Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Linear lichen planus of the genitalia.","authors":"Ariharasudhan Varadharajan, Prateek Nayak, Gitesh U Sawatkar, Nisha Meshram","doi":"10.25259/IJDVL_1441_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1441_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of oral sirolimus - A mammalian target of rapamycin (m-TOR) inhibitor in the treatment of kaposiform haemangioendothelioma with Kasabach-Merritt phenomenon.","authors":"Shekhar Neema, Senkadhir Vendhan, Biju Vasudevan, Silky Priya, A W Kashif, Shweta Pandey","doi":"10.25259/IJDVL_871_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_871_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgA Vasculitis in adults: Importance of recognising diverse cutaneous and systemic manifestations and associations.","authors":"Sukhdeep Singh, Anuradha Bishnoi, Mude Hemalatha, Hitaishi Mehta, Akshay Meena, Vinay Keshavamurthy, Debajyoti Chatterjee, Vaneet Jearth, Raja Ramachandran, Aman Sharma, Sunil Dogra","doi":"10.25259/IJDVL_518_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_518_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-4"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance and biofilm formation in Cutibacterium acnes: A descriptive cross-sectional study.","authors":"Navya Anna Paul, Ramesh Bhat M, Beena Antony, Jyothi Jayaraman","doi":"10.25259/IJDVL_539_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_539_2024","url":null,"abstract":"<p><p>Background The issue of antibiotic resistance in acne vulgaris has emerged as a significant concern in recent times. Though the ability of Cutibacterium acnes to form biofilms have been established, its role in acne vulgaris has yet to be ascertained. Aims This descriptive cross-sectional study was aimed to investigate the ability of C. acnes to form biofilms and its potential association with resistance to the commonly used antibiotics. Methods A total of 88 patients with acne vulgaris were selected for this study. Clinical examination and severity grading was done. The collected samples were analysed with Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) and further subjected to biofilm testing using the microtiter plate assay. Results C. acnes were isolated from 43.1 of the samples (n = 38). The highest resistance was observed with azithromycin (73.7%) followed by clindamycin (65.8%), doxycycline (15.8%), ampicillin (31.6%) and minocycline (5.3%). Thirty-seven per cent of the isolates were resistant to at least two antibiotics, 63.2% of C. acnes had a weak capacity to form biofilms and more than 60 percent of the isolates showed resistance to atleast two types of antibiotics as well as weak biofilm forming capacity. Limitations Single-centre study, small sample, long-term follow-up of the patients was not done. In addition, this study is representative of only C. acnes species. Conclusion While C. acnes have the ability to create biofilms, its effectiveness in antibiotic resistance can be deemed as modest based on the findings of this study. It is important to consider alternative mechanisms such as genetic or biochemical plasticity that may contribute to antibiotic resistance.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating tissue expression of STAT 1, 3 and 6 in prurigo nodularis to clinical efficacy of oral tofacitinib - A prospective single-arm investigational study.","authors":"Kabir Sardana, Sinu Rose Mathachan, Aishwarya Muddebihal, Diksha Agrawal, Arvind Ahuja","doi":"10.25259/IJDVL_1017_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1017_2024","url":null,"abstract":"<p><p>Background Interleukin (IL)-4, IL-13, IL-17, IL-22 and IL-3 are overexpressed in prurigo nodularis (PN). They mediate their action via the Janus Kinase (JAK) Signal transducer and activator of transcription (STAT) pathway. Objectives Our aim was to study the expression of tissue STAT1, STAT3, and STAT6, as well as the efficacy of the JAK-STAT inhibitor, tofacitinib, in PN. Methods A prospective study was conducted in a tertiary care hospital. Patients with PN were recruited after excluding secondary causes. Pruritus was graded using Pruritus Grading System Score (PGSS). All cases underwent histological assessment using immunohistochemical markers for STAT1, STAT3, and STAT6 in both lesional and perilesional skin. Tofacitinib was initiated at a dose of 5 mg twice daily or 11 mg once daily and then tapered to a maintenance dose. The final PGSS at the time of data evaluation, as well as the occurrence of remissions and relapses, was assessed. Results The majority of the 17 patients included in the study had moderate to severe disease. Immunohistochemical analysis revealed marked tissue expression of STAT6 in 13 and STAT3 in 10 patients, while STAT1 expression was seen in only 4 patients [p < 0.05], suggesting a Th2/Th17 tissue response. The mean onset of action of tofacitinib was 11.2 ± 6.44 days and the mean duration of treatment was 5.6 ± 2.2 months. A significant reduction in PGSS was noted after treatment (66.1%, P value 0.0004). Fourteen of the patients maintained remission on low-dose therapy (5 mg OD or A/D) while one patient experienced a relapse. No serious adverse effects were noted. Limitation We could not study the tissue cytokines and the expression of STATs after achieving clinical response on oral tofacitinib. Conclusion The efficacy of tofacitinib in PN is based on its inhibitory effect on Th2 and Th17 cytokines, which is dependent on STAT6 and STAT3.