Shany Sherman, Hadar Duskin-Bitan, Tamir Agiv, Danielle Bar, Lilach Marom-Haham, Assi Levi, Daniel Mimouni, Li-Chi Chen, John E Harris, Jen Barak Levitt, Yochai Schonmann, Arnon D Cohen, Doron Netzer
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引用次数: 0
摘要
背景白癜风和黄褐斑的双重诊断及其相关性研究很少。目的验证白癜风与黄褐斑之间存在独立双向关联的假说。方法对24436例白癜风患者和119205例匹配对照者进行人群研究。采用回顾性队列设计和嵌套病例对照设计,计算校正风险比(hr)和优势比(ORs)。结果白癜风组每1000人年黄褐斑发生率为1.38 (95% CI 1.22-1.54),对照组为0.88 (95% CI 0.84-0.96)。无论激素治疗、光疗和甲状腺疾病,白癜风患者发生黄褐斑的风险增加了60%(调整后HR, 1.58; 95% CI, 1.35-1.86)。白癜风患者中已有黄褐斑的患病率高于匹配比较组(0.9% vs. 0.5%, P
Bidirectional association between vitiligo and melasma: A large-scale population-based study.
Background The dual diagnosis of vitiligo and melasma and their association has hardly been studied. Objective To test our hypothesis of an independent bidirectional association between vitiligo and melasma. Methods A population-based study was conducted on 24,436 patients with vitiligo and 119,205 matched comparators. Both a retrospective cohort design and a nested case-control design were used, with the calculation of adjusted hazard ratios (HRs) and odds ratios (ORs). Results The incidence of melasma per 1000 person-years was 1.38 (95% CI 1.22-1.54) in the vitiligo group and 0.88 (95% CI 0.84-0.96) in the comparison group. Patients with vitiligo had a 60% increased risk of developing melasma regardless of hormonal treatment, phototherapy, and thyroid disorders (adjusted HR, 1.58; 95% CI, 1.35-1.86). The prevalence of pre-existing melasma was higher in patients with vitiligo than in matched comparators (0.9% vs. 0.5%, P<0.001). Melasma was associated with a 30% increase in the odds of developing vitiligo (adjusted OR 1.32; 95% CI 1.12-1.55), regardless of hydroquinone treatment. Limitations Retrospective data collection. Conclusion A bidirectional association between vitiligo and melasma was observed. Treatment strategies for individuals with a dual diagnosis warrant further investigation.
期刊介绍:
The Indian Association of Dermatologists, Venereologists & Leprologists (IADVL) is the national association of Indian medical specialists who manage patients with skin disorders, sexually transmitted infections (STIs) or leprosy. The current member strength of the association is about 3800. The association works for the betterment of the specialty by holding academic meetings, printing a journal and publishing a textbook. The IADVL has several state branches, each with their own office bearers, which function independently within the constitution of the IADVL.
Established in 1940, the Indian Journal of Dermatology, Venereology and Leprology (IJDVL, ISSN 0378-6323) is the official publication of the IADVL (Indian Association of Dermatologists, Venereologists and Leprologists).