Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Fractional carbon dioxide laser treatment for refractory exfoliative cheilitis.","authors":"Nanlan Yu, Xiaofang Zhou, Xin Wang, Mingwang Zhang","doi":"10.25259/IJDVL_894_2024","DOIUrl":"10.25259/IJDVL_894_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"523-527"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purpuric paradigm: Multiple purpuric lesions on palms.","authors":"Apoorva Sharma, Narayanan Baskaran, Debajyoti Chatterjee, Sanjeev Handa","doi":"10.25259/IJDVL_478_2024","DOIUrl":"10.25259/IJDVL_478_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"547-549"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures in chronic urticaria: A comprehensive review.","authors":"Shikha Shah, Manavi Gupta, Anuradha Bishnoi, Davinder Parsad, Muthu Sendhil Kumaran","doi":"10.25259/IJDVL_523_2024","DOIUrl":"10.25259/IJDVL_523_2024","url":null,"abstract":"<p><p>Chronic urticaria, characterised by pruritic wheals, angioedema or both significantly impacts individuals' quality of life. This review article examines the patient-reported outcome measures (PROMs) in chronic urticaria assessment, aiming to enhance understanding and management of this condition The review categorises PROMs into urticaria-specific and angioedema-specific tools. Urticaria-specific PROMs such as the Urticaria Activity Score (UAS), Urticaria Control Test (UCT), Chronic Urticaria Quality of Life Questionnaire (CU-QoL) and Urticaria Severity Score (USS) focus on disease activity, control, severity and quality of life. Angioedema-specific tools include the Angioedema Activity Score (AAS), Angioedema Control Test (AECT) and Angioedema Quality of Life Questionnaire (AE-QoL), assessing disease activity, control and quality of life specific to angioedema. Non-specific PROMs like the Dermatology Life Quality Index (DLQI) provide a broader assessment of health-related quality of life across dermatological conditions. Newer developments include disease-specific PROMs like the Cold Urticaria Activity Score (ColdUAS), CholU-QoL for chronic inducible urticarias and the Urticaria Activity and Impact Measure (U-AIM) for retrospective patient-reported outcome assessment. Additionally, the review discusses the integration of smartphone applications and artificial intelligence (AI) tools like Convolutional Neural Networks (CNNs) in automating PROMs, showing promise in improving chronic urticaria management. Despite the progress made in PROMs, ongoing challenges such as limited data on specific populations and languages underscore the need for continued research and standardised PROM usage across clinical settings. This approach can significantly enhance patient management and contribute to a more holistic and effective strategy for addressing chronic urticaria.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"455-461"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining treatment success: Shifting from p-value to clinical meaningfulness.","authors":"Vishal Gupta","doi":"10.25259/IJDVL_857_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_857_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 4","pages":"421-422"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leprosy reactions: New knowledge on pathophysiology, diagnosis, treatment and prevention.","authors":"Hitaishi Mehta, Sejal Jain, Tarun Narang, Seema Chhabra, Sunil Dogra","doi":"10.25259/IJDVL_915_2024","DOIUrl":"10.25259/IJDVL_915_2024","url":null,"abstract":"<p><p>Leprosy, or Hansen's disease, caused by Mycobacterium leprae and Mycobacterium lepromatosis, is a chronic granulomatous infectious disease. Leprosy reactions, characterised by neurocutaneous inflammation, complicate the disease's indolent course, leading to significant morbidity. However, limited knowledge of reaction pathophysiology stems from a lack of experimental models and the abrupt onset of reactional episodes, posing challenges in delineating initial pathogenic steps. In type 1 reactions, ongoing studies explore the roles of interferon-gamma which results in increased interleukin (IL)-15 and autophagy. Leprosy reactions also exhibit an increase in T helper 17 (Th17) and a decrease in T-regulatory cell (Treg) populations, resulting in diminished tumour growth factor-beta and heightened IL-6 and IL-21 production. Exploring the pathogenesis of erythema nodosum leprosum (ENL) reveals insights into neutrophils, Toll-like receptor 9, B-cells, myeloid-derived suppressor cells, IL-10 pathway and neurotrophins. Noteworthy therapeutic targets include increased expression of cyclooxygenase 2 and vascular endothelial growth factor. Early reaction diagnosis is crucial to limit neural damage, with high-resolution ultrasonography showing promise in detecting minimal nerve involvement. Therapies for ENL management, such as thalidomide, methotrexate, apremilast, minocycline and tumour necrosis factor-alpha inhibitors, hold potential. This review addresses recent advances in leprosy reaction pathogenesis and diagnostics, offering therapeutic insights and preventive strategies to mitigate their onset.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"470-481"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety of upadacitinib in the treatment of palmoplantar pustulosis: A single-center retrospective study.","authors":"Yunhong Zheng, Xiaoxu Zhang, Huiping Wang, Runping Yang, Suju Luo","doi":"10.25259/IJDVL_751_2024","DOIUrl":"10.25259/IJDVL_751_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"540-543"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of oral sirolimus - A mammalian target of rapamycin (m-TOR) inhibitor in the treatment of kaposiform haemangioendothelioma with Kasabach-Merritt phenomenon.","authors":"Shekhar Neema, Senkadhir Vendhan, Biju Vasudevan, Silky Priya, A W Kashif, Shweta Pandey","doi":"10.25259/IJDVL_871_2024","DOIUrl":"10.25259/IJDVL_871_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"527-530"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-utility skin clamp for clinical examination and minor procedures in dermatology and other specialities.","authors":"Karalikkattil T Ashique, Puravoor Jayasree, Feroze Kaliyadan","doi":"10.25259/IJDVL_1550_2024","DOIUrl":"10.25259/IJDVL_1550_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"562-563"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging