Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Clinico-histopathological review of cutaneous sarcoidosis: A retrospective descriptive study.","authors":"Akash Deep Chandra, Sujay Khandpur, M Ramam, Neetu Bhari, Vishal Gupta, Shipra Agarwal","doi":"10.25259/IJDVL_368_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_368_2024","url":null,"abstract":"<p><p>Background Sarcoidosis is a systemic, non-caseating granulomatous disease characterised by clinical and histopathological variability. Objective To review cases of cutaneous sarcoidosis and describe their clinical and histopathological features. Methods A retrospective study was conducted to analyse the clinical and histopathological frecords of all available skin biopsy slides signed out as 'sarcoidal tissue reaction' or 'sarcoidosis' from 2014 till 2022. Results A total of 25 cases were studied. The lesions were most commonly located on the head and neck (18 cases, 72%). Morphologically plaques (20%) were the most common, and the majority of cases had lesions of ≥2 distinct morphologies (44%). Histologically, classical naked granulomas were observed in 72% of cases. The granulomatous infiltrate was pandermal in 56% of cases, perivascular and interstitial in 16%, and perivascular, perieccrine, and interstitial in 12%. Granulomas with a 'leprosy' pattern were observed in 20% of cases. High-density granulomas (occupying >30% of the dermis) were present in 64% of cases. Fibrinoid necrosis and fibrosis between granulomas were observed in 16% and 8% cases, respectively. Inclusion bodies, such as asteroid and Schaumann bodies, were seen in 24% and 4% cases, respectively. Reticulin-rich granulomas were observed in 54% cases, while reticulin-poor granulomas were seen in 8.3%. Elevated serum ACE levels were found in 14 cases, and tuberculin skin test, conducted in 22 cases, was negative. Extracutaneous involvement was found in 11 cases, with 10 having pulmonary and 1 with pulmonary and splenic involvement. Limitation Retrospective nature of the study and small sample size. Conclusion Cutaneous sarcoidosis presents with a wide range of clinical and histomorphological features, necessitating clinico-histopathological correlation and ancillary investigations to establish the diagnosis and rule out mimickers.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal dermal hypoplasia - A report of two cases with review of literature.","authors":"Young Denla, Shreya K Gowda, M L Amulya, Adhyatm Bhandari","doi":"10.25259/IJDVL_96_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_96_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented nodular lesion below eyelid in a retro positive patient.","authors":"Poongodi Rajagopal, Likhitha Reddy C, Hima Gopinath, Arundhathi Shankaralingappa","doi":"10.25259/IJDVL_1464_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1464_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral neuritis: Tuberculosis as a rare diagnostic contender.","authors":"Srishti Tripathi, Vasav Tyagi, Deepika Rawat, Anand Srivastava, Kiranpreet Malhotra, Darshan Kumar Bajaj, Urmila Singh, Swastika Suvirya","doi":"10.25259/IJDVL_811_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_811_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of dermoscopy in paediatric vascular anomalies.","authors":"Abhishek Bhagwat, Nikhil Mehta, Ankur Goyal, Sudheer Arava, M Ramam, Gomathy Sethuraman, Somesh Gupta, Neetu Bhari","doi":"10.25259/IJDVL_1053_2023","DOIUrl":"https://doi.org/10.25259/IJDVL_1053_2023","url":null,"abstract":"<p><p>Background Vascular anomalies show highly variable morphology, making clinical identification difficult. Dermoscopy is a non-invasive tool which can aid in their diagnosis, but studies of dermoscopy in vascular anomalies are limited. Aim This study aimed to describe the dermoscopic findings in vascular anomalies in children and evaluate their usefulness over clinical examination alone. Methods Consecutive children with congenital or acquired vascular lesions diagnosed by two experienced dermatologists after detailed history and examination were recruited. Predominant dermoscopic findings of a representative lesion were recorded in a pre-designed proforma with a consensus of two dermatologists trained in dermoscopy. In cases of clinical diagnostic uncertainty, suitable histopathological and radiological investigations were done. Results Sixty-one patients (33 tumours, 26 malformations, and 2 unclassified anomalies) were recruited. The most observed condition was infantile haemangioma (IH) (37.7%) which showed red lacunae and irregularly branched thick-tortuous and thin-serpentine vessels in mixed haemangiomas (30.4%), prominent lacunae in superficial haemangiomas (34.8%) and only branched vessels in deep and treated/involuting (34.8%) haemangiomas. Lacunae were predominantly seen in superficial haemangiomas (p=0.0498) and were missing in deep and involuting haemangiomas (p=0.0027). Port-wine stain (13.1%) showed irregular reticular vessels along with dots and globules with thickness of the network being proportionate to the darker shade clinically. In all, there were nine (14.75%) cases where there was diagnostic uncertainty using clinical features alone and histopathological/radiological investigations were required to establish the final diagnosis. In them, dermoscopy showed findings (as described in previous literature) suggestive of the correct final diagnosis. Limitations Histopathological and radiological investigations were done only in cases where the clinical diagnosis was uncertain. Conclusion Dermoscopy is a useful tool in differentiating between different vascular anomalies such as IH and capillary malformations (CMs) which have different management strategies. Dermoscopy may also be useful in differentiating superficial from deep haemangiomas and proliferating from involuting haemangiomas. It can also help in determining the depth of CMs. Thus, it can obviate the need for invasive diagnostic procedures in paediatric vascular lesions and can guide appropriate treatment and prognosis.