Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Association between lichen sclerosus and thyroid diseases: A systematic review and meta-analysis.","authors":"Po-Chien Wu, I-Hsin Huang, Cheng-Chen Tai, Ching-Chi Chi","doi":"10.25259/IJDVL_54_2025","DOIUrl":"10.25259/IJDVL_54_2025","url":null,"abstract":"<p><p>Background Lichen sclerosus (LS) is a chronic inflammatory dermatosis characterised by ivory-white patches to plaques. Evidence suggests an autoimmune aetiology for LS, given its association with various autoimmune conditions, such as autoimmune thyroiditis, alopecia areata (AA), and vitiligo. However, the association between LS and thyroid diseases remained controversial. Aim We aimed to investigate the association between LS and thyroid diseases. Methods We performed a systematic review of studies on the association between LS and thyroid diseases. We searched CENTRAL, MEDLINE, and Embase from inception to May 28, 2024. Studies were included if they were case-control designs with LS patients and controls, reported thyroid disease outcomes, and provided effect estimates; two authors screened titles and abstracts to exclude studies without LS or thyroid data, lacking controls, reviews, case reports, or grey literature, with disagreements resolved by the corresponding author. Odds ratio (OR) of various thyroid conditions in relation to LS was calculated using a random-effects model meta-analysis. When adjusted estimates were available, the pooled adjusted OR (aOR) was calculated. The risk of bias in the selected studies was assessed using the Newcastle-Ottawa Scale for case-control studies. Results We included nine studies involving 1,77,488 LS patients and 2,21,77,269 controls. Most patients, primarily middle-aged females, were recruited from USA, and others were recruited from Poland, Sweden, UK, Finland, and Serbia. All the studies scored 7 or higher for quality in selection, comparability, and exposure. Significant associations were identified between LS and various thyroid conditions, including thyroid diseases (OR 2.48; 95% confidence interval (CI) 2.01-3.05, from two studies, 1,055 LS patients and 2,040 controls), thyroiditis (OR 2.07; 95% CI 1.18-3.63, from two studies, 1,202 LS patients and 2,252 controls), autoimmune thyroid disease (OR 4.07; 95% CI 3.78-4.38, from one study, 10,004 LS patients and 21,672,016 controls), autoimmune thyroiditis/Hashimoto thyroiditis (OR 2.97; 95% CI 1.92-4.59, from three studies, 21,461 LS patients and 21,707,152 controls), and Graves' disease (OR 2.34; 95% CI 2.02-2.71, from 1 study, 10,004 LS patients and 21,672,016 controls) based on crude estimates. The adjusted estimates revealed significantly increased odds of family history of thyroid disease (aOR 9.10; 95% CI 2.30-36.00), hypothyroidism (aOR 1.91; 95% CI 1.24-2.95), thyroiditis (aOR 2.00; 95% CI 1.22-3.29), and autoimmune thyroiditis/Hashimoto thyroiditis (aOR 2.88; 95% CI 1.95-4.25) among LS patients. Limitations Limitations such as a small number of included studies, lack of subgroup data, reliance on a few studies for analysis, absence of long-term cohort data, potential influence of systemic treatments, and variability in thyroid disease terminology highlight the need for future research with more diverse populations, standardised definit","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"171-178"},"PeriodicalIF":3.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.","authors":"Japnoor Kaur, Vaishnavi Verma, Balamurugan Thirunavukkarasu, Vishal Gupta","doi":"10.25259/IJDVL_1364_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1364_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).","authors":"Avanija Sai Gajula, Sheetanshu Kumar, Akshay Meena, Sivaranjini Ramassamy","doi":"10.25259/IJDVL_1099_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1099_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.4,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.","authors":"Chirag Ashwin Desai, Ram Kumar K R","doi":"10.25259/IJDVL_1350_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1350_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1"},"PeriodicalIF":3.4,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patch testing in India: Are we missing clinically relevant allergens?","authors":"Surabhi Sinha, Archana Singal","doi":"10.25259/IJDVL_1719_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1719_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-4"},"PeriodicalIF":3.4,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.","authors":"Vibhu Mendiratta, Anukriti Yadav, Sampurna Dash, Anita Nangia, Harsh Vardhan Gautam, Simar Mendiratta","doi":"10.25259/IJDVL_660_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_660_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.4,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camille Melchoir Gibert (1797-1866): Pityriasis rosea and beyond.","authors":"Amiya Kumar Mukhopadhyay","doi":"10.25259/IJDVL_1247_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1247_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-5"},"PeriodicalIF":3.