International Journal for Numerical Methods in Biomedical Engineering最新文献

{"title":"A Novel Method to Calibrate Spring-Network Cell Model in Hydrodynamic Flow","authors":"Aravind Anandan,&nbsp;Mehdi Maleki,&nbsp;Céline Thomann,&nbsp;Axelle Perraud,&nbsp;Robin Chatelin,&nbsp;Avigaël Ohayon,&nbsp;Christophe Marquette,&nbsp;Edwin-Joffrey Courtial","doi":"10.1002/cnm.3902","DOIUrl":"https://doi.org/10.1002/cnm.3902","url":null,"abstract":"<div>\u0000 \u0000 <p>One of the primary challenges encountered during the extrusion bioprinting process involves managing mechanical stresses within the printer nozzle. These stresses ultimately have an impact on the health and functionality of the cells within the printed structure. Statistical models in bioprinting predict cell damage but are empirical, disregard key interactions, and lack single-cell prediction. Our ultimate objective is to develop an efficient validated computational model simulating human dermal fibroblast deformability in extrusion bioprinting, considering all important interactions. The spring-network model shows promise in simulating cellular deformation. However, its widespread adoption and efficiency rely on a significant challenge of accurately calibrating model coefficients. This calibration process is complex due to the lack of a manual method tailored for eukaryotic cells suspended in hydrodynamic flow. In this study, we described a new method to calibrate the model coefficients manually for human dermal fibroblasts. To achieve this calibration, experimental data of human dermal fibroblasts passing through narrow microfluidics constriction was used. The calibration process was initiated by using coefficients associated with red blood cells and subsequently adjusted by comparing the model's behavior with experimental data. The elastic coefficients were calibrated to closely replicate the entry time observed in the experiments with a 5% error margin. However, notable differences persisted in the cell deformation behavior between simulation and experiment. Moreover, adding membrane viscosity minimally reduced transient cell deformation by less than 10% without affecting steady-state deformation.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production","authors":"Christian Bilas,&nbsp;Claus Kratzer,&nbsp;Arne Hinrichs,&nbsp;Andreas Maier,&nbsp;Stephen Wildhirt,&nbsp;Eckhard Wolf,&nbsp;Michael W. Gee","doi":"10.1002/cnm.3906","DOIUrl":"https://doi.org/10.1002/cnm.3906","url":null,"abstract":"<p>Signaling networks can be used to describe the dynamic interplay of hormonal and mechanical factors that regulate heart growth. However, a qualitative analysis of signaling networks is often difficult due to their complexity and nonlinear behavior. In this work, a global sensitivity analysis of signaling networks is conducted to determine the most influential factors for heart growth over a range of model inputs. Furthermore, the local production of the hormone insulin-like growth factor 1 (IGF1) in response to high mechanical stretches as recently described by Zaman et al.(<i>Immunity</i>, 54, 2057) and Wong et al.(<i>Immunity</i>, 54, 2072) is incorporated. The computational results show that this increases the influence of mechanical stretch on heart growth significantly. Further key influential factors are the hormones norepinephrine (NE), angiotensin II (AngII), and globally produced IGF1 (g-IGF1). Our sensitivity analysis indicates that the novel consideration of local IGF1 (l-IGF1) production has to be considered in signaling networks for heart growth.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.3906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical Simulation of Fluid–Structure Interaction in Axillary Artery Venoarterial Extracorporeal Membrane Oxygenation for Heart Failure Patients","authors":"Shuai Yue,&nbsp;Haojie Yan,&nbsp;Junjie Shao,&nbsp;Jingjing Zhou,&nbsp;Shujin Shi,&nbsp;Haiming Wang,&nbsp;Xiaoyang Hong,&nbsp;Jun Li,&nbsp;Ran Zhang","doi":"10.1002/cnm.70001","DOIUrl":"https://doi.org/10.1002/cnm.70001","url":null,"abstract":"<div>\u0000 \u0000 <p>Although axillary artery venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been utilized as a mechanical circulatory support for patients with end-stage heart failure (HF), there is currently insufficient evidence to support its effectiveness and safety. The objective of this study was to analyze the hemodynamic effects of axillary artery VA-ECMO. To this end, we obtained CT angiographic imaging data of the aorta from a carefully selected heart failure patient with a cardiac output of 2.1 L/min. These data were used to construct a detailed fluid–structure interaction model of the aorta. Axillary artery VA-ECMO was then simulated within this