Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Efficacy of topical tofacitinib 2% cream in the treatment of nail lichen planus.","authors":"Matilde Iorizzo","doi":"10.25259/IJDVL_1443_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1443_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear cell anaplastic large cell lymphoma in a young male: A rare lymphoma variant.","authors":"Apoorva Sharma, Debajyoti Chatterjee, Gaurav Prakash, Pratibha Bansal, Tarun Narang","doi":"10.25259/IJDVL_964_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_964_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures in chronic urticaria: A comprehensive review.","authors":"Shikha Shah, Manavi Gupta, Anuradha Bishnoi, Davinder Parsad, Muthu Sendhil Kumaran","doi":"10.25259/IJDVL_523_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_523_2024","url":null,"abstract":"<p><p>Chronic urticaria, characterised by pruritic wheals, angioedema or both significantly impacts individuals' quality of life. This review article examines the patient-reported outcome measures (PROMs) in chronic urticaria assessment, aiming to enhance understanding and management of this condition The review categorises PROMs into urticaria-specific and angioedema-specific tools. Urticaria-specific PROMs such as the Urticaria Activity Score (UAS), Urticaria Control Test (UCT), Chronic Urticaria Quality of Life Questionnaire (CU-QoL) and Urticaria Severity Score (USS) focus on disease activity, control, severity and quality of life. Angioedema-specific tools include the Angioedema Activity Score (AAS), Angioedema Control Test (AECT) and Angioedema Quality of Life Questionnaire (AE-QoL), assessing disease activity, control and quality of life specific to angioedema. Non-specific PROMs like the Dermatology Life Quality Index (DLQI) provide a broader assessment of health-related quality of life across dermatological conditions. Newer developments include disease-specific PROMs like the Cold Urticaria Activity Score (ColdUAS), CholU-QoL for chronic inducible urticarias and the Urticaria Activity and Impact Measure (U-AIM) for retrospective patient-reported outcome assessment. Additionally, the review discusses the integration of smartphone applications and artificial intelligence (AI) tools like Convolutional Neural Networks (CNNs) in automating PROMs, showing promise in improving chronic urticaria management. Despite the progress made in PROMs, ongoing challenges such as limited data on specific populations and languages underscore the need for continued research and standardised PROM usage across clinical settings. This approach can significantly enhance patient management and contribute to a more holistic and effective strategy for addressing chronic urticaria.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and dermoscopic profile of non-venereal genital dermatoses and its impact on the quality of life: A cross-sectional study of 550 cases.","authors":"Subhajit Sadhukhan, Anupama Bains, Abhishek Bhardwaj, Suman Patra, Deepak Vedant, Charu Sharma, Gautam Ram Chaudhary","doi":"10.25259/IJDVL_776_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_776_2024","url":null,"abstract":"<p><p>Background Non-venereal genital dermatoses cover a broad spectrum of conditions with varying aetiologies and can be confused with venereal disorders. This may cause significant anxiety to the patient as well as diagnostic difficulties for the clinician. Objective The purpose was to study the clinico-epidemiological pattern of non-venereal genital dermatoses along with their dermoscopic features and to assess their impact on the quality of life. Methods This was a prospective, cross-sectional, observational study of 503 consecutive adult patients with non-venereal genital dermatoses. Relevant history and clinical examination, dermoscopy findings were documented and histopathology was performed where indicated. Statistical analyses was done using SPSS software v.23. Results Five hundred and three individuals with non-venereal genital lesions were enrolled. Some patients had multiple dermatoses, so a total of 550 cases were analysed. Men outnumbered women (5.8:1). A total of 49 different non-venereal genital dermatoses were identified. The most common ones were scabies 97 (17.6%), vitiligo 54 (9.8%), lichen simplex chronicus 43 (7.8%), lichen sclerosus 43 (7.8%) and lichen planus 39 (7.1%). Other dermatoses included psoriasis, Zoon's balanitis, lichen nitidus, angiokeratoma and idiopathic scrotal calcinosis. Physiological conditions were noted in 56 (10.2%) cases, while 5 (1%) cases were premalignant and malignant disorders. The commonest symptom was genital pruritus 337 (60.9%). Scrotum was most frequently affected site in men (54.6%) and labia majora in women (81.6%). Comparative analysis between the dermoscopic features of similar-looking disorders like vitiligo versus lichen sclerosus, scrotal dermatitis versus psoriasis and lichen planus versus psoriasis was statistically significant (p<0.05). There was a large effect on the quality of life in 8(1.5%), moderate effect in 87(16.2%) and small effect in 385 (71.8%) patients. Dermatology life quality index was significantly elevated in women. Seventy six (15.1%) patients suffered from venerophobia. Limitations Because of the cross-sectional study design, dermatoscopic examinations were performed at various phases of the diseases. Histopathology was performed in a limited number of cases, so findings on dermoscopy and histopathology could not be correlated. Conclusion Non-venereal genital dermatoses are common and more so among men. The most common dermatoses noted was scabies followed by vitiligo and lichen simplex chronicus. The present study provides detailed clinical and dermoscopy features in Indian patients. Dermoscopy is a useful tool in the diagnosis of these diseases. These dermatoses have mild to moderate effects on patients' quality of life; some of these patients suffer from venereophobia. Recognising and treating this issue will aid in properly managing these patients.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-histopathological review of cutaneous sarcoidosis: A retrospective descriptive study.","authors":"Akash Deep Chandra, Sujay Khandpur, M Ramam, Neetu Bhari, Vishal Gupta, Shipra Agarwal","doi":"10.25259/IJDVL_368_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_368_2024","url":null,"abstract":"<p><p>Background Sarcoidosis is a systemic, non-caseating granulomatous disease characterised by clinical and histopathological variability. Objective To review cases of cutaneous sarcoidosis and describe their clinical and histopathological features. Methods A retrospective study was conducted to analyse the clinical and histopathological frecords of all available skin biopsy slides signed out as 'sarcoidal tissue reaction' or 'sarcoidosis' from 2014 till 2022. Results A total of 25 cases were studied. The lesions were most commonly located on the head and neck (18 cases, 72%). Morphologically plaques (20%) were the most common, and the majority of cases had lesions of ≥2 distinct morphologies (44%). Histologically, classical naked granulomas were observed in 72% of cases. The granulomatous infiltrate was pandermal in 56% of cases, perivascular and interstitial in 16%, and perivascular, perieccrine, and interstitial in 12%. Granulomas with a 'leprosy' pattern were observed in 20% of cases. High-density granulomas (occupying >30% of the dermis) were present in 64% of cases. Fibrinoid necrosis and fibrosis between granulomas were observed in 16% and 8% cases, respectively. Inclusion bodies, such as asteroid and Schaumann bodies, were seen in 24% and 4% cases, respectively. Reticulin-rich granulomas were observed in 54% cases, while reticulin-poor granulomas were seen in 8.3%. Elevated serum ACE levels were found in 14 cases, and tuberculin skin test, conducted in 22 cases, was negative. Extracutaneous involvement was found in 11 cases, with 10 having pulmonary and 1 with pulmonary and splenic involvement. Limitation Retrospective nature of the study and small sample size. Conclusion Cutaneous sarcoidosis presents with a wide range of clinical and histomorphological features, necessitating clinico-histopathological correlation and ancillary investigations to establish the diagnosis and rule out mimickers.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal dermal hypoplasia - A report of two cases with review of literature.","authors":"Young Denla, Shreya K Gowda, M L Amulya, Adhyatm Bhandari","doi":"10.25259/IJDVL_96_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_96_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented nodular lesion below eyelid in a retro positive patient.","authors":"Poongodi Rajagopal, Likhitha Reddy C, Hima Gopinath, Arundhathi Shankaralingappa","doi":"10.25259/IJDVL_1464_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1464_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral neuritis: Tuberculosis as a rare diagnostic contender.","authors":"Srishti Tripathi, Vasav Tyagi, Deepika Rawat, Anand Srivastava, Kiranpreet Malhotra, Darshan Kumar Bajaj, Urmila Singh, Swastika Suvirya","doi":"10.25259/IJDVL_811_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_811_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of dermoscopy in paediatric vascular anomalies.","authors":"Abhishek Bhagwat, Nikhil Mehta, Ankur Goyal, Sudheer Arava, M Ramam, Gomathy Sethuraman, Somesh Gupta, Neetu Bhari","doi":"10.25259/IJDVL_1053_2023","DOIUrl":"https://doi.org/10.25259/IJDVL_1053_2023","url":null,"abstract":"<p><p>Background Vascular anomalies show highly variable morphology, making clinical identification difficult. Dermoscopy is a non-invasive tool which can aid in their diagnosis, but studies of dermoscopy in vascular anomalies are limited. Aim This study aimed to describe the dermoscopic findings in vascular anomalies in children and evaluate their usefulness over clinical examination alone. Methods Consecutive children