International Journal for Numerical Methods in Biomedical Engineering最新文献

{"title":"Uncertainty Quantification and Sensitivity Analysis for Non-invasive Model-Based Instantaneous Wave-Free Ratio Prediction","authors":"Caterina Dalmaso,&nbsp;Fredrik Eikeland Fossan,&nbsp;Anders Tjellaug Bråten,&nbsp;Lucas Omar Müller","doi":"10.1002/cnm.3898","DOIUrl":"10.1002/cnm.3898","url":null,"abstract":"<p>The main objectives of this work are to validate a 1D-0D unsteady solver with a distributed stenosis model for the patient-specific estimation of resting haemodynamic indices and to assess the sensitivity of instantaneous wave-free ratio (iFR) predictions to uncertainties in input parameters. We considered 52 patients with stable coronary artery disease, for which 81 invasive iFR measurements were available. We validated the performance of our solver compared to 3D steady-state and transient results and invasive measurements. Next, we used a polynomial chaos approach to characterise the uncertainty in iFR predictions based on the inputs associated with boundary conditions (coronary flow, compliance and aortic/left ventricular pressures) and vascular geometry (radius). Agreement between iFR and the ratio between cardiac cycle averaged distal and aortic pressure waveforms (resting <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>P</mi>\u0000 <mi>d</mi>\u0000 </msub>\u0000 <mo>/</mo>\u0000 <msub>\u0000 <mi>P</mi>\u0000 <mi>a</mi>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {P}_d/{P}_a $$</annotation>\u0000 </semantics></math>) obtained through 1D-0D and 3D models was satisfactory, with a bias of 0.0–0.005 (±0.016–0.026). The sensitivity analysis showed that iFR estimation is mostly affected by uncertainties in vascular geometry and coronary flow (steady-state parameters). In particular, our 1D-0D method overestimates invasive iFR measurements, with a bias of −0.036 (±0.101), indicating that better flow estimates could significantly improve our modelling pipeline. Conversely, we showed that standard pressure waveforms could be used for simulations, since the impact of uncertainties related to inlet-pressure waveforms on iFR prediction is negligible. Furthermore, while compliance is the most relevant transient parameter, its effect on iFR estimates is negligible compared to that of vascular geometry and flow. Finally, we observed a strong correlation between iFR and resting <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>P</mi>\u0000 <mi>d</mi>\u0000 </msub>\u0000 <mo>/</mo>\u0000 <msub>\u0000 <mi>P</mi>\u0000 <mi>a</mi>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {P}_d/{P}_a $$</annotation>\u0000 </semantics></math>, suggesting that steady-state simulations could replace unsteady simulations for iFR prediction.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Central Aortic Pressure Waveforms by Combination of a Meta-Learning Neural Network and a Physics-Driven Method","authors":"Hao Sun,&nbsp;Junling Ma,&nbsp;Bao Li,&nbsp;Youjun Liu,&nbsp;Jincheng Liu,&nbsp;Xue Wang,&nbsp;Gerold Baier,&nbsp;Jian Liu,&nbsp;Liyuan Zhang","doi":"10.1002/cnm.3905","DOIUrl":"https://doi.org/10.1002/cnm.3905","url":null,"abstract":"<div>\u0000 \u0000 <p>The accurate non-invasive detection and estimation of central aortic pressure waveforms (CAPW) are crucial for reliable treatments of cardiovascular system diseases. But the accuracy and practicality of current estimation methods need to be improved. Our study combines a meta-learning neural network and a physics-driven method to accurately estimate CAPW based on personalized physiological indicators. We collected data from 260 patients who underwent catheterization surgery, using measured CAPW and personalized physiological indicators (e.g., weight, body mass index (BMI), radial mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), radial systolic blood pressure (SBP), and radial diastolic blood pressure (DBP)) as input for neural network training. The output of the neural network are the Gaussian characteristic parameters of the single-period decomposed CAPW. The neural network model was constructed using the model-agnostic meta-learning (MAML) algorithm framework. Applying the physical characteristics of CAPW to the loss function, served to increase the constraints on the output and improve the accuracy of CAPW estimation. To verify the accuracy of the model, we compared measured and estimated CAPW in 52 patients. The results are consistent with a normalized root mean square error (NRMSE) of 0.0206. The predictions had low biases, namely SBP: 4.97 ± 4.42 mmHg, DBP: 4.78 ± 5.98 mmHg, and MAP: 0.35 ± 3.36 mmHg. The results demonstrate the accuracy and practicability of the approach to estimate CAPW. It can provide personalized parameters to calculate myocardial ischemia indicators (e.g., instantaneous wave-free ratio [iFR] and fractional flow reserve [FFR]) and may contribute to the early monitoring and prevention of cardiovascular diseases.