Indian Journal of Dermatology Venereology & Leprology最新文献

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A rare case of systemic amyloidosis presenting as palmar purpuric eczematous eruption. 一例罕见的系统性淀粉样变,表现为手掌紫癜性湿疹疹。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-07 DOI: 10.25259/IJDVL_137_2025
Anamika Choudhary, Shreya K Gowda, Ritu Sharma, Sudheer Arava, Kanika Sahni
{"title":"A rare case of systemic amyloidosis presenting as palmar purpuric eczematous eruption.","authors":"Anamika Choudhary, Shreya K Gowda, Ritu Sharma, Sudheer Arava, Kanika Sahni","doi":"10.25259/IJDVL_137_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_137_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics for dermatologists. Part 1: Fundamental concepts of structure, function, and clinical application. 皮肤科医生的遗传学。第一部分:结构、功能和临床应用的基本概念。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-02 DOI: 10.25259/IJDVL_243_2025
Divya Gupta, Tim George Jose, Gurudatta Baraka Vishwanathan
{"title":"Genetics for dermatologists. Part 1: Fundamental concepts of structure, function, and clinical application.","authors":"Divya Gupta, Tim George Jose, Gurudatta Baraka Vishwanathan","doi":"10.25259/IJDVL_243_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_243_2025","url":null,"abstract":"<p><p>Dermatology encompasses a broad range of conditions, ranging from single-gene disorders to common complex disorders characterised by polygenic risk factors like psoriasis and atopic dermatitis. For clinicians, understanding the genetic basis of these conditions is essential for accurate diagnosis, effective management, and appropriate genetic counselling. This article aims to revisit fundamental genetic concepts, offering a foundation to a better understanding of their application in clinical practice. It introduces the fundamental genetic terminology relevant for dermatologists, along with types of mutations, inheritance patterns, key elements of pedigree charts, and major online genetic databases, which serve as valuable resources for interpreting test results and identifying disease-associated variants. Additionally, it briefly explores the basics of genetic epidemiology, including linkage analysis, and association studies.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cross-sectional analysis of inflammatory markers as a severity and prognostic indicator in severe cutaneous adverse drug reactions. 炎症标志物作为严重皮肤药物不良反应的严重程度和预后指标的横断面分析。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-02 DOI: 10.25259/IJDVL_1284_2024
Nayana Thara Gs, Varadraj V Pai, Akshay Kadkol, Elreema Fernandes, Pankaj Shulka
{"title":"A cross-sectional analysis of inflammatory markers as a severity and prognostic indicator in severe cutaneous adverse drug reactions.","authors":"Nayana Thara Gs, Varadraj V Pai, Akshay Kadkol, Elreema Fernandes, Pankaj Shulka","doi":"10.25259/IJDVL_1284_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1284_2024","url":null,"abstract":"<p><p>Background The inflammatory markers (IMs) are a set of biomarkers used clinically to assess a patient for the presence of an active inflammatory disease or disease activity. They are elevated in conditions like infections, malignancies, mental illness and drug reactions among others. Aim The study aimed at identifying the IMs that reflect the severity and recovery in severe cutaneous adverse drug reactions (SCARs). Methods A cross-sectional observational study was conducted among patients with SCARs (Stevens Johnson syndrome [SJS]/ toxic epidermal necrolysis [TEN] and drug reaction with eosinophilia and systemic symptoms [DRESS]) admitted to a tertiary care hospital over 18 months. Results Twenty SJS/TEN and 8 DRESS cases were included in the study. There were more females in the study (F: M = 2:1). Comparing the IMs of SJS/TEN and DRESS revealed that most markers on day 7 were lower as compared to day 0. There was a significant difference in eosinophil count (EC), procalcitonin (PCT) (p-value <0.05), and recovery time between the two groups. In the SJS/TEN group, markers like ferritin (>2000 ng/mL) and PCT (>2.0 ng/mL) were significantly higher, around the septic range, in patients with concurrent connective tissue disease and culture positivity. Ferritin (p-value- 0.025, rho- 0.578), PCT (p-value- 0.013, rho- 