model, maintaining a constant flow rate of 3 L/min. The intra-aortic balloon counterpulsation (IABP) balloon was simulated to inflate and deflate in synchrony with the diastolic and systolic phases of the cardiac cycle. Hemodynamic effects, including left ventricular (LV) pressure afterload, vessel wall stress, perfusion of vital organs, blood flow pulsatility, and the watershed region, were calculated using fluid–structure interaction analysis. We found that axillary artery VA-ECMO delivers well-distributed, oxygen-rich blood flow but may increase left ventricular (LV) afterload and reduce cerebral blood flow. However, when combined with IABP, it unloads LV pressure and increases cerebral blood flow. Integrating axillary artery VA-ECMO with IABP can promote cardiac function recovery and improve oxygen-rich blood perfusion to the vital organs of heart failure patients.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Structural Behavior Following Bone Scaffold Implantation in Multi-Resolution Proximal Femur Images","authors":"Jun Won Choi,&nbsp;Jung Jin Kim","doi":"10.1002/cnm.70015","DOIUrl":"https://doi.org/10.1002/cnm.70015","url":null,"abstract":"<div>\u0000 \u0000 <p>Bone scaffolds are increasingly regarded as viable alternatives to autografts and allografts in clinical settings. However, their effectiveness can vary based on certain anatomical characteristics, highlighting the importance of image-based structural analysis. High-resolution imaging is crucial to accurately assess the performance of bone scaffolds. Despite this, the resolution of current clinical medical images is constrained by concerns regarding radiation exposure. The efficacy of these analyses can be improved by quantitatively evaluating the similarities and differences between low- and high-resolution images. This study quantitatively compared the structural behavior of bone scaffolds using both high- and low-resolution images. This study downscaled a high-resolution image, implanted a bone scaffold, and conducted finite element analysis. The findings suggest that the resolution needed for accurate structural analysis of skeletal images varies based on the implantation site of the scaffold. Additionally, it was found that the less influence the loading conditions have, the higher the resolution required to accurately assess the structural behavior.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Health Deterioration in Transfemoral Prosthetic Users: An Analytical Biomechanical Explanation","authors":"Jose L. Zavaleta-Ruiz,&nbsp;Matthew J. Major,&nbsp;Pankaj Pankaj","doi":"10.1002/cnm.70014","DOIUrl":"https://doi.org/10.1002/cnm.70014","url":null,"abstract":"<p>There is a five-decade recorded history indicating that persons with transfemoral amputation experience bone loss in their amputated femur at levels seen in bedridden and post-menopausal individuals, irrespective of age or mobility levels. We used computer simulation to recreate the mechanical environment created by the mechanical design of a prosthetic device in the surviving femur of individuals with transfemoral amputations. Finite element models of gait instances were developed from the hip joint computerized tomography scan of a subject along with a coupled ischial containment prosthetic socket fitted as per standard clinical guidelines. Accompanying mirror models, assembled similarly but without the prosthetic socket were used for stimulus comparison. Simulation showed that more than 90% of the trabecular bone volume in the amputated femur with an ischial containment socket registered compressive strain magnitudes below 300με. These strain magnitudes are below the threshold for bone maintenance as per mechanotransduction theory (i.e., they lie within the disuse window). Only 50% of the bone was in the disuse window for the mirror model for the gait instances considered. These results are consistent with reported in vivo evidence which shows that transfemoral prosthesis users may lose bone mass irrespective of age or mobility levels when using traditional socket designs. Clinically, this study shows that prosthetic sockets that support load through the ischium alter the kinetic chain and preclude application of mechanical stimulus that sustains healthy levels of bone mass in the proximal femur. The study also shows that femur length, prosthetic alignment and tissue tone influence this stimulus.