International Journal for Numerical Methods in Biomedical Engineering最新文献

{"title":"A Continuum Approach With Adaptive Mesh Refinement for Platelet Plug Formation","authors":"Ugo Pelissier,&nbsp;Philippe Meliga,&nbsp;Elie Hachem","doi":"10.1002/cnm.70073","DOIUrl":"https://doi.org/10.1002/cnm.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>Platelet plug formation is a critical physiological response to vascular injury, serving as a cornerstone of primary hemostasis. Understanding and simulating this process are essential for advancing patient-specific treatments and interventions. However, achieving a balance between model accuracy and computational efficiency, in particular, for patient-specific scenarios, remains a challenge. In this work, we present a continuum-based approach for simulating platelet plug formation using adaptive mesh refinement, providing a novel solution in this field that enables both accuracy and computational feasibility. Indeed, it integrates a stabilized finite element method within the Variational Multiscale framework to model blood flow dynamics, treated as a non-Newtonian fluid, along with the transport of biochemical species such as platelets and agonists. The platelet plug is represented by an extra stress term in the Navier–Stokes equation, capturing its influence on local blood flow dynamics as a rigid body. A key feature is related to anisotropic mesh adaptation, enabling high-resolution representation of the evolving platelet plug boundary while drastically reducing computational cost. We validate the model against two-dimensional benchmarks under varying shear rates and apply it to a 3D scenario, demonstrating its scalability and precision in simulating thrombosis under complex hemodynamic conditions. The results highlight the model's unique capability to facilitate accurate and efficient patient-specific simulations, offering a transformative tool for advancing personalized medicine.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Parameterized Cross-Sectional Model for Simulating Balloon Angioplasty in Atherosclerotic Arteries","authors":"Sanne M. B. Kwakman,&nbsp;Michele Terzano,&nbsp;Malte Rolf,&nbsp;Gerhard A. Holzapfel","doi":"10.1002/cnm.70058","DOIUrl":"https://doi.org/10.1002/cnm.70058","url":null,"abstract":"<p>Atherosclerotic arteries exhibit geometric alterations due to plaque deposition, which often leads to luminal narrowing. Balloon angioplasty is a common and suggested treatment to restore blood flow. However, depending on balloon oversizing, rupture at the plaque shoulder or the fibrous cap may occur. The rupture risk is influenced by factors such as the geometry of the fibrous cap, the lipid pool size, and calcifications. Despite advances in clinical imaging, predicting plaque rupture remains challenging because of lesion variability. This study addresses this gap by identifying key geometrical factors that influence stress distribution during balloon angioplasty, thus improving biomechanical insights and risk assessment. In this work, we develop a parameterized cross-sectional model of the atherosclerotic artery to investigate the influence of these components on stress distribution during balloon angioplasty. This model can be adapted to different stages and geometries of atherosclerosis. The parametric model enables the evaluation of the influence of uncertain input parameters, especially geometrical parameters, on the outcome of a finite element analysis. Experimental data from a layer-specific mechanical test on an iliac artery and pressure–diameter curves from balloon inflation tests are used to calibrate the respective constitutive models. Balloon angioplasty is then simulated by inflating a balloon in the narrowed artery without explicitly considering balloon unfolding. We perform <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mn>3</mn>\u0000 <mspace></mspace>\u0000 <mn>000</mn>\u0000 </mrow>\u0000 <annotation>$$ 3kern0.1em 000 $$</annotation>\u0000 </semantics></math> simulations for a local sensitivity analysis by varying the six most influential geometrical parameters and leaving the remaining parameters and the material parameters unchanged. The results show that the amount of the lipid pool has the largest influence on the maximum principal stress in the arterial tissue. Furthermore, the thickness of the fibrous cap plays a critical role in determining the specific location where this maximum occurs. These findings offer valuable insights into potential initiation sites of damage in atherosclerotic arteries.