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Fetal and Pediatric Pathology最新文献

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Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type: A Case Report with Summary of Prior Published Cases. 睾丸混合性畸胎瘤和卵黄囊肿瘤，青春期前型：一例病例报告及既往发表病例总结。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2023-11-09 DOI: 10.1080/15513815.2023.2279132
Md Mohin, Soumya Dey, Raktim Ray, Firdous Wasim Sk, Oindrila Das, Uttara Chatterjee
{"title":"Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type: A Case Report with Summary of Prior Published Cases.","authors":"Md Mohin, Soumya Dey, Raktim Ray, Firdous Wasim Sk, Oindrila Das, Uttara Chatterjee","doi":"10.1080/15513815.2023.2279132","DOIUrl":"10.1080/15513815.2023.2279132","url":null,"abstract":"<p><strong>Background: </strong>Testicular mixed germ cell tumor is common in the post-pubertal age, less so in prepuberty. There are only 3 reports of prepubertal mixed teratoma and yolk sac tumor. Two of these cases had immature teratoma component and were in the neonatal age group. The third case in a toddler had a mature teratoma component.</p><p><strong>Case report: </strong>An 18-month-old boy presented with a testicular mass. Serum AFP was elevated (2200 ng/ml). The orchidectomy specimen contained a yolk-sac tumor and a small epidermoid cyst, indicating a mature teratomatous component.</p><p><strong>Conclusion: </strong>We report a testicular mixed teratoma and yolk sac tumor, prepubertal type along with summary of prior published cases. There is only one report describing this combination of mature teratoma with yolk sac tumor in the prepubertal testis.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"182-187"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus. 妊娠糖尿病孕妇与非妊娠糖尿病孕妇分娩后脐带血中阿法明值的比较
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI: 10.1080/15513815.2023.2300981
Yasemin Dogan, Oguz Arslan, Berrin Oztas, Aylin Kurtali, Ayse Seda Daryal, Müzeyyen Dilsad Eser
{"title":"Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus.","authors":"Yasemin Dogan, Oguz Arslan, Berrin Oztas, Aylin Kurtali, Ayse Seda Daryal, Müzeyyen Dilsad Eser","doi":"10.1080/15513815.2023.2300981","DOIUrl":"10.1080/15513815.2023.2300981","url":null,"abstract":"<p><strong>Objective: </strong>Afamin is a protein that increases in gestational diabetes but its concentration in neonates hasn't been investigated. Our objective is to compare cord blood afamin levels in neonates born to mothers with and without diabetes, and to explore its relationship with maternal and neonatal variables.</p><p><strong>Methods: </strong>In this case control study, umbilical cord blood was collected for afamin measurement in pregestational/gestational diabetic pregnancies (<i>n</i> = 40) and healthy pregnancies (<i>n</i> = 45) after delivery. Correlation analysis was conducted to examine the relationship between afamin levels and maternal BMI, age, HbA1c, fasting and postprandial blood glucose, gestational age, birth weight.</p><p><strong>Results: </strong>The diabetic group had a higher median afamin level (<i>p</i> < 0.001). Afamin concentrations did not differ significantly between diabetic subgroups. The concentration of afamin in cord blood was independent of maternal BMI, age, HbA1c, blood glucose, gestational age, birth weight.</p><p><strong>Conclusion: </strong>The concentration of afamin in cord blood of diabetic pregnancies is significantly higher, irrespective of other clinical factors.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"83-93"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Ichthyosis: Current Approaches to Prenatal Diagnoses. 先天性鱼鳞病：目前的产前诊断方法。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-10 DOI: 10.1080/15513815.2023.2301468
Manahel Mahmood Alsabbagh
{"title":"Congenital Ichthyosis: Current Approaches to Prenatal Diagnoses.","authors":"Manahel Mahmood Alsabbagh","doi":"10.1080/15513815.2023.2301468","DOIUrl":"10.1080/15513815.2023.2301468","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital ichthyosis represents a wide spectrum of diseases. This article reviews prenatal testing for ichthyosis.</p><p><strong>Methods: </strong>We used pubmed.ncbi.nlm.nih.gov to search for 38 types of congenital ichthyosis combined with 17 words related to prenatal testing.</p><p><strong>Results: </strong>Search resulted in 408 publications covering 13 types of ichthyoses and four types of tests.