0.1%阿达帕林乳膏治疗女性皮肤老化的有效性和耐受性:一项随机对照试验。

IF 3.4 4区 医学 Q2 DERMATOLOGY
Quyen Thi Tran, Duc Van Le, Yen Hai Vu, My Huyen Le, Luong Huy Vu, Doanh Huu Le, Minh Nguyet Vu
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引用次数: 0

摘要

阿达帕林已被皮肤科医生用于治疗皮肤老化。目的评价0.1%阿达帕林乳膏治疗皮肤老化的疗效和耐受性。方法对皮肤中度老化的女性进行随机对照试验。受试者被随机分配使用0.1%阿达帕林乳膏或不治疗。两组的所有参与者都遵循日常护肤方案,包括使用防晒霜、保湿霜和洗面奶。使用皮肤老化评分(SAS)和皮肤镜光老化评分(DPAS)在1、2、4和6个月时评估皮肤老化。安全性和耐受性也通过每次随访时不良事件的系统记录、患者报告的症状、脱皮、刺痛、红斑、痤疮和色素沉着的临床检查来评估。结果共58名受试者完成研究。阿达帕林组治疗6个月后,治疗组的平均(SD)总SAS从38.2(5.5)下降到32.5(3.2),而对照组保持不变(基线38.5(4.2),6个月37.9(4.2))。6个月时两组总SAS差异显著(平均差异为-5.40,95% CI为-7.26 ~ -3.54
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness and tolerability of adapalene cream 0.1% in the treatment of female skin ageing: A randomised controlled trial.

Background Adapalene has been used off-label by dermatologists to manage skin ageing. Objectives To evaluate the effectiveness and tolerability of adapalene cream 0.1% in the treatment of skin ageing. Methods We conducted a randomised controlled trial on women with moderate skin ageing. Subjects were randomly assigned to either adapalene cream 0.1% or no treatment. All participants from both groups followed a daily skincare regimen that included use of sunscreen, moisturiser, and facial cleanser. Skin ageing was assessed at 1, 2, 4, and 6 months using the Skin Ageing Score (SAS) and Dermoscopic Photoaging Score (DPAS). Safety and tolerability were also assessed by systematic recording of adverse events at each follow-up visit, patient-reported symptoms, and clinical examination for signs of peeling, stinging, erythema, acne, and hyperpigmentation. Results A total of 58 subjects completed the study. While the mean (SD) total SAS of the treatment arm decreased from 38.2 (5.5) to 32.5 (3.2) after 6 months of treatment in the adapalene group, it remained unchanged in the control arm (baseline 38.5 (4.2), 6 months 37.9 (4.2)). The difference in total SAS between the two arms at 6 months was significant (mean difference -5.40, 95% CI -7.26 to -3.54; p<0.001). Pigmentation and wrinkles significantly improved in the treatment arm. The mean DPAS decreased over time in both arms but the difference between two arms was not significant. Stinging sensation and xerosis were the most common side effects (64.3% and 25%, respectively), that mostly improved after 2 months. Limitations Small sample size, short treatment follow-up period, and single-centre validation Conclusions Adapalene cream 0.1% cream significantly improved signs of skin ageing, particularly wrinkles and pigmentation, and was well-tolerated. It can be a promising treatment for skin ageing.

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来源期刊
CiteScore
2.10
自引率
10.30%
发文量
247
审稿时长
6-12 weeks
期刊介绍: The Indian Association of Dermatologists, Venereologists & Leprologists (IADVL) is the national association of Indian medical specialists who manage patients with skin disorders, sexually transmitted infections (STIs) or leprosy. The current member strength of the association is about 3800. The association works for the betterment of the specialty by holding academic meetings, printing a journal and publishing a textbook. The IADVL has several state branches, each with their own office bearers, which function independently within the constitution of the IADVL. Established in 1940, the Indian Journal of Dermatology, Venereology and Leprology (IJDVL, ISSN 0378-6323) is the official publication of the IADVL (Indian Association of Dermatologists, Venereologists and Leprologists).
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