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bundles of Intercrossing Fibers of the Extensor Mechanism of the Fingers Greatly Influence the Transmission of Muscle Forces","authors":"Anton A. Dogadov,&nbsp;Francisco J. Valero-Cuevas,&nbsp;Christine Servière,&nbsp;Franck Quaine","doi":"10.1002/cnm.70068","DOIUrl":"https://doi.org/10.1002/cnm.70068","url":null,"abstract":"<p>The extensor mechanism is a tendinous structure that plays an important role in finger function. It transmits forces from several intrinsic and extrinsic muscles to multiple bony attachments along the finger via sheets of collagen fibers. The most important attachments are located at the base of the middle and distal phalanges. How the forces from the muscles contribute to the forces at the attachment points, however, is not fully known. In addition to the well-accepted extensor medial and interosseous lateral bands of the extensor mechanism, there exist two layers of intercrossing fiber bundles (superficial interosseous medial fiber layer and deeper extensor lateral fiber layer), connecting them. In contrast to its common idealization as a minimal network of distinct strings, we built a numerical model consisting of fiber bundles to evaluate the role of multiple intercrossing fiber bundles in the production of static finger forces. We compared this more detailed model of the extensor mechanism to the idealized minimal network that only includes the extensor medial and interosseous lateral bands. We find that including bundles of intercrossing fiber bundles significantly affects force transmission, which itself depends on finger posture. We conclude that the intercrossing fiber bundles—traditionally left out in prior models since Zancolli's simplification—play an important role in force transmission and variation of the latter with posture.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Finite Element Analysis Aided Multiobjective Shape Optimization Approach for Cementless Femoral Components in Hip Implants","authors":"Mohammad Ali Yazdi,&nbsp;Siavash Kazemirad","doi":"10.1002/cnm.70049","DOIUrl":"https://doi.org/10.1002/cnm.70049","url":null,"abstract":"<div>\u0000 \u0000 <p>The purpose of this study was to propose a multiobjective shape optimization approach using the MOPSO algorithm for the femoral stems with the aim of increasing the long-term survivorship of hip implants. The Taperloc Complete femoral stem was selected and its reference geometry was defined with 67 variables. 10 new stem shapes were produced as the swarm members by randomly changing the values of the variables. The values of the stress shielding, initial relative micro-motion, and bone-implant interface stress for each stem shape were calculated as the objectives by the finite element analysis and the position of each swarm member was updated iteratively. The geometry that caused a 37% and 45% decrease in the interface stress and stress shielding, respectively, and a 65% increase in the initial micro-motion compared to the Taperloc Complete stem was selected as the optimized shape. It was shown that thinning the femoral stems without changing their length reduced the induced stress shielding and initial micro-motion and increased the interface stress, whereas shortening the femoral stems reduced the stress shielding and interface stress and increased the initial micro-motion. The proposed approach may be used for the shape optimization of commercial femoral stems to increase their lifetime.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Remodelling in Lumbar Spine: A Comparative Analysis of Ti-Alloy, PEEK and CFR-PEEK Implant Materials","authors":"Kishore Pradeep,&nbsp;Swapnil Mahadev Dhobale,&nbsp;Bidyut Pal","doi":"10.1002/cnm.70071","DOIUrl":"https://doi.org/10.1002/cnm.70071","url":null,"abstract":"<div>\u0000 \u0000 <p>Long-term performance-based study to comprehend the biomechanics of Ti-6Al-4V, PEEK and CFR-PEEK implant materials in fusing a lumbar spine is not available in literature. The present study investigates the performance of these implant materials in fusing an L4–L5 segment by executing a strain energy density-based bone remodelling theory. The FE models of intact and implanted lumbar spines were reconstructed from computed tomography scan images and simulated for 500 N compressive load and a combination of 150 N preload and 10 Nm moment. The models attained equilibrium state when the apparent bone density change became less than 0.005 g cm⁻³ between two consecutive iterations. The implanted models' range of motion (ROM) has been reduced by 73%–85% for Ti-6Al-4V, 64%–78% for PEEK and 69%–81% for CFR-PEEK implanted models. All models exhibit a substantial rise in bone density (30%) in the implant-bone interface region and cancellous bone. However, the CFR-PEEK implanted model exhibited a bone density loss of only 0%–0.3%, compared to the Ti-6Al-4V implanted model (0.3%–6.7%) and the PEEK model (1.5%–30%). The findings indicate that CFR-PEEK material may be a better implant material than PEEK and Ti-6Al-4V while considering bone density distributions and equivalent strains from immediate post-operative to equilibrium conditions.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patient-Specific Mesoscopic Fluid–Structure Interaction Model of the Coronary Artery","authors":"Elisabeth Steadman,&nbsp;Daphne Meza,&nbsp;David A. Rubenstein,&nbsp;Wei Yin","doi":"10.1002/cnm.70061","DOIUrl":"https://doi.org/10.1002/cnm.