Journal of AaposPub Date : 2026-09-21DOI: 10.1016/j.jaapos.2026.105300
Anne M Lynch, Nathan C Grove, Emily A Auer, Sunni L Mumford, Robert S McDuffie, Amber A Berning, Erica M Wymore, Arden J McReynolds, Jennifer L Patnaik, Emily A McCourt, Jennifer L Jung, Kirk A Bol, Naresh Mandava, Ronald S Gibbs, Brandie D Wagner
{"title":"Hypertensive disorders of pregnancy in the development of retinopathy of prematurity.","authors":"Anne M Lynch, Nathan C Grove, Emily A Auer, Sunni L Mumford, Robert S McDuffie, Amber A Berning, Erica M Wymore, Arden J McReynolds, Jennifer L Patnaik, Emily A McCourt, Jennifer L Jung, Kirk A Bol, Naresh Mandava, Ronald S Gibbs, Brandie D Wagner","doi":"10.1016/j.jaapos.2026.105300","DOIUrl":"10.1016/j.jaapos.2026.105300","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether there is an association between hypertensive disease of pregnancy (HDP) and the development of retinopathy of prematurity (ROP).</p><p><strong>Methods: </strong>This retrospective cohort study was based on the records of an ROP screening registry, which included infants who fulfilled the standard screening criteria for ROP. Analyses included multinomial logistic regression, with sensitivity analyses incorporating inverse probability weighting to account for potential collider bias arising from restriction to preterm infants and subgroups defined by gestational age (GA).</p><p><strong>Results: </strong>In this cohort of 2,100 infants in the registry, 698 (33.2%) developed ROP, and 261 (12.4%) developed severe ROP (type 1 or type 2). Severe HDP (preeclampsia with severe features, HELLP, and eclampsia) was found in 644 infants from mothers (30.7%). The mean GA at delivery was 28.8 ± 2.5 weeks. Across GA, severe HDP was associated with a higher risk of severe ROP compared with normotensive pregnancies up to approximately 28-29 weeks' gestation, with the largest differences observed between 26 and 27 weeks. Among infants born at ≤29 weeks, severe HDP was associated with severe ROP with respect to normotensive births and no ROP (adjusted odds ratio [AOR] = 1.5; 95% CI, 1.0-2.1; P = 0.04). In sensitivity analyses to account for selection into the preterm cohort, results were similar, with severe HDP related to the development of severe ROP (AOR = 1.7; CI, 1.5-2.0, P < 0.01).</p><p><strong>Conclusions: </strong>The association of HDP with ROP varied with GA. Compared with normotensive pregnancies, severe HDP was a risk factor for severe ROP at earlier GA but not for infants born at 29 weeks' gestation or later.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"105300"},"PeriodicalIF":1.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Botulinum toxin injection versus conventional surgery in the management of residual esotropia: a retrospective cohort study.","authors":"Yasser Almuzaini, Taghreed Alnajjar, Shatha Alfrehi","doi":"10.1016/j.jaapos.2026.105299","DOIUrl":"10.1016/j.jaapos.2026.105299","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the success rates of botulinum toxin (BTX) injection and conventional strabismus surgery in treating residual esotropia.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with residual esotropia of >15<sup>Δ</sup> following strabismus surgery treated at a single instituion from 2015 to 2023. Patients were categorized into two groups based on intervention type: the surgery group and the BTX group. The success rate was defined as an angle of deviation of <10<sup>Δ</sup> of esotropia during the last follow-up, at least 3 months after the last intervention.</p><p><strong>Results: </strong>A total of 41 patients were included: 20 in the surgery group and 21 in the BTX group. No statistically significant differences were observed between the groups in terms of age, sex, spherical equivalent, amblyopia, diagnosis, or preintervention angle of deviation. Mean preintervention angles of deviation were 25.40<sup>Δ</sup> ± 9.36<sup>Δ</sup> in the surgical group and 25.14<sup>Δ</sup> ± 6.76<sup>Δ</sup> in the BTX group, which decreased to 10.45<sup>Δ</sup> ± 9.36<sup>Δ</sup> and 11.52<sup>Δ</sup> ± 13.11<sup>Δ</sup>, respectively, after treatment, with no statistically significant difference (P = 0.555). The success rates were 47.6% in the BTX group and 60% in the surgery group (P = 0.427). Exotropia developed in a single patient in each group. Dissociated vertical deviation developed in 2 patients from the surgical group and 1 patient from the BTX group. In the surgical group, 2 patients developed hypertropia; in the BTX group, 4 patients.</p><p><strong>Conclusions: </strong>BTX is comparable to conventional surgery and can be considered in the management of residual esotropia.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"105299"},"PeriodicalIF":1.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2026-08-10DOI: 10.1016/j.jaapos.2026.105279
Sila Dogan Tosun, Alex G Miller, David G Miller, Nancy Hanna