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Fibrous Tissue in Vascular Fluid–Structure Interaction: A Morphology-Based Pipeline and Biomechanical Significance","authors":"Yujie Sun,&nbsp;Jiayi Huang,&nbsp;Qingshuang Lu,&nbsp;Xinhai Yue,&nbsp;Xuanming Huang,&nbsp;Wei He,&nbsp;Yun Shi,&nbsp;Ju Liu","doi":"10.1002/cnm.3892","DOIUrl":"10.1002/cnm.3892","url":null,"abstract":"<div>\u0000 \u0000 <p>Modeling fibrous tissue for vascular fluid–structure interaction analysis poses significant challenges due to the lack of effective tools for preparing simulation data from medical images. This limitation hinders the physiologically realistic modeling of vasculature and its use in clinical settings. Leveraging an established lumen modeling strategy, we propose a comprehensive pipeline for generating thick-walled artery models. A specialized mesh generation procedure is developed to ensure mesh continuity across the lumen and wall interface. Exploiting the centerline information, a series of procedures are introduced for generating local basis vectors within the arterial wall. The procedures are tailored to handle thick-walled tissues where basis vectors may exhibit transmural variations. Additionally, we propose methods for accurately identifying the centerline in multi-branched vessels and bifurcating regions. These modeling approaches are algorithmically implementable, rendering them readily integrable into mainstream cardiovascular modeling software. The developed fiber generation method is evaluated against the strategy using linear elastostatics analysis, demonstrating that the proposed approach yields satisfactory fiber definitions in the considered benchmark. Finally, we examine the impact of anisotropic arterial wall models on the vascular fluid–structure interaction analysis through numerical examples, employing the neo-Hookean model for comparative purposes. The first case involves an idealized curved geometry, while the second studies an image-based abdominal aorta model. Our numerical results reveal that the deformation and stress distribution are critically related to the constitutive model of the wall, whereas hemodynamic factors are less sensitive to the wall model. This work paves the way for more accurate image-based vascular modeling and enhances the prediction of arterial behavior under physiologically realistic conditions.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Vessel Geometry, Flow Conditions, and Thrombin Concentration on Fibrin Accumulation and Cerebral Aneurysm Occlusion After Flow Diversion","authors":"Juan R. Cebral,&nbsp;Fernando Mut,&nbsp;Rainald Löhner,&nbsp;Laurel Marsh,&nbsp;Alireza Chitsaz,&nbsp;Cem Bilgin,&nbsp;Esref Bayraktar,&nbsp;David Kallmes,&nbsp;Ramanathan Kadirvel","doi":"10.1002/cnm.3904","DOIUrl":"10.1002/cnm.3904","url":null,"abstract":"<p>As the number of cerebral aneurysms treated with flow diverters continues to increase, it is important to understand what factors influence not only thrombus formation within the aneurysm cavity but also fibrin accumulation across the device and its associated disruption and blockage of the inflow stream. Both processes contribute to the eventual occlusion of the aneurysm or its continued patency and incomplete occlusion which may require future re-treatment. To investigate fibrin accumulation on flow diverters placed across the neck of cerebral aneurysms, a previously developed computational model that couples flow and fibrin dynamics is used in combination with experimental in vitro models of cerebral aneurysms treated with flow diverters. Fibrin accumulation was previously investigated in four glass models of cerebral aneurysms with varying parent artery geometries placed in a flow loop at different flow rates. Corresponding computational models were constructed and compared with the experimental findings. The computational model based on fibrin production stimulated from flow shear stress and subsequent adhesion to device wires was able to reproduce and explain the fibrin accumulation patterns observed in the experimental aneurysms treated with flow diverters. Specifically, these models indicated that increasing vessel curvature, flow rate, and thrombin concentration induced faster fibrin accumulation and associated aneurysm inflow disruption and blockage. The models described and tested in this paper are valuable to understand the detailed mechanisms leading to aneurysm occlusion and healing or incomplete occlusions after treatment with flow diverting devices.