0.239), and ESR (p-value- 0.041, rho- 0.482) were associated with the severity of SJS/TEN. Patients with DRESS had an early recovery with a statistically significantly shorter hospital stay than SJS/TEN (p<0.005). Baseline severity-of-illness score for TEN levels, total counts, and day 7 PCT significantly reflected the time taken for recovery. Limitations Marker analysis was performed at baseline and on day 7 of admission, but not after complete clinical recovery, therefore indicating a trend but limited conclusive behaviour of markers at the time of recovery. Conclusion The progression of IMs in a SCAR follows the clinical course of the illness. IMs like ferritin and PCT, along with routine haematological investigation, aid in identifying the severity, differentiating it among patients with comorbidities, and helping predict the recovery time in SCARs.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive approach to child sexual abuse: Insights for dermatologists. 儿童性虐待的综合方法:皮肤科医生的见解。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-02 DOI: 10.25259/IJDVL_246_2025
Krithiga Muralidharan, Daniel Manoj, Dharshini Sathishkumar, Ranjit Immanuel James, Jagadeesh Narayanareddy
{"title":"A comprehensive approach to child sexual abuse: Insights for dermatologists.","authors":"Krithiga Muralidharan, Daniel Manoj, Dharshini Sathishkumar, Ranjit Immanuel James, Jagadeesh Narayanareddy","doi":"10.25259/IJDVL_246_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_246_2025","url":null,"abstract":"<p><p>Child sexual abuse (CSA) is a serious public health issue in India, with long-lasting physical, emotional and psychological consequences. Dermatologists play a crucial, though often underappreciated, role in the identification and management of CSA due to expertise in recognising and interpreting cutaneous signs, which are the most common and visible indicators of abuse. The authors explore the pivotal role of dermatologists in the multidisciplinary approach to CSA, emphasising their involvement in history-taking, physical examination, injury interpretation, and forensic evidence collection. The article also discusses the importance of timely reporting to authorities and adhering to treatment protocols based on the prevalent guidelines. This article attempts to create awareness among practising dermatologists in India about their role in the early detection and comprehensive care of CSA survivors. We also believe that this article will act as a guiding force for them to manage CSA cases effectively.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-8"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of anti-desmoglein antibodies titres and anti-M3 muscarinic acetylcholine receptor antibody titres as biomarker for potential pemphigus between subjects who are occupationally exposed and not exposed to pesticides. 职业农药暴露与非职业农药暴露人群潜在天疱疮生物标志物抗粘粒蛋白抗体滴度与抗m3毒蕈碱乙酰胆碱受体抗体滴度的比较
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-02 DOI: 10.25259/IJDVL_256_2024
Dipankar De, Divya Kamat, Maninder Kaur, Dev Kumari, Arnab Pal, Sanjeev Handa, Siby John, Ravindra Khaiwal
{"title":"Comparison of anti-desmoglein antibodies titres and anti-M3 muscarinic acetylcholine receptor antibody titres as biomarker for potential pemphigus between subjects who are occupationally exposed and not exposed to pesticides.","authors":"Dipankar De, Divya Kamat, Maninder Kaur, Dev Kumari, Arnab Pal, Sanjeev Handa, Siby John, Ravindra Khaiwal","doi":"10.25259/IJDVL_256_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_256_2024","url":null,"abstract":"<p><p>Background The pathogenesis of pemphigus is multifactorial, and pesticides have been implicated as one of the triggering factors due to their interaction with acetylcholine receptors. Aim The aim of this study was to observe the effect of exposure to pesticides (by blood pesticide levels) on serological markers of pemphigus (anti-Dsg1, anti-Dsg3, and anti-M3 ACh receptor antibodies) amongst healthy individuals involved in pesticide use. Methods This was an observational, cross-sectional pilot study performed in Punjab. The study subjects were 45 couples (husband and wife) wherein the husband was involved in activities like spraying and handling pesticides, and the wife was considered a non-genetically related control (not