</p><p><strong>Discussion: </strong>Biochemical testing is diagnostic in trichothiodystrophy, but nonspecific in X-linked ichthyosis and Refsum syndrome. Except in X-linked ichthyosis, biochemical testing requires invasive procedures to obtain fetal skin biopsy, amniocytes, or chorionic villus samples. It is superior to histological and cytological examination of fetal skin biopsy or amniocytes because keratinization occurs later in pregnancy and microscopy cannot differentiate between ichthyosis types. Imaging is more acceptable due to noninvasiveness and routine use, although ultrasonography is operator-dependent, nonspecific, and captures abnormalities at late stage. Molecular tests are described in at-risk pregnancies but testing of free fetal DNA was not described.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"157-175"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardizing Minimally Invasive Tissue Sampling of Postmortem Brain Using Bard Monopty Needle in Newborns with Neurological Injury. 使用 Bard Monopty 针对神经损伤新生儿进行脑死亡后微创组织取样的标准化。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-10 DOI: 10.1080/15513815.2023.2301448
Athira Sreenivas, Leslie Lewis, Jayashree Purkayastha, Vani Lakshmi R, Mary Mathew
{"title":"Standardizing Minimally Invasive Tissue Sampling of Postmortem Brain Using Bard Monopty Needle in Newborns with Neurological Injury.","authors":"Athira Sreenivas, Leslie Lewis, Jayashree Purkayastha, Vani Lakshmi R, Mary Mathew","doi":"10.1080/15513815.2023.2301448","DOIUrl":"10.1080/15513815.2023.2301448","url":null,"abstract":"<p><strong>Introduction: </strong>Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic utility in brain tissue biopsies.</p><p><strong>Method: </strong>Twenty newborns underwent postmortem minimally invasive tissue sampling of the brain through the anterior fontanelle and posterior approach, using the engraved lines on the needle labeled from mark 0 to 13. The cores were correlated with conventional autopsy findings.</p><p><strong>Results: </strong>Meninges were best obtained at marks 0 and 1 from the anterior fontanelle and mark 1 from posterior fontenelle in 85% of cases. Periventricular brain parenchyma was best obtained from mark 3 and mark 1 from anterior and posterior fontanel, respectively in 90% cases. The sampling success in obtaining brain cores was 100%.</p><p><strong>Discussion: </strong>This modified technique increases the yield of meninges and brain tissue in newborns and aids in diagnosis.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"94-110"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease. 神经节段炎症反应对赫氏肠病术后小肠结肠炎的影响
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-25 DOI: 10.1080/15513815.2024.2306280
Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan
{"title":"The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease.","authors":"Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan","doi":"10.1080/15513815.2024.2306280","DOIUrl":"10.1080/15513815.2024.2306280","url":null,"abstract":"<p><strong>Introduction: </strong>We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC).</p><p><strong>Methods: </strong>Thirty cases (M:27, F:3) operated on due to HD. The cases were divided into three groups: group 1 with pre and post operative EC, group 2 with post-operative, and group 3 with pre-operative EC. The intestinal segments were evaluated by immunohistochemistry for interleukin 1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6).</p><p><strong>Results: </strong>IL-1β staining was significantly higher in the ganglionic zone of groups with enterocolitis compared to the control group (<i>p</i> = 0.012). TNF-α staining in the transitional zone of Group 3 and IL-1β staining in the ganglionic zone of Group 1 was significantly higher than the control group (<i>p</i> = 0.030, <i>p</i> = 0.020).</p><p><strong>Conclusion: </strong>In our study, older age at diagnosis and more than 20% IL-1ß staining in the ganglionic segment were found to be risk factors for HAEC. It is noteworthy that the increase in IL-1ß can be associated with HAEC.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"140-150"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry. CD30和CD56在淋巴母细胞淋巴瘤中的表达和临床意义：通过免疫组化对石蜡包埋组织的回顾性分析。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-11 DOI: 10.1080/15513815.2023.2301459
Shuqi Li, Shuang Zheng, Xinyi Huang, Wenhui Zhang, Fang Liu, Qinghua Cao
