Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Efficacy and safety of intralesional triple combination versus intralesional triamcinolone acetonide for the treatment of keloids: A randomised controlled trial.","authors":"T Sanjay Kumar Menon, Jude Ernest Dileep, Sheela Kuruvila, Damayandhi Kaliyaperumal, Ilakkia Priya Sadasivam, Sushmitha Dharanisankar, Gayathri Jayabalan, Divya Mani","doi":"10.25259/IJDVL_1263_2024","DOIUrl":"10.25259/IJDVL_1263_2024","url":null,"abstract":"<p><p>Background Treatment of keloids presents a significant therapeutic challenge due to their tendency to recur and their impact on a patient's quality of life. This randomised controlled trial aimed to compare the effectiveness of intralesional triple combination regimen versus intralesional triamcinolone acetonide monotherapy in treating keloids. Aims To compare the efficacy and safety of intralesional triple combination versus intralesional triamcinolone acetonide monotherapy in treating keloids at any site. Methods This study was conducted in the outpatient department of Dermatology, Venereology and Leprosy in a tertiary care hospital at Puducherry. Seventy two patients aged ≥18 years with a clinical diagnosis of keloids of any duration, involving any site and without any prior treatment were included in the study. Patients were randomised into two groups: Group A received intralesional triple combination (triamcinolone acetonide, 5-fluorouracil and hyaluronidase), while Group B received intralesional triamcinolone acetonide monotherapy. Treatments were administered every three weeks for four sessions or till complete flattening, whichever was earlier. The Vancouver Scar Scale was used for assessment at baseline and every three weeks for four sessions, and monthly for three months post treatment. Results Both groups showed significant improvement in the Vancouver Scar Scale scores at each follow-up compared to baseline. The mean (percentage) improvement in the Vancouver Scar Scale score in Group A was 0.58 ± 0.5 (7.08%) at three weeks, which progressively increased to 4.47 ± 1.29 (54.55%) at the final follow-up. In Group B, the improvement was lesser, with 0.08 ± 0.28 (0.95%) at three weeks, increasing to 3.08 ± 0.81 (36.65%) at the final follow-up. This improvement was significantly more in Group A at all time points compared to Group B (p < 0.05). Post-procedure pain, which lasted for a few hours, was noted in three and two patients in Groups A and B, respectively (p = 0.642). None of the patients had a recurrence of keloids during the study. Limitations Limitations of this study include small sample size, single centre design, short follow-up period, lack of blinding and patient-reported outcome measures, which may impact the generalisability of the findings. Conclusion Intralesional triple combination is more effective than triamcinolone acetonide monotherapy in treating keloids, offering significantly superior improvements in the Vancouver Scar Scale scoring.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"425-431"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards standardised and effective keloid therapy: Lessons from a randomised controlled trial.","authors":"Pooja Arora","doi":"10.25259/IJDVL_858_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_858_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 4","pages":"423-424"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic agents for Hailey-Hailey disease: A narrative review.","authors":"Kabir Sardana, Abhinav Bansal, Aishwarya Muddebihal, Ananta Khurana","doi":"10.25259/IJDVL_906_2024","DOIUrl":"10.25259/IJDVL_906_2024","url":null,"abstract":"<p><p>Hailey-Hailey disease (HHD) is an autosomal dominant genetic disorder of keratinocyte adhesion. It occurs due to mutations in ATP2C1, a gene on chromosome 3q21-24 which encodes human secretory pathway Ca2+/Mn2+ ATPase isoform 1, a calcium pump on the Golgi apparatus membrane. Recently, there has been a focus on certain pro-inflammatory cytokines such as IL-6 and IL-8 which play a role in HHD. Various triggers include excessive heat, menstruation, pregnancy, sweating, friction, exposure to sunlight and superficial infections. The therapy of the disorder is better understood by the varied pathogenetic steps and we aimed to comprehensively search for the various medical therapies used in HHD and align them with the existing knowledge on the pathogenesis and delineate them according to their major mode of action.