Economic Cost Analysis of Acanthamoeba Keratitis Among Contact Lens Wearers.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI:10.1097/ICL.0000000000001216

Dereje Hayilu Anbesse, Stephanie Yeo, Bryan Chong, Blake Angell, Fiona Stapleton, Constantinos Petsoglou, Nicole Ann Carnt

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Abstract

Objectives: This study aimed to estimate direct and indirect economic costs associated with Acanthamoeba keratitis and explore variations in individual and healthcare characteristics.

Methods: Patients treated at Moorfields Eye Hospital, UK, between January 2011 and August 2014 were surveyed. Patients were included if they had a confirmed diagnosis and wore contact lenses. Direct costs included healthcare expenses, whereas indirect costs encompassed lost wages for patients and caregivers. The Mann-Whitney U test and generalized linear models were used to analyze cost data and their associated factors, with P <0.05 being considered statistically significant.

Results: A total of 73 patients were included, with a mean age of 39.3 years (19-81); 40 patients (54.8%) were female, and 41 (56.2%) had good outcomes. Median direct, indirect, and total costs were £2,966.5 (IQR £5,553.2), £1,776.0 (IQR £3,223.3), and £6,678.6 (IQR £17,268.4), respectively. Higher direct costs were independently associated with multiple medical visits ( P <0.001), steroids before antiamoeba therapy ( P =0.042), and keratoplasty ( P <0.001).

Conclusions: The cost of managing Acanthamoeba keratitis is substantial. Future research should focus on optimizing treatment strategies and improving patient outcomes to help alleviate the financial burden on patients and healthcare systems.

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隐形眼镜佩戴者棘阿米巴角膜炎的经济成本分析。

目的：本研究旨在估计与棘阿米巴角膜炎相关的直接和间接经济成本，并探讨个体和医疗保健特征的变化。方法：对2011年1月至2014年8月在英国Moorfields眼科医院就诊的患者进行调查。确诊并佩戴隐形眼镜的患者被纳入研究范围。直接成本包括医疗费用，而间接成本包括患者和护理人员的工资损失。采用Mann-Whitney U检验和广义线性模型对成本数据及其相关因素进行分析，结果：共纳入73例患者，平均年龄39.3岁（19-81岁）；40例（54.8%）为女性，41例（56.2%）预后良好。直接、间接和总成本的中位数分别为2966.5英镑（5553.2英镑）、1776.0英镑（32223.3英镑）和6678.6英镑（17268.4英镑）。较高的直接成本与多次就诊独立相关(结论：处理棘阿米巴角膜炎的成本是可观的。未来的研究应侧重于优化治疗策略和改善患者的结果，以帮助减轻患者和医疗保健系统的经济负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.