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical egg yolk oil (4% cholesterol) and oral rosuvastatin for the treatment of disseminated superficial actinic porokeratosis.","authors":"Chang-Yu Hsieh, Tsen-Fang Tsai","doi":"10.25259/IJDVL_1026_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1026_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topical tofacitinib 2% cream in the treatment of nail lichen planus.","authors":"Matilde Iorizzo","doi":"10.25259/IJDVL_1443_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1443_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear cell anaplastic large cell lymphoma in a young male: A rare lymphoma variant.","authors":"Apoorva Sharma, Debajyoti Chatterjee, Gaurav Prakash, Pratibha Bansal, Tarun Narang","doi":"10.25259/IJDVL_964_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_964_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures in chronic urticaria: A comprehensive review.","authors":"Shikha Shah, Manavi Gupta, Anuradha Bishnoi, Davinder Parsad, Muthu Sendhil Kumaran","doi":"10.25259/IJDVL_523_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_523_2024","url":null,"abstract":"<p><p>Chronic urticaria, characterised by pruritic wheals, angioedema or both significantly impacts individuals' quality of life. This review article examines the patient-reported outcome measures (PROMs) in chronic urticaria assessment, aiming to enhance understanding and management of this condition The review categorises PROMs into urticaria-specific and angioedema-specific tools. Urticaria-specific PROMs such as the Urticaria Activity Score (UAS), Urticaria Control Test (UCT), Chronic Urticaria Quality of Life Questionnaire (CU-QoL) and Urticaria Severity Score (USS) focus on disease activity, control, severity and quality of life. Angioedema-specific tools include the Angioedema Activity Score (AAS), Angioedema Control Test (AECT) and Angioedema Quality of Life Questionnaire (AE-QoL), assessing disease activity, control and quality of life specific to angioedema. Non-specific PROMs like the Dermatology Life Quality Index (DLQI) provide a broader assessment of health-related quality of life across dermatological conditions. Newer developments include disease-specific PROMs like the Cold Urticaria Activity Score (ColdUAS), CholU-QoL for chronic inducible urticarias and the Urticaria Activity and Impact Measure (U-AIM) for retrospective patient-reported outcome assessment. Additionally, the review discusses the integration of smartphone applications and artificial intelligence (AI) tools like Convolutional Neural Networks (CNNs) in automating PROMs, showing promise in improving chronic urticaria management. Despite the progress made in PROMs, ongoing challenges such as limited data on specific populations and languages underscore the need for continued research and standardised PROM usage across clinical settings. This approach can significantly enhance patient management and contribute to a more holistic and effective strategy for addressing chronic urticaria.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and dermoscopic profile of non-venereal genital dermatoses and its impact on the quality of life: A cross-sectional study of 550 cases.","authors":"Subhajit Sadhukhan, Anupama Bains, Abhishek Bhardwaj, Suman Patra, Deepak Vedant, Charu Sharma, Gautam Ram Chaudhary","doi":"10.25259/IJDVL_776_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_776_2024","url":null,"abstract":"<p><p>Background Non-venereal genital dermatoses cover a broad spectrum of conditions with varying aetiologies and can be confused with venereal disorders. This may cause significant anxiety to the patient as well as diagnostic difficulties for the clinician. Objective The purpose was to study the clinico-epidemiological pattern of non-venereal genital dermatoses along with their dermoscopic features and to assess their impact on the quality of life. Methods This was a prospective, cross-sectional, observational study of 503 consecutive adult patients with non-venereal genital dermatoses. Relevant history and clinical examination, dermoscopy findings were documented and histopathology was performed where indicated. Statistical analyses was done using SPSS software v.23. Results Five hundred and three individuals with non-venereal genital lesions were enrolled. Some patients had multiple dermatoses, so a total of 550 cases were analysed. Men outnumbered women (5.8:1). A total of 49 different non-venereal genital dermatoses were identified. The most common ones were scabies 97 (17.6%), vitiligo 54 (9.8%), lichen simplex chronicus 43 (7.8%), lichen sclerosus 43 (7.8%) and lichen planus 39 (7.1%). Other dermatoses included psoriasis, Zoon's balanitis, lichen nitidus, angiokeratoma and idiopathic scrotal calcinosis. Physiological conditions were noted in 56 (10.2%) cases, while 5 (1%) cases were premalignant and malignant disorders. The commonest symptom was genital pruritus 337 (60.9%). Scrotum was most frequently affected site in men (54.6%) and labia majora in women (81.6%). Comparative analysis between the dermoscopic features of similar-looking disorders like vitiligo versus lichen sclerosus, scrotal dermatitis versus psoriasis and lichen planus versus psoriasis was statistically significant (p<0.05). There was a large effect on the quality of life in 8(1.5%), moderate effect in 87(16.2%) and small effect in 385 (71.8%) patients. Dermatology life quality index was significantly elevated in women. Seventy six (15.1%) patients suffered from venerophobia. Limitations Because of the cross-sectional study design, dermatoscopic examinations were performed at various phases of the diseases. Histopathology was performed in a limited number of cases, so findings on dermoscopy and histopathology could not be correlated. Conclusion Non-venereal genital dermatoses are common and more so among men. The most common dermatoses noted was scabies followed by vitiligo and lichen simplex chronicus. The present study provides detailed clinical and dermoscopy features in Indian patients. Dermoscopy is a useful tool in the diagnosis of these diseases. These dermatoses have mild to moderate effects on patients' quality of life; some of these patients suffer from venereophobia. Recognising and treating this issue will aid in properly managing these patients.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}