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"462-469"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Neisseria gonorrhoeae susceptibility trends (MIC creep) from North India: A 15-years' experience!","authors":"Seema Sood, Somesh Gupta, Rachna Verma, Rajendra Singh, Sonu Kumari Agrawal, Neeraj Mahajan, Vinod Kumar Sharma","doi":"10.25259/IJDVL_1096_2024","DOIUrl":"10.25259/IJDVL_1096_2024","url":null,"abstract":"<p><p>Background Neisseria gonorrhoeae (NG) is a highly transformable strict human pathogen with the potential to evolve into a 'superbug' Resource-limited settings like ours rely on the syndromic diagnostic approach recommended by the WHO and adopted by the National AIDS Control Organisation (NACO) for the management of sexually transmitted infections (STIs). The 'Grey kit\" comprising of cefixime 400 mg and azithromycin 1 gm is recommended for genitourinary discharge in India. Aim The objective of this study was to examine putative changes in minimum inhibitory concentration (MICs) of ceftriaxone/cefixime and azithromycin during a ∼15-year period to assess the need for dosage adjustment. Methods All clinical isolates of NG obtained from patients attending the STI clinic of our hospital were included in the study. The MIC for penicillin, tetracycline, ciprofloxacin, ceftriaxone, cefixime, azithromycin, and spectinomycin was determined using the E-test method. The results were interpreted according to the Calibrated Dichotomous Sensitivity (CDS) criteria except for azithromycin (up to 2011) and cefixime, where Clinical & Laboratory Standards Institute (CLSI) guidelines were used. We analysed our data by years (2008-2012 vs. 2013-2017) and examined the limited data available thereafter until June 2023 (in light of COVID). MIC50 and MIC90 (MIC values that stop the growth of 50% and 90% of bacterial isolates respectively) data were analysed for determination of MIC creep. Results A total of 183 NG isolates were collected during the study period (151 during 2008-2017 and 32, 2018 onwards). All isolates were from male patients presenting with urethritis. High resistance levels were observed for penicillin, tetracycline, and ciprofloxacin, but decreased susceptibility to ceftriaxone or cefixime remained (<10%), as did resistance to azithromycin (<5%). Notably, no ceftriaxone resistance was detected over the ∼15-year period, and no significant increase in MIC (MIC creep) was observed for ceftriaxone and azithromycin. Only two isolates showed concurrent resistance to azithromycin and decreased susceptibility to ceftriaxone. All isolates were susceptible to spectinomycin. Limitations The clinical isolates were obtained from a single site, and the numbers were limited. There is a paucity of data during the COVID-19 pandemic due to limited clinical services being offered. Conclusion There appears to be no immediate threat to the therapies currently being used in syndromic management for genitourinary discharge. However, MIC-based monitoring of crucial antimicrobials is imperative.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"432-439"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blaschkoid lichen planus pigmentosus on face.","authors":"Singamsetty Sushma, Kollipara Haritha, Gandikota Raghu Rama Rao, Sudhir Babu K","doi":"10.25259/IJDVL_709_2024","DOIUrl":"10.25259/IJDVL_709_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"555-556"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate dosage and laboratory monitoring in patients with psoriasis and psoriatic arthritis: A retrospective analysis of prescription patterns and financial impact in dermatology and rheumatology settings.","authors":"Gopikrishnan Anjaneyan, Prateek Nayak, Jyothish R Pillai, Mithun Cb, Lekshmi Sajini, Soumya Jagadeesan, Vinitha Varghese Panicker","doi":"10.25259/IJDVL_1384_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1384_2024","url":null,"abstract":"<p><p>Background Methotrexate (MTX) is a disease-modifying drug used for psoriasis (PsO) and psoriatic arthritis (PsA), but dermatology and rheumatology guidelines differ in dosing and monitoring recommendations. Objectives To compare methotrexate dosing and monitoring practices in dermatology and rheumatology, assess adverse drug reactions, and analyse the financial impact of rigorous monitoring. Methods This observational, electronic medical record-based retrospective chart review included psoriasis and psoriatic arthritis patients started on methotrexate at the dermatology and rheumatology departments at a tertiary care centre in 