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid–Structure Interaction Analysis of Trapezoidal and Arc-Shaped Membranes Mimicking the Organ of Corti","authors":"Kentaro Doi,&nbsp;Sho Takeuchi,&nbsp;Hiroki Yamazaki,&nbsp;Tetsuro Tsuji,&nbsp;Satoyuki Kawano","doi":"10.1002/cnm.3896","DOIUrl":"10.1002/cnm.3896","url":null,"abstract":"<p>In a previous study [H. Shintaku et al., <i>Sensors and Actuators A: Physical</i> 158 (2010): 183–192], an artificially developed auditory sensor device showed a frequency selectivity in the range from 6.6 to 19.8 kHz in air and from 1.4 to 4.9 kHz in liquid. Furthermore, the sensor succeeded in obtaining auditory brain-stem responses in deafened guinea pigs [T. Inaoka et al., <i>Proceedings of the National Academy of Sciences of the United States of America</i> 108 (2011): 18390–18395]. Since then, several research groups have developed piezoelectric auditory devices that have the capability of acoustic/electric conversion. However, the piezoelectric devices are required to be optimally designed with respect to the frequency range in liquids. In the present study, focusing on the trapezoidal shape of the piezoelectric membrane, the vibration characteristics are numerically and experimentally investigated. In the numerical analysis, solving a three-dimensional fluid-structure interaction problem, resonant frequencies of the trapezoidal membrane are evaluated. Herein, Young's modulus of the membrane, which is made of polyvinylidene difluoride and is different from that of bulk, is properly determined to reproduce the experimental results measured in air. Using the modified elastic modulus for the membrane, the vibration modes and resonant frequencies in liquid are in good agreement with experimental results. It is also found that the resonant characteristics of the artificial basilar membrane for guinea pigs are quantitatively reproduced, considering the fluid–structure interaction. The present numerical method predicts experimental results and is available to improve the frequency selectivity of the piezoelectric membranes for artificial cochlear devices.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Convulsive Maternal Seizures on Fetus Dynamics","authors":"Milan Toma,&nbsp;Jonathan Mayer,&nbsp;Molly Bekbolatova,&nbsp;Tim Devine,&nbsp;Paula Ryo","doi":"10.1002/cnm.3901","DOIUrl":"10.1002/cnm.3901","url":null,"abstract":"<div>\u0000 \u0000 <p>The study findings demonstrate that the amniotic fluid plays an important role in protecting the fetus during convulsive maternal seizures. The amniotic fluid was found to be an effective buffer, significantly reducing the transfer of kinetic energy to the fetus during these events. This highlights the sufficient protection provided by the amniotic fluid in such circumstances. The research was conducted using a model that simulates the complex interactions between a pregnant woman's anatomy, the uterus, and the fetus immersed in amniotic fluid. Key parameters such as speed, acceleration, and Euler angles were captured using sensors and used as input for the computational model in the simulations. The results showed that during an oscillatory movement, which is characteristic of a maternal seizure, the fetus and placenta exhibit variable kinematics relative to the uterus. Despite these variations, the amniotic fluid was found to be a significant protective buffer. The discovery of the protective role of the amniotic fluid during maternal seizures provides valuable insights for obstetricians. It can help in managing patient care during such pregnancy complications, emphasizing the importance of the amniotic fluid in fetal protection.