Causal Relationship Between Gut Microbiota and Cataract: A Two-Sample Bidirectional Mendelian Randomization Study.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI:10.1097/ICL.0000000000001209

Han-Dan Xiao, Ji-Ang Li, Chen-Han Zhou, Yi Zhang

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引用次数: 0

Abstract

Purpose: To identify the causal relationship between the gut microbiota and cataracts using a two-sample Mendelian randomization (MR) approach.

Methods: Genetic instrumental variables for gut microbiota were derived from a genome-wide association study (GWAS) of 18,340 participants. The aggregated statistics for cataracts, which involved 8,890 cases and 454,120 controls, were also obtained from GWAS. In addition, the inverse variance weighted method served as the primary analysis. Moreover, the weighted median method, MR-Egger regression, and MR Multieffect residual and outlier tests were performed to test the robustness of our results.

Results: Ultimately, we found a suggestive association between five bacterial traits and cataract risk: the ChristensenellaceaeR.7 group ( P =0.00175, odds ratio [OR]=0.995, 95% confidence interval [CI]: 0.991-0.998), Sellimonas ( P =0.0309, OR=0.998, 95% CI: 0.997-1.000), and Eubacterium ruminantium group ( P =0.0498, OR=0.998, 95% CI: 0.997-1.000) were negatively correlated with cataract, whereas Eggerthella ( P =0.0157, OR=1.002, 95% CI: 1.000-1.005) and Odoribacter ( P =0.0471, OR=1.004, 95% CI: 1.000-1.007) were positively associated with cataract. Heterogeneity was not observed in any of the five bacteria.

Conclusions: Our analysis provides evidence supporting a potential causal relationship between the gut microbiota and cataract risk. However, more research is needed to further elaborate on how gut microbiota affects cataract development.

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肠道菌群与白内障的因果关系：一项双样本双向孟德尔随机研究。

目的：采用双样本孟德尔随机化（MR）方法确定肠道微生物群与白内障之间的因果关系。方法：肠道微生物群的遗传工具变量来自18340名参与者的全基因组关联研究（GWAS）。GWAS还获得了8,890例白内障和454,120例对照白内障的汇总统计数据。采用方差逆加权法进行初步分析。此外，我们还采用加权中位数法、MR- egger回归、MR多效应残差和离群值检验来检验结果的稳健性。结果：最终，我们发现了五种细菌特征与白内障风险之间的相关性：christensenellacaer。7组（P=0.00175，优势比[OR]=0.995, 95%可信区间[CI]: 0.991-0.998）、沙门氏菌组（P=0.0309， OR=0.998, 95% CI: 0.997-1.000）和反刍真杆菌组（P=0.0498， OR=0.998, 95% CI: 0.997-1.000）与白内障呈负相关，而蛋菌组（P=0.0157， OR=1.002, 95% CI: 1.000-1.005）和臭杆菌组（P=0.0471， OR=1.004, 95% CI: 1.000-1.007）与白内障呈正相关。在五种细菌中均未观察到异质性。结论：我们的分析提供了支持肠道微生物群和白内障风险之间潜在因果关系的证据。然而，需要更多的研究来进一步阐明肠道微生物群如何影响白内障的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.