胡桃钳综合征血流数值模拟:血流动力学参数的获取及临床应用

IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Lei Chen, Guoqiu Liu, Lei Xian, Bo Zhang, Wen-Quan Tao
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引用次数: 0

摘要

采用无创技术为胡桃夹子综合征的临床诊断和治疗提供更精确的参数是目前胡桃夹子综合征研究的重点。然而,由于患者的个体差异和监测技术的限制,迫切需要一种新的方法来获得更准确的参数。本研究基于两例胡桃夹子综合征患者的影像学资料,数值模拟左肾静脉血流过程,揭示血流速度、压力和壁剪应力变化引起的不同临床症状。此外,本工作还比较了两种不同压缩程度下血流参数的动态变化。研究表明,左肾静脉入口压力升高会增加静脉充血的风险。流动分离使血液流速降低50%-60%,造成一系列流动障碍。压缩区附近壁面剪切应力增加15 ~ 20倍,加重左肾静脉血流损伤。压缩程度的增加加剧了血流障碍和血流对血管壁的影响。本研究介绍了一种通过计算流体力学获得血流动力学参数的方法,并总结了不同血流参数异常变化引起的临床症状。该方法不受监测技术的限制,为胡桃夹子综合征的临床诊断和体外支架结构的优化设计提供了更可靠的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Numerical Simulation of Blood Flow in Nutcracker Syndrome: Acquisition of Hemodynamic Parameters and Clinical Application

Adopting noninvasive techniques to provide more precise parameters related to the clinical diagnosis and treatment of nutcracker syndrome is currently the focus of research on nutcracker syndrome. However, due to individual differences in patients and limitations in monitoring techniques, there is an urgent need for a new method to obtain more accurate parameters. This work is based on imaging data from two patients with nutcracker syndrome and numerically simulates the blood flow process in the left renal vein, revealing different clinical symptoms caused by changes in flow velocity, pressure, and wall shear stress. Besides, this work also compares the dynamic changes of blood flow parameters under two different degrees of compression. The study indicates that an increase in pressure at the entrance of the left renal vein increases the risk of venous congestion. The flow separation reduces the blood flow rate by 50%–60%, causing a series of flow obstacles. The wall shear stress near the compressed area increased by 15–20 times, exacerbating the damage of blood flow to the left renal vein. The increase in the degree of compression exacerbates flow barriers and the impact of blood flow on the vascular wall. This study introduces a method of obtaining hemodynamic parameters through computational fluid dynamics and summarizes the clinical symptoms caused by abnormal changes in different blood flow parameters. This method provides a more reliable approach for the clinical diagnosis of nutcracker syndrome and the optimization design of extracorporeal stent structures since it is not limited by monitoring techniques.

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来源期刊
International Journal for Numerical Methods in Biomedical Engineering
International Journal for Numerical Methods in Biomedical Engineering ENGINEERING, BIOMEDICAL-MATHEMATICAL & COMPUTATIONAL BIOLOGY
CiteScore
4.50
自引率
9.50%
发文量
103
审稿时长
3 months
期刊介绍: All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.
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