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupled Finite Element Model of the Middle and Inner Ear as Virtual Test Environment for Stapes Surgery","authors":"D. Burovikhin,&nbsp;M. Lauxmann","doi":"10.1002/cnm.70013","DOIUrl":"https://doi.org/10.1002/cnm.70013","url":null,"abstract":"<p>In order to evaluate the performance of different types of middle-ear prostheses, a model of human ear was developed. The model was created using finite element (FE) method with the ossicles modeled as rigid bodies. First, the middle-ear FE model was developed and validated using the middle-ear transfer function measurements available in literature including pathological cases. Then, the inner-ear FE model was developed and validated using tonotopy, impedance, and relative BM motion level curves from literature. Both models are based on preexisting research with some improvements and were combined into one coupled FE model. The stapes in the coupled FE ear model was replaced with a model of a stapes prosthesis to create a reconstructed ear model that can be used to estimate how different types of stapes protheses perform relative to each other as well as to the natural ear. The influence of the diameter of the prosthesis as well as the influence of the sealing and opening of the gap in the footplate were investigated along with different measures such as maximum basilar membrane displacement, intracochlear pressure, pressure in scala vestibuli, oval and round window volume displacements, and prosthesis displacement. This will help in designing new innovative types of stapes prostheses or any other type of middle-ear prostheses, as well as to improve the ones that are already available on the market.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computation of Viscoelastic Shear Shock Waves Using Finite Volume Schemes With Artificial Compressibility","authors":"Harold Berjamin","doi":"10.1002/cnm.70012","DOIUrl":"https://doi.org/10.1002/cnm.70012","url":null,"abstract":"<p>The formation of shear shock waves in the brain has been proposed as one of the plausible explanations for deep intracranial injuries. In fact, such singular solutions emerge naturally in soft viscoelastic tissues under dynamic loading conditions. To improve our understanding of the mechanical processes at hand, the development of dedicated computational models is needed. The present study concerns three-dimensional numerical models of incompressible viscoelastic solids whose motion is analysed by means of shock-capturing finite volume methods. More specifically, we focus on the use of the artificial compressibility method, a technique that has been frequently employed in computational fluid dynamics. The material behaviour is deduced from the Fung–Simo quasi-linear viscoelasiticity (QLV) theory where the elastic response is of Yeoh type. We analyse the accuracy of the method and demonstrate its applicability for the study of nonlinear wave propagation in soft solids. The numerical results cover accuracy tests, shock formation and wave focusing.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnm.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Scale Computational Model of the Hepatic Circulation Applied to Predict the Portal Pressure After Transjugular Intrahepatic Portosystemic Shunt (TIPS)","authors":"Tianqi Wang,&nbsp;Yi Xiang,&nbsp;Jitao Wang,&nbsp;Jiaqi Gu,&nbsp;Ling Yang,&nbsp;Deqiang Ma,&nbsp;He Zhu,&nbsp;Tianyu Liu,&nbsp;Chunlong Li,&nbsp;Qi Zhang,&nbsp;Jiahao Han,&nbsp;Deping Ding,&nbsp;Wei Wang,&nbsp;Qianlong Li,&nbsp;Haoguang Wan,&nbsp;Xiaolong Qi","doi":"10.1002/cnm.3908","DOIUrl":"10.1002/cnm.3908","url":null,"abstract":"<div>\u0000 \u0000 <p>Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertension. In clinical practice, the diameter of the stent forming a shunt is usually selected empirically, which will influence the postoperative portal pressure. Clinical studies found that inappropriate portal pressure after TIPS is responsible for poor prognosis; however, there is no scheme to predict postoperative portal pressure. Therefore, this study aims to develop a computational model applied to predict the portal pressure after TIPS ahead of the surgery. For this purpose, a patient-specific 0-3-D multi-scale computational model of the hepatic circulation was developed based on preoperative clinical data. The model was validated using the prospectively collected clinical data of 18 patients. Besides, the model of a representative patient was employed in the numerical experiment to further investigate the influences of multiple pathophysiological and surgical factors. Results showed that the difference between the simulated and in vivo measured portal pressures after TIPS was −1.37 ± 3.51 mmHg, and the simulated results were significantly correlated with the in vivo measured results (<i>r</i> = 0.93, <i>p</i> &lt; 0.0001). Numerical experiment revealed that the estimated model parameters and the severity of possible inherent portosystemic collaterals slightly influenced the simulated results, while the shunt diameter considerably influenced the results. In particular, the existence of catheter for pressure measurement would markedly influence postoperative portal pressure. These findings demonstrated that this computational model is a promising tool for predicting postoperative portal pressure, which would guide the selection of stent diameter and promote individualization and precision of TIPS.