninvasive tear film break-up time, significant prolongation was observed only at 5 and 15 min after instillation in the DQL group.

Conclusions: Topical instillation of 3% diquafosol ophthalmic solution effectively increased tear volume on the ocular surface, with the long-acting DQL formulation demonstrating a more sustained effect in healthy eyes.

查看原文本刊更多论文

四种干眼滴眼液对健康受试者泪膜稳定性的影响。

目的：比较人工泪液（AT）、3%长效双喹泊钠（DQL）、3%长效双喹泊钠（DQS）和利巴米胺（RB） 4种干眼治疗后泪液半月板高度（TMH）和无创泪膜破裂时间的变化。方法：60只健康眼随机分为4个治疗组。使用无创泪膜分析仪在基线和滴入后1、5、15、30、60、120和180 min测量TMH和无创泪膜破裂时间。结果：两组间TMH和无创撕裂膜破裂时间差异无统计学意义。与基线相比，AT组和RB组在给药后1 min TMH显著增加。在DQS组中，TMH升高持续时间长达60分钟，而DQL组的升高时间更长，持续时间长达120分钟。对于无创撕裂膜破裂时间，DQL组仅在滴入后5和15分钟显著延长。结论：局部滴注3%双萘酚眼液可有效增加眼表泪液体积，长效DQL配方在健康眼睛中效果更持久。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.