{"title":"Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.","authors":"Shuqi Li, Shuang Zheng, Xinyi Huang, Wenhui Zhang, Fang Liu, Qinghua Cao","doi":"10.1080/15513815.2023.2301459","DOIUrl":"10.1080/15513815.2023.2301459","url":null,"abstract":"<p><p><b>Background:</b> We evaluated CD30 and CD56 expression in lymphoblastic lymphoma (LBL) and correlated the results with clinicopathological features and prognosis. <b>Methods:</b> Immunohistochemical (IHC) staining was performed on 85 formalin-fixed paraffin-embedded LBL specimens using two CD30 clones and one CD56 antibody clone. <b>Results:</b> Weak and diffuse expression of CD30 was expressed in 4.7% (clone Ber-H2) or 14.1% (clone EPR4102) in LBL, while CD56 was expressed in 24.7%. CD30 and CD56 expression correlated with lactate dehydrogenase levels. CD56-positive expression was closely associated with an unfavorable prognosis. Although CD30 expression exhibited a trend toward poorer overall survival, it did not reach statistical significance. <b>Conclusion:</b> CD56 is a potential negative prognostic marker. These findings suggest that CD30 and CD56 targeted therapies could be potential therapeutic targets for LBL patients.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"111-122"},"PeriodicalIF":1.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor 肾原性息肉低分化亚群的分化潜能及其与 Wilms 肿瘤预后的关系
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-12 DOI: 10.1080/15513815.2024.2303081
Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu
{"title":"Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor","authors":"Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu","doi":"10.1080/15513815.2024.2303081","DOIUrl":"https://doi.org/10.1080/15513815.2024.2303081","url":null,"abstract":"Background Wilms tumor (WT) is highly curable, although anaplastic histology or relapse imparts a worse prognosis. Nephrogenic rests (NR) associated with a high risk of developing WT are abnormally...","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":"128 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter Regarding "Clinicopathological Analysis of Sturge-Weber Syndrome With Focal Cortical Dysplasia FCD IIIc". 关于“Sturge-Weber综合征伴局灶性皮质发育不良FCD IIIc的临床病理分析”的信函。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI: 10.1080/15513815.2023.2270678
Törehan Özer, Yonca Anik
{"title":"Letter Regarding \"Clinicopathological Analysis of Sturge-Weber Syndrome With Focal Cortical Dysplasia FCD IIIc\".","authors":"Törehan Özer, Yonca Anik","doi":"10.1080/15513815.2023.2270678","DOIUrl":"10.1080/15513815.2023.2270678","url":null,"abstract":"","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"76-78"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child. 一名 10 岁儿童的单灶 3 型混合组织细胞增生症
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2023-08-22 DOI: 10.1080/15513815.2023.2245489
Arturo Bonometti
{"title":"Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child.","authors":"Arturo Bonometti","doi":"10.1080/15513815.2023.2245489","DOIUrl":"10.1080/15513815.2023.2245489","url":null,"abstract":"<p><strong>Background: </strong>Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndromes defined by the histological overlap of Langerhans cell histiocytosis and other histiocytic proliferations that include three clinically and prognostically different conditions (i.e., Type-1-3 mixed histiocytosis).</p><p><strong>Case report: </strong>We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis - Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.</p><p><strong>Discussion: </strong>Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"66-70"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Frontal Phocomelia in a 3-Year-Old Girl. 一名 3 岁女孩的额叶畸形。
IF 1.1 4区 医学
Fetal and Pediatric Pathology Pub Date : 2024-01-01 Epub Date: 2023-09-16 DOI: 10.1080/15513815.2023.2258417
Martina Vidová Uğurbaş, René Hako, Miloš Kňazovický
{"title":"The Frontal Phocomelia in a 3-Year-Old Girl.","authors":"Martina Vidová Uğurbaş, René Hako, Miloš Kňazovický","doi":"10.1080/15513815.2023.2258417","DOIUrl":"10.1080/15513815.2023.2258417","url":null,"abstract":"<p><p><b>Background:</b> Phocomelia is a congenital limb deformity in which the proximal part of the upper or lower limb does not develop. Occasionally the malformed limb may be located ectopically. <b>Case report:</b> We present a frontal phocomelia in a three-year-old girl with right-hand phocomelia and thoracoschisis. The patient's arm was connected directly from the front of the chest, with a rudimentary thumb and two fingers. The truncated arm was not functional. The acromioclavicular joint was abnormal and ectopic, the limb articulated with the medial side of sternum. The thoracoschisis manifested as eventration of the right liver lobe and right side of chest wall. <b>Conclusion:</b> Ectopic phocomelia can be associated with thoracoschisis, it can be nonfunctional, and can articulate with the sternum.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"71-75"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10269095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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