Indian Journal of Dermatology Venereology & Leprology最新文献

{"title":"Cardiac involvement in dermatological disorders: A narrative review.","authors":"Yashdeep Singh Pathania","doi":"10.25259/IJDVL_1305_2023","DOIUrl":"10.25259/IJDVL_1305_2023","url":null,"abstract":"<p><p>Recent studies have highlighted several pathogenic connections between skin disorders and cardiac manifestations. Dermatologists frequently encounter several genetic or inherited skin conditions that can have significant cardiac implications, including septal defects, cardiomyopathy, and valvular heart disease, which may sometimes be life-threatening. In this review, primary cutaneous disorders having cardiac manifestations are described. A comprehensive narrative review of the literature was conducted by searching articles published through November 2023 in the PubMed and Google Scholar databases. Original research articles, review articles, case reports, case series and other relevant English-language publications were included. The review identified several congenital diseases, inflammatory conditions, connective tissue disorders, and adverse drug reactions that have both skin and cardiac involvement. Diagnosing these cardiac manifestations in patients with skin conditions is crucial for appropriate management, timely intervention and effective patient counselling.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"332-337"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ribociclib induced vitiligo-like lesions.","authors":"Rohit Kothari, H S Darling, Anuj Bhatnagar, Manasa Janney, Shilpa Mohan, Rahul Kumar","doi":"10.25259/IJDVL_239_2024","DOIUrl":"10.25259/IJDVL_239_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"396-397"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle radiofrequency ablation (RFA) and topical tacrolimus combination therapy for primary localised cutaneous nodular amyloidosis.","authors":"Mohammad Danish, Rhea Ahuja, Somesh Gupta, Neetu Bhari","doi":"10.25259/IJDVL_851_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_851_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indian expert Delphi consensus on the diagnosis and management of flares of generalised pustular psoriasis.","authors":"Vijay Venkatraj Aithal, Ramesh Bhat, Sudip Das, Sunil Dogra, Kiran Godse, D S Krupa Shankar, Chitra Shivanand Nayak, Sathish B Pai, Shrichand Gordhandas Parasramani, Anchala Parthasaradhi, Bela Shah, Sushil T Tahiliani, Tomson Toms, Arun Kumar Dahiya","doi":"10.25259/IJDVL_219_2024","DOIUrl":"10.25259/IJDVL_219_2024","url":null,"abstract":"<p><p>Generalised pustular psoriasis (GPP) is a chronic, multisystemic, autoinflammatory disease with predominantly cutaneous manifestations, characterised by recurrent episodes of widespread, macroscopic and aseptic pustules. It has a highly unpredictable, heterogeneous and unstable clinical course. There are no consensus guidelines in India for the management of GPP. The objective of this Delphi panel study was to achieve consensus on problem areas in the understanding and management of GPP. Based on the inputs from an expert panel, 19 topics across six domains were identified as being important regarding the understanding and management of GPP. Statements were developed for these 19 topics, and consensus for the statements was sought using the modified Delphi method. Twelve experts evaluated the statements, indicating their agreement or disagreement. Consensus was considered to be reached when ≥80% of experts agreed with a statement. After two rounds of discussion, consensus was reached for 17 out of 19 (89%) statements and no consensus was achieved for two (11%) statements. We have presented the statements along with the respective degrees of consensus. Wherever relevant, clarifications or additional comments by experts are provided in the document.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"338-345"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serpentine and annular presentation of extragenital lichen sclerosus-morphea overlap.","authors":"Divya Bhatia, Anupama Bains, Vikarn Vishwajeet","doi":"10.25259/IJDVL_1317_2023","DOIUrl":"10.25259/IJDVL_1317_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S43-S45"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety profile of handheld narrow band ultraviolet B device therapy in vitiligo - Systematic review and meta-analysis.","authors":"Sujay Khandpur, Suvesh Singh, Debopriya Paul","doi":"10.25259/IJDVL_71_2024","DOIUrl":"10.25259/IJDVL_71_2024","url":null,"abstract":"<p><p>Background Handheld narrowband ultraviolet B (NB-UVB) device is a portable, home-based, patient-friendly equipment used in vitiligo. It is a newer promising treatment that lacks generalised consensus due to heterogenicity among studies. Objective To determine the clinical efficacy and safety profile of handheld NB-UVB devices in the treatment of vitiligo. Methods Following the PRISMA guidelines and using appropriate keywords, the Embase, PubMed and Scopus databases were searched on 28 November 2023. Data on the proportion of patients with a percentage of re-pigmentation and toxicity were extracted from the included studies. Random effects and fixed model were utilised to generate pooled estimates via meta-analysis. Results Out of 250 articles, 13 studies (557 patients) were included. The extent of repigmentation achieved over a median duration of 6 months (range 3-12 months) was quantified to be > 25%, > 50%, and >75 % in 63.6% (95% CI: 51.0-75.3%), 40.8% (95% CI: 30.4-51.6%) and 15.4% (95% CI: 7.6-25.3%) of patients respectively. After 12 weeks of treatment, the proportions of patients achieving > 25%, > 50%, and >75% re-pigmentation were 31.1% (95% CI: 9.6-58.3%), 12.9% (95% CI: 3.1-28.1%) and 6.5% (95% CI: 1.7-14.1%), respectively. Similarly, at 