gaps in pediatric dermatology via telemedicine: An analytical cross-sectional study on 961 children in resource-limited areas of North India using the e-Sanjeevani 2.0 platform.","authors":"Kanya Rani Vashisht, Priyadarshini Sahu, Phani Priya Mandula, Nabaneeta Dash, Amit Agarwal, Richa Gupta, Biman Saikia","doi":"10.25259/IJDVL_1223_2024","DOIUrl":"10.25259/IJDVL_1223_2024","url":null,"abstract":"<p><p>Background Pediatric tele-dermatology (PTD) offers a potential solution for delivering specialised dermatological care to children in remote areas. Objectives To evaluate the scope, utilisation, receptivity, and factors influencing the optimisation of PTD practice within the context of a developing country's demographic. Methods The study analysed 961 PTD consultations over six months, conducted in underserved areas of North India via an assisted telemedicine platform, e-Sanjeevani 2.0. Data were gathered cross-sectionally through standardised forms, complemented by a retrospective survey to capture the perceptions of referring healthcare providers (RHPs). Patient clinico-demographics and various consultation characteristics were assessed for their impact on clinical decision-making. Results Among the 961 cases studied (median age 5 years, IQR: 2-11; 52.1% female), the majority consisted of infections, infestations, and dermatitis, 1.35% cases were acute/emergency dermatoses managed empirically, and only 4.47% required referral. Friedman test revealed highly significant differences in perceived helpfulness amongst the four consultation variables (p<0.001) - image quality being the most helpful, followed by audiovisual/text interaction, multiple images, and past/medical/family history. Wilcoxon Signed Ranks tests indicated significant differences in perceived helpfulness between each pair of variables (p<0.001). The RHP survey reflected a strong endorsement of the process and a high perceived parent/guardian satisfaction rate (4.47 ± 0.87 on a 5-point scale). Limitations The study did not evaluate diagnostic or management concordance due to a lack of in-person evaluation. Other limitations included a low follow-up rate, short duration of study that may have missed seasonal variations in paediatric dermatoses. Additionally, clinical outcomes, cost-effectiveness, and technical factors such as connectivity and video quality were not assessed. Conclusion The findings support the use of real-time PTD to manage less complex, non-procedural cases, reduce in-person consultations, and improve access to paediatric dermatology care in resource-constrained settings. High-quality images and effective audiovisual communication are pivotal for its optimisation. The service had clinical and educational value and was well-received by parents and providers. The integration of eSanjeevani into India's healthcare infrastructure offers a functional foundation for larger scale expansion of PTD services. Further studies in diverse settings are needed to identify operational barriers to broader implementation and evaluate diagnostic accuracy through direct comparisons with in-person evaluations.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"496-502"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intralesional triple combination versus intralesional triamcinolone acetonide for the treatment of keloids: A randomised controlled trial.","authors":"T Sanjay Kumar Menon, Jude Ernest Dileep, Sheela Kuruvila, Damayandhi Kaliyaperumal, Ilakkia Priya Sadasivam, Sushmitha Dharanisankar, Gayathri Jayabalan, Divya Mani","doi":"10.25259/IJDVL_1263_2024","DOIUrl":"10.25259/IJDVL_1263_2024","url":null,"abstract":"<p><p>Background Treatment of keloids presents a significant therapeutic challenge due to their tendency to recur and their impact on a patient's quality of life. This randomised controlled trial aimed to compare the effectiveness of intralesional triple combination regimen versus intralesional triamcinolone acetonide monotherapy in treating keloids. Aims To compare the efficacy and safety of intralesional triple combination versus intralesional triamcinolone acetonide monotherapy in treating keloids at any site. Methods This study was conducted in the outpatient department of Dermatology, Venereology and Leprosy in a tertiary care hospital at Puducherry. Seventy two patients aged ≥18 years with a clinical diagnosis of keloids of any duration, involving any site and without any prior treatment were included in the study. Patients were randomised into two groups: Group A received intralesional triple combination (triamcinolone acetonide, 5-fluorouracil and hyaluronidase), while Group B received intralesional triamcinolone acetonide monotherapy. Treatments were administered every three weeks for four sessions or till complete flattening, whichever was earlier. The Vancouver Scar Scale was used for assessment at baseline and every three weeks for four sessions, and monthly for three months post treatment. Results Both groups showed significant improvement in the Vancouver Scar Scale scores at each follow-up compared to baseline. The mean (percentage) improvement in the Vancouver Scar Scale score in Group A was 0.58 ± 0.5 (7.08%) at three weeks, which progressively increased to 4.47 ± 1.29 (54.55%) at the final follow-up. In Group B, the improvement was lesser, with 0.08 ± 0.28 (0.95%) at three weeks, increasing to 3.08 ± 0.81 (36.65%) at the final follow-up. This improvement was significantly more in Group A at all time points compared to Group B (p < 0.05). Post-procedure pain, which lasted for a few hours, was noted in three and two patients in Groups A and B, respectively (p = 0.642). None of the patients had a recurrence of keloids during the study. Limitations Limitations of this study include small sample size, single centre design, short follow-up period, lack of blinding and patient-reported outcome measures, which may impact the generalisability of the findings. Conclusion Intralesional triple combination is more effective than triamcinolone acetonide monotherapy in treating keloids, offering significantly superior improvements in the Vancouver Scar Scale scoring.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"425-431"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}