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Spinal Cord Stimulation With Different Electrode Configurations: A Numerical Study","authors":"Elif Feyza Aydin,&nbsp;Reyhan Zengĺn","doi":"10.1002/cnm.3894","DOIUrl":"10.1002/cnm.3894","url":null,"abstract":"<div>\u0000 \u0000 <p>Spinal cord stimulation (SCS) represents a therapeutic approach for chronic pain management in patients refractory to conventional treatments. By implanting electrodes in the epidural space, SCS aims to mitigate pain transmission to the brain through electrical stimulation, often resulting in sensory perceptions such as paresthesia. This study investigates the influence of electrode configurations on electrical parameters, including current density and electric potential, within the spinal cord environment. Utilizing computational models of the spinal canal incorporating components such as epidural fat, cerebrospinal fluid (CSF), gray matter, and white matter, our analysis explores the distribution of electric potential and current density. Specifically, configurations employing four and nine electrodes are evaluated under both direct current (DC) and alternating current (AC) stimulations. For DC stimulations at currents of 1, 5, and 10 mA, our findings indicate that the four-electrode model generated current density values in epidural fat ranging from 107.90 to 130.98 mA/cm² and electric potential values ranging from 3.51 to 4.78 V. Similarly, the nine-electrode model produced current density values ranging from 92.51 to 223.61 mA/cm² and electric potential values ranging from 1.27 to 7.83 V under the same conditions. The results demonstrate a proportional relationship between applied current, current density, and electric potential. Furthermore, our investigation reveals a gradual decrease in electrical potential and current density from the epidural space to the gray matter. Discussions encompass the safety implications of these findings, examining whether the observed electrical parameters remain within tolerable limits for patient well-being. Additionally, the study explores the effects of AC stimulation across frequencies ranging from 250 Hz to 10 kHz, revealing an inverse correlation between frequency and charge parameters. Specifically, higher frequencies corresponded to reduced charge per phase and charge density, underscoring the frequency-dependent nature of these electrical properties.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Congestion in Human Lung Investigated Using Dual-Scale Porous Medium Models","authors":"Aarthi Thangavelu,&nbsp;Arunn Narasimhan","doi":"10.1002/cnm.3893","DOIUrl":"10.1002/cnm.3893","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic obstructive pulmonary disease (COPD) is a primary chronic respiratory disease associated with pulmonary congestion that restricts airflow and thereby affects the exchange of gases between the alveoli and the blood capillaries in the lungs. Dual scale—global and local—porous medium models have been developed and reported in this work, to study the effects of air-side congestion on the blood-oxygen content in the alveolar region of the human lung. The human lung is model as a global, equivalent, heterogeneous porous medium comprising three zones with distinct permeabilities related to their progressively complex branching structure. Airflow for each breathing cycle is determined by solving mass and momentum transfer equations across the three porous medium zones. The congestion is introduced by appropriate modification of the porous medium properties of the zones considered. The congestion-affected air velocity reaching Zone 3 is given as input to a separate “local model” employed at several locations of the alveoli of Zone 3. The local model determines the oxygen content in the blood flow in the capillaries of the alveoli by solving suitable mass, momentum and species transport equations. The transient simulation results performed for a long duration of multiple breathing cycles, demonstrate that a normal, healthy human lung is functional for up to 40% volume congestion or when 50% of the lung is congested to about 23.5%. Increasing congestion beyond this value, quickly—within a few hours—depletes the oxygen exchange in the blood flow of the alveolar region (of Zone 3), leading to hypoxemia. The effects of congestion progression on oxygen exchange dynamics determined through the dual-scale porous medium modelling approach provide researchers and medical professionals with in silico predictive estimates to generate treatment strategies for chronic respiratory diseases.