Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Clinical and immunological predictors of chronicity in erythema nodosum.","authors":"Kriti Jain, Prita Pradhan, Hemanta Kumar Kar, Debasmita Behera, Riya Sukhija, Sejal Bajoria, Garima Manocha, Sakir Ahmed","doi":"10.25259/IJDVL_1626_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1626_2024","url":null,"abstract":"<p><p>Background Erythema nodosum (EN) is a painful inflammatory disorder of the subcutaneous fat and the most common type of septal panniculitis. It often presents as erythematous, tender subcutaneous nodules, typically affecting the shins. EN is frequently a hypersensitivity reaction that can serve as a warning sign for an underlying systemic disorder, making it crucial to identify the cause. Though self-limiting in many cases, EN can sometimes become chronic, leading to significant discomfort. The pathogenesis of EN and the predictors of chronicity remain unclear, necessitating further investigation. Aims This study aimed to evaluate the various etiologies of EN and determine the clinical, laboratory, and immunohistochemical predictors of chronicity. Methods We conducted a prospective hospital-based study between July 2022 and June 2024 at a tertiary care centre in Eastern India. Clinical and histopathologically confirmed cases of EN presenting within 2-3 days of onset, without prior treatment, were enrolled. A detailed clinical examination and laboratory investigations were performed during the initial visit, including immunohistochemical analysis of skin biopsies. The total number of T cells (CD3+), helper T cells (CD4+), cytotoxic T cells (CD8+), CD4:CD8 ratio, and NK (natural killer) cells (CD56+) were quantified per skin biopsy specimen using a standardised technique. Patients were treated at the discretion of the treating physician. Patients were monitored monthly for three months and categorised as either having \"Classic EN\" (lesions resolving within three months) or \"Chronic EN\" (lesions persisting beyond three months). Data collected at the initial visit were correlated between the two groups to identify potential predictors of chronicity. Results Out of 63 suspected cases, EN was confirmed in 41 patients, who were predominantly females (65.85%), with a median age of 49 years (Q1 - Q3: 32 - 57). Pulmonary tuberculosis was the most frequent underlying condition (n = 15, 36.59%), followed by sarcoidosis (n = 8, 19.51%) and rheumatoid arthritis (n = 6, 14.63%). Chronic EN was observed in 36.59% of cases, with significantly elevated baseline C-reactive protein (CRP) levels (p = 0.003) and Mantoux test readings (p = 0.002). Immunohistochemistry revealed higher CD3, CD4, CD8, and CD56 levels in chronic EN cases (p < 0.05). Limitations The study's limitations include a small sample size and short follow-up duration. Multivariable analysis could not be performed due to the small sample size. Conclusion This study identified clinical and immunohistochemical markers associated with the chronicity of EN and highlighted pulmonary tuberculosis as the most common underlying cause. Elevated CRP levels, positive Mantoux test results, and increased expression of CD3, CD4, CD8, and CD56 observed at baseline were linked to chronicity. The findings suggest the predominant role of T helper 1 (Th1) cell response and innate immunity in the pathogenesis of c","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 Supplementary 1","pages":"S1-S7"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serpentine and annular presentation of extragenital lichen sclerosus-morphea overlap.","authors":"Divya Bhatia, Anupama Bains, Vikarn Vishwajeet","doi":"10.25259/IJDVL_1317_2023","DOIUrl":"10.25259/IJDVL_1317_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S43-S45"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear lichen planus of the genitalia.","authors":"Ariharasudhan Varadharajan, Prateek Nayak, Gitesh U Sawatkar, Nisha Meshram","doi":"10.25259/IJDVL_1441_2024","DOIUrl":"10.25259/IJDVL_1441_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S92"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the diagnostic capability of ChatGPT through clinical case scenarios in dermatology.","authors":"Perumal Manoharan, Krishna Mohan Surapaneni","doi":"10.25259/IJDVL_1267_2023","DOIUrl":"10.25259/IJDVL_1267_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S27-S28"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic features of primary cutaneous extranodal natural killer (NK)/T-cell lymphoma.","authors":"Xiaopo Wang","doi":"10.25259/IJDVL_1222_2023","DOIUrl":"10.25259/IJDVL_1222_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S46-S49"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A curious case of solitary black nail.","authors":"Shekhar Neema, Vikas Pathania, Akansha Tripathi, Rohit Kothari, Vikram Singh, Anshuman Singh","doi":"10.25259/IJDVL_1028_2024","DOIUrl":"10.25259/IJDVL_1028_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S90-S91"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newer entities in dermatology: A short review on the newly defined dermatoses and acronyms.","authors":"Sukhdeep Singh, Manavi Gupta, Anuradha Bishnoi, Sanjeev Handa","doi":"10.25259/IJDVL_710_2024","DOIUrl":"10.25259/IJDVL_710_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"412-416"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An eye on Artificial intelligence (AI) from the Editor's perspective.","authors":"Feroze Kaliyadan, Archana Singal","doi":"10.25259/IJDVL_574_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_574_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 3","pages":"285-286"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of dermoscopy in pediatric vascular anomalies.","authors":"Abhishek