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post cellulitis lymphoedema en plaque: A presentation needing recognition.","authors":"Suman Patra, Abhishek Bhardwaj, Maninder Kaur, Meenakshi Rao","doi":"10.25259/IJDVL_758_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_758_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes in patients of livedoid vasculopathy following antithrombotic therapy: A retrospective observational study.","authors":"Priyansh Gupta, Vishal Thakur, Biswanath Behera, Bikash Ranjan Meher, Madhusmita Sethy, Pavithra Ayyanar, Priyanka Sangwan, Bhini Ameta","doi":"10.25259/IJDVL_673_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_673_2025","url":null,"abstract":"<p><p>Background Livedoid vasculopathy, characterised by painful ulcers and atrophie blanche, significantly affects the quality of life of patients. Data pertaining to the efficacy of various available treatment options for this condition is limited, especially in India. Aim The study aimed to evaluate the treatment outcomes, clinicodemographic features, and associated laboratory abnormalities in patients with livedoid vasculopathy at a tertiary care centre. Methods This retrospective observational study analysed the case records and clinical photos of all clinically and histologically proven cases of livedoid vasculopathy who received antithrombotic treatment and were followed up for a minimum of 6 months. The primary endpoint was the proportion of patients who achieved a pain visual analogue (VAS) score of zero and complete healing of livedoid vasculopathy ulcers at 3 months. The secondary endpoint was the proportion of patients who achieved a pain VAS score of zero and complete healing of livedoid vasculopathy ulcers at 6 months. Side-effects, improvements in the dermatological life quality index (DLQI), clinicodemographic features, and associated laboratory abnormalities were also analysed. Results Of the 26 patients who satisfied the inclusion and exclusion criteria, 20 were males. At 3 months, 65.3% (17) of patients achieved the primary endpoint. Of these, 11 had received rivaroxaban (10mg) once daily and six had received aspirin (150mg) once daily. At 6 months, 96.1% (25) of patients had complete ulcer healing and achieved a VAS pain score of 0. Of these, 11 patients had received rivaroxaban, eight had received a combination of rivaroxaban and aspirin, and six had received aspirin. The improvements in VAS and DLQI at 3 months and 6 months were significant. None of the patients had any adverse effects from the therapy. Limitations The small sample size and its retrospective nature were limitations of the study. Conclusion Monotherapy with rivaroxaban or aspirin can effectively heal the ulcers, successfully achieve pain control, and improve the quality of life in livedoid vasculopathy. However, a fraction of patients may need a combination of the two to achieve these therapeutic goals. Both monotherapy and combination therapy are safe and not associated with significant side effects.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-9"},"PeriodicalIF":3.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leprosy-tuberculosis co-infection: A case series.","authors":"Mohammad Adil, Syed Suhail Amin, Saima Naaz, Ayesha Sharmeen","doi":"10.25259/IJDVL_1172_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_1172_2025","url":null,"abstract":"<p><p>Background Leprosy and tuberculosis (TB) share common characteristics, such as acid-fastness of causative bacteria, geographic endemicity, route of spread, large number of asymptomatic infections, and requirement of multiple drugs for long periods of time to prevent resistance and provide treatment. Being relatively common, co-infection with the two diseases should occur based on chance alone. However, coinfection is surprisingly rare, with less than 20 cases being reported in the last decade. Aim The purpose of this case series was to study the clinico-epidemiological profile of patients with leprosy and TB co-infection. Methods This prospective, descriptive, case series describes leprosy patients with a past or current diagnosis of TB who visited the leprosy clinic of a tertiary care hospital over 3 years. The demographic details of the patients, details about the type of leprosy, slit skin smear, lepra reaction, and use of corticosteroids were noted for all patients. The type of TB, chest X-ray findings, sputum positivity, Interferon gamma release assay (IGRA) test, and Mantoux test results were recorded. The gap between the two diagnoses, the first disease to be diagnosed, family history of either disease, and the presence of predisposing factors were noted. Results This case series describes a total of 20 patients with leprosy co-infected with TB. There were 11 (55%) males, and the mean age of patients was 32.7 years. Half of these patients had lepromatous leprosy, and a similar number had type 2 lepra reaction. Pulmonary TB was seen in 12 (60%) patients, and tubercular pleural effusion in two (10%) patients. Multidrug-resistant TB was seen in two patients, and only one patient had received the bacilli of Calmette-Guerin (BCG) vaccination. Of the two diseases, leprosy was diagnosed first in six (30%) patients, while it was TB in 12 (60%) patients, and two (10%) patients had a concomitant diagnosis. Limitations The small number of patients in this single-centre study from a tertiary care hospital may not be reflective of the general population. Conclusion Leprosy and TB co-infection may present several management issues involving diagnosis and treatment, including drug resistance to tubercular bacilli. Management guidelines for such coinfections are needed to facilitate treatment of such patients and prevent high mortality and morbidity associated with such coinfections. More studies are needed to correctly define the clinico-epidemiological parameters of patients with co-infection.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}