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a Cochlear Implant Be Used as an Electrical Impedance Tomography Device?","authors":"Friedemarie Fourie,&nbsp;Joshua Thiselton,&nbsp;Tania Hanekom","doi":"10.1002/cnm.3907","DOIUrl":"10.1002/cnm.3907","url":null,"abstract":"<p>The imaging of the live cochlea is a challenging task. Regardless of the quality of images obtained from modern clinical imaging techniques, the internal structures of the cochlea mainly remain obscured. Electrical impedance tomography (EIT) is a safe, low-cost alternative medical imaging technique with applications in various clinical scenarios. In this article, EIT is investigated as an alternative method to image and extract the centre of gravity of the modiolus in vivo. This information can be used to augment present postoperative medical imaging techniques to investigate the cochlea. The cochlear implant EIT system was simulated by modelling user-specific electrode array trajectories within a simple conductive medium containing an inhomogeneity representing the modiolus. The method included an adapted adjacent stimulation protocol for data collection. For the image reconstruction, NOSER and Tikhonov priors were considered. A parameter analysis was conducted to find the most robust combination of image priors and hyperparameters for this application. The cochlear implant EIT methodology was validated at different noise levels for four electrode array trajectories. Comparing the NOSER and Tikhonov priors, it was observed that the NOSER prior exhibits superior centre of gravity localisation performance in cochlear implant EIT image reconstruction for different noise levels and user-dependent variability in electrode array trajectories. Image reconstruction, using a NOSER prior at a hyperparameter value of approximately 0.001, resulted in an average centre of gravity localisation error of less than 4% for all electrode array trajectories using difference imaging and less than 5.5% using absolute imaging.</p>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Evaluation of Intra-Aortic Dual-Balloon Pump Based on Fluid–Structure Interaction","authors":"Hongchao Ma,&nbsp;Yuhan Wang,&nbsp;Bin Gao,&nbsp;Shu Li,&nbsp;Zhiming Song,&nbsp;Yu Chang,&nbsp;Ran Zhang","doi":"10.1002/cnm.3899","DOIUrl":"10.1002/cnm.3899","url":null,"abstract":"<div>\u0000 \u0000 <p>The intra-aortic balloon pump (IABP) is a widely-used mechanical circulatory support device that enhances hemodynamics in patients with heart conditions. Although the IABP is a common clinical tool, its effectiveness in enhancing outcomes for patients with acute myocardial infarction and cardiogenic shock remains disputed. This study aimed to assess the effectiveness of intra-aortic dual-balloon pump (IADBP) and its impact on aortic hemodynamics compared with an IABP. Three-dimensional finite element models were constructed for the aorta, IABP, and IADBP, followed by numerical simulation using the fluid–structure coupling (FSI) method. Three simulations were conducted: Heart failure patients without assistive devices (Case A), those with IABP (Case B), and those with IADBP (Case C). The study assessed the IADBP's hemodynamic effects by measuring aortic branch blood flow, left ventricular afterload, aortic wall stress, and wall shear stress. IADBP outperformed IABP in enhancing blood flow to the coronary arteries, upper limbs, and brain vessels (left and right coronary arteries: 0.88 vs. 1.27, 1.27 vs. 1.99 mL/beat; brachiocephalic artery, left common carotid artery, and left subclavian artery: 6.08 vs. 12.39, 2.48 vs. 4.97, 2.31 vs. 5.08 mL/beat). IADBP also demonstrated superior performance in counterpulsation pressure and left ventricular ejection (counterpulsation phase: 97.41 mmHg vs. 110.03 mmHg; ventricular unloading phase: 72.21 mmHg vs. 66.46 mmHg). The use of IADBP elevates stress on the aortic wall and wall shear stress, potentially affecting vascular health. IADBP effectively addresses upper limb and cerebral hypoperfusion issues associated with IABP, demonstrating superior performance in enhancing counterpulsation pressure and left ventricular ejection. Despite potential vascular biomechanical effects, IADBP provide a promising clinical treatment option. Further studies are needed to refine IADBP ‘s design and evaluate its long-term clinical efficacy.</p>\u0000 </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}