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence Mechanism of Screw Internal Fixation on the Biomechanics of Lateral Malleolus Oblique Fractures","authors":"Xinyuan Shi,&nbsp;Shuanzhu Wang,&nbsp;Yongzhi Gong,&nbsp;Shibo Gu,&nbsp;Haiquan Feng","doi":"10.1002/cnm.3895","DOIUrl":"10.1002/cnm.3895","url":null,"abstract":"<div>\u0000 \u0000 <p>It remains inconclusive about the stability and optimal fixation scheme of screw internal fixation for lateral malleolus oblique fractures in clinical practice. In this study, the effects of different screw internal fixation methods on the biomechanics of lateral malleolus oblique fractures were investigated. These efforts are expected to lay a theoretical foundation for the selection of internal fixation methods and rehabilitation training regimens in the treatment of lateral malleolus fractures. A healthy ankle joint model and a lateral malleolus fracture internal fixation model were established based on CT data with the aid of some software. Besides, the effects of screw internal fixation modalities on the fracture displacement of fibula fractures, fibula Von Mises stress, and screw Von Mises stress under different physiological conditions and loading conditions were investigated using finite element methods (FEMs) and in vitro physical experiments. The double screw vertical fibular axis internal fixation approach had the lowest fracture displacement of fibula fractures and screw Von Mises stress values; while the double screw vertical fracture line internal fixation approach had the lowest fibula Von Mises stress values. Under different physiological conditions, the magnitude of the peak Von Mises stress of the fibula and screw was ranked as plantarflexion 20° &gt; plantarflexion 10° &gt; neutral position &gt; dorsiflexion 10° &gt; dorsiflexion 20°; and the magnitude of the peak displacement of the fibula fracture breaks was ranked as plantarflexion 20° &gt; plantarflexion 10° &gt; neutral position &gt; dorsiflexion 20° &gt; dorsiflexion 10°. The results of in vitro physical experiments and finite element analyses were in good agreement, which validated the validity of finite element analyses. The vertical fracture line screw implantation method displays a better load-sharing ability; while the vertical fibular axis screw implantation method exhibits a better ability to prevent axial shortening of the fibula and also reduces the risk of screw fatigue damage. Overall, the double screw achieves better therapeutic effects than the single screw. Given that the ankle joint has high stability in the dorsiflexion position, it is recommended to prioritize dorsiflexion rehabilitation training, rather than dorsiflexion and plantarflexion rehabilitation training with too large angles, in the treatment of lateral malleolus fractures.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multiscale Mathematical Model for Fetal Gas Transport and Regulatory Systems During Second Half of Pregnancy","authors":"Bettine G. Van Willigen,&nbsp;M. Beatrijs van der Hout-van der Jagt,&nbsp;Wouter Huberts,&nbsp;Frans N. van de Vosse","doi":"10.1002/cnm.3881","DOIUrl":"10.1002/cnm.3881","url":null,"abstract":"<p>Fetal asphyxia, a condition resulting from the combined effects of hypoxia and hypercapnia, leads to approximately 900,000 annual deaths worldwide. One cause is umbilical cord compression during labor-induced uterine contractions, disrupting the transport of metabolites to and from the placenta, and resulting in asphyxia. Current fetal well-being assessment relies on monitoring fetal heart rate and uterine contractions as indicators of oxygen delivery to the brain. To enhance our understanding of this complex relationship, this study aims to develop a modular mathematical model including fetal blood gas dynamics, the autonomic nervous system, and cerebral blood flow regulation. The novelty of this study lies in the capability of the model to simulate fetal growth. These submodels are part of a larger multiscale mathematical model describing fetal circulation in the second half of pregnancy. The blood gas model realistically replicates partial oxygen and carbon dioxide pressures in umbilical arteries and veins during healthy fetal development reported in the literature. An <i>in silico</i> experiment is conducted to simulate umbilical cord occlusion and is compared with lamb experiments to verify the realism of the regulation models during fetal growth. Our findings suggest that premature infants are more susceptible to umbilical cord occlusion, exhibiting elevated cerebral perfusion pressure and flow. This modular mathematical model may serve as a valuable tool for testing hypotheses related to the fetal regulatory system.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}