{"title":"Delayed Staphylococcus warneri endophthalmitis in a pediatric marfan patient after scleral-sutured intraocular lens implantation.","authors":"Sila Dogan Tosun, Alex G Miller, David G Miller, Nancy Hanna","doi":"10.1016/j.jaapos.2026.105279","DOIUrl":"10.1016/j.jaapos.2026.105279","url":null,"abstract":"<p><p>Pediatric endophthalmitis is a rare but vision-threatening condition, most commonly associated with trauma worldwide. A case of delayed-onset postoperative Staphylococcus warneri endophthalmitis was identified in a 7-year-old boy with Marfan syndrome after scleral-sutured Akreos AO60 intraocular lens (IOL) implantation. After lensectomy, pars plana vitrectomy, and Gore-Tex-fixated IOL placement with intraoperative moxifloxacin, early postoperative examinations were unremarkable. At postoperative day 59, the patient developed progressive vision loss with white, spherical deposits coating the IOL and hazy fundus view. Despite initially mild inflammation treated with topical corticosteroids, the condition progressed to anterior chamber inflammation with biofilm-like refractile deposits involving the IOL and scleral sutures, prompting vitreous tap, intravitreal vancomycin and ceftazidime, and membrane peeling. Cultures grew rare S. warneri. After transient improvement, recurrent endophthalmitis with vitritis necessitated vitrectomy with IOL and Gore-Tex suture explantation and adjunctive systemic antibiotics. The patient underwent repeat scleral-sutured IOL implantation 4 months later, and best-corrected visual acuity improved to 20/40, with no apparent recurrence of endophthalmitis at 6 months following explantation of the initial scleral-sutured IOL.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"105279"},"PeriodicalIF":1.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe bilateral ocular coloboma and microphthalmia in a neonate with WDR37-associated neurooculocardiogenitourinary syndrome.","authors":"Susana Cerdá Checa, Carolina Vizcaíno Díaz, Cristian Fernández Martínez","doi":"10.1016/j.jaapos.2026.105275","DOIUrl":"10.1016/j.jaapos.2026.105275","url":null,"abstract":"<p><p>We describe a neonate with severe bilateral ocular abnormalities associated with WDR37-related neurooculocardiogenitourinary syndrome. Ocular findings identified at birth included bilateral microphthalmia, microcornea, corneal edema, marked anterior segment dysgenesis, and bilateral colobomatous posterior pole abnormalities. The patient also had multiple systemic anomalies, including complex congenital heart disease, renal dysplasia, skeletal abnormalities, and cerebellar malformation. Clinical exome sequencing identified a de novo pathogenic variant in the WDR37 gene, confirming the diagnosis. This case is notable for the severity and very early neonatal presentation of ocular involvement and further illustrates the phenotypic variability of WDR37-associated disease. Early ophthalmologic evaluation in neonates with multisystem congenital anomalies may provide important diagnostic clues to rare genetic syndromes.</p>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":" ","pages":"105275"},"PeriodicalIF":1.3,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2026-08-01Epub Date: 2026-08-28DOI: 10.1016/j.jaapos.2026.104968
Gil Binenbaum, Kimberly Wei, Chao Phung, Yinxi Yu, Adva Buzi
{"title":"055 Safety and efficacy of systemic corticosteroids in children with orbital cellulitis","authors":"Gil Binenbaum, Kimberly Wei, Chao Phung, Yinxi Yu, Adva Buzi","doi":"10.1016/j.jaapos.2026.104968","DOIUrl":"10.1016/j.jaapos.2026.104968","url":null,"abstract":"","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 4","pages":"Article 104968"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148843107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2026-08-01Epub Date: 2026-08-28DOI: 10.1016/j.jaapos.2026.104969
Brenda Bohnsack, Fatema Ghasia, Shelley Hancock, Naomie Warner, Eric Gaier
{"title":"056 Visual acuity gains maintained with dual-mechanism digital treatment in children with unilateral amblyopia: PUPiL Registry results","authors":"Brenda Bohnsack, Fatema Ghasia, Shelley Hancock, Naomie Warner, Eric Gaier","doi":"10.1016/j.jaapos.2026.104969","DOIUrl":"10.1016/j.jaapos.2026.104969","url":null,"abstract":"","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 4","pages":"Article 104969"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2026-08-01Epub Date: 2026-08-28DOI: 10.1016/j.jaapos.2026.104913
Michael C. Brodsky
{"title":"001 Ocular motor atavisms: the evolutionary basis of infantile strabismus and nystagmus","authors":"Michael C. Brodsky","doi":"10.1016/j.jaapos.2026.104913","DOIUrl":"10.1016/j.jaapos.2026.104913","url":null,"abstract":"","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 4","pages":"Article 104913"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of AaposPub Date : 2026-08-01Epub Date: 2026-08-28DOI: 10.1016/j.jaapos.2026.104964
Mohammadali Ashraf, Nicholas A. Tomaras, Hasan Khan, Anubhav Pradeep, Abdullah Ahmed, Mohamad Alzein, Abdelrahman Elhusseiny, Mehmet Cem Mocan, Hajirah Saeed
{"title":"051 Etiology, demographics, and clinical features of dense pediatric cataracts","authors":"Mohammadali Ashraf, Nicholas A. Tomaras, Hasan Khan, Anubhav Pradeep, Abdullah Ahmed, Mohamad Alzein, Abdelrahman Elhusseiny, Mehmet Cem Mocan, Hajirah Saeed","doi":"10.1016/j.jaapos.2026.104964","DOIUrl":"10.1016/j.jaapos.2026.104964","url":null,"abstract":"","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"30 4","pages":"Article 104964"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}