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>A mesoscopic fluid–structure interaction (FSI) model focusing on a small region of interest (ROI) in the left coronary artery was developed using COMSOL Multiphysics. This model was on the basis of a previously developed patient-specific coronary artery macroscopic FSI model. With element size comparable to that of endothelial cells, the spatial resolution of the mesoscopic model was significantly improved. Blood flow-induced shear stress and derivatives, vascular wall von Mises stress, and tensile strain (radial and circumferential) in normal and stenosed (50% and 71% occlusion) coronary artery ROIs were calculated, and the results were compared between the current mesoscopic model and the previously developed macroscopic model. Significant differences were observed in shear stress and circumferential strain in the 50% stenosis models. The mesoscopic stenosis model-derived shear stress and tensile strain were applied to human coronary artery endothelial cells concurrently using a shearing-stretching device, and endothelial cell responses (cell morphology and cell surface ICAM-1 expression) were measured. The results demonstrated that the difference in shear stress–tensile strain conditions calculated from the mesoscopic FSI model and the previously developed macroscopic model had a significant impact on endothelial cell responses, suggesting that large-scale FSI models may not be sufficient to characterize local biomechanical conditions at the cellular level.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Surgical Technique for the Repair of Meniscus Root Tears Using Finite Element Analysis","authors":"Cengizhan Kurt,&nbsp;Mehmet Hakan Ozsoy,&nbsp;Arif Gok,&nbsp;Sermet İnal,&nbsp;Kadir Gok","doi":"10.1002/cnm.70064","DOIUrl":"https://doi.org/10.1002/cnm.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigates an alternative surgical approach for repairing meniscal root tears, a common knee injury that can significantly impact joint stability and function. Traditional repair methods often face challenges such as high rates of retear and persistent pain. To address these limitations, this research utilizes finite element analysis (FEA) to compare the biomechanical performance of an alternative technique against established surgical procedures. FEA models were carefully constructed to accurately represent the complex anatomy of the knee joint, including the medial meniscus, cartilage, ligaments, and surrounding bone structures. These models were then subjected to various loading conditions that simulated physiological activities such as walking, running, and squatting to assess the stress and strain experienced by the repaired tissue under realistic conditions. The results of the FEA simulations demonstrated a significant reduction in stress and strain on the repaired medial meniscus root when the alternative technique was employed compared to traditional methods. This reduction in biomechanical load is crucial for promoting tissue healing and minimizing the risk of retear. By reducing excessive stress on the repair site, the alternative surgical technique may enhance long-term patient outcomes, potentially improving knee function, reducing pain, and decreasing the likelihood of further surgical interventions such as meniscectomy or knee prosthesis replacement. In conclusion, this study provides strong evidence for the potential benefits of the alternative surgical technique in repairing meniscal root tears. The findings suggest that this approach may offer a promising alternative to traditional methods by optimizing biomechanical stability and promoting more favorable healing conditions. Further clinical studies are warranted to validate these findings and translate these promising results into improved patient care.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical Poromechanical Approach to Investigate the Impact of Mechanical Loading on Human Skin Micro-Circulation","authors":"Thomas Lavigne,&nbsp;Stéphane Urcun,&nbsp;Bérengère Fromy,&nbsp;Audrey Josset-Lamaugarny,&nbsp;Alexandre Lagache,&nbsp;Camilo A. Suarez-Afanador,&nbsp;Stéphane P. A. Bordas,&nbsp;Pierre-Yves Rohan,&nbsp;Giuseppe Sciumè","doi":"10.1002/cnm.70066","DOIUrl":"https://doi.org/10.1002/cnm.70066","url":null,"abstract":"<p>Extensive research on human skin anatomy has revealed that the skin functions as a complex multi-scale and multi-phase system, containing up to 70% of bounded and free circulating water. The presence of moving fluids significantly influences the mechanical and biological responses of the skin, affecting its time-dependent behavior and the transport of essential nutrients and oxygen to cells. Poroelastic modeling emerges as a promising approach to investigate biologically relevant phenomena at finer scales while embedding crucial mechanisms at larger scales as it facilitates the integration of multi-scale and multi-physics processes. Despite extensive use of poromechanics in other tissues, no hierarchical multi-compartment porous model that incorporates blood supply has yet been experimentally evaluated to simulate the in vivo mechanical and micro-circulatory response of human skin. This paper introduces a hierarchical two-compartment model that accounts for fluid distribution within the interstitium and the micro-circulation of blood. A general theoretical framework, which includes a biphasic interstitium (comprising interstitial fluid and non-structural cells), is formulated and studied through a one-dimensional consolidation test of a 100 <i>μ</i>m column. The inclusion of a biphasic interstitium allows the model to account separately for the motion of cells and interstitial fluid, recognising their differing characteristic times. An extension of the model to include biological exchanges such as oxygen transport is discussed in the appendix. The preliminary evaluation demonstrated that cell viscosity introduces a second characteristic time beyond that of interstitial fluid movement. However, at high cell viscosity