Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI:10.1080/15513815.2023.2300981

Yasemin Dogan, Oguz Arslan, Berrin Oztas, Aylin Kurtali, Ayse Seda Daryal, Müzeyyen Dilsad Eser

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引用次数: 0

Abstract

Objective: Afamin is a protein that increases in gestational diabetes but its concentration in neonates hasn't been investigated. Our objective is to compare cord blood afamin levels in neonates born to mothers with and without diabetes, and to explore its relationship with maternal and neonatal variables.

Methods: In this case control study, umbilical cord blood was collected for afamin measurement in pregestational/gestational diabetic pregnancies (n = 40) and healthy pregnancies (n = 45) after delivery. Correlation analysis was conducted to examine the relationship between afamin levels and maternal BMI, age, HbA1c, fasting and postprandial blood glucose, gestational age, birth weight.

Results: The diabetic group had a higher median afamin level (p < 0.001). Afamin concentrations did not differ significantly between diabetic subgroups. The concentration of afamin in cord blood was independent of maternal BMI, age, HbA1c, blood glucose, gestational age, birth weight.

Conclusion: The concentration of afamin in cord blood of diabetic pregnancies is significantly higher, irrespective of other clinical factors.

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妊娠糖尿病孕妇与非妊娠糖尿病孕妇分娩后脐带血中阿法明值的比较

目的：阿法明是一种在妊娠期糖尿病中会增加的蛋白质，但其在新生儿中的浓度尚未得到研究。我们的目的是比较有糖尿病和无糖尿病母亲所生新生儿的脐带血阿法铵水平，并探讨其与母亲和新生儿变量的关系：在这项病例对照研究中，我们采集了妊娠前/妊娠期糖尿病孕妇（n = 40）和健康孕妇（n = 45）分娩后的脐带血进行阿法铵测量。研究人员进行了相关分析，以探讨阿法铵水平与产妇体重指数、年龄、HbA1c、空腹和餐后血糖、胎龄、出生体重之间的关系：结果：糖尿病组的阿法明中位数水平较高（p 结论：糖尿病组的阿法明中位数水平较低，而糖尿病组的阿法明中位数水平较高：无论其他临床因素如何，糖尿病孕妇脐带血中的阿法明浓度明显更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.