使用 Bard Monopty 针对神经损伤新生儿进行脑死亡后微创组织取样的标准化。

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-03-01 Epub Date: 2024-01-10 DOI:10.1080/15513815.2023.2301448

Athira Sreenivas, Leslie Lewis, Jayashree Purkayastha, Vani Lakshmi R, Mary Mathew

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引用次数: 0

摘要

导言：使用 Bard Monopty 穿刺针对新生儿进行微创脑组织取样，有助于通过获取相关脑芯诊断各种神经系统疾病。我们设计了一种改良程序，以在脑组织活检中提供最大的诊断效用：方法：20 名新生儿通过前囟门和后部入路接受了死后微创脑组织取样，取样时使用了针上刻有标记的 0 至 13 号线。取芯结果与常规尸检结果一致：结果：85%的病例在前囟门0号和1号位置以及后囟门1号位置获得的脑芯最好。在 90% 的病例中，脑室周围脑实质的最佳取样点分别是前囟门第 3 点和后囟门第 1 点。取样成功率为 100%：讨论：这一改良技术提高了新生儿脑膜和脑组织的产量，有助于诊断。

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Standardizing Minimally Invasive Tissue Sampling of Postmortem Brain Using Bard Monopty Needle in Newborns with Neurological Injury.

Introduction: Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic utility in brain tissue biopsies.

Method: Twenty newborns underwent postmortem minimally invasive tissue sampling of the brain through the anterior fontanelle and posterior approach, using the engraved lines on the needle labeled from mark 0 to 13. The cores were correlated with conventional autopsy findings.

Results: Meninges were best obtained at marks 0 and 1 from the anterior fontanelle and mark 1 from posterior fontenelle in 85% of cases. Periventricular brain parenchyma was best obtained from mark 3 and mark 1 from anterior and posterior fontanel, respectively in 90% cases. The sampling success in obtaining brain cores was 100%.

Discussion: This modified technique increases the yield of meninges and brain tissue in newborns and aids in diagnosis.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.