24 weeks, these proportions were 53.2% (95% CI: 24.5-80.7%), 36.7% (95% CI: 15.8-60.5%), and 11.1% (95% CI: 2.9-23.7%). Minimal erythema dose (MED) calculation-based therapy was not significantly better than therapy given without MED calculation (p = 0.43). The studies with only stable vitiligo patients did not achieve significantly greater > 25% (p = 0.06), > 50% (p = 0.80), and > 75% (p = 0.25) re-pigmentation compared to the studies that also included active or slowly progressive vitiligo. Three sessions per week resulted in significantly higher > 50% (p < 0.01) and > 75% (p = 0.01) re-pigmentation. Totally, 11.3% (38/334) of patients showed no response to therapy. The most commonly reported adverse event was erythema in 33.4% (95% CI: 19.3-49.2%) of patients, with grade 3 and 4 erythema in 27 and 15 patients, respectively. Other adverse events included pruritus, burning, hyperpigmentation, dryness, and blister formation observed in 22.1%, 16.4%, 19.1%, 9.8%, and 9.7% of patients, respectively. Conclusion Handheld NB-UVB portable home-based devices are an efficacious and safe treatment option in vitiligo patients even without MED calculation, when the treatment frequency is three to four sessions per week.</p>","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"321-331"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunological predictors of chronicity in erythema nodosum.","authors":"Kriti Jain, Prita Pradhan, Hemanta Kumar Kar, Debasmita Behera, Riya Sukhija, Sejal Bajoria, Garima Manocha, Sakir Ahmed","doi":"10.25259/IJDVL_1626_2024","DOIUrl":"https://doi.org/10.25259/IJDVL_1626_2024","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Background Erythema nodosum (EN) is a painful inflammatory disorder of the subcutaneous fat and the most common type of septal panniculitis. It often presents as erythematous, tender subcutaneous nodules, typically affecting the shins. EN is frequently a hypersensitivity reaction that can serve as a warning sign for an underlying systemic disorder, making it crucial to identify the cause. Though self-limiting in many cases, EN can sometimes become chronic, leading to significant discomfort. The pathogenesis of EN and the predictors of chronicity remain unclear, necessitating further investigation. Aims This study aimed to evaluate the various etiologies of EN and determine the clinical, laboratory, and immunohistochemical predictors of chronicity. Methods We conducted a prospective hospital-based study between July 2022 and June 2024 at a tertiary care centre in Eastern India. Clinical and histopathologically confirmed cases of EN presenting within 2-3 days of onset, without prior treatment, were enrolled. A detailed clinical examination and laboratory investigations were performed during the initial visit, including immunohistochemical analysis of skin biopsies. The total number of T cells (CD3+), helper T cells (CD4+), cytotoxic T cells (CD8+), CD4:CD8 ratio, and NK (natural killer) cells (CD56+) were quantified per skin biopsy specimen using a standardised technique. Patients were treated at the discretion of the treating physician. Patients were monitored monthly for three months and categorised as either having \"Classic EN\" (lesions resolving within three months) or \"Chronic EN\" (lesions persisting beyond three months). Data collected at the initial visit were correlated between the two groups to identify potential predictors of chronicity. Results Out of 63 suspected cases, EN was confirmed in 41 patients, who were predominantly females (65.85%), with a median age of 49 years (Q1 - Q3: 32 - 57). Pulmonary tuberculosis was the most frequent underlying condition (n = 15, 36.59%), followed by sarcoidosis (n = 8, 19.51%) and rheumatoid arthritis (n = 6, 14.63%). Chronic EN was observed in 36.59% of cases, with significantly elevated baseline C-reactive protein (CRP) levels (p = 0.003) and Mantoux test readings (p = 0.002). Immunohistochemistry revealed higher CD3, CD4, CD8, and CD56 levels in chronic EN cases (p &lt; 0.05). Limitations The study's limitations include a small sample size and short follow-up duration. Multivariable analysis could not be performed due to the small sample size. Conclusion This study identified clinical and immunohistochemical markers associated with the chronicity of EN and highlighted pulmonary tuberculosis as the most common underlying cause. Elevated CRP levels, positive Mantoux test results, and increased expression of CD3, CD4, CD8, and CD56 observed at baseline were linked to chronicity. The findings suggest the predominant role of T helper 1 (Th1) cell response and innate immunity in the pathogenesis of c","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":"91 Supplementary 1","pages":"S1-S7"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear lichen planus of the genitalia.","authors":"Ariharasudhan Varadharajan, Prateek Nayak, Gitesh U Sawatkar, Nisha Meshram","doi":"10.25259/IJDVL_1441_2024","DOIUrl":"10.25259/IJDVL_1441_2024","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S92"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the diagnostic capability of ChatGPT through clinical case scenarios in dermatology.","authors":"Perumal Manoharan, Krishna Mohan Surapaneni","doi":"10.25259/IJDVL_1267_2023","DOIUrl":"10.25259/IJDVL_1267_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S27-S28"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic features of primary cutaneous extranodal natural killer (NK)/T-cell lymphoma.","authors":"Xiaopo Wang","doi":"10.25259/IJDVL_1222_2023","DOIUrl":"10.25259/IJDVL_1222_2023","url":null,"abstract":"","PeriodicalId":50376,"journal":{"name":"Indian Journal of Dermatology Venereology & Leprology","volume":" ","pages":"S46-S49"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}