Autopsy-Based Growth Charts May under-Detect Fetal Growth Restriction at Autopsy.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-08 DOI:10.1080/15513815.2023.2299491

Min Jung Kim, Jennifer A Hutcheon, Anna F Lee, Jessica Liauw

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引用次数: 0

Abstract

Background: Accurate identification of fetal growth restriction in fetal autopsy is critical for assessing causes of death. We examined the impact of using a chart derived from ultrasound measurements of healthy fetuses (World Health Organization fetal growth chart) versus a chart commonly used by pathologists (Archie et al.) derived from fetal autopsy-based populations in diagnosing small-for-gestational-age (SGA) birth in perinatal deaths. Study Design: We examined perinatal deaths that underwent autopsy at BC Women's Hospital, 2015-2021. Weight centiles were assigned using the ultrasound-based fetal growth chart for birthweight and autopsy-based growth chart for autopsy weight. Results: Among 352 fetuses, 30% were SGA based on the ultrasound-based fetal growth chart versus 17% using the autopsy-based growth chart (p < 0.001). Weight centiles were lower when using the ultrasound-based versus autopsy-based growth chart (median difference of 9 centiles [IQR 2, 20]). Conclusions: Autopsy-based growth charts may under-classify SGA status compared to ultrasound-based fetal growth charts.

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基于尸检的生长曲线图可能无法在尸检时检测到胎儿生长受限。

背景：在胎儿尸检中准确识别胎儿生长受限对于评估死亡原因至关重要。我们研究了在围产期死亡病例中，使用根据健康胎儿超声测量得出的图表（世界卫生组织胎儿生长图表）与病理学家常用的根据胎儿尸检得出的图表（Archie 等人）对诊断小于妊娠年龄（SGA）新生儿的影响。研究设计：我们研究了2015-2021年在不列颠哥伦比亚省妇女医院接受尸检的围产期死亡病例。使用基于超声波的胎儿生长曲线图计算出生体重，使用基于尸检的生长曲线图计算尸检体重。结果显示在 352 个胎儿中，根据超声胎儿生长曲线图得出的 SGA 胎儿占 30%，而根据尸检生长曲线图得出的 SGA 胎儿占 17%（P 结论：根据超声胎儿生长曲线图得出的 SGA 胎儿占 30%，而根据尸检生长曲线图得出的 SGA 胎儿占 17%：与基于超声的胎儿生长曲线图相比，基于尸检的生长曲线图可能对 SGA 胎儿分类不足。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.