values and short time scales, cells exhibit behavior akin to that of solid materials. Based on these observations, a simplified version of the model was used to replicate an experimental campaign carried out on short time scales. Local pressure (up to 31 kPa) was applied to the skin of the dorsal face of the middle finger through a laser Doppler probe PF801 (Perimed Sweden) attached to an apparatus as previously described (Fromy Brain Res 1998). The model demonstrated its qualitative ability to represent both ischaemia and post-occlusive reactive hyperaemia, aligning with experimental observations. All numerical simulations were performed using the open source software FEniCSx v0.9.0. To promote transparency and reproducibility, the anonymized experimental data and the corresponding finite element codes are publicly available on GitHub.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Glaucoma Surgery Procedure in the Human Eye. A Fluid Structure Interaction Study","authors":"Elena Redaelli,&nbsp;Letizia Maria Perri,&nbsp;Begoña Calvo,&nbsp;Jorge Grasa,&nbsp;Giulia Luraghi","doi":"10.1002/cnm.70062","DOIUrl":"https://doi.org/10.1002/cnm.70062","url":null,"abstract":"<p>Aqueous humor is a clear fluid pressurized at an intraocular pressure (IOP) within a range of 8–20 mmHg in healthy conditions that fills and shapes the anterior and posterior chambers of the eye. It is typically drained through the trabecular meshwork, but reduced permeability of this structure can lead to impaired drainage, elevated IOP, and the development of glaucoma. Minimally invasive glaucoma surgeries (MIGS) offer a treatment option by implanting micro stents to create alternative pathways for aqueous humor drainage. Despite their potential, limited research has explored the biomechanical changes in ocular tissues and the hydrodynamic interactions following MIGS implantation. This paper aims to study the aqueous humor flow after the surgery by means of computational simulations. For the first time, the implantation process has been simulated to assess residual stresses on ocular structures post-implantation. Then, this study introduces a Fluid–Structure Interaction (FSI) simulation to model the aqueous humor dynamics after MIGS implantation. The results demonstrate the necessity of FSI simulations, as they reveal the interplay between the eye's biomechanical properties and the aqueous humor dynamics. The advantage of using an FSI simulation is its ability to capture the aqueous humor dynamics, providing a more realistic representation compared to the Computational Fluid Dynamic (CFD) simulations found in the literature. Using only CFD, the outflow velocity of the aqueous humor through the stent is approximately 1e−4 m/s, whereas with an FSI approach, the velocity reaches up to 0.8 m/s as the deformation of the ocular tissues has a substantial impact on the flow dynamics and cannot be neglected. This novel methodology can be potentially used for visualizing and quantifying the aqueous humor flow as a function of implant design, position and dimensions in order to design next-generation MIGS devices and optimize implantation strategies, offering significant advancements in glaucoma treatment.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Imaging Performance and Resolution in Magneto-Acoustic Electrical Tomography With Magnetic Field Measurements (MAET-MI) Using Figure-of-Eight and High-Quality Factor Circular Coils","authors":"Ahmet Önder Tetik,&nbsp;Nevzat Güneri Gençer","doi":"10.1002/cnm.70063","DOIUrl":"https://doi.org/10.1002/cnm.70063","url":null,"abstract":"<p>Magneto-acousto-electrical tomography with magnetic field measurement technique (MAET-MI) is a hybrid imaging method that brings high spatial resolution of ultrasound imaging in electrical impedance tomography. This study investigates the impact of the quality factor of circular and figure-of-eight coils on the imaging performance of MAET-MI. Induced MAET signals on the circular coil are accurately obtained by modeling a circuit representation of an air-cored circular coil and deriving its transfer function through impedance measurements. The study demonstrates a significant improvement in signal-to-noise ratio (SNR) using high-quality factor coils compared to unity quality factor coils. Additionally, a 16-element linear phased array (LPA) ultrasound transducer, an air core circular coil, and a figure-of-eight coil are numerically modeled to obtain sector scan images of two-dimensional conductivity distributions. Point spread function (PSF) is characterized, and the lateral resolution of sector scan conductivity images is enhanced through two-dimensional deconvolution with PSF. The combined use of circular and figure-of-eight coils provides comprehensive imaging coverage. Notably, this research presents a practical method for estimating both circular and figure-of-eight coils' transfer functions, achieving 12.9 dB SNR improvement with high-quality factor coils. A simplified breast model is rotated 16 steps, and sector scan conductive boundary images are reconstructed for both coils. A two-dimensional image of a breast model is obtained by combining images from two different coils. These findings offer significant advancements in MAET-MI imaging, particularly in low SNR environments.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}