Fetal and Pediatric Pathology最新文献_第8页

Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age. 南印度适龄和小胎龄新生儿胎盘中igf轴基因甲基化状态

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2280660

Nithya M N, Krishnappa J, Sheela S R, Venkateswarlu Raavi

{"title":"Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age.","authors":"Nithya M N, Krishnappa J, Sheela S R, Venkateswarlu Raavi","doi":"10.1080/15513815.2023.2280660","DOIUrl":"10.1080/15513815.2023.2280660","url":null,"abstract":"Objective: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women.Methods: Placental samples were collected from AGA (n = 40) and SAG (n = 40) neonates. The methylation of IGF-axis genes promoter was analyzed using MS-PCR.Results: IGF2, H19, IGF1, and IGFR1 genes promoter methylation was 2.5, 1.5, 5, and 7.5% lower in SGA compared to AGA, respectively. Co-methylation of IGF-axis genes promoter was 40% and 20% in AGA and SGA, respectively. IGF-axis gene promoter methylation significantly (p < 0.05) influenced the levels of IGFBP3 protein, birth weight, mitotic index, gestational weeks, and IGFR1 and IGFR2 gene expression.Conclusion: IGF-axis genes methylation was lower in SGA than in AGA, and the methylation significantly influenced the IGF-axis components.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"5-20"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Role of a Pediatric Pathologist during and after a Disaster. 儿童病理学家在灾难期间和之后的作用。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2285578

Randall Craver

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Magnitude and Determinants of Intestinal Parasites among Children under Five in Ethiopia During 2010-2023: A Systematic Review and Meta-Analysis. 2010-2023年埃塞俄比亚5岁以下儿童肠道寄生虫数量和决定因素:系统回顾和荟萃分析

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2284920

Abayeneh Girma, Amere Genet

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Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade. 人类胎盘与先兆子痫病理变化的演变：近十年的综合回顾。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2274823

Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru

{"title":"Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade.","authors":"Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru","doi":"10.1080/15513815.2023.2274823","DOIUrl":"10.1080/15513815.2023.2274823","url":null,"abstract":"The placenta, the foremost and multifaceted organ in fetal and maternal biology, is pivotal in facilitating optimal intrauterine fetal development. Remarkably, despite its paramount significance, the placenta remains enigmatic, meriting greater comprehension given its central influence on the health trajectories of both the fetus and the mother. Preeclampsia (PE) and intrauterine fetal growth restriction (IUGR), prevailing disorders of pregnancy, stem from compromised placental development. PE, characterized by heightened mortality and morbidity risks, afflicts 5-7% of global pregnancies, its etiology shrouded in ambiguity. Pertinent pathogenic hallmarks of PE encompass inadequate restructuring of uteroplacental spiral arteries, placental ischemia, and elevated levels of vascular endothelial growth factor receptor-1 (VEGFR-1), also recognized as soluble FMS-like tyrosine kinase-1 (sFlt-1). During gestation, the placental derivation of sFlt-1 accentuates its role as an inhibitory receptor binding to VEGF-A and placental growth factor (PlGF), curtailing target cell accessibility. This review expounds upon the placenta's defining cellular component of the trophoblast, elucidates the intricacies of PE pathogenesis, underscores the pivotal contribution of sFlt-1 to maternal pathology and fetal safeguarding, and surveys recent therapeutic strides witnessed in the past decade.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"33-46"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ectopic Salivary Glands - a Differential Diagnosis to a Thyroglossal Duct Cyst. 异位唾液腺——甲状腺舌管囊肿的鉴别诊断。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2266035

Thomas Menter, Stefan Holland-Cunz

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Placental Histopathologic Findings in Fetal Hereditary Pyropoikilocytosis after Undergoing Successful Intrauterine Transfusion 成功接受宫内输血后胎儿遗传性成纤维细胞增多症的胎盘组织病理学结果

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2023-12-18 DOI: 10.1080/15513815.2023.2293739

Anna Dar, Rachel Brancamp, Garrett S. Booth, Caitlin E. Hughes

引用次数: 0

Group B Streptococcus and Perinatality in the South of Tunisia: Epidemiology, Serotype Distribution, and Antibiotic Susceptibility 突尼斯南部的 B 群链球菌和围产期：流行病学、血清型分布和抗生素敏感性

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2023-12-08 DOI: 10.1080/15513815.2023.2287519

Rim Kharrat, Nour El Houda Ben Ayed, S. Ktari, Chiraz Regaieg, Sonda Mezghani, N. Hmida, F. Mahjoubi, A. Gargouri, Adnene Hammami

引用次数: 0

Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches. 通过机器学习方法解码儿童肾母细胞瘤和横纹肌样瘤的可能分子机制。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2023-12-01 Epub Date: 2023-08-07 DOI: 10.1080/15513815.2023.2242979

Seyed Mahdi Hosseiniyan Khatibi, Yalda Rahbar Saadat, Seyyedeh Mina Hejazian, Simin Sharifi, Mohammadreza Ardalan, Mohammad Teshnehlab, Sepideh Zununi Vahed, Saeed Pirmoradi