2020-2021. Patients with concurrent hepatotoxic/myelotoxic medications, inadequate follow-up, or abnormal baseline laboratory tests were excluded. Data regarding demographics, relevant medical histories, clinical variables, methotrexate dosing, frequency of laboratory monitoring, adverse events, and resource utilization were recorded and analysed. Descriptive statistics (means/percentages) and inferential tests (Chi-Square Test or Mann- Whitney Test) were used based on data normality (p<0.05 considered significant). Results The study included 100 psoriasis and psoriatic arthritis patients each. The psoriatic arthritis patients were given higher methotrexate doses initially but underwent less frequent laboratory monitoring compared to psoriasis patients. The incidence of hepatotoxicity was comparable between the two groups. However, leukopenia was observed more frequently in psoriatic arthritis patients. Methotrexate monitoring under dermatologists cost 44% more than that under rheumatologists over 6 months (Rs 4766.08± 1631.9 vs Rs 3290.32± 1207.8). Limitations The single centre, small sample size, retrospective chart review, and convenience sampling in this study may all limit the generalisability of the findings. Conclusion Current methotrexate guidelines in dermatology recommend lower doses and more frequent monitoring than rheumatology guidelines. Insights from this study and comparison with rheumatology practices and existing literature highlight the potential for designing large-scale, multicentric, non-inferiority studies that could eventually help develop more efficient and streamlined methotrexate monitoring protocols for dermatology and rheumatology, ultimately improving patient adherence, safety and affordability.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail involvement in Kaposi sarcoma: A rare location.","authors":"Zineb Bennouna, Hanane Baybay, Zakia Douhi, Meryem Soughi, Sara Elloudi, Fatimazahra Mernissi","doi":"10.25259/IJDVL_37_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_37_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-4"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Box counting serial image index (BCSI) versus point counting serial image index (PCSI) in scoring melasma: A comparative, non-interventional validation study.","authors":"Papishetty Prathyusha, Jabeen Nihaa, Rangappa Vinutha, Pss Ranugha, N Srilakshmi, Shastry Veeranna, Garehatty Rudrappa Kanthraj","doi":"10.25259/IJDVL_1417_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1417_2024","url":null,"abstract":"<p><p>Background Point counting serial image index (PCSI) is a scoring method used to assess the area and severity of melasma. Double tracing and the inability to assess scattered pigmentation are its limitations. Objectives To propose modifications to PCSI, the Box counting serial image index (BCSI) was compared and validated with PCSI. Methods In BCSI, a preset grid was placed, and serial images were captured. One speck of pigmentation was counted as one box. The area involved and time taken were recorded by the principal investigator and coinvestigator using BCSI and PCSI methods, respectively. The intensity of the pigmentation was recorded on a scale of 0-5. Melasma score = Area x Intensity of pigmentation. The difference in the total scores and time taken were analysed. Results A significant decrease (p<0.0003) in the total scores between baseline and first follow-up and baseline and second follow-up was observed in both methods. Similarly to PCSI, BCSI was found to be sensitive to changes over time with treatment (p<0.0003). These p values were recalculated using Bonferroni corrections. The mean time taken by PCSI was significantly higher than BCSI (p < 0.0003). Limitations Grid placement over bony prominences and interference of facial hair. Conclusion BCSI overcomes the limitations of PCSI by directly capturing images and it is easy and rapid.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"District residency programme for postgraduates in India: Dermatology residents' perspectives.","authors":"Ankitha Adiga, Swathi Nagabushan, Ramesh Bhat M","doi":"10.25259/IJDVL_187_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_187_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple epidermoid cysts on the glans in an adolescent patient.","authors":"Hao Zhao, Tao Yang, Jie Liu, Lang Xie, Cong You","doi":"10.25259/IJDVL_510_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_510_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}