Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Beyond the surface: Link between Demodex mite and frictional facial melanosis.","authors":"Kesha Shailesh Patel, Abhishek R Parekh, Nayan Sevantilal Prajapati, Hiral A Shah","doi":"10.25259/IJDVL_1383_2023","DOIUrl":"10.25259/IJDVL_1383_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S164-S166"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of adult diaper as an absorbing agent in hair transplant procedure.","authors":"Prashantha Gb, Vikas Pathania, Shekhar Neema, Parul Kamboj","doi":"10.25259/IJDVL_88_2025","DOIUrl":"https://doi.org/10.25259/IJDVL_88_2025","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 5","pages":"693-694"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute generalised exanthematous pustulosis secondary to spider bite.","authors":"Ranjana Beniwal, Akriti Agrawal, Yogi Raj Joshi, Arpita Singhvi","doi":"10.25259/IJDVL_249_2024","DOIUrl":"10.25259/IJDVL_249_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S130-S131"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alopecia areata sparing vitiligo: Another Renbök phenomenon.","authors":"Yu-Ting Zhang, Bo Xie","doi":"10.25259/IJDVL_405_2024","DOIUrl":"10.25259/IJDVL_405_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S132-S133"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A de novo case of ankyloblepharon, ectodermal defects, cleft lip/palate syndrome with TP63 mutation diagnosed prenatally.","authors":"Sirisha Varala, Surekha Challa, Nagu Gugulothu, Venkata Krishna Ananthula, Rajeev Singh Thakur","doi":"10.25259/IJDVL_152_2024","DOIUrl":"10.25259/IJDVL_152_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S151-S153"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary hypotrichosis simplex with SNRPE gene mutation.","authors":"Yumi Won, Byungsoo Kim, Moon-Bum Kim, Hyun-Chang Ko","doi":"10.25259/IJDVL_191_2024","DOIUrl":"10.25259/IJDVL_191_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"661-663"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating tissue expression of STAT 1, 3 and 6 in prurigo nodularis to clinical efficacy of oral tofacitinib - A prospective single-arm investigational study.","authors":"Kabir Sardana, Sinu Rose Mathachan, Aishwarya Muddebihal, Diksha Agrawal, Arvind Ahuja","doi":"10.25259/IJDVL_1017_2024","DOIUrl":"10.25259/IJDVL_1017_2024","url":null,"abstract":"<p><p>Background Interleukin (IL)-4, IL-13, IL-17, IL-22 and IL-3 are overexpressed in prurigo nodularis (PN). They mediate their action via the Janus Kinase (JAK) Signal transducer and activator of transcription (STAT) pathway. Objectives Our aim was to study the expression of tissue STAT1, STAT3, and STAT6, as well as the efficacy of the JAK-STAT inhibitor, tofacitinib, in PN. Methods A prospective study was conducted in a tertiary care hospital. Patients with PN were recruited after excluding secondary causes. Pruritus was graded using Pruritus Grading System Score (PGSS). All cases underwent histological assessment using immunohistochemical markers for STAT1, STAT3, and STAT6 in both lesional and perilesional skin. Tofacitinib was initiated at a dose of 5 mg twice daily or 11 mg once daily and then tapered to a maintenance dose. The final PGSS at the time of data evaluation, as well as the occurrence of remissions and relapses, was assessed. Results The majority of the 17 patients included in the study had moderate to severe disease. Immunohistochemical analysis revealed marked tissue expression of STAT6 in 13 and STAT3 in 10 patients, while STAT1 expression was seen in only 4 patients [p < 0.05], suggesting a Th2/Th17 tissue response. The mean onset of action of tofacitinib was 11.2 ± 6.44 days and the mean duration of treatment was 5.6 ± 2.2 months. A significant reduction in PGSS was noted after treatment (66.1%, P value 0.0004). Fourteen of the patients maintained remission on low-dose therapy (5 mg OD or A/D) while one patient experienced a relapse. No serious adverse effects were noted. Limitation We could not study the tissue cytokines and the expression of STATs after achieving clinical response on oral tofacitinib. Conclusion The efficacy of tofacitinib in PN is based on its inhibitory effect on Th2 and Th17 cytokines, which is dependent on STAT6 and STAT3.