with congenital or acquired vascular lesions diagnosed by two experienced dermatologists after detailed history and examination were recruited. Predominant dermoscopic findings of a representative lesion were recorded in a pre-designed proforma with a consensus of two dermatologists trained in dermoscopy. In cases of clinical diagnostic uncertainty, suitable histopathological and radiological investigations were done. Results Sixty-one patients (33 tumours, 26 malformations, and 2 unclassified anomalies) were recruited. The most observed condition was infantile haemangioma (IH) (37.7%) which showed red lacunae and irregularly branched thick-tortuous and thin-serpentine vessels in mixed haemangiomas (30.4%), prominent lacunae in superficial haemangiomas (34.8%) and only branched vessels in deep and treated/involuting (34.8%) haemangiomas. Lacunae were predominantly seen in superficial haemangiomas (p=0.0498) and were missing in deep and involuting haemangiomas (p=0.0027). Port-wine stain (13.1%) showed irregular reticular vessels along with dots and globules with thickness of the network being proportionate to the darker shade clinically. In all, there were nine (14.75%) cases where there was diagnostic uncertainty using clinical features alone and histopathological/radiological investigations were required to establish the final diagnosis. In them, dermoscopy showed findings (as described in previous literature) suggestive of the correct final diagnosis. Limitations Histopathological and radiological investigations were done only in cases where the clinical diagnosis was uncertain. Conclusion Dermoscopy is a useful tool in differentiating between different vascular anomalies such as IH and capillary malformations (CMs) which have different management strategies. Dermoscopy may also be useful in differentiating superficial from deep haemangiomas and proliferating from involuting haemangiomas. It can also help in determining the depth of CMs. Thus, it can obviate the need for invasive diagnostic procedures in paediatric vascular lesions and can guide appropriate treatment and prognosis.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety profile of handheld narrow band ultraviolet B device therapy in vitiligo - Systematic review and meta-analysis.","authors":"Sujay Khandpur, Suvesh Singh, Debopriya Paul","doi":"10.25259/IJDVL_71_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_71_2024","url":null,"abstract":"<p><p>Background Handheld narrowband ultraviolet B (NB-UVB) device is a portable, home-based, patient-friendly equipment used in vitiligo. It is a newer promising treatment that lacks generalised consensus due to heterogenicity among studies. Objective To determine the clinical efficacy and safety profile of handheld NB-UVB devices in the treatment of vitiligo. Methods and Materials Following the PRISMA guidelines and using appropriate keywords, the Embase, PubMed and Scopus databases were searched on 28 November 2023. Data on the proportion of patients with a percentage of re-pigmentation and toxicity were extracted from the included studies. Random effects and fixed model were utilised to generate pooled estimates via meta-analysis. Results Out of 250 articles, 13 studies (557 patients) were included. The extent of repigmentation achieved over a median duration of 6 months (range 3-12 months) was quantified to be > 25%, > 50%, and >75 % in 63.6% (95% CI: 51.0-75.3%), 40.8% (95% CI: 30.4-51.6%) and 15.4% (95% CI: 7.6-25.3%) of patients respectively. After 12 weeks of treatment, the proportions of patients achieving > 25%, > 50%, and >75% re-pigmentation were 31.1% (95% CI: 9.6-58.3%), 12.9% (95% CI: 3.1-28.1%) and 6.5% (95% CI: 1.7-14.1%), respectively. Similarly, at 24 weeks, these proportions were 53.2% (95% CI: 24.5-80.7%), 36.7% (95% CI: 15.8-60.5%), and 11.1% (95% CI: 2.9-23.7%). Minimal erythema dose (MED) calculation-based therapy was not significantly better than therapy given without MED calculation (p = 0.43). The studies with only stable vitiligo patients did not achieve significantly greater > 25% (p = 0.06), > 50% (p = 0.80), and > 75% (p = 0.25) re-pigmentation compared to the studies that also included active or slowly progressive vitiligo. Three sessions per week resulted in significantly higher > 50% (p < 0.01) and > 75% (p = 0.01) re-pigmentation. Totally, 11.3% (38/334) of patients showed no response to therapy. The most commonly reported adverse event was erythema in 33.4% (95% CI: 19.3-49.2%) of patients, with grade 3 and 4 erythema in 27 and 15 patients, respectively. Other adverse events included pruritus, burning, hyperpigmentation, dryness, and blister formation observed in 22.1%, 16.4%, 19.1%, 9.8%, and 9.7% of patients, respectively. Conclusion Handheld NB-UVB portable home-based devices are an efficacious and safe treatment option in vitiligo patients even without MED calculation, when the treatment frequency is three to four sessions per week.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}