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety profile of handheld narrow band ultraviolet B device therapy in vitiligo - Systematic review and meta-analysis.","authors":"Sujay Khandpur, Suvesh Singh, Debopriya Paul","doi":"10.25259/IJDVL_71_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_71_2024","url":null,"abstract":"<p><p>Background Handheld narrowband ultraviolet B (NB-UVB) device is a portable, home-based, patient-friendly equipment used in vitiligo. It is a newer promising treatment that lacks generalised consensus due to heterogenicity among studies. Objective To determine the clinical efficacy and safety profile of handheld NB-UVB devices in the treatment of vitiligo. Methods and Materials Following the PRISMA guidelines and using appropriate keywords, the Embase, PubMed and Scopus databases were searched on 28 November 2023. Data on the proportion of patients with a percentage of re-pigmentation and toxicity were extracted from the included studies. Random effects and fixed model were utilised to generate pooled estimates via meta-analysis. Results Out of 250 articles, 13 studies (557 patients) were included. The extent of repigmentation achieved over a median duration of 6 months (range 3-12 months) was quantified to be > 25%, > 50%, and >75 % in 63.6% (95% CI: 51.0-75.3%), 40.8% (95% CI: 30.4-51.6%) and 15.4% (95% CI: 7.6-25.3%) of patients respectively. After 12 weeks of treatment, the proportions of patients achieving > 25%, > 50%, and >75% re-pigmentation were 31.1% (95% CI: 9.6-58.3%), 12.9% (95% CI: 3.1-28.1%) and 6.5% (95% CI: 1.7-14.1%), respectively. Similarly, at 24 weeks, these proportions were 53.2% (95% CI: 24.5-80.7%), 36.7% (95% CI: 15.8-60.5%), and 11.1% (95% CI: 2.9-23.7%). Minimal erythema dose (MED) calculation-based therapy was not significantly better than therapy given without MED calculation (p = 0.43). The studies with only stable vitiligo patients did not achieve significantly greater > 25% (p = 0.06), > 50% (p = 0.80), and > 75% (p = 0.25) re-pigmentation compared to the studies that also included active or slowly progressive vitiligo. Three sessions per week resulted in significantly higher > 50% (p < 0.01) and > 75% (p = 0.01) re-pigmentation. Totally, 11.3% (38/334) of patients showed no response to therapy. The most commonly reported adverse event was erythema in 33.4% (95% CI: 19.3-49.2%) of patients, with grade 3 and 4 erythema in 27 and 15 patients, respectively. Other adverse events included pruritus, burning, hyperpigmentation, dryness, and blister formation observed in 22.1%, 16.4%, 19.1%, 9.8%, and 9.7% of patients, respectively. Conclusion Handheld NB-UVB portable home-based devices are an efficacious and safe treatment option in vitiligo patients even without MED calculation, when the treatment frequency is three to four sessions per week.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rule-based dermatological strategies: From diagnosis to treatment.","authors":"Alla Akhila, Jothiram Bhuvana, Ramamoorthy Logamoorthy, Kaliaperumal Karthikeyan","doi":"10.25259/IJDVL_1337_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1337_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-4"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haim-Munk syndrome caused by mutation in the CTSC gene in an Indian consanguineous family.","authors":"Meera Lalu, Sahana M Srinivas","doi":"10.25259/IJDVL_1120_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1120_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-4"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal injection of botulinum toxin for erythema in rosacea: A scoping review and meta-analysis.","authors":"Marvin Chia-Han Yeh, Ya-Chu Shih, Yu-Chen Huang","doi":"10.25259/IJDVL_274_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_274_2024","url":null,"abstract":"<p><p>Background Rosacea is a skin condition characterised by persistent facial erythema, flushing, papules, pustules, and telangiectasia. Botulinum toxin A (BoNT-A) has been used to treat a variety of conditions, but its effectiveness in improving facial erythema in rosacea patients is uncertain. Objectives The aim of the study is to evaluate the effectiveness and determine the optimal dose of BoNT-A treatment for rosacea. Methods An online database search (Pubmed, Cochrane Library and Embase) was conducted on 30th June 2023 to identify studies that used intradermal injection of BoNT-A to treat facial erythema in rosacea patients and excluded studies in which BoNT-A was used for facial erythema due to other known medical condition such as menopause, drug or pregnancy. The primary outcome measure for this study was the improvement in erythema score as objectively assessed. A random effect model was used in the meta-analysis. Results Seven studies involving a total of 167 rosacea patients were included in the meta-analysis. Meta-analysis of two randomised controlled trials showed improvement of erythema on the third month after treatment standardized mean difference (SMD): 1.676, 95% confidence interval (CI): 2.278-1.074, I2: 35.76%). A separate analysis of seven single-armed treatment studies found significant improvement in erythema with intradermal injection of BoNT-A at one, two and three months after treatment (first month: SMD: 2.712, 95% CI: 4.1182-1.243; second month: SMD:2.213, 95% CI: 3.702-0.725; third month: SMD: 1.912, 95% CI: 2.882-0.941). Adverse events, including mild facial paralysis and injectional purpura, were reported in some studies. Limitation The limitations of this study include heterogeneity in study design and a small sample size. Conclusion Intradermal injection of BoNT-A may be an effective treatment for facial erythema in rosacea. Unwanted facial muscle paralysis was seen in different BoNT-A concentration but not noted when the dose was less than 0.02ml per site. Future studies particularly randomised trials are required to identify the volume of injection required to reduce the erythema.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of variants IKBKG exon4-10 del and c.1167dupC using a novel gene-specific gap-PCR and long accurate-PCR in two families with incontinentia pigmenti.","authors":"Xiangyou Leng, Xinyi Liu, Jin Wang, Shengfang Qin, Xueyan Wang","doi":"10.25259/IJDVL_1229_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1229_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}