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"631-636"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutation analysis in three Chinese pedigrees with palmoplantar keratoderma caused by SERPINB7 gene mutations.","authors":"Hongmin Han, Jing Li, Yaqi Cao, Chunyu Han, Xin Li, Yi Zhang, Jianwen Han","doi":"10.25259/IJDVL_1062_2024","DOIUrl":"10.25259/IJDVL_1062_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S102-S104"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate dosage and laboratory monitoring in patients with psoriasis and psoriatic arthritis: A retrospective analysis of prescription patterns and financial impact in dermatology and rheumatology settings.","authors":"Gopikrishnan Anjaneyan, Prateek Nayak, Jyothish R Pillai, Mithun Cb, Lekshmi Sajini, Soumya Jagadeesan, Vinitha Varghese Panicker","doi":"10.25259/IJDVL_1384_2024","DOIUrl":"10.25259/IJDVL_1384_2024","url":null,"abstract":"<p><p>Background Methotrexate (MTX) is a disease-modifying drug used for psoriasis (PsO) and psoriatic arthritis (PsA), but dermatology and rheumatology guidelines differ in dosing and monitoring recommendations. Objectives To compare methotrexate dosing and monitoring practices in dermatology and rheumatology, assess adverse drug reactions, and analyse the financial impact of rigorous monitoring. Methods This observational, electronic medical record-based retrospective chart review included psoriasis and psoriatic arthritis patients started on methotrexate at the dermatology and rheumatology departments at a tertiary care centre in 2020-2021. Patients with concurrent hepatotoxic/myelotoxic medications, inadequate follow-up, or abnormal baseline laboratory tests were excluded. Data regarding demographics, relevant medical histories, clinical variables, methotrexate dosing, frequency of laboratory monitoring, adverse events, and resource utilization were recorded and analysed. Descriptive statistics (means/percentages) and inferential tests (Chi-Square Test or Mann- Whitney Test) were used based on data normality (p<0.05 considered significant). Results The study included 100 psoriasis and psoriatic arthritis patients each. The psoriatic arthritis patients were given higher methotrexate doses initially but underwent less frequent laboratory monitoring compared to psoriasis patients. The incidence of hepatotoxicity was comparable between the two groups. However, leukopenia was observed more frequently in psoriatic arthritis patients. Methotrexate monitoring under dermatologists cost 44% more than that under rheumatologists over 6 months (Rs 4766.08± 1631.9 vs Rs 3290.32± 1207.8). Limitations The single centre, small sample size, retrospective chart review, and convenience sampling in this study may all limit the generalisability of the findings. Conclusion Current methotrexate guidelines in dermatology recommend lower doses and more frequent monitoring than rheumatology guidelines. Insights from this study and comparison with rheumatology practices and existing literature highlight the potential for designing large-scale, multicentric, non-inferiority studies that could eventually help develop more efficient and streamlined methotrexate monitoring protocols for dermatology and rheumatology, ultimately improving patient adherence, safety and affordability.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"625-630"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and tolerability of adapalene cream 0.1% in the treatment of female skin ageing: A randomised controlled trial.","authors":"Quyen Thi Tran, Duc Van Le, Yen Hai Vu, My Huyen Le, Luong Huy Vu, Doanh Huu Le, Minh Nguyet Vu","doi":"10.25259/IJDVL_673_2024","DOIUrl":"10.25259/IJDVL_673_2024","url":null,"abstract":"<p><p>Background Adapalene has been used off-label by dermatologists to manage skin ageing. Objectives To evaluate the effectiveness and tolerability of adapalene cream 0.1% in the treatment of skin ageing. Methods We conducted a randomised controlled trial on women with moderate skin ageing. Subjects were randomly assigned to either adapalene cream 0.1% or no treatment. All participants from both groups followed a daily skincare regimen that included use of sunscreen, moisturiser, and facial cleanser. Skin ageing was assessed at 1, 2, 4, and 6 months using the Skin Ageing Score (SAS) and Dermoscopic Photoaging Score (DPAS). Safety and tolerability were also assessed by systematic recording of adverse events at each follow-up visit, patient-reported symptoms, and clinical examination for signs of peeling, stinging, erythema, acne, and hyperpigmentation. Results A total of 58 subjects completed the study. While the mean (SD) total SAS of the treatment arm decreased from 38.2 (5.5) to 32.5 (3.2) after 6 months of treatment in the adapalene group, it remained unchanged in the control arm (baseline 38.5 (4.2), 6 months 37.9 (4.2)). The difference in total SAS between the two arms at 6 months was significant (mean difference -5.40, 95% CI -7.26 to -3.54; p<0.001). Pigmentation and wrinkles significantly improved in the treatment arm. The mean DPAS decreased over time in both arms but the difference between two arms was not significant. Stinging sensation and xerosis were the most common side effects (64.3% and 25%, respectively), that mostly improved after 2 months. Limitations Small sample size, short treatment follow-up period, and single-centre validation Conclusions Adapalene cream 0.1% cream significantly improved signs of skin ageing, particularly wrinkles and pigmentation, and was well-tolerated. It can be a promising treatment for skin ageing.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 5","pages":"571-576"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}