{"title":"Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches.","authors":"Seyed Mahdi Hosseiniyan Khatibi, Yalda Rahbar Saadat, Seyyedeh Mina Hejazian, Simin Sharifi, Mohammadreza Ardalan, Mohammad Teshnehlab, Sepideh Zununi Vahed, Saeed Pirmoradi","doi":"10.1080/15513815.2023.2242979","DOIUrl":"10.1080/15513815.2023.2242979","url":null,"abstract":"Objective: Wilms tumor (WT) and Rhabdoid tumor (RT) are pediatric renal tumors and their differentiation is based on histopathological and molecular analysis. The present study aimed to introduce the panels of mRNAs and microRNAs involved in the pathogenesis of these cancers using deep learning algorithms. Methods: Filter, graph, and association rule mining algorithms were applied to the mRNAs/microRNAs data. Results: Candidate miRNAs and mRNAs with high accuracy (AUC: 97%/93% and 94%/97%, respectively) could differentiate the WT and RT classes in training and test data. Let-7a-2 and C19orf24 were identified in the WT, while miR-199b and RP1-3E10.2 were detected in the RT by analysis of Association Rule Mining. Conclusion: The application of the machine learning methods could identify mRNA/miRNA patterns to discriminate WT from RT. The identified miRNAs/mRNAs panels could offer novel insights into the underlying molecular mechanisms that are responsible for the initiation and development of these cancers. They may provide further insight into the pathogenesis, prognosis, diagnosis, and molecular-targeted therapy in pediatric renal tumors.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"825-844"},"PeriodicalIF":1.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10319610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies. IUGR并发症妊娠分离脐动脉和子宫肌层的功能和组织学改变。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2023-12-01 Epub Date: 2023-08-14 DOI: 10.1080/15513815.2023.2245892

Mustafa Sengul, Baris Karadas, Selin Acar-Sahan, Fatma Simsek, Ersan Horoz, Işık Cem Özok, Tijen Temiz

{"title":"Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies.","authors":"Mustafa Sengul, Baris Karadas, Selin Acar-Sahan, Fatma Simsek, Ersan Horoz, Işık Cem Özok, Tijen Temiz","doi":"10.1080/15513815.2023.2245892","DOIUrl":"10.1080/15513815.2023.2245892","url":null,"abstract":"Objective: To investigate the relaxation responses mediated by L-type Ca2+ channels and big-conductance Ca2+-activated K+ (BKCa) channels and histological changes in the human umbilical artery (HUA) and myometrium smooth muscle isolated from pregnancies complicated with intrauterine growth restriction (IUGR).Methods: The muscle reactivity and the histology of the smooth muscle of the HUA and myometrium retrieved from 14 women with IUGR and 14 controls were investigated by the isolated tissue bath and immunohistochemical method.Results: In HUA, the maximum relaxation responses and pD2 values of nifedipine and NS11021 (BKCa channel opener) were significantly increased and significant histopathological changes are observed in the IUGR group.Conclusions: The pathogenesis of IUGR might be associated with the impairment in the functional responses of L-type Ca2+ channels and BKCa channels in HUA smooth muscle. The increased staining of myometrium and UC with HIF-1α in IUGR may indicate apoptosis, histological damage, and impaired fetal growth.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"845-859"},"PeriodicalIF":1.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9991223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Prevalence and Genotype Distribution of Human Adenovirus in Iranian Children with Gastroenteritis. 伊朗儿童胃肠炎中人腺病毒的分子患病率和基因型分布。

IF 1.1 4区医学

Fetal and Pediatric Pathology Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.1080/15513815.2023.2262576

Abdulhussain Kadhim Jwaziri, Mohammad Hadi Karbalaie Niya, Pegah Khales, Atefeh Kachooei, Milad Sabaei, Soheil Rahmani Fard, Ahmad Tavakoli

{"title":"Molecular Prevalence and Genotype Distribution of Human Adenovirus in Iranian Children with Gastroenteritis.","authors":"Abdulhussain Kadhim Jwaziri, Mohammad Hadi Karbalaie Niya, Pegah Khales, Atefeh Kachooei, Milad Sabaei, Soheil Rahmani Fard, Ahmad Tavakoli","doi":"10.1080/15513815.2023.2262576","DOIUrl":"10.1080/15513815.2023.2262576","url":null,"abstract":"Objective: We determined the molecular prevalence and genotype distribution of human adenovirus (HAdV) among children under five years of age with gastroenteritis in Iran.Methods: One hundred stool samples from children hospitalized were tested by PCR for adenovirus, and some of the positive samples were sequenced to determine the specific genotype.Results: HAdV DNA was found in 15 samples (15%). The highest and the lowest prevalence of HAdV was observed in the age groups 24-60 months (n = 6; 40%) and 7-12 months (n = 2; 13.3%), respectively (p = 0.01). Nine HAdV-positive samples were sequenced, of which four isolates were HAdV type 2 and five isolates were HAdV type 41.Conclusion: HAdV was most common in the 24-60-month-old children. Of the samples sequenced, we found only types 2 and 41. Our results show that in addition to HAdV types 40 and 41, HAdV type 2 may also play a role in causing gastroenteritis in children.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"901-913"},"PeriodicalIF":1.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0