International Journal for Numerical Methods in Biomedical Engineering最新文献_第6页

IF 2.4 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-07

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IF 2.4 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-04

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IF 2.4 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-04

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IF 2.4 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-04

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Tissue-Level Neck Response in Rotary-Wing Aircrew With Head-Supported Mass Assessed With Finite Element Model. 基于有限元模型的头部支撑质量旋翼机组组织级颈部响应评估。

IF 2.1 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-01 DOI: 10.1002/cnm.70178

Prasannaah Hadagali, Steven L Fischer, Jack P Callaghan, Duane S Cronin

{"title":"Tissue-Level Neck Response in Rotary-Wing Aircrew With Head-Supported Mass Assessed With Finite Element Model.","authors":"Prasannaah Hadagali, Steven L Fischer, Jack P Callaghan, Duane S Cronin","doi":"10.1002/cnm.70178","DOIUrl":"10.1002/cnm.70178","url":null,"abstract":"Epidemiological studies have reported a prevalence of neck pain among rotary-wing aircrew (RWA), attributed in part to head-supported mass (HSM) including helmet and night vision goggles (NVG). Combined HSM and movement of the head away from the neutral position results in increased muscle activation and increased loads in the neck; however, the effect of HSM has not been quantified at the tissue level. In the present study, the tissue-level response to HSM was investigated using a detailed human finite element head-neck (HN) model. Non-neutral HN positions were achieved by activating the neck muscles, and three conditions were simulated for 25° flexion: (1) baseline HN model (HNF), (2) HN with helmet (HNF-H), and (3) HN with helmet, NVG and counterweight (HNF-N). In addition, a combined HN position was investigated with the helmet, NVG and counterweight, comprising 25° flexion, 8° lateral bending, and 23° axial rotation (HNC-N). Endplate stresses and annulus fibrosus (AF) fiber strains increased by 17% and 4%, respectively, with the added helmet (HNF to HNF-H). Endplate stresses and AF fiber strains increased by 24% and 12%, respectively, with the inclusion of NVG and counterweight to the helmet (HNF-H to HNF-N). In HNC-N, endplate stresses and AF fiber strains further increased by 10% and 9%, respectively, relative to HNF-N. The addition of NVG and counterweight to the helmet had a stronger influence than the helmet alone. The results can potentially quantify the high incidence of neck pain in RWA and can be applied to assess the consequences of mass additions and distribution in future systems.","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"42 5","pages":"e70178"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Aneurysm Morphology Based on Conformal Geometry. 基于保形几何的动脉瘤形态学。

IF 2.1 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-01 DOI: 10.1002/cnm.70177

Yuanpeng Liu, Zhou Zhao, Siyu Fang, Donglian Liu, Chander Sadasivan, Apostolos Tassiopoulos, Shikui Chen, Xianfeng Gu

{"title":"Aneurysm Morphology Based on Conformal Geometry.","authors":"Yuanpeng Liu, Zhou Zhao, Siyu Fang, Donglian Liu, Chander Sadasivan, Apostolos Tassiopoulos, Shikui Chen, Xianfeng Gu","doi":"10.1002/cnm.70177","DOIUrl":"10.1002/cnm.70177","url":null,"abstract":"Several morphological parameters such as aortic neck length, angulation, or centerline curvature have previously been evaluated to define \"hostile\" anatomies that predispose to poor outcomes after endovascular aneurysm repair. In this study, we present a new method for classifying aneurysm morphologies using their conformal structures. The conformal structure of a surface is determined by its Riemannian metric, and conformal mappings between surfaces with complex topologies preserve their conformal structures. To classify aneurysm shapes, the aortic aneurysm is first segmented from CT scans and represented as a discrete surface. Next, holomorphic differential forms are computed based on the discrete Hodge Theory. The aneurysm surface can be conformally mapped onto a pair of planar rectangles with an aortic bifurcation point by integrating a special holomorphic differential. This canonical configuration gives the conformal invariants, or \"conformal fingerprints,\" which can then be used to classify aneurysm morphologies. This novel methodology shows promise in providing an improved understanding of aneurysm morphologies, which can aid in better predicting and managing potential complications after endovascular aneurysm repair.","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"42 5","pages":"e70177"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Progression of Cerebral Atrophy in Alzheimer's Disease and Its Consequences on Traumatic Brain Injury: Insights From Longitudinal MRI Studies. 阿尔茨海默病脑萎缩的进展及其对创伤性脑损伤的影响：来自纵向MRI研究的见解。

IF 2.1 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-01 DOI: 10.1002/cnm.70180

Hamed Abdi, David Sanchez-Molina, Silvia Garcia-Vilana, Sajad Azizi, Vafa Rahimi-Movaghar