Bhagwat, Nikhil Mehta, Ankur Goyal, Sudheer Arava, M Ramam, Gomathy Sethuraman, Somesh Gupta, Neetu Bhari","doi":"10.25259/IJDVL_1053_2023","DOIUrl":"10.25259/IJDVL_1053_2023","url":null,"abstract":"<p><p>Background Vascular anomalies show highly variable morphology, making clinical identification difficult. Dermoscopy is a non-invasive tool which can aid in their diagnosis, but studies of dermoscopy in vascular anomalies are limited. Aim This study aimed to describe the dermoscopic findings in vascular anomalies in children and evaluate their usefulness over clinical examination alone. Methods Consecutive children with congenital or acquired vascular lesions diagnosed by two experienced dermatologists after detailed history and examination were recruited. Predominant dermoscopic findings of a representative lesion were recorded in a pre-designed proforma with a consensus of two dermatologists trained in dermoscopy. In cases of clinical diagnostic uncertainty, suitable histopathological and radiological investigations were done. Results Sixty-one patients (33 tumours, 26 malformations, and 2 unclassified anomalies) were recruited. The most observed condition was infantile haemangioma (IH) (37.7%) which showed red lacunae and irregularly branched thick-tortuous and thin-serpentine vessels in mixed haemangiomas (30.4%), prominent lacunae in superficial haemangiomas (34.8%) and only branched vessels in deep and treated/involuting (34.8%) haemangiomas. Lacunae were predominantly seen in superficial haemangiomas (p=0.0498) and were missing in deep and involuting haemangiomas (p=0.0027). Port-wine stain (13.1%) showed irregular reticular vessels along with dots and globules with thickness of the network being proportionate to the darker shade clinically. In all, there were nine (14.75%) cases where there was diagnostic uncertainty using clinical features alone and histopathological/radiological investigations were required to establish the final diagnosis. In them, dermoscopy showed findings (as described in previous literature) suggestive of the correct final diagnosis. Limitations Histopathological and radiological investigations were done only in cases where the clinical diagnosis was uncertain. Conclusion Dermoscopy is a useful tool in differentiating between different vascular anomalies such as IH and capillary malformations (CMs) which have different management strategies. Dermoscopy may also be useful in differentiating superficial from deep haemangiomas and proliferating from involuting haemangiomas. It can also help in determining the depth of CMs. Thus, it can obviate the need for invasive diagnostic procedures in paediatric vascular lesions and can guide appropriate treatment and prognosis.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"363-368"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of multivariant enzyme-linked immunosorbent assay (ELISA) in the diagnosis of autoimmune bullous disorders in a resource-limited setting: A single-center experience.","authors":"Vinod Kumar, Dipankar De, Smriti Gupta, Vignesh Narayan R, Rahul Mahajan, Debajyoti Chatterjee, Sanjeev Handa","doi":"10.25259/IJDVL_1195_2023","DOIUrl":"10.25259/IJDVL_1195_2023","url":null,"abstract":"<p><p>Background Autoimmune blistering disorders (AIBD) result from the formation of auto-antibodies against adhesion proteins of the skin/mucosa(e). These auto-antibodies can be detected in the bound form in the tissue using direct immunofluorescence (DIF) or blood circulation using enzyme-linked immunosorbent assay (ELISA) or other methods. Objectives The objective of this study was to evaluate the concordance rate between the results of multivariant ELISA and the diagnosis of AIBD made using DIF and histopathology in an appropriate clinical context. Methods This was a retrospective study (December 2020 to April 2023) in which the multivariant ELISA assay (able to detect antibodies against desmoglein 1, desmoglein 3, BP180, BP230, envoplakin, and collagen VII) data were retrieved from the dermatology laboratory. Corresponding clinical and histopathology data were searched from relevant institutional databases. As per routine practice, the final diagnosis was assigned based on the clinical presentation, histopathology features and corresponding DIF report. Results After screening the records of 338 patients during the study period, 253 patients were included. Of them, 194 had AIBD and 59 had non-AIBD. In the autoimmune blistering disorder group, 122 and 72 patients had pemphigus and pemphigoid, respectively. Overall, a good level of agreement was found between multivariant ELISA results and the final diagnosis (Fleiss kappa = 0.631, p-value < 0.001). The pemphigus vulgaris group exhibited good agreement (kappa = 0.796, p < 0.001), while pemphigus foliaceous, bullous pemphigoid and non-autoimmune blistering disorders demonstrated moderate agreement (kappa = 0.641, 0.651, 0.533, respectively; p < 0.001). The mucous membrane pemphigoid group had a fair agreement (kappa = 0.289; p < 0.001). Limitations The limitations for the study were its retrospective design, fewer number of patients in certain groups like paraneoplastic pemphigus and gold-standard single antigen specific ELISA was not done. Conclusion Considering good agreement between the multivariant ELISA and the gold-standard diagnosis (clinical findings plus histopathology plus DIF), multivariant ELISA can be used for the diagnosis of AIBDs in places where facilities for DIF are unavailable. Multivariant ELISA can improve etiological diagnosis for a set of autoimmune blistering disorders whose target antigens are represented in the multivariant panel.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"300-304"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}