occupationally exposed to pesticides). Clinical data were collected by a structured questionnaire, and venous blood was collected to test blood pesticide levels. Gas chromatography - mass spectroscopy (GC-MS) and enzyme-linked immunosorbent assay (ELISA) were used for anti-Dsg-1, anti-Dsg-3, and anti-M3Ach receptor antibody level detection. Results Pesticides were detected in both husband and wife. There was no correlation between the duration of pesticide exposure and their blood levels. Chlorpyrifos was most frequently detected in husbands and β- endosulfan in wives. The levels of anti-Dsg-1 and anti-Dsg-3 titres were below the diagnostic cut-off values (20 RU/mL) for pemphigus in all participants. Husbands had significantly higher anti-Dsg3 values (p=0.029). There was no statistically significant association between the presence of pesticides and anti-Dsg-1, anti-Dsg-3, and anti-M3 ACh receptor antibodies in the sera. Anti-Dsg-1 antibodies had a significant positive correlation with chlorpyrifos serum levels (r= 0.3, p=0.005). Limitation Determining aspects like expression of adhesion proteins on keratinocyte cell lines, long term follow up of healthy subjects and correlation with pesticide levels with cases of pemphigus was not done as it is cost intensive. Conclusion The exposure to pesticides did not significantly increase any of the biomarkers above clinical cut-off levels in any of the healthy participants. Considering the rarity of clinically manifest pemphigus, many healthy subjects need to be studied with the current study design. Alternatively, the expression of adhesion proteins or their adhesion function can be assessed in keratinocyte cell lines upon incubation with varying concentrations of pesticides.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teprenone: The unexpected culprit behind erythroderma. 泰普瑞诺:红皮病背后意想不到的罪魁祸首。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-06-02 DOI: 10.25259/IJDVL_209_2025
Haiyang He, Yi Liu, Chengchen Gong, Mingyuan Han, Yan Wang, Weihua Pan
{"title":"Teprenone: The unexpected culprit behind erythroderma.","authors":"Haiyang He, Yi Liu, Chengchen Gong, Mingyuan Han, Yan Wang, Weihua Pan","doi":"10.25259/IJDVL_209_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_209_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the surface: Link between Demodex mite and frictional facial melanosis. 表面之外:蠕形螨与摩擦性面部黑色素病之间的联系。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-05-31 DOI: 10.25259/IJDVL_1383_2023
Kesha Shailesh Patel, Abhishek R Parekh, Nayan Sevantilal Prajapati, Hiral A Shah
{"title":"Beyond the surface: Link between Demodex mite and frictional facial melanosis.","authors":"Kesha Shailesh Patel, Abhishek R Parekh, Nayan Sevantilal Prajapati, Hiral A Shah","doi":"10.25259/IJDVL_1383_2023","DOIUrl":"https://doi.org/10.25259/IJDVL_1383_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kikuchi-Fujimoto disease and Behcet's disease: A rare association. 菊chi- fujimoto病和白塞氏病:罕见的关联。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-05-31 DOI: 10.25259/IJDVL_196_2025
Divya Bhatia, Suman Patra, Neeharika Verma, Poonam Abhay Elhence
{"title":"Kikuchi-Fujimoto disease and Behcet's disease: A rare association.","authors":"Divya Bhatia, Suman Patra, Neeharika Verma, Poonam Abhay Elhence","doi":"10.25259/IJDVL_196_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_196_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Huntley's papules: A dermatologic clue to diabetes. 亨特利丘疹:糖尿病的皮肤病学线索。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-05-31 DOI: 10.25259/IJDVL_531_2025
Resham Vasani, Kavya Baddireddy
{"title":"Huntley's papules: A dermatologic clue to diabetes.","authors":"Resham Vasani, Kavya Baddireddy","doi":"10.25259/IJDVL_531_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_531_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Areata's whisper: A silent storm. 阿蕾塔的低语:无声的风暴。
IF 3.2 4区 医学
Indian Journal of Dermatology Venereology & Leprology Pub Date : 2025-05-29 DOI: 10.25259/IJDVL_560_2025
Sharang Gupta
{"title":"Areata's whisper: A silent storm.","authors":"Sharang Gupta","doi":"10.25259/IJDVL_560_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_560_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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