{"title":"Progression of Cerebral Atrophy in Alzheimer's Disease and Its Consequences on Traumatic Brain Injury: Insights From Longitudinal MRI Studies.","authors":"Hamed Abdi, David Sanchez-Molina, Silvia Garcia-Vilana, Sajad Azizi, Vafa Rahimi-Movaghar","doi":"10.1002/cnm.70180","DOIUrl":"10.1002/cnm.70180","url":null,"abstract":"Alzheimer's disease (AD) is characterized by progressive cerebral atrophy that alters the brain's biomechanical response to external loading and may increase susceptibility to traumatic brain injury (TBI). This study aimed to quantify how varying degrees of AD-related atrophy affect intracranial dynamics under impact conditions and to compare these effects with those observed in normal aging. Three-dimensional finite-element head models were constructed in COMSOL Multiphysics, incorporating skull, cerebrospinal fluid (CSF), and brain tissue. Longitudinal MRI data informed annual volume-reduction rates of 0.5% (healthy aging), 1% (moderate AD), and 4% (severe AD) over a four-year period. Fluid-structure interaction (FSI) was employed to simulate dynamic interactions between the CSF and deformable brain tissue under a standardized blunt impact scenario. Key biomechanical metrics-relative brain-skull displacement and peak intracranial pressure-were recorded in frontal and occipital regions. At approximately 15.07% total volume reduction (severe AD), relative brain-skull displacement increased by 12.6% in the frontal region and 28.0% in the occipital region compared with healthy aging. Peak intracranial pressure decreased by 5.51% in the frontal region and 4.95% in the occipital region under severe atrophy, indicating enhanced energy absorption by the expanded CSF layer but greater overall brain motion. The amplified displacement patterns suggest elevated strain on bridging veins and a higher risk of subdural hematoma formation. Progressive brain atrophy in AD significantly modifies intracranial biomechanics under impact, underscoring the importance of accounting for neurodegenerative changes in TBI risk assessments. Incorporation of patient-specific viscoelastic properties-obtainable via Magnetic Resonance Elastography-into future models may further enhance predictive accuracy for vulnerable populations.","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"42 5","pages":"e70180"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Investigation of Red Blood Cell Properties on Impedance Signatures Generated in a Coulter Counter. 基于库尔特计数器阻抗特征的红细胞特性研究。

IF 2.1 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-01 DOI: 10.1002/cnm.70172

Pierre Pottier, Pierre Taraconat, Jean-Philippe Gineys, Damien Isèbe, Franck Nicoud, Simon Mendez

{"title":"Investigation of Red Blood Cell Properties on Impedance Signatures Generated in a Coulter Counter.","authors":"Pierre Pottier, Pierre Taraconat, Jean-Philippe Gineys, Damien Isèbe, Franck Nicoud, Simon Mendez","doi":"10.1002/cnm.70172","DOIUrl":"10.1002/cnm.70172","url":null,"abstract":"The ability of red blood cells (RBCs) to deform is essential for microcirculation and oxygen delivery. Any changes in RBC deformability can lead to significant cardiovascular complications, necessitating timely detection. Although specialized microdevices can be designed to assess RBC deformability, leveraging instruments already used in clinical settings would enable easier integration and accelerate clinical translation. Coulter counter (CC) systems are routinely used to count, size, and analyze RBCs and the possibility to extend their diagnostic capabilities to RBC deformability is currently examined. In this study, the effects of RBCs' geometrical, morphological, and rheological properties on CC measurement have been investigated numerically, thanks to a simulation framework predicting the RBC dynamics in a CC and the associated impedance signature. Subsequently, a numerical parametric study has been performed, and the resulting pulses have been compared with experimental results, confirming the simulation's accuracy in predicting CC measurements. In addition to the RBC volume and the RBC trajectory in the sensing region, which had been investigated before, present results show that in our modeling framework, RBC sphericity, membrane viscosity, and cytoplasm viscosity are the main RBC characteristics contributing to the broad CC measurement spectrum observed experimentally when analyzing healthy blood samples.","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"42 5","pages":"e70172"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A Compact Computational Model for Hyperthermia-Controlled Drug Release Based on Krogh-Cylinder Approach. 基于krogh -圆柱体方法的热控药物释放紧凑计算模型。

IF 2.1 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-05-01 DOI: 10.1002/cnm.70176

Gabriele Adabbo, Alberto Coccarelli, Marcello Iasiello, Assunta Andreozzi

{"title":"A Compact Computational Model for Hyperthermia-Controlled Drug Release Based on Krogh-Cylinder Approach.","authors":"Gabriele Adabbo, Alberto Coccarelli, Marcello Iasiello, Assunta Andreozzi","doi":"10.1002/cnm.70176","DOIUrl":"10.1002/cnm.70176","url":null,"abstract":"Hyperthermia-mediated drug delivery offers a promising strategy to enhance the efficacy of chemotherapy while minimizing systemic toxicity. Thermosensitive liposomes (TSLs) release their therapeutic payload in response to elevated temperature, enabling targeted delivery to tumor tissues. Here we introduce a hybrid multiscale model based on a Krogh cylinder approach to describe temperature-sensitive liposome transport and drug release in tumor tissue. Spatial transport of liposomes and released drug in the vascular and interstitial domains is described by one-dimensional (1D) transport equations, while intracellular drug internalization is represented by local compartmental (0D) kinetics. The model incorporates key physiological processes including blood flow, passive transvascular diffusion of liposomes, interstitial diffusion of released drug, and cellular uptake via receptor binding and internalization. The temperature field is calculated using the Pennes' bioheat equation, and its effects on physiological parameters-such as permeability, diffusivity, and blood velocity-are incorporated via temperature-dependent functions. A sensitivity analysis was performed to identify dominant transport parameters. Microvascular permeability, tissue diffusivity and Krogh cylinder radius were identified as the most influential parameters affecting drug delivery. Simulation results revealed that a 30-min preheating phase prior to drug administration significantly enhances treatment efficacy, increasing internalized doxorubicin concentrations by 29.4% while maintaining a low probability (5%) of tissue necrosis. This compact and computationally efficient model provides an effective framework for designing and optimizing hyperthermia-assisted chemotherapy. Its computational efficiency and physiological detail make it specifically suitable for use in treatment planning and real-time therapeutic decision-making in solid tumors.","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"42 5","pages":"